Research and reports in neonatology最新文献

{"title":"Perlman Syndrome with Deletion of DIS3L2 Gene","authors":"K. Salameh, B. Viswanathan, Z. Nawaz, L. Habboub, A. Tomerak, Rajesh Pattuvalappil","doi":"10.2147/rrn.s270490","DOIUrl":"https://doi.org/10.2147/rrn.s270490","url":null,"abstract":": Perlman syndrome is a rare genetic disorder with autosomal recessive inheritance. It is caused by deletion of the DIS3L2 gene on the long arm of chromosome 2. Though more than 30 cases have been reported in the literature with clinical features of the syndrome, very few cases have identified underlying genetic defects. The clinical features of Perlman syndrome have similarities with those of Beckwith–Wiedemann syndrome (BWS), prune belly syndrome (PBS) and Simpson–Golabi–Behmel syndrome (SGBS1). Affected patients have macrosomia, dysmorphic features, hypotonia, laxity of abdominal wall, cryptorchidism, renal anomalies and risk of development of Wilm’s tumour. Here we report a neonate with typical clinical features of Perlman syndrome, with deletion of DIS3L2 gene confirmed by array comparative genomic hybridization (aCGH).","PeriodicalId":87354,"journal":{"name":"Research and reports in neonatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47439079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge Outcome of Helping Babies Breathe Training in Southern Nations, Nationalities and People’s Region, Ethiopia: A Pre- and Post-Test Study","authors":"Lalisa Chewaka Gamtessa, Kindie Mitiku Kebede","doi":"10.2147/RRN.S274235","DOIUrl":"https://doi.org/10.2147/RRN.S274235","url":null,"abstract":"Introduction: Helping Babies Breathe (HBB) training is a key strategy to decrease neonatal mortality. The objectives of this study were to evaluate the effect of HBB on knowledge outcome and to assess the knowledge outcome in relation to different variables in Southern Nations, Nationalities and People’s Region (SNNPR), Ethiopia. Methods: A pre- and post-test study was conducted using data from HBB trainings given for health workers. The training was given for 2.5 days and the knowledge outcome was evaluated using validated 18 questions. The post-test was given immediately after the training. Data were entered into Epi Info 7 and imported to SPSS version 21. The paired sample t -test was used to compare pre- and post-test means. The independent sample t -test was used to determine the relationship between knowledge outcome with sex, education level, and health facility. One way ANOVA with post hoc test was computed for comparing the knowledge outcome of the training among different professions. The general linear model (GLM) was used to determine the main and interaction effects. The statistical significance was determined at p<0.05. Results: In this study, we assessed the knowledge outcome of 98 trainees. The trainees’ mean knowledge score increased from 64.4% (pre-test) to 80.7% (post-test). The difference was statistically significant with p <0.001. Sex (pre-test p =0.003, post-test p =0.005) and education level (pre-test p =0.017, post-test p =0.037) of the trainees were significantly associated with the knowledge outcome while profession and type of health facility were not significant ( p >0.05). The GLM showed that the interaction effects of sex, education level, profession, and type of health facility over the knowledge outcome were non-significant ( p >0.05). Conclusion: The knowledge outcome of trainees significantly improved after the HBB training. It was significantly varied with sex and education level both at pre- and post-test. Therefore, these variables need consideration when arranging HBB trainings.","PeriodicalId":87354,"journal":{"name":"Research and reports in neonatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47575535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor Universal Coverage of Immediate Essential Newborn Care at Hospitals of Wollega Zones, The Case of Western Ethiopia","authors":"H. Kasaye, M. Yilma, F. Bobo, Ginenus Fekadu","doi":"10.2147/rrn.s260369","DOIUrl":"https://doi.org/10.2147/rrn.s260369","url":null,"abstract":"Background: Thousands of neonates die annually in Ethiopia related to preventable causes. Low-quality care enhances neonatal morbidity and mortality unless remedial action is taken based on evidence. Here, we show the magnitude of essential newborn care service provisions and factors contributing to substandard care. Methods: We conducted a cross-sectional study in four hospitals of Wollega Zones from April to August 2017. We calculated 390 samples using