Journal of rheumatology research最新文献_第6页

Primary Care in rheumatoid arthritis 类风湿关节炎的初级保健

Journal of rheumatology research Pub Date : 2019-01-01 DOI: 10.22631/rr.2019.69997.1077

Nahid Kianmehr, A. Afrasiabi, Shabnoor Abdullatif, H. Ansari, F. Shirani, Ali Sobhani Firoozabadi, A. Haghighi

{"title":"Primary Care in rheumatoid arthritis","authors":"Nahid Kianmehr, A. Afrasiabi, Shabnoor Abdullatif, H. Ansari, F. Shirani, Ali Sobhani Firoozabadi, A. Haghighi","doi":"10.22631/rr.2019.69997.1077","DOIUrl":"https://doi.org/10.22631/rr.2019.69997.1077","url":null,"abstract":"BackgroundGeneral practitioners (GPs) have an important role in early diagnosis, treatment, and referring rheumatoid arthritis (RA) patients. Many patients didn’t receive rheumatologist care on appropriate time. Therefore, it seems necessary to evaluate GPs’ knowledge and attitude about RA to identify some of the barriers in the optimal care of patients with RA delivered by GPs.Methods 120 GPs who were selected through simple and non-random sampling from physicians participating in 5 educational seminars which were held in Tehran. The survey questioned their confronting with RA, experience with prescribing disease-modifying anti-rheumatic drugs (DMARDs) and referral to the rheumatologist.Results28.3% of GPs had no RA patients monthly. 35.8% declared that they visit 3-5 RA patients per month on average. 95 out of 120 (79.2%) referred RA to a rheumatologist as soon as possible. Physicians' knowledge sources about rheumatoid arthritis were mostly general medical training (87.5%). 47.5% had low and 5% lacked self-esteem in managing RA patients. 92.5% of GPs were familiar with DMARDs but 22.1% of them have been ordered them. Lack of knowledge about the side effects of DMARDs was the main reason for hesitance to prescribe them. Also, we found being older, male and more experienced GPs are more comfortable in managing RA patients.ConclusionRA care delivered by GPs was not consistent with current treatment guidelines focusing on early DMARDs therapy. GPs do not have enough information and confidence in managing patients with RA. Improving physicians’ knowledge and continued educational programs are suggested.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90525531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Association of TYK2 rs34536443 polymorphism with Susceptibility to Systemic Lupus Erythematous in the Iranian Population 伊朗人群中TYK2 rs34536443多态性与系统性红斑狼疮易感性的关系

Journal of rheumatology research Pub Date : 2018-10-01 DOI: 10.22631/RR.2018.69997.1057

S. Faezi, S. Soltani, M. Akbarian, S. Aslani, Elham Hamzeh, Ali Jamshidi, N. Ahmadzadeh, M. Mahmoudi

{"title":"Association of TYK2 rs34536443 polymorphism with Susceptibility to Systemic Lupus Erythematous in the Iranian Population","authors":"S. Faezi, S. Soltani, M. Akbarian, S. Aslani, Elham Hamzeh, Ali Jamshidi, N. Ahmadzadeh, M. Mahmoudi","doi":"10.22631/RR.2018.69997.1057","DOIUrl":"https://doi.org/10.22631/RR.2018.69997.1057","url":null,"abstract":"Systemic lupus erythematous (SLE) is a multifactorial autoimmune disorder which affects many organs and displays various symptoms. Genetic components contribute to the incidence and development of SLE. A rare functional variant within the tyrosine kinase 2 (TYK2) gene (rs34536443) is a common genetic candidate for several autoimmune diseases, including SLE. This case control study was performed to investigate the possible association of TYK2 single nucleotide polymorphism (SNP) with a predisposition for and clinical features of SLE in the Iranian population.Genotyping was conducted on 600 patients with SLE and 600 sex-, age- and ethnicity-matched control subjects from the Iranian population. Patient and control samples were genotyped for one SNP (rs34536443) by applying allelic discrimination real-time PCR.Statistical analysis of the allele distribution revealed no significant association (OR = 0.67, CI: 0.38-1.17, P value = 0.163) between the rs34536443 C allele and susceptibility to SLE. The CC genotype was not detected in either the patients or controls. Moreover, the CG genotypes showed no significant association with the risk of SLE (OR = 0.66, CI: 0.37-1.72, P value = 0.15).These findings suggest that TYK2 rs34536443 is not associated with SLE susceptibility in the Iranian population. Further investigation is required to examine the mechanisms by which polymorphisms in this gene lead to SLE development.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73655377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Is there any association between human T-lymphotropic virus type 1 (HTLV-1) infection and Behcet’s disease? 人类嗜t淋巴病毒1型(HTLV-1)感染与白塞氏病之间是否存在关联?

