{"title":"Foreword.","authors":"B. Levy","doi":"10.1097/GRF.0000000000000490","DOIUrl":"https://doi.org/10.1097/GRF.0000000000000490","url":null,"abstract":"The practice of medicine and the science informing that practice is changing so rapidly that no one physician can keep abreast of current guidelines and best practices. Many of us have limited our practices to a subspecialty within women’s health care which makes it even more challenging to read and absorb the vast array of data published every month. In addition, our patients have immediate access to “Dr Google” and various online sources—be they evidence-based, scientifically sound, or biased, inflammatory or financially motivated—which drive their choices and their appointments with us. It is critically important for actively practicing women’s health care physicians and providers to have a basic understanding of all aspects of medicine that impact our patients. In this series, we have compiled a commentary on some of the most controversial and difficult aspects of current practice by experts in the respective areas. Their practical summary of the current literature and guidelines, along with recommendations for management, should help inform each of our daily practices. We have endeavored to provide short, pointed and carefully considered chapters to give readers a quick overview of various areas in women’s health care that are of high impact and for which there may be considerable controversy. From approaching women with chronic pelvic pain to the cutting edge of Precision Medicine, I hope you will find the subject matter interesting, engaging and valuable in your daily care of patients. I am grateful for the dedicated and expert authors who contributed their time and lent their vast experience to help all of us understand the nuances of these complicated and difficult topics.","PeriodicalId":87233,"journal":{"name":"Clinical obstetrics, gynecology and reproductive medicine","volume":"153 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86389456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pancreatic Disorders of Pregnancy.","authors":"Stacy L Beck","doi":"10.1097/GRF.0000000000000503","DOIUrl":"https://doi.org/10.1097/GRF.0000000000000503","url":null,"abstract":"The pancreas is an organ with both exocrine and endocrine functions that has a vital role in both digestion as well as glucose metabolism. Although pancreatic dysfunction and disorders are rare in pregnancy, they are becoming increasingly more common. Recognition of these disorders and understanding how they can affect pregnancy is imperative to allow for proper management. We provide an overview of the most common pancreatic disorders that are seen in pregnancy.","PeriodicalId":87233,"journal":{"name":"Clinical obstetrics, gynecology and reproductive medicine","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89369704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Integration of Clinical and Molecular Features into Prediction Models for Outcomes in Endometrial Cancer.","authors":"Marina D Miller, E. Devor","doi":"10.1097/GRF.0000000000000498","DOIUrl":"https://doi.org/10.1097/GRF.0000000000000498","url":null,"abstract":"Endometrial cancer recurrence carries a poor prognosis. The rising incidence of endometrial cancer calls for improvements in treatment of advanced and recurrent diseases. Efforts have been made to molecularly characterize endometrial cancer with the goal of improving therapies. The study presented here describes the utilization of molecular features of endometrial cancer tumors that are likely to recur, along with clinical characteristics utilized together to predict recurrence. This work further studies recurrent endometrial cancers to group them into \"clusters\" based on the tumor's molecular makeups with the ultimate aim to focus therapy on the molecular pathways potentially leading to recurrence.","PeriodicalId":87233,"journal":{"name":"Clinical obstetrics, gynecology and reproductive medicine","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76580254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Halime Goktepe, E. Turkyilmaz, G. Doğan Durdağ, Murat Sonmezer, C. Atabekoğlu, B. Ozmen
{"title":"Oocyte Cryopreservation: Retrospective Analysis Of 5 Years Experience","authors":"Halime Goktepe, E. Turkyilmaz, G. Doğan Durdağ, Murat Sonmezer, C. Atabekoğlu, B. Ozmen","doi":"10.21613/gorm.2019.1014","DOIUrl":"https://doi.org/10.21613/gorm.2019.1014","url":null,"abstract":"OBJECTIVE: To analyze demographic and clinical data of patients who resorted to oocyte freezing between January 2014 and December 2018. STUDY DESIGN: Patients who applied to the Reproductive Endocrinology and Infertility Unit of Ankara University School of Medicine between January 2014 and December 2018 with the request of oocyte freezing were included in this study. The files and computer records of the patients were analyzed retrospectively and sociodemographic, clinical and laboratory data were evaluated. RESULTS: A total of 46 cycles were recorded in 40 patients over a 5-year period. The main indications were low ovarian reserve and/or advanced age (68.3%) and malignancy diagnosis (31.7%). There was a significant difference between elective fertility preservation and oncofertility preservation (Onco-FP) groups in terms of the age (38.4±4.7 vs 28.4±6.1; p=0.001). There was a significant difference between two groups in favor of oncofertility group in terms of anti-Mullerian hormone level, basal follicle-stimulating hormone level, antral follicle count, trigger day estradiol (E2) level, number of obtained oocytes, MII oocytes, and frozen oocytesCONCLUSION: According to our study, the most prominent oocyte cryopreservation indication was advanced age and/or low ovarian reserve. The number of oocytes collected from patients in the Onco-FP group and thus the number of frozen oocytes was significantly higher than in the elective fertility preservation group, due to younger ages and better ovarian reserve in the Onco-FP group. Abdominal administration of the technique is particularly important for virgin patients in our country. Oocyte freezing is a fertility protection method available in a wide range of indications for reproductive-aged women.","PeriodicalId":87233,"journal":{"name":"Clinical obstetrics, gynecology and reproductive medicine","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86338715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Technique to Reduce Trendelenburg Degree during Gynaecological Laparoscopic Surgeries","authors":"Razan Nasir","doi":"10.24966/rmgo-2574/100029","DOIUrl":"https://doi.org/10.24966/rmgo-2574/100029","url":null,"abstract":"The