Fertility research and practice最新文献

{"title":"Ovarian morphology is associated with insulin resistance in women with polycystic ovary syndrome: a cross sectional study.","authors":"Sara Pittenger Reid,&nbsp;Chia-Ning Kao,&nbsp;Lauri Pasch,&nbsp;Kanade Shinkai,&nbsp;Marcelle I Cedars,&nbsp;Heather G Huddleston","doi":"10.1186/s40738-017-0035-z","DOIUrl":"https://doi.org/10.1186/s40738-017-0035-z","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a very common disorder well known to be associated with insulin resistance and metabolic disease. Insulin resistance is likely involved in the promotion of the PCOS reproductive phenotype and may mediate some of the ovarian morphology seen in the disorder. The phenotype of each individual woman with PCOS can vary widely as can her metabolic risk.</p><p><strong>Methods: </strong>This is a cross-sectional study of patients seen in a multidisciplinary PCOS clinic at the University of California at San Francisco between 2006 and 2014. All participants underwent systematic evaluation with anthropometric measurements, comprehensive skin exam, transvaginal ultrasound and laboratory studies at the time of their initial visit to the clinic. Serum samples were stored and androgen studies were carried out on all stored samples at the University of Virginia. Logistic regression was employed to evaluate the association between ovarian volume or follicle number and metabolic parameters (fasting insulin, HOMA-IR, fasting glucose, 2 h glucose, waist circumference) and hyperandrogenism (free testosterone, total testosterone, DHEAS, acanthosis nigricans), controlling for age.</p><p><strong>Results: </strong>Three-hundred thirteen patients seen during the study period met Rotterdam criteria for PCOS and had sufficient measurements for inclusion in our analysis. The odds ratio of elevated HOMA-IR for patients with a maximum ovarian volume >10 cc was 1.9 compared to those with a maximum ovarian volume of ≤10 cc (95% CI 1.0-3.4). The odds ratio of abnormal fasting insulin for patients with higher ovarian volume was 1.8 (95% CI 1.0-3.4) compared with those with lower ovarian volume. Follicle number was not significantly associated with any metabolic parameters.</p><p><strong>Conclusions: </strong>Increased ovarian volume is associated with markers of insulin resistance in PCOS. In concordance with prior studies, we did not find follicle number to be predictive of metabolic risk. Ovarian volume may serve as a useful tool to aid clinicians in their risk stratification and counseling of patients with PCOS.</p>","PeriodicalId":87254,"journal":{"name":"Fertility research and practice","volume":"3 ","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2017-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40738-017-0035-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35092889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular risk factors among women with self-reported infertility.","authors":"Shruthi Mahalingaiah,&nbsp;Fangui Sun,&nbsp;J Jojo Cheng,&nbsp;Erika T Chow,&nbsp;Kathryn L Lunetta,&nbsp;Joanne M Murabito","doi":"10.1186/s40738-017-0034-0","DOIUrl":"https://doi.org/10.1186/s40738-017-0034-0","url":null,"abstract":"<p><strong>Background: </strong>Amongst women with certain types of ovulatory disorder infertility, the studies are conflicting whether there is an increased risk of long-term cardiovascular disease risk. This paper evaluates the associations of several CVD risk factors among Framingham women with self-reported infertility.</p><p><strong>Methods: </strong>Women who completed the Framingham Heart Study Third Generation and Omni Cohort 2 Exam 2 (2008-2011), and reported on past history of infertility and current cardiovascular disease status were included in this cross-sectional study. Directly measured CVD risk factors were: resting blood pressure, fasting lipid levels, fasting blood glucose, waist circumference, and body mass index (BMI). Multivariable models adjusted for age, smoking, physical activity, and cohort. Generalized estimating equations adjusted for family correlations. We performed sensitivity analyses to determine whether the association between infertility and CVD risk factors is modified by menopausal status and menstrual cycle length.</p><p><strong>Results: </strong>Comparing women who self-reported infertility to those who did not, there was an average increase in BMI (β = 1.03 kg/m², 95% CI: 0.18, 1.89), waist circumference (β = 3.08 in., 95% CI: 1.06, 5.09), triglycerides (β = 4.47 mg/dl, 95% CI:-1.54, 10.49), and a decrease in HDL cholesterol (β = -1.60 mg/dl, 95% CI: -3.76, 0.56). We estimated that infertile premenopausal women have an increased odds of obesity (BMI ≥ 30 kg/m²) (OR = 1.56, 95% CI: 1.11, 4.49) and diabetes (OR = 1.96, 95% CI: 0.86, 4.49).