Journal of rheumatology research Pub Date : 2018-10-01 DOI: 10.22631/RR.2018.69997.1054

M. Yazdanpanah, M. Hedayati-Moghaddam, M. Sahebari, M. Mahmoudi, Mehran Radfar, Elham Vosoughi, H. Esmaily, Z. Mirfeizi

{"title":"Is there any association between human T-lymphotropic virus type 1 (HTLV-1) infection and Behcet’s disease?","authors":"M. Yazdanpanah, M. Hedayati-Moghaddam, M. Sahebari, M. Mahmoudi, Mehran Radfar, Elham Vosoughi, H. Esmaily, Z. Mirfeizi","doi":"10.22631/RR.2018.69997.1054","DOIUrl":"https://doi.org/10.22631/RR.2018.69997.1054","url":null,"abstract":"Both human T-cell lymphotropic virus type 1 (HTLV-1) infection and Behcet’s disease (BD) are common to a similar geographic area. Furthermore, some clinical presentations of BD and HTLV-1 infection, such as ocular lesions and neurologic involvement, are the same. The aim of this study was to assess a possible association between BD and HTLV-1 infection.In this case-control study, the HTLV-1 infection frequency in BD patients was compared with that for the general population. The case group consisted of 68 patients with a definite diagnosis of BD who referred to a research center at Mashhad University of Medical Sciences in Mashhad, Iran. The control group consisted of 210 healthy individuals selected from the general population of Mashhad. The presence of HTLV antibodies in the sera was assessed using enzyme-linked immunosorbent assay and the seroreactive samples were confirmed by polymerase chain reaction.HTLV-1 infection was detected in 4.41% (3/68) and 1.43% (3/210) of cases and controls, respectively; however, the difference was not statistically significant (P value = 0.16).The prevalence of HTLV1 infection in patients with BD was three-fold higher than in the general population, which suggests an association between these two conditions.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81891017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Assessment of 10-year mortality causes among inpatients with systemic lupus erythematosus 系统性红斑狼疮住院患者10年死亡原因评估

Journal of rheumatology research Pub Date : 2018-10-01 DOI: 10.22631/RR.2018.69997.1056

S. Shenavandeh, A. Nasiri, Gholamreza Abdollahifard

{"title":"Assessment of 10-year mortality causes among inpatients with systemic lupus erythematosus","authors":"S. Shenavandeh, A. Nasiri, Gholamreza Abdollahifard","doi":"10.22631/RR.2018.69997.1056","DOIUrl":"https://doi.org/10.22631/RR.2018.69997.1056","url":null,"abstract":"Systemic lupus erythematosus (SLE) is a potentially life-threatening systemic autoimmune disease that increases the patient’s risk of mortality if left untreated. This study examined the causes of mortality over 10 years in rheumatologic hospitals as referral centers for patients from southern Iran.Medical records and death certificates of patients diagnosed with SLE as the underlying cause of death were retrospectively assessed. Patients were of similar ages (more than 16 years) and had been admitted to Hafez, Shahid Faghihi, or Namazi teaching hospital (affiliated with Shiraz University of Medical Sciences) during the 10-year period from April 2001 to March 2011.A total of 101 (3.3%) SLE inpatients (from 3026 admissions) died in the named hospitals during the study period. Approximately nine deaths had occurred per year. Among them were 85 females and 16 males (female-to-male ratio of 5.3:1). The mean patient age was 36.9±12.8 years (ranging from 16-85) on admission before death. Moreover, the mean disease duration was 5.4±5.8 years. Dyspnea, a decrease in the level of consciousness, chills, and fever were the chief complaints of the majority of patients upon admission. Infections (34.7%) and cardiovascular diseases (28.7%) were the most common causes of death.Infections followed by cardiovascular diseases are still the most frequent causes of in-hospital deaths in SLE patients. No in-hospital deaths occurred due to malignancy during this study.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84970601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Thromboembolism in Behcet’s Disease: A Case Report 白塞病并发肺血栓栓塞1例

Journal of rheumatology research Pub Date : 2018-10-01 DOI: 10.22631/RR.2018.69997.1058