Epi-info stat calc using necessary assumptions. A systematic random sampling method was used to select study participants. Non-participatory observations of essential newborn care service provisions were conducted using a World Health Organization checklist. We used binary logistic regression models to identify the independent predictors and reported variables having P-values less than 0.05 at 95% confidence intervals of odds ratios as significantly associated variables. Results: A total of 375 childbirths were observed and among these, only 11 (2.9%) neonates were given all components of immediate essential newborn care, while 315 (84.0%) of the newborns initiated early breast-feeding, 131 (34.9%) kept warm, 108 (28.8%) got disease prevention measures (89 (23.7%) helped to breathe, and only 14 (3.7%) kept clean immediately following the birth. Maternal highest annual income, maternal age, need of resuscitation, presence of assistant to a birth attendant, childbirth during the weekends were statistically significantly associated with immediate essential neonatal care categories in various predictive level. Conclusion: The essential newborn care provided for the neonates during childbirth at the health facilities was found to be poor. Continued efforts at improving access to quality essential newborn care provided for neonates are required. Hospital administrators need to consider enhancing the number of skilled delivery attendants, and enforcing implementations of essential newborn care standards is mandatory to protect the lives of neonates.","PeriodicalId":87354,"journal":{"name":"Research and reports in neonatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41632623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Plasma Lactate Dehydrogenase Testing in the Prediction of Severe Conditions in Newborn Infants: A Prospective Study","authors":"T. N. V. Anh, Hao Tran Kiem, H. Hoang","doi":"10.2147/rrn.s254500","DOIUrl":"https://doi.org/10.2147/rrn.s254500","url":null,"abstract":"Purpose: Plasma lactate dehydrogenase (LDH) is an indicator of body tissue hypoxia. This study aimed to determine the relationship between plasma lactate dehydrogenase concentrations and severe conditions in newborn infants. Patients and Methods: A cross-sectional study was performed on newborn infants who were admitted to the newborn care unit at Hue University hospital from April 2016 to May 2017 in the early neonatal period (within 12 hours postpartum). Plasma LDH was measured at the time of admission and correlated to clinical conditions. Results: In 275 newborn infants, plasma LDH levels in the term infants were significantly higher than that in the preterm infants [751 (IQR: 602–922) vs 594 (IQR: 496.75–767.25), p=0.0006]. There was a relationship between the signs of feeding problems, tachypnea, and cyanosis with plasma LDH levels (p < 0.01). Infants with asphyxia had significantly higher LDH values than the non-asphyxia group [756 (640–1110) vs 712 (576–882.25) p=0.0289]. Infants with early-onset neonatal sepsis had significantly higher LDH values than those without early-onset neonatal sepsis [755.5 (IQR: 645–960.5) vs 707 (IQR: 562.25–881.25) p=0.0035]. Infants with respiratory distress requiring continuous positive airway pressure (CPAP) had significantly higher LDH values than those with illnesses not requiring CPAP [903 (IQR: 628.75–1285.25) vs 719 (IQR: 576.5–882) p=0.0421]. By using multivariate regression analysis, we found a significant multifactorial correlation between gestational age, early-onset neonatal sepsis, asphyxia, and respiratory distress requiring CPAP with plasma LDH levels (p <0.05). Conclusion: Plasma LDH level can be a good marker for the prognosis of severe conditions in newborn infants, including early-onset neonatal sepsis, asphyxia, and respiratory-distress.","PeriodicalId":87354,"journal":{"name":"Research and reports in neonatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/rrn.s254500","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44638103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualizing Oral Feeding Assessment and Therapies in the Newborn","authors":"D. Azuma, Jill L. Maron","doi":"10.2147/rrn.s223472","DOIUrl":"https://doi.org/10.2147/rrn.s223472","url":null,"abstract":": Oral feeding competency is a milestone most infants must achieve prior to discharge. It is a developmentally complex task that requires integration of multiple sensory inputs, central nervous system maturation, motor coordination, and respiratory stability. While ensuring safety