</p><p><strong>Conclusions: </strong>BMI and waist circumference were the most strongly correlated CVD risk factors amongst women reporting a history of infertility.</p>","PeriodicalId":87254,"journal":{"name":"Fertility research and practice","volume":"3 ","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2017-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40738-017-0034-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35093998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"I am anxious and desperate\": psychological experiences of women with infertility in The Greater Accra Region, Ghana.","authors":"Ernestina S Donkor,&nbsp;Florence Naab,&nbsp;Deborah Y Kussiwaah","doi":"10.1186/s40738-017-0033-1","DOIUrl":"https://doi.org/10.1186/s40738-017-0033-1","url":null,"abstract":"<p><strong>Background: </strong>Research has shown that infertility affects millions of couples worldwide. Infertility is considered one of the most difficult life experiences and can result in psychological consequences for couples, especially for women. The purpose of this study was to explore the psychological experiences of women with infertility.</p><p><strong>Methods: </strong>A qualitative exploratory descriptive approach was used to conduct in-depth interviews. The psychological component of the bio-psychosocial model was used as a guiding framework to understand the experiences of women with infertility. Fourteen women were selected based on the purpose of the study and provided their informed consent, and were interviewed between November 2015 and January 2016. All the women were recruited from the Greater Accra Region of Ghana. Each interview lasted for 30 to 40 min. All interviews were audio taped, transcribed verbatim and analyzed using thematic content analysis.</p><p><strong>Results: </strong>The findings from the study showed that women with fertility problems experienced many emotional difficulties such as loneliness, anxiety, depression, lack of concentration, worrying, and reduced sexual satisfaction.</p><p><strong>Conclusions: </strong>Women in this study encountered psychological challenges and experienced emotional distress. Such women would benefit from psychological support such as counseling to help alleviate their psychological problems. These findings have implications for the care of women with infertility in Ghana.</p>","PeriodicalId":87254,"journal":{"name":"Fertility research and practice","volume":"3 ","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2017-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40738-017-0033-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35093997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tablet terminals: a useful tool to explain in vitro fertilization treatment.","authors":"Atsushi Yanaihara,&nbsp;Shirei Ohgi,&nbsp;Kenichirou Motomura,&nbsp;Takumi Yanaihara","doi":"10.1186/s40738-017-0031-3","DOIUrl":"https://doi.org/10.1186/s40738-017-0031-3","url":null,"abstract":"<p><strong>Background: </strong>Explanations that involve medical care treatment take time. This also applies to explanations of in vitro fertilization (IVF) in the field of infertility treatment. This is because the cause of infertility differs from couple to couple, and because the explanations must begin with the mechanism of pregnancy. Recently, explanations facilitated by tablet terminals have been used in the field of medicine. In the present study, the efficacy and problems of explanations facilitated by tablet terminals were evaluated and compared with the explanations of IVF facilitated by paper-based pamphlets.</p><p><strong>Methods: </strong>A total of 249 couples were asked to read a paper-based pamphlet explaining IVF treatment, while 252 couples were asked to view an explanation on a tablet terminal. The patients then answered a seven-item questionnaire. The answers to the questionnaire were based on a three-point scale, and statistical analysis was performed with the Mann-Whitney <i>U</i> test.</p><p><strong>Results: </strong>Patients responded that the explanation facilitated by the tablet terminal was significantly easier to understand for all seven questionnaire items (<i>p</i> <0.05). The answer 'I did not understand' was selected for the items related to 'The treatment fees' (4.8% of answers) and 'Things to take note of, such as consultation times' (6.7% of answers).</p><p><strong>Conclusion: </strong>While patients generally did not understand the mechanism of pregnancy, explanations of IVF treatment facilitated by a tablet terminal were found to be more effective than paper-based explanations, although there is room for improvement.