Cellscience最新文献

FGF ligands emerge as potential specifiers of synaptic identity. FGF 配体成为突触特性的潜在指定者。

Cellscience Pub Date : 2010-07-27

Kieran Jones, M Albert Basson

{"title":"FGF ligands emerge as potential specifiers of synaptic identity.","authors":"Kieran Jones, M Albert Basson","doi":"","DOIUrl":"","url":null,"abstract":"The central nervous system (CNS) consists of trillions of interconnected neurons. The specialised regions of intercellular contact between neurons where information, usually in chemical form, is transmitted are called synapses. The last decade has seen an unprecedented advance in our understanding of the molecular nature, formation and maintenance of synapses. A major question that remains is how synaptic identity is established to ensure the coordinated recruitment of the correct synaptic components on both sides of the synapse so that the neurotransmitter accumulating on the presynaptic side is matched with its cognate receptor on the postsynaptic membrane. Until recently, Fibroblast Growth Factors (FGFs) have been thought of as general regulators of synaptic aptitude through their ability to increase the expression of synaptic proteins or promote neurite branching. A recent study shows that the decision to form an excitatory vs. inhibitory synapse may to a large extent be determined by the identity of the FGF ligand present at the postsynaptic membrane. This observation establishes FGFs as key target-derived cues that are involved in determining synaptic identity.","PeriodicalId":87394,"journal":{"name":"Cellscience","volume":"7 1","pages":"33-42"},"PeriodicalIF":0.0,"publicationDate":"2010-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948530/pdf/ukmss-31661.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29326721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The epigenetics of memory storage in the brain. 大脑中记忆储存的表观遗传学。

Cellscience Pub Date : 2010-07-01

R Ryley Parrish, Swati Gupta, Farah D Lubin

引用次数: 0

Influenza antigenic drift: what is the driving force? 流感抗原漂移:驱动力是什么?

Cellscience Pub Date : 2010-01-01

Qinghua Wang

引用次数: 0

CFTR is a mechanosensitive anion channel: a real stretch? CFTR 是一种机械敏感性阴离子通道：真正的伸展？

Cellscience Pub Date : 2010-01-01

Michael A Gray

{"title":"CFTR is a mechanosensitive anion channel: a real stretch?","authors":"Michael A Gray","doi":"","DOIUrl":"","url":null,"abstract":"The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel represents the rate-limiting step for chloride and fluid secretion in most epithelial tissues in the body. More recently, CFTR activity has also been shown to regulate muscle contraction, neuroendocrine function, and cartilage formation, implicating the channel in many important physiological activities from diverse systems. A major interest in the channel stems from the fact that loss of function mutations in the gene encoding CFTR result in the inherited disease cystic fibrosis, one of the most common, life threatening, diseases found in the Caucasian population. At the other end of the spectrum, and affecting far more people globally, over active CFTR causes clinically important secretory diarrhoea induced by toxins from pathogenic bacteria like cholera. Therefore, it is not surprising that much research has focussed on understanding how CFTR channel activity is regulated and what goes wrong in disease states. For the channel to open, it must be first phosphorylated by PKA, and then ATP must also bind to CFTR's cytoplasmic domains. Now a recent Nature Cell Biology paper has shown that CFTR can also be activated by increases in membrane tension (or stretch), through a phosphorylation and ATP- independent mechanism. This unexpected and novel finding identifies CFTR as a mechanosensitive ion channel. This work could have major implications for our understanding of the biological control of CFTR as well identifying new roles for this channel in mechanosensitive tissues and processes such as regulatory volume decrease and muscle contraction.","PeriodicalId":87394,"journal":{"name":"Cellscience","volume":"7 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000599/pdf/ukmss-32205.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29530665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How can studying psychopaths help us understand the neural mechanisms of moral judgment? 研究精神病患者如何帮助我们理解道德判断的神经机制?

Cellscience Pub Date : 2010-01-01

Andrea L Glenn

引用次数: 0

The role of CCK8 in the inhibition of glucose production. CCK8在抑制葡萄糖生成中的作用。

Cellscience Pub Date : 2009-10-27

Christopher J Ramnanan, Dale S Edgerton, Alan D Cherrington

引用次数: 0

Roles of retrotransposons in benign and malignant hematologic disease. 反转录转座子在良性和恶性血液疾病中的作用。

Cellscience Pub Date : 2009-10-27

Anna M Schneider, Amy S Duffield, David E Symer, Kathleen H Burns