Ernst Schering Foundation symposium proceedings最新文献_第5页

Asymmetric organocatalysis on a technical scale: current status and future challenges. 技术规模上的不对称有机催化:现状与未来挑战。

Ernst Schering Foundation symposium proceedings Pub Date : 2007-01-01

H Gröger

引用次数: 0

Nucleophilic carbenes as organocatalysts. 亲核羰基作为有机催化剂。

Ernst Schering Foundation symposium proceedings Pub Date : 2007-01-01

F Glorius, K Hirano

引用次数: 0

Role of the metabolic stress responses of apoptosis and autophagy in tumor suppression. 凋亡和自噬的代谢应激反应在肿瘤抑制中的作用。

Ernst Schering Foundation symposium proceedings Pub Date : 2007-01-01 DOI: 10.1007/2789_2008_087

E White

引用次数: 32

Cancer diagnostics using 1H-NMR-based metabonomics. 利用基于核磁共振的代谢组学进行癌症诊断。

Ernst Schering Foundation symposium proceedings Pub Date : 2007-01-01 DOI: 10.1007/2789_2008_095

K Odunsi

{"title":"Cancer diagnostics using 1H-NMR-based metabonomics.","authors":"K Odunsi","doi":"10.1007/2789_2008_095","DOIUrl":"https://doi.org/10.1007/2789_2008_095","url":null,"abstract":"For several solid human malignancies, currently available serum biomarkers are insufficiently reliable to distinguish patients from healthy individuals. Metabonomics, the study of metabolic processes in biologic systems, is based on the use of 1H-NMR spectroscopy and multivariate statistics for biochemical data generation and interpretation and may provide a characteristic fingerprint in disease. Here we review our initial experiences utilizing the metabonomic approach for discriminating sera from women with epithelial ovarian cancer (EOC) from healthy controls. 1H-NMR spectroscopic analysis was performed on preoperative serum specimens of 38 EOC patients, 12 patients with benign ovarian cysts and 53 healthy women. PCA analysis allowed correct separation of all serum specimens from 38 patients with EOC (100%) from all of the 21 premenopausal normal samples (100%) and from all the sera from patients with benign ovarian disease (100%). In addition, it was possible to correctly separate 37 of 38 (97.4%) cancer specimens from 31 of 32 (97%) postmenopausal control sera. ROC analysis indicated that the sera from patients with and without disease could be identified with 100% sensitivity and specificity at the 1H-NMR regions 2.77 parts per million (ppm) and 2.04 ppm from the origin (AUC of ROC curve = 1.0). These findings indicate that the 1H-NMR metabonomic approach deserves further evaluation as a potential novel strategy for the early detection of EOC.","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 4","pages":"205-26"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2008_095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27691254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Defining personal nutrition and metabolic health through metabonomics. 通过代谢组学定义个人营养和代谢健康。

Ernst Schering Foundation symposium proceedings Pub Date : 2007-01-01 DOI: 10.1007/2789_2008_097

S Rezzi, F-P J Martin, S Kochhar

{"title":"Defining personal nutrition and metabolic health through metabonomics.","authors":"S Rezzi, F-P J Martin, S Kochhar","doi":"10.1007/2789_2008_097","DOIUrl":"https://doi.org/10.1007/2789_2008_097","url":null,"abstract":"A major charter for modern nutrition is to provide a molecular basis for health outcome resulting from different food choices and how this could be designed to maintain individual health free of disease. Nutrigenomic techniques have been developed to generate information at various levels of biological organization, i.e. genes, proteins, and metabolites. Within this frame, metabonomics targets the molecular characterization of a living system through metabolic profiling. The metabolic profiles are explored with sophisticated data mining techniques mainly based on multivariate statistics, which can recover key metabolic information to be further linked to biochemical processes and physiological events. The power of metabonomics relies on its unique ability to assess functional changes in the metabolism of complex organisms stemming from multiple influences such as lifestyle and environmental factors. In particular, metabolic profiles encapsulate information on the metabolic activity of symbiotic partners, i.e. gut microflora, in complex organisms, which represent major determinant in nutrition and health. Therefore, applications of metabonomics to nutrition sciences led to the nutrimetabonomics approach for the classification of dietary responses in populations and the possibility of optimized or personalized nutritional management.","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 4","pages":"251-64"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2008_097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27691256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Estrogens, progestins, and risk of breast cancer. 雌激素，孕激素和乳腺癌的风险。

Ernst Schering Foundation symposium proceedings Pub Date : 2007-01-01 DOI: 10.1007/2789_2007_059

