Blood and genomics最新文献_第4页

An analysis of intraoperative blood transfusion of cardiac surgery in one hospital from 2014 to 2016 某医院2014 - 2016年心脏外科术中输血情况分析

Blood and genomics Pub Date : 2019-01-01 DOI: 10.46701/apjbg.2019022019122

S. Yi, Cuicui Chai, Jing Lin, Hongliang Zhang, Qi Luo, Han Wang, Jiangbo Chen, Dan Li

引用次数: 0

The role of free immunoglobulin light chains in serum from SLE patients with or without renal involvement 游离免疫球蛋白轻链在累及或不累及肾脏的SLE患者血清中的作用

Blood and genomics Pub Date : 2019-01-01 DOI: 10.46701/apjbg.2019022019121

J. Granados, A. Villa-Romero, M. M. Mayo, Miriam Santiago Ortíz, María Fernanda García Gutiérrez, Víctor Hugo Tovar Méndez, Daniela Ruíz Gómez, Susana Maricela Hernández Doo, Citlaly López Orozco, Adriana Aguirre Telio

引用次数: 0

The prevalence of alloantibody in the population of Xinjiang area of China 新疆地区人群中同种异体抗体的流行情况

Blood and genomics Pub Date : 2019-01-01 DOI: 10.46701/apjbg.2019012018139

Limin Zhang, E. Xiao, Haiying Wang, Mingjun Huang, Gulinuer Kuerban, Xiaoli Sun, Senru Zhang, Yanchao Xing

引用次数: 0

Genomic instability in Multiple Myeloma-relevance for Clinical Outcome and Efficacy of Therapy 多发性骨髓瘤的基因组不稳定性与临床结果和治疗效果的相关性

Blood and genomics Pub Date : 2019-01-01 DOI: 10.46701/apjbg.2019022019126

Fumou Sun, Yan Cheng, S. Janz

{"title":"Genomic instability in Multiple Myeloma-relevance for Clinical Outcome and Efficacy of Therapy","authors":"Fumou Sun, Yan Cheng, S. Janz","doi":"10.46701/apjbg.2019022019126","DOIUrl":"https://doi.org/10.46701/apjbg.2019022019126","url":null,"abstract":"Genomic instability is a driving force in the natural history of blood cancers including multiple myeloma,an incurable neoplasm of immunoglobulin producing plasma cells that reside in the hematopoietic bone marrow. Long recognized manifestations of genomic instability in myeloma at the cytogenetic level include abnormal chromosome numbers (aneuploidy) caused by trisomy of odd-numbered chromosomes; recurrent oncogene-activating chromosomal translocations that involve immunoglobulin loci;and large-scale amplifications, inversions, and insertions / deletions (indels). Catastrophic genetic rearrangements that either shatter and illegitimately reassemble a single chromosome (chromotripsis) or lead to disordered segmental rearrangements of multiple chromosomes (chromoplexy) also occur. Genomic instability at the nucleotide level results in base substitution mutations and small indels that affect both the coding and non-coding genome. Distinctive signatures of somatic mutations that can be attributed to defects in DNA repair pathways, the DNA damage response or aberrant activity of mutator genes including members of the APOBEC family have been identified. Here we review recent findings on genomic stability control in myeloma that are not only relevant for myeloma development and progression, but also underpin disease relapse and acquisition of drug resistance in patients with myeloma.","PeriodicalId":87226,"journal":{"name":"Blood and genomics","volume":"347 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88147619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High CCNB2 expression correlates with poor prognosis in hepatocellular carcinoma CCNB2在肝细胞癌中高表达与预后不良相关

Blood and genomics Pub Date : 2019-01-01 DOI: 10.46701/APJBG.2019012019110

X. Zhai, Yingjing Wang, Peijie Chen, Mengjing Sun, Jianwei Qiu, Yao-Xian Wang

引用次数: 2

Method verification study for nucleic acid test system 核酸检测系统方法验证研究

Blood and genomics Pub Date : 2019-01-01 DOI: 10.46701/apjbg.2019012019111

Libo Zhang, Chengping Ma, Rongrong Pang, Yuan Ke, Min Huang, Wenping Han, Xiaojun Lu

引用次数: 0

An establishment of the procedures to eliminate incorrect blood due to non-matched or mislabeled tubes 建立消除因不匹配或标签错误而导致的不正确血液的程序