</p>","PeriodicalId":87254,"journal":{"name":"Fertility research and practice","volume":"3 ","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2017-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40738-017-0031-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35093996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preconception consultations with Maternal Fetal Medicine for obese women: a retrospective chart review.","authors":"Charlotte M Page,&nbsp;Elizabeth S Ginsburg,&nbsp;Randi H Goldman,&nbsp;Chloe A Zera","doi":"10.1186/s40738-016-0030-9","DOIUrl":"https://doi.org/10.1186/s40738-016-0030-9","url":null,"abstract":"<p><strong>Background: </strong>Obesity is associated with impaired fertility and pregnancy complications, and preconception weight loss may improve some of these outcomes. The purpose of this study was to evaluate the quality and effectiveness of Maternal Fetal Medicine (MFM) preconception consults for obese women.</p><p><strong>Methods: </strong>We performed a retrospective chart review examining 162 consults at an academic medical center from 2008 to 2014. The main outcome measures included consultation content - e.g. discussion of obesity-related pregnancy complications, screening for comorbidities, and referrals for weight loss interventions - and weight loss.</p><p><strong>Results: </strong>Screening for diabetes and hypertension occurred in 48% and 51% of consults, respectively. Discussion of obesity-related pregnancy complications was documented in 96% of consults. During follow-up (median 11 months), 27% of patients saw a nutritionist, 6% saw a provider for a medically supervised weight loss program, and 6% underwent bariatric surgery. The median weight change was a loss of 0.6% body weight.</p><p><strong>Conclusions: </strong>In this discovery cohort, a large proportion of MFM preconception consultations lacked appropriate screening for obesity-related comorbidities. While the vast majority of consultations included a discussion of potential pregnancy complications, relatively few patients achieved significant weight loss. More emphasis is needed on weight loss resources and delaying pregnancy to achieve weight loss goals.</p>","PeriodicalId":87254,"journal":{"name":"Fertility research and practice","volume":"3 ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2017-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40738-016-0030-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35093994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrete survival model analysis of a couple's smoking pattern and outcomes of assisted reproduction.","authors":"Jose C Vanegas,&nbsp;Jorge E Chavarro,&nbsp;Paige L Williams,&nbsp;Jennifer B Ford,&nbsp;Thomas L Toth,&nbsp;Russ Hauser,&nbsp;Audrey J Gaskins","doi":"10.1186/s40738-017-0032-2","DOIUrl":"https://doi.org/10.1186/s40738-017-0032-2","url":null,"abstract":"<p><strong>Background: </strong>Cigarette smoking has been associated with worse infertility treatment outcomes, yet some studies have found null or inconsistent results.</p><p><strong>Methods: </strong>We followed 225 couples who underwent 354 fresh non-donor assisted reproductive technology (ART) cycles between 2006 and 2014. Smoking history was self-reported at study entry. We evaluated the associations between smoking patterns and ART success using multivariable discrete time Cox proportional hazards models with six time periods: cycle initiation to egg retrieval, retrieval to fertilization, fertilization to embryo transfer (ET), ET to implantation, implantation to clinical pregnancy, and clinical pregnancy to live birth to estimate hazard ratios (HR) and 95% CIs. Time-dependent interactions between smoking intensity and ART time period were used to identify vulnerable periods.</p><p><strong>Results: </strong>Overall, 26% of women and 32% of men reported ever smoking. The HR of failing in the ART cycle without attaining live birth for male and female ever smokers was elevated, but non-significant, compared to never smokers regardless of intensity (HR = 1.02 and 1.30, respectively). Female ever smokers were more likely to fail prior to oocyte retrieval (HR: 3.37; 95% CI: 1.00, 12.73). Every one cigarette/day increase in smoking intensity for females was associated with a HR of 1.02 of failing ART (95% CI: 0.97, 1.08), regardless of duration or current smoking status. Women with higher smoking intensities were most likely to fail a cycle prior to oocyte retrieval (HR: 1.07; 95% CI: 1.00, 1.16). Among past smokers, every additional year since a man had quit smoking reduced the risk of failing ART by 4% (HR: 0.96; 95% CI: 0.91, 1.00) particularly between clinical pregnancy and live birth (HR: 0.86; 95% CI: 0.76, 0.96).</p><p><strong>Conclusions: </strong>Female smoking intensity, regardless of current smoking status, is positively associated with the risk of failing ART cycles between initiation and oocyte retrieval. In men who ever smoked, smoking cessation may reduce the probability of failing ART, particularly between clinical pregnancy and live birth.