trendelenburg position in awake and anaesthetised patient’s increases Pulmonary Arterial Pressures (PAP), Central Venous Pressure (CVP) and Pulmonary Capillary Wedge Pressure (PCWP). Trendelenburg position in laparoscopic surgeries generally increases venous return and Cardiac Output. If the patient is placed in extreme trendelenburg, a decrease in venous return from the head may result, thus leading to increased intracranial and intraocular pressures. If this position is maintained for an extended duration, cerebral edema and retinal detachment may occur. Because of venous stagnation, cyanosis and edema in the face and neck may be expected. Hence, our study aims to demonstrate a new technique which can help to reduce the angle degree of trendelenburg position, thereby reducing the adverse effects of prolonged decreased venous return from the head, like increased intracranial and intraocular pressures, cyanosis or oedema of the face.","PeriodicalId":87233,"journal":{"name":"Clinical obstetrics, gynecology and reproductive medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88343131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lichen Sclerosis Involving Vagina and Cervix","authors":"","doi":"10.24966/rmgo-2574/100026","DOIUrl":"https://doi.org/10.24966/rmgo-2574/100026","url":null,"abstract":"Background: Lichen Sclerosus (LS) is commonly a disease of the vulva usually seen in postmenopausal women. It presents as an atrophic white patchy area in a figure of 8 pattern. Fissuring is also commonly seen because of skin fragility. It is diagnosed by history and clinical assessment but usually confirmed with a biopsy. There is no cure for LS. The mainstay of treatment is potent topical steroids and in some cases oral immunosuppressive medicines may also be used. It is important to acknowledge the role of laser surgery in treat ing the sequel of scarring secondary to LS. Because LS is associ ated with increased risk of squamous cell carcinoma in women with genital involvement, it is important for those affected to have lifelong screening examinations as well as continued treatment to keep the disorder under control. Only six cases of vaginal LS, but no cases of cervical LS exist in the literature. Case: The authors present a case of a postmenopausal lady pre senting with a 30 year history of prolapse and a urinary tract infec tion. Examination revealed, 3rd degree utero-vaginal prolapse with widespread whitish discoloration of anterior, posterior and lateral vaginal walls, which also included the cervix. After counseling the patient and presenting her with the options for treatment, she chose to have the gellhorn pessary inserted in the outpatient clinic. Vaginal and cervical biopsy was taken under local anesthesia and histology confirmed LS. Patient was followed up in clinic and prescribed ste -roids. Conclusion: LS involving the vagina and cervix is a rare occurrence, unlike lichen planus, which can present in the vagina. Long term untreated genital prolapse may have a role in the development. As the occurrence of this condition is rare, each case should be treated individually and ideally after discussion in MDT meeting.","PeriodicalId":87233,"journal":{"name":"Clinical obstetrics, gynecology and reproductive medicine","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80586344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Indemnification of Risk by Obstetrical Providers","authors":"Steven BCherry","doi":"10.24966/rmgo-2574/100028","DOIUrl":"https://doi.org/10.24966/rmgo-2574/100028","url":null,"abstract":"When providing medical expert review of obstetrical cases that result in an adverse fetal outcome, one is expected to determine whether or not the obstetrical provider met established standards of care. The two most common adverse outcomes encountered in such cases are hypoxic ischemic encephalopathy and neonatal brachial plexus palsy [1]. The injuries associated with such cases, cerebral palsy and upper extremity dysfunction, have long range consequences for the newborn and are often associated with large financial settlements.","PeriodicalId":87233,"journal":{"name":"Clinical obstetrics, gynecology and reproductive medicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87955161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Correlation between CGB Gene Splice Variants in Women with Recurrent Spontaneous Abortions","authors":"A. Psarris, Alexandra","doi":"10.24966/rmgo-2574/100027","DOIUrl":"https://doi.org/10.24966/rmgo-2574/100027","url":null,"abstract":"","PeriodicalId":87233,"journal":{"name":"Clinical obstetrics, gynecology and reproductive medicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75309641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Kraiem, Leila Souilem, Dhekra Toumi, H. Bouchahda
{"title":"Obstetric and Perinatal Outcomes in Women ≥40 Years of Age: A Retrospective Study About 421 Cases in Mahdia","authors":"S. Kraiem, Leila Souilem, Dhekra Toumi, H. Bouchahda","doi":"10.21613/gorm.2019.912","DOIUrl":"https://doi.org/10.21613/gorm.2019.912","url":null,"abstract":"OBJECTIVES: All this study is aimed to evaluate obstetrical and neonatal outcomes among women age 40 years and older.STUDY DESIGN: Among 9962 women who delivered in Mahdia’s hospital between January 2015 and December 2016, 421 women (4.22%) were 40 years old or older at the time of delivery. Our retrospective study included 421 pregnant women aged more than 40 years and 421 controls aged 18-39, stratified to parity. Data were analyzed using Pearson’s χ22 test.RESULTS: The mean age of the case group was 41.32 years and that for the control group was 31.25 years. Preeclampsia and diabetes were the most common pathologies (p=0.01), the mode of delivery was marked by a high rate of cesarean section. The rate of instrumental extractions was not influenced by age. The rate of neonatal admission and 10-minute Apgar Scores<7 were significantly higher in the older group (p<0.05). The rate of abruption placenta, placenta previa, postpartum hemorrhage, and stillbirth were increased in mothers over 40 years but there was no difference statically. CONCLUSION: Based on findings, maternal age over 40 years is associated with a high rate of obstetrical, medical complications and cesarean section deliveries. Better pregnancy monitoring helps to improve this risky situation.","PeriodicalId":87233,"journal":{"name":"Clinical obstetrics, gynecology and reproductive medicine","volume":"1549 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86506680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}