Sepideh Tahsini Tekantapeh, F. Rashidi, A. Khabbazi

{"title":"Pulmonary Thromboembolism in Behcet’s Disease: A Case Report","authors":"Sepideh Tahsini Tekantapeh, F. Rashidi, A. Khabbazi","doi":"10.22631/RR.2018.69997.1058","DOIUrl":"https://doi.org/10.22631/RR.2018.69997.1058","url":null,"abstract":"Behcet’s disease is a vasculitis which presents as recurrent oral and genital aphthous ulceration, uveitis and skin lesions. Unlike other types of vasculitis, venous system involvement is a common manifestation of Behcet’s disease. Despite the high incidence of deep vein thrombosis in Behcet’s disease, pulmonary artery thromboembolism (PTE) is a rare complication. In this article, we report on a 44-year old man who experienced recurring painful oral ulcers, bilateral panuveitis, superficial phlebitis and positive pathergy which had led to a diagnosis of Behcet’s disease 12 years earlier. He developed sudden onset dyspnea, pleuritic chest pain and hemoptysis two days before admission. The patient had tachypnea and mild respiratory distress at the time of admission. CT angiography showed filling defects in the inter-lobar arteries of both lungs with sub-segmental consolidation. A lung perfusion scan showed multiple segmental and sub-segmental perfusion defects in both lungs which did not match the ventilation scan. A diagnosis of PTE was made and anticoagulation with enoxaparin and warfarin was begun. The tachypnea, chest pain and hemoptysis disappeared after three days and he was discharged after 10 days with warfarin. His disease was in complete remission at eight months after discharge.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83574388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The importance of synovial adiponectin values in patients with rheumatoid arthritis in comparison with osteoarthritis 与骨关节炎相比，滑膜脂联素值在类风湿关节炎患者中的重要性

Journal of rheumatology research Pub Date : 2018-10-01 DOI: 10.22631/RR.2018.69997.1053

K. Hashemzadeh, M. Sahebari, M. Nodeh, Z. Rezaieyazdi, Zhaleh Shariati Sarabi, Z. Mirfeizi

引用次数: 0

Downregulation of Drosha, Dicer, and DGCR8 mRNAs in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis 类风湿关节炎患者外周血单个核细胞中Drosha、Dicer和DGCR8 mrna的下调

Journal of rheumatology research Pub Date : 2018-10-01 DOI: 10.22631/RR.2018.69997.1055

M. Akhlaghi, S. Soltani, F. Jamshidi, S. Faezi, S. Aslani, Shiva Poursani, Ali Jamshidi, M. Mahmoudi

{"title":"Downregulation of Drosha, Dicer, and DGCR8 mRNAs in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis","authors":"M. Akhlaghi, S. Soltani, F. Jamshidi, S. Faezi, S. Aslani, Shiva Poursani, Ali Jamshidi, M. Mahmoudi","doi":"10.22631/RR.2018.69997.1055","DOIUrl":"https://doi.org/10.22631/RR.2018.69997.1055","url":null,"abstract":"Rheumatoid arthritis (RA) is a systemic autoimmune disorder causing irreversible joint damage. MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that degrade or translate inhibition of mRNAs. miRNAs can be used as therapeutic targets and predictive biomarkers in many disordres. This study was undertaken to investigate whether or not the expression of key elements in miRNA biogenesis, Drosha, DGCR8 and Dicer mRNAs is dysregulated in RA patients.In this case-control study, 50 patients with RA and 50 age- and gender-matched healthy subjects participated. The peripheral blood mononuclear cells (PBMCs) were separated from the whole blood, the total RNA content of the cells was isolated and the first strand cDNA was synthesized. Quantitative analysis was performed through real-time polymerase chain reaction (PCR) using SYBR Green gene expression master mix to detect mRNA level expression of Drosha, DGCR8 and Dicer.The expression levels of Drosha and DGCR8 were significantly downregulated in patients with RA in comparison with the healthy controls (P value = 0.043, P value = 0.000365, respectively). The expression level of Dicer was downregulated in RA patients when compared to the healthy controls, although the difference in expression was not significant (P value= 0.156). RA patients with a familial history of autoimmune rheumatic disease recorded significant overexpression of all three genes. Moreover, DAS28 was significantly correlated with mRNA exoressiom of Drosha, Dicer and DGCR8.The data suggests that downregulated expression of Drosha, DGCR8 and Dicer mRNAs may be contributing to the pathogenesis of RA.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78181065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

IL-17A gene polymorphism at position G197A and systemic lupus erythematosus IL-17A基因G197A位点多态性与系统性红斑狼疮的关系

Journal of rheumatology research Pub Date : 2018-07-01 DOI: 10.22631/RR.2018.69997.1050