during oral feeding is important to reduce morbidities, we must optimize developmental windows to expedite feeding maturation. Currently, many of the assessments and therapies related to oral feeding skills focus solely on nutritive and non-nutritive sucking. Yet, this essential re fl ex is only one component of oral feeding. Speci fi c challenges faced by individual newborns are often unique, and delays in development in any one of the many systems involved in oral feeding can lead to prolonged oral feeding maturation. Expanding the fi eld to go beyond targeting oral motor skills to consider all aspects of feeding maturity, inclusive of sensory integration and hunger signaling, is needed to advance care. As technology continues to develop at a rapid pace, the fi eld must compare the ef fi cacy of these clinical and technologic assessments and therapies. In this review, we will address the complexity of neonatal feeding, review assessment tools and interventions for feeding safety and developmental readiness, and propose an individualized, multi-faceted approach to oral feeding evaluation and intervention.","PeriodicalId":87354,"journal":{"name":"Research and reports in neonatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/rrn.s223472","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44233206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal (and Infant) Coarctation of the Aorta: Management Challenges","authors":"P. Rao","doi":"10.2147/rrn.s189545","DOIUrl":"https://doi.org/10.2147/rrn.s189545","url":null,"abstract":": Surgical correction of coarctation of the aorta was described in the mid-1940s and balloon angioplasty was introduced in the early 1980s. Several types of surgical methods were devised to treat native coarctation, but eventually, resection and end-to-end anastomosis became a standard approach with the use of extended end-to-end anastomosis for babies with hypoplasia of the isthmus and/or transverse aortic arch. Balloon angioplasty was considered as a substitute for surgical correction and was so used for some time, but because of high rate of recurrence in the neonate and young infant, most centers have reverted back to surgical correction as a primary mode of treatment of aortic coarctation in the neonate. Further research into feasibility of using stents in the management of coarctation in neonates and young infants are necessary. It is generally agreed that balloon angioplasty is the treatment of choice for post-surgical aortic recoarctations.","PeriodicalId":87354,"journal":{"name":"Research and reports in neonatology","volume":"54 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/rrn.s189545","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41303948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Function and Systolic Blood Pressure in Very Low Birth Weight Infants at 34 - 36 Weeks of Corrected Age.","authors":"Ladawna L Gievers,&nbsp;Randall D Jenkins,&nbsp;Amy Laird,&nbsp;Marissa C Macedo,&nbsp;Diane Schilling,&nbsp;Cindy T McEvoy","doi":"10.2147/rrn.s208194","DOIUrl":"https://doi.org/10.2147/rrn.s208194","url":null,"abstract":"<p><strong>Purpose: </strong>Preterm infants are at increased risk of systemic hypertension compared to term infants. Bronchopulmonary dysplasia (BPD) has been shown to be associated with hypertension in preterm infants albeit with no causation reported. BPD is characterized by abnormal pulmonary function tests (PFTs), specifically elevated passive respiratory resistance (Rrs), decreased passive respiratory compliance (Crs) and decreased functional residual capacity (FRC). There have been no studies comparing PFTs in very low birth weight (VLBW) infants with and without hypertension. We hypothesized that stable VLBW infants with hypertension will have altered PFTs.</p><p><strong>Patients and methods: </strong>Retrospective cohort study of infants < 1500 grams at birth (VLBW) who had PFTs performed near 34-36 weeks of corrected gestational age (CGA). We excluded infants with congenital anomalies, known hypertensive disorders or those at risk of medication-induced hypertension. Data obtained included PFT parameters (Rrs, Crs, FRC) and mean systolic blood pressure (SBP).</p><p><strong>Results: </strong>59 VLBW infants were identified for analysis, 14 with and 45 without hypertension. Hypertensive and normotensive patients were similar in terms of mean gestational age (26.6 vs 27.4 weeks), mean CGA at PFTs (36.1 vs 34.6 weeks) and proportion of BPD (36% vs 36%). The Rrs was significantly higher in hypertensive versus normotensive patients [median Rrs of 0.080 (0.069, 0.090) versus 0.066 (0.054, 0.083) cmH₂O/mL/sec; <i>p</i> = 0.04]. There was no difference in systolic blood pressure in the infants with and without BPD.