</p><p><strong>Trial registration: </strong>NCT00011713. Registered: 27 February 2001.</p>","PeriodicalId":87254,"journal":{"name":"Fertility research and practice","volume":"3 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40738-017-0032-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34975447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review.","authors":"Holly R Harris,&nbsp;Kathryn L Terry","doi":"10.1186/s40738-016-0029-2","DOIUrl":"https://doi.org/10.1186/s40738-016-0029-2","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with an estimated prevalence of 4-21% in reproductive aged women. The altered metabolic and hormonal environment among women with PCOS may increase their risk of some types of cancer.</p><p><strong>Methods: </strong>We performed a comprehensive review of the literature using numerous search terms for all studies examining the associations between polycystic ovary syndrome and related characteristics and cancer published in English through October 2016. This review summarizes the epidemiological findings on the associations between PCOS and endometrial, ovarian, and breast cancers and discusses the methodological issues, complexities, and underlying mechanisms of these associations.</p><p><strong>Results: </strong>We identified 11 individual studies and 3 meta-analyses on the associations between PCOS and endometrial cancer, 8 studies and 1 meta-analysis for ovarian cancer, and 10 studies and 1 meta-analysis for breast cancer. Multiple studies reported that women with PCOS were at a higher risk for endometrial cancer; however, many did not take into account body mass index (BMI), a strong and well-established risk factor for endometrial cancer. The association with ovarian cancer was less clear, but a potentially increased risk of the borderline serous subtype was reported by two studies. No consistent association between PCOS risk and breast cancer was observed.</p><p><strong>Conclusion: </strong>The associations between PCOS and endometrial, ovarian, and breast cancer are complex, with the need to consider many methodological issues in future analyses. Larger well-designed studies, or pooled analyses, may help clarify these complex associations.</p>","PeriodicalId":87254,"journal":{"name":"Fertility research and practice","volume":"2 ","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2016-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40738-016-0029-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35093995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple, less invasive stripper micropipetter-based technique for day 3 embryo biopsy.","authors":"Luciano Cedillo,&nbsp;Azucena Ocampo-Bárcenas,&nbsp;Israel Maldonado,&nbsp;Francisco J Valdez-Morales,&nbsp;Felipe Camargo,&nbsp;Esther López-Bayghen","doi":"10.1186/s40738-016-0027-4","DOIUrl":"10.1186/s40738-016-0027-4","url":null,"abstract":"<p><strong>Background: </strong>Preimplantation genetic screening (PGS) is an important procedure for in vitro fertilization (IVF). A key step of PGS, blastomere removal, is abundant with many technical issues. The aim of this study was to compare a more simple procedure based on the Stipper Micropipetter, named S-biopsy, to the conventional aspiration method.</p><p><strong>Methods: </strong>On Day 3, 368 high-quality embryos (>7 cells on Day3 with <10% fragmentation) were collected from 38 women. For each patient, their embryos were equally separated between the conventional method (<i>n</i> = 188) and S-biopsy method (<i>n</i> = 180). The conventional method was performed using a standardized protocol. For the S-biopsy method, a laser was used to remove a significantly smaller portion of the zona pellucida. Afterwards, the complete embryo was aspirated with a Stripper Micropipetter, forcing the removal of the blastomere. Selected blastomeres went to PGS using CGH microarrays. Embryo integrity and blastocyst formation were assessed on Day 5. Differences between groups were assessed by either the Mann-Whitney test or Fisher Exact test.</p><p><strong>Results: </strong>Both methods resulted in the removal of only one blastomere. The S-biopsy and the conventional method did not differ in terms of affecting embryo integrity (95.0% vs. 95.7%) or blastocyst formation (72.7% vs. 70.7%). PGS analysis indicated that aneuploidy rate were similar between the two methods (63.1% vs. 65.2%). However, the time required to perform the S-biopsy method (179.2 ± 17.5 s) was significantly shorter (5-fold) than the conventional method.</p><p><strong>Conclusion: </strong>The S-biopsy method is comparable to the conventional method that is used to remove a blastomere for PGS, but requires less time. Furthermore, due to the simplicity of the S-biopsy technique, this method is more ideal for IVF laboratories.