M C Pike, A H Wu, D V Spicer, S Lee, C L Pearce

{"title":"Estrogens, progestins, and risk of breast cancer.","authors":"M C Pike, A H Wu, D V Spicer, S Lee, C L Pearce","doi":"10.1007/2789_2007_059","DOIUrl":"https://doi.org/10.1007/2789_2007_059","url":null,"abstract":"Obesity is associated with a decreased risk of breast cancer in premenopausal women but an increased risk in postmenopausal women, an effect that increases with time since menopause. Analysis of these effects of obesity shows that there is a ceiling to the carcinogenic effect of estrogen on the breast; increases in nonsex hormone-binding globulin-bound estradiol (non-SHBG bound E2) exceeding approximately 10.2 pg/ml have no further effect on breast cancer risk; this ceiling is lower than the lowest level seen during the menstrual cycle. This suggests that the effects of menopausal estrogen therapy (ET) and menopausal estrogen-progestin therapy (EPT) on a woman's breast cancer risk will greatly depend on her body mass index (BMI; weight in kilograms/height in meters squared, kg/m2) with the largest effects being in slender women. Epidemiological studies confirm this prediction. Our best estimates, per 5 years of use, of the effects of ET on breast cancer risk is a 30% increase in a woman with a BMI of 20 kg/m2 decreasing to an 8% increase in a woman with a BMI of 30 kg/m2; the equivalent figures for EPT are 50% and 26%. The analysis of the effects of estrogen also shows that even reducing the dose of estrogen in ET and EPT by as much as a half will have little or no effect on these risks. Reducing the progestin dose is likely to significantly reduce the risk of EPT: this is possible with an endometrial route of administration.","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 1","pages":"127-50"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2007_059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27487550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Molecular imaging of tumor metabolism and apoptosis. 肿瘤代谢与凋亡的分子影像学研究。

Ernst Schering Foundation symposium proceedings Pub Date : 2007-01-01 DOI: 10.1007/2789_2008_092

U. Haberkorn, A. Altmann, W. Mier, M. Eisenhut

引用次数: 24

In vivo characterization of progestins with reduced non-genomic activity in vitro. 体外非基因组活性降低的孕激素的体内表征。

Ernst Schering Foundation symposium proceedings Pub Date : 2007-01-01 DOI: 10.1007/2789_2008_077

C. Otto, B. Rohde-Schulz, G. Schwarz, I. Fuchs, M. Klewer, H. Altmann, K. Fritzemeier

引用次数: 3

The interplay between MYC and HIF in the Warburg effect. Warburg效应中MYC和HIF的相互作用。

Ernst Schering Foundation symposium proceedings Pub Date : 2007-01-01 DOI: 10.1007/2789_2008_088

C V Dang

{"title":"The interplay between MYC and HIF in the Warburg effect.","authors":"C V Dang","doi":"10.1007/2789_2008_088","DOIUrl":"https://doi.org/10.1007/2789_2008_088","url":null,"abstract":"c-MYC and the hypoxia-inducible factors (HIFs) are critical factors for tumorigenesis in a large number of human cancers. While the normal function of MYC involves the induction of cell proliferation and enhancement of cellular metabolism, the function of HIF, particularly HIF-1, involves adaptation to the hypoxic microenvironment, including activation of anaerobic glycolysis. When MYC-dependent tumors grow, the hypoxic tumor microenvironment elevates the levels of HIF, such that oncogenic MYC and HIF collaborate to enhance the cancer cell's metabolic needs through increased uptake of glucose and its conversion to lactate. HIF is also able to attenuate mitochondrial respiration through the induction of pyruvate dehydrogenase kinase 1 (PDK1), which in part accounts for the Warburg effect that describes the propensity for cancers to avidly take up glucose and convert it to lactate with the concurrent decrease in mitochondrial respiration. Target genes that are common to both HIF and MYC, such as PDK1, LDHA, HK2, and TFRC, are therefore attractive therapeutic targets, because their coordinate induction by HIF and MYC widens the therapeutic window between cancer and normal tissues.","PeriodicalId":87471,"journal":{"name":"Ernst Schering Foundation symposium proceedings","volume":" 4","pages":"35-53"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/2789_2008_088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27690207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 111

Mitochondria and cancer. 线粒体和癌症。

Ernst Schering Foundation symposium proceedings Pub Date : 2007-01-01 DOI: 10.1007/2789_2008_086

P Rustin, G Kroemer

引用次数: 10