</p><p><strong>Conclusion: </strong>In this cohort of contemporary VLBW infants, those with hypertension had increased Rrs. This finding warrants a prospective study with a larger sample size and long-term follow-up.</p>","PeriodicalId":87354,"journal":{"name":"Research and reports in neonatology","volume":"9 ","pages":"21-30"},"PeriodicalIF":0.0,"publicationDate":"2019-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/rrn.s208194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39075384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal sepsis biomarkers: where are we now?","authors":"Margaret Gilfillan, V. Bhandari","doi":"10.2147/RRN.S163082","DOIUrl":"https://doi.org/10.2147/RRN.S163082","url":null,"abstract":"php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Research and Reports in Neonatology 2019:9 9–20 Research and Reports in Neonatology Dovepress","PeriodicalId":87354,"journal":{"name":"Research and reports in neonatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/RRN.S163082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43711089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal sepsis and associated factors among newborns in hospitals of Wolaita Sodo Town, Southern Ethiopia","authors":"Abera Mersha, T. Worku, Shitaye Shibiru, Agegnehu Bante, A. Molla, Genzeb Seifu, Girma Huka, Eyerusalem Abraham, T. Teshome","doi":"10.2147/RRN.S193074","DOIUrl":"https://doi.org/10.2147/RRN.S193074","url":null,"abstract":"and Materials and methods: This hospital-based cross-sectional study was conducted in 275 newborns from April 22 to June 29, 2018. Structured interviewer-administered pre-tested questionnaire and check list were used to collect the data. The collected data were entered into Epi data version and then exported into SPSS Windows version 22 for analysis. Bivariate and multivariate analyses were done by using binary logistic regression. The goodness of fit was tested by Hosmer–Lemeshow statistic and Omnibus tests. Multi-co-linearity test was carried out to determine the correlation between independent variables by using standard error and collinearity statistics. Variables with P < 0.25 in the bivariate analysis were included in the final model, and statistical significance was declared at P < 0.05. Results: This study found that 33.8% (95% CI: 28%–39%) of the neonates had neonatal sepsis during admission. Factors such as maternal age, multiple per digital vaginal examination, exclusive and immediate breastfeeding within an hour, put on kangaroo mother care (KMC) within 1 hour, and neonatal age were statistically significantly associated with neonatal sepsis. Conclusion and recommendations: This study indicated that the current rate of neonatal sepsis was still high. As such, strengthening the provision of health information on exclusive and immediate breastfeeding and KMC on postnatal and antenatal care services and decrease multiple per digital vaginal examination as not indicated should better to be promoted.","PeriodicalId":87354,"journal":{"name":"Research and reports in neonatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/RRN.S193074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43791549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incontinentia pigmenti in a term neonate: an atypical presentation","authors":"Sasi Bhushan Gottimukkala, Madhu Jagalasar, G. Sethuraman, S. Kitchanan","doi":"10.2147/RRN.S175262","DOIUrl":"https://doi.org/10.2147/RRN.S175262","url":null,"abstract":": Incontinentia pigmenti is a rare X-linked dominant multi-system disorder that is clinically suspected, based on the characteristic evolution of skin lesions through four stages. We describe a term neonate who presented at birth with pleomorphic skin rashes, including linear hyperpigmented hyperkeratotic lesions and erythematous vesicles, and then developed seizures. She was later histologically and genetically confirmed as a case of incontinentia pigmenti. The simultaneous presence of three stages of skin lesions in the neonatal period is an atypical presentation, which has not been previously well described.","PeriodicalId":87354,"journal":{"name":"Research and reports in neonatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/RRN.S175262","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44502599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}