Madison H. Williams, Ryan M. Williams, D. Mahadevan, C. Ramamurthy
{"title":"Evolving Therapies for Urothelial Carcinoma—Novel Paradigms and Future Directions","authors":"Madison H. Williams, Ryan M. Williams, D. Mahadevan, C. Ramamurthy","doi":"10.17925/OHR.2021.16.2.82","DOIUrl":"https://doi.org/10.17925/OHR.2021.16.2.82","url":null,"abstract":"<p />","PeriodicalId":87332,"journal":{"name":"Oncology & hematology review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67597716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Granger, T. Subhawong, G. D'Amato, Emily E. Jonczak, Erika L. Garbrecht, S. Conway, J. Trent
{"title":"Pexidartinib and CSF1R Inhibitors as Treatment for Tenosynovial Giant Cell Tumors","authors":"C. Granger, T. Subhawong, G. D'Amato, Emily E. Jonczak, Erika L. Garbrecht, S. Conway, J. Trent","doi":"10.17925/OHR.2021.16.2.119","DOIUrl":"https://doi.org/10.17925/OHR.2021.16.2.119","url":null,"abstract":"<p />","PeriodicalId":87332,"journal":{"name":"Oncology & hematology review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67598171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karishma Khullar, Nell Maloney Patel, Cristan Anderson, Anupama Chundury, Darren Carpizo, Daniel Feingold, Miral Grandhi, Howard Hochster, Krupa Jani, Timothy Kennedy, Russell Langan, Kristen Spencer, David August, Salma K Jabbour
{"title":"The Evolving Role of Radiotherapy in Locally Advanced Rectal Cancer and the Potential for Nonoperative Management.","authors":"Karishma Khullar, Nell Maloney Patel, Cristan Anderson, Anupama Chundury, Darren Carpizo, Daniel Feingold, Miral Grandhi, Howard Hochster, Krupa Jani, Timothy Kennedy, Russell Langan, Kristen Spencer, David August, Salma K Jabbour","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Locally advanced rectal cancer has broadly been defined as T3, T4, or lymph node-positive disease. In the 1990s, adjuvant chemoradiation was considered the optimal management for locally advanced rectal cancer. However, the paradigm shifted when the German CAO/ARO/AIO-94 Rectal Cancer trial established neoadjuvant chemoradiation as the standard of care, based on reduced rates of toxicity and local recurrence, as well as higher rates of sphincter preservation compared with postoperative chemoradiation. Both short-course radiation and long-course chemoradiation are currently accepted methods for neoadjuvant treatment, with recent trials showing equivalence in outcomes. While surgery remains the cornerstone of treatment, there are data supporting the use of magnetic resonance imaging for risk stratification in rectal cancer and encouraging prospective data regarding nonoperative management. This review summarizes data on the evolution of treatment for locally advanced rectal cancer and discusses emerging evidence for nonoperative management.</p>","PeriodicalId":87332,"journal":{"name":"Oncology & hematology review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439775/pdf/nihms-1589985.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38300648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristy A Brown, Eleni Andreopoulou, Panagiota Andreopoulou
{"title":"Endocrine Therapy-related Endocrinopathies-Biology, Prevalence and Implications for the Management of Breast Cancer.","authors":"Kristy A Brown, Eleni Andreopoulou, Panagiota Andreopoulou","doi":"10.17925/ohr.2020.16.1.17","DOIUrl":"https://doi.org/10.17925/ohr.2020.16.1.17","url":null,"abstract":"<p><p>Nearly 270,000 new breast cancer cases are predicted to be diagnosed in the USA in 2019 with more than 70% being estrogen receptor positive and treated using endocrine therapy. The suppression of estrogen biosynthesis or action via the use of ovarian suppression, aromatase inhibitors and selective estrogen receptor modulators/degraders, respectively, is effective in approximately 70% of women. The systemic inhibition of estrogen during breast cancer treatment is also associated with side effects due to the important endocrine functions of this steroid hormone, including its role in the maintenance of energy homeostasis and bone health. The current work will present perspectives of the impact of endocrine therapy from the point of view of breast medical oncology, endocrinology, and basic science.</p>","PeriodicalId":87332,"journal":{"name":"Oncology & hematology review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034602/pdf/nihms-1673368.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25590707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypothermic Intraperitoneal Chemotherapy for Gastrointestinal Malignancies—A Relic of the Past or Useful Tool for Today?","authors":"M. Greally, D. Ilson","doi":"10.17925/ohr.2019.15.2.83","DOIUrl":"https://doi.org/10.17925/ohr.2019.15.2.83","url":null,"abstract":"<p />","PeriodicalId":87332,"journal":{"name":"Oncology & hematology review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67597253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neoantigen Vaccine Delivery for Personalized Anticancer Immunotherapy—the PSV™ Platform","authors":"Paisley T. Myers, Lexington Ma Usa Agenus","doi":"10.17925/ohr.2019.15.2.64","DOIUrl":"https://doi.org/10.17925/ohr.2019.15.2.64","url":null,"abstract":"<p />","PeriodicalId":87332,"journal":{"name":"Oncology & hematology review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67597559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Updates in Lung Cancer 2018—What the Pulmonologist Needs to Know","authors":"M. Rivera","doi":"10.17925/OHR.2019.15.1.20","DOIUrl":"https://doi.org/10.17925/OHR.2019.15.1.20","url":null,"abstract":"<p />","PeriodicalId":87332,"journal":{"name":"Oncology & hematology review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67597239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advances in the Treatment of Endometrial and Ovarian Cancer","authors":"D. Mutch","doi":"10.17925/OHR.2019.15.1.23","DOIUrl":"https://doi.org/10.17925/OHR.2019.15.1.23","url":null,"abstract":"<p />","PeriodicalId":87332,"journal":{"name":"Oncology & hematology review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67597302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}