Mahboobeh Sharifzadeh, S. Naeimi, M. Nasiri, Saideh Ariannia, R. Farrokhseresht

引用次数: 8

Evaluation of oxidant and anti-oxidant balance in Behcet’s disease and its correlation with disease activity 白塞病中氧化剂和抗氧化剂平衡的评价及其与疾病活动性的关系

Journal of rheumatology research Pub Date : 2018-07-01 DOI: 10.22631/RR.2018.69997.1048

Vahid Yahyavi Alvar, Z. Mirfeizi, M. Jokar, Nafiseh Abdollahi, Saeed Kerdari

{"title":"Evaluation of oxidant and anti-oxidant balance in Behcet’s disease and its correlation with disease activity","authors":"Vahid Yahyavi Alvar, Z. Mirfeizi, M. Jokar, Nafiseh Abdollahi, Saeed Kerdari","doi":"10.22631/RR.2018.69997.1048","DOIUrl":"https://doi.org/10.22631/RR.2018.69997.1048","url":null,"abstract":"Behcet’s disease (BD) is a multi-system, progressive disease which usually presents with oral aphthous and genital ulcers. It may involve other organs such as the eyes, joints, nervous and vascular systems. Although the origin of BD is unknown, it is proposed that immunological, viral, and toxic factors are responsible. The current study evaluated the oxidant/antioxidant balance (redox index) in Behcet’s disease and its correlation with disease activity. Thirty BD patients were enrolled in the study based on International Study Group (ISG 1992) criteria. An age- and gender-matched control group was selected from healthy hospital staff. In this study, 3, 3, 5, 5 tetramethylbenzene (TMB) was used to determine oxidant/antioxidant balance. In the first enzymatic reaction, TBM was oxidized to a colorful cation. In the second chemical reaction, the colorful cation was regenerated to a colorless substance. In such way, the redox index was achieved. The redox index was significantly higher in the BD group than in the healthy group (P=0.0140). The mean redox index varied significantly in different levels of disease activity and was higher in patients with a severe case in comparison with those with a moderate form (P=0.038). There was a positive correlation between disease activity and redox index (r=0.450; P=0.013). A positive correlation was observed between the redox index and the WBC count in patients (P=0.033). The findings of this study demonstrate the presence of oxidative stress in BD, and the severity of BD has a moderately positive correlation with the redox index.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81733340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of heart dysfunction in patients with rheumatoid arthritis 类风湿关节炎患者心功能障碍的评价

Journal of rheumatology research Pub Date : 2018-07-01 DOI: 10.22631/RR.2018.69997.1049

N. Saadati, M. Moosavi

{"title":"Evaluation of heart dysfunction in patients with rheumatoid arthritis","authors":"N. Saadati, M. Moosavi","doi":"10.22631/RR.2018.69997.1049","DOIUrl":"https://doi.org/10.22631/RR.2018.69997.1049","url":null,"abstract":"Cardiovascular diseases are the most common causes of death in patients diagnosed with rheumatoid arthritis (RA). The high prevalence of cardiovascular disease is independent of known risk factors in RA patients. The present study aimed to estimate the left ventricular diastolic function in patients suffering from RA using conventional Doppler and tissue Doppler echocardiographic imaging (TDI). This descriptive, cross-sectional study was conducted on 40 patients who had an established diagnosis of RA for over five years (2, 7, 9) and referred to the Rheumatology Department and Clinic of Ghaem Hospital, affiliated with Mashhad University of Medical Sciences. Patients with normal electrocardiography, chest examination, and chest radiography were subjected to M-mode, two-dimensional Doppler echocardiography. Data analysis was performed with the SPSS statistical software package (version 11.5). A p-value less than 0.05 was considered statistically significant. According to the results, mitral and tricuspid insufficiencies were the most common valvular diseases (72.5% and 52%, respectively). In 70% of the patients, diastolic function was normal. A significant relationship was observed between systolic function and diastolic abnormality (P=0.001). Pulmonary hypertension was detected in 40% of patients. Nevertheless, no significant relationship was observed between E and Em or between A and Am (P=0.432, P=0.844, respectively). The Mann-Whitney U test revealed a statistical difference between the two groups in terms of EF, which was significantly lower in the diastolic dysfunction group (P=0.047). A wide and frequent variety of cardiac diseases, especially mitral, aortic, and tricuspid regurgitation, may be found in RA patients. It can be concluded that active RA patients have a significantly high incidence of diastolic dysfunction in the absence of clinical evidence of heart disease.","PeriodicalId":87314,"journal":{"name":"Journal of rheumatology research","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90503685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2