</p>","PeriodicalId":87254,"journal":{"name":"Fertility research and practice","volume":"2 ","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2016-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40738-016-0027-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35093993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful pregnancy with donor eggs in-vitro fertilization after premature ovarian insufficiency in a tertiary hospital in a low-income setting: a case report.","authors":"Thomas Obinchemti Egbe, Carine Youta Wafo, Berthe Bebey Bollo, Christian Pany, Monique Jong Onomo, Guy Sandjon","doi":"10.1186/s40738-016-0028-3","DOIUrl":"10.1186/s40738-016-0028-3","url":null,"abstract":"<p><strong>Background: </strong>Premature Ovarian Insufficiency (POI) is classically defined as 4-6 months of cessation of menses (amenorrhea) in women under 40, associated with menopausal level of serum gonadotropins FSH > 40 IU/L and hypo-estrogenism and is also referred to as hypergonadotropic hypogonadism. This disorder can manifest as primary amenorrhea without the onset of menses (menarche), or as secondary amenorrhea after menarche and pubertal development. The diagnosis of this condition in Cameroon is sometimes difficult because of the high cost of hormonal assays and the few laboratories offering these services.</p><p><strong>Case presentation: </strong>The patient was a 38-year-old G2P0020, blood group O Rh positive, genotype AA and BMI 19 kg/m2 who came to our service because of secondary amenorrhea and infertility of 2 years' duration. She has a history of pulmonary tuberculosis that was treated in Cameroon. After laparoscopy and hormonal profile, the diagnosis of premature ovarian insufficiency was reached. The woman underwent a successful donor egg in-vitro fertilization cycle and delivered a female fetus. Two years later YE requested IVF with autologous eggs, which was not possible, and since then she has remained with one child.</p><p><strong>Conclusion: </strong>The diagnosis of premature ovarian insufficiency is difficult in Cameroon because of the high cost of laboratory investigations and difficult access to the tests. In-vitro fertilization with donor egg is a better treatment option. Unfortunately, it is not accessible to most Cameroonians because of lack of technical ability and the existence of cultural and financial barriers.</p>","PeriodicalId":87254,"journal":{"name":"Fertility research and practice","volume":"2 ","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2016-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40738-016-0028-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35093992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle and in vitro fertilization: what do patients believe?","authors":"Brooke V Rossi,&nbsp;Leah Hawkins Bressler,&nbsp;Katharine F Correia,&nbsp;Shane Lipskind,&nbsp;Mark D Hornstein,&nbsp;Stacey A Missmer","doi":"10.1186/s40738-016-0026-5","DOIUrl":"https://doi.org/10.1186/s40738-016-0026-5","url":null,"abstract":"<p><strong>Background: </strong>Patients have many beliefs regarding lifestyle factors and IVF outcomes.</p><p><strong>Methods: </strong>Observational study of 208 IVF patients at an academic infertility center. Main outcome measures were perceived influence of various lifestyle factors assessed by multivariable logistic regression and <i>p</i>-value tests for linear trend (P_t).</p><p><strong>Results: </strong>A majority of participants believed that there were many women's lifestyle choices that were influential, compared to fewer male factors (cessation of tobacco (72 %), alcohol (69 %), caffeine (62 %), and use of vitamins (88 %)). Compared to participants with less education, participants with a higher education level were less likely to believe vitamins were helpful and some alcohol use was not harmful. As income decreased, participants were less likely to consider dietary factors contributory to IVF success, such as women (p-trend, <i>p</i> = 0.02) and men (p-trend, <i>p</i> = 0.009) consuming a full-fat dairy diet. Participants' beliefs were most commonly influenced by physicians (84 %) and the internet (71 %).</p><p><strong>Conclusions: </strong>Patients believed many lifestyle factors are associated with IVF success. Understanding patients' assumptions regarding the effect of lifestyle factors on IVF success may better allow physicians to counsel patients about IVF outcomes.</p>","PeriodicalId":87254,"journal":{"name":"Fertility research and practice","volume":"2 ","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2016-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40738-016-0026-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35093991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}