Blood and genomics Pub Date : 2019-01-01 DOI: 10.46701/apjbg.2019022019113

He Zi-yi, W. Qing, Chen Shaobin, Yu Lin, Chen Qing-kai

{"title":"An establishment of the procedures to eliminate incorrect blood due to \u0000non-matched or mislabeled tubes","authors":"He Zi-yi, W. Qing, Chen Shaobin, Yu Lin, Chen Qing-kai","doi":"10.46701/apjbg.2019022019113","DOIUrl":"https://doi.org/10.46701/apjbg.2019022019113","url":null,"abstract":"This study aims to establish a set of procedures to eliminate incorrect blood due to non-matched tubes or mislabeled tubes. The errors such as these are suspected to have occurred when upon first and second-detection. Under the identical laboratory conditions, the results of re-detection of blood bag samples and rare type antigen samples, as well as re-collected samples from donor, and plasma diluted are not consistent with the original results. Here, 20 antigen erythrocytes were detected for blood bag samples and original samples, in which no incorrect blood was mistakenly administered or mislabeled. Samples taken under identical laboratory conditions were not found to have incorrect blood administered to a non-matched tube. The results showed nonlinear changes by HBsAg ELSIA after plasma dilution. The study suggests that the second-detection taken shortly after first detection is the most appropriate method to detect errors at the earliest time point. Blood bag samples are identical to those of the original antigen identification group, which means that the probability of the samples coming from the same donor is extremely highly. At same time, space and plasma diluted, re-detection can effectively exclude incorrect blood being added to a non-matched tube.","PeriodicalId":87226,"journal":{"name":"Blood and genomics","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76945841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticle interactions with blood proteins and what it means: a tutorial review 纳米粒子与血液蛋白的相互作用及其意义:教程回顾

Blood and genomics Pub Date : 2019-01-01 DOI: 10.46701/apjbg.2019022019129

E. Reimhult

{"title":"Nanoparticle interactions with blood proteins and what it means: a tutorial review","authors":"E. Reimhult","doi":"10.46701/apjbg.2019022019129","DOIUrl":"https://doi.org/10.46701/apjbg.2019022019129","url":null,"abstract":"Nanoparticles find many uses in medicine and biomedical technology. Such applications imply that they must be colloidally stable and do not interact with proteins in the blood or blood serum. A nanoparticle put into the blood will instantaneously be covered by a protein corona that compromises the function of the nanoparticle core, changes the effective size of the nanoparticle, and determines its biological fate. Strategies developed to gain control over nanoparticles in biological fluids, particular in blood, heavily rely on creating a hydrated polymer shell that sterically and osmotically prevents a protein corona from forming. In this tutorial review, we provide an over-view of factors that affect the formation of the protein corona in blood and how to prevent it forming. We focus on describing the latest advances in our understanding of how small core - shell nanoparticles (core diameter 4-20 nm in diameter) with a shell of densely grafted polymer chains, a so - called polymer brush, interact with proteins and cells in vitro . Such nanoparticles are among the most well - defined and well - characterized colloids used for biomedical applications, from which an improved understanding of how nanoparticle architecture influences their biological fate can be obtained in detail. of stickier but less abundant proteins lead to the creation of a hard corona. On the hard corona, a new soft corona can form in dynamic equilibrium with the pool of proteins in the blood.","PeriodicalId":87226,"journal":{"name":"Blood and genomics","volume":"191 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75157798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The polymorphisms of HLA class Ⅰ and Ⅱalleles were not associated with severe acute respiratory syndrome among recovered patients in Beijing: a case-control study 北京地区康复患者HLA类Ⅰ和Ⅱ等位基因多态性与严重急性呼吸综合征无相关性

Blood and genomics Pub Date : 2019-01-01 DOI: 10.46701/apjbg.2019012018140

Dongmei Li, Dongjing Liu, Yi Zha, Tao Wu, Yan Qiu

{"title":"The polymorphisms of HLA class Ⅰ and Ⅱalleles were not associated with severe acute respiratory syndrome among recovered patients in Beijing: a case-control study","authors":"Dongmei Li, Dongjing Liu, Yi Zha, Tao Wu, Yan Qiu","doi":"10.46701/apjbg.2019012018140","DOIUrl":"https://doi.org/10.46701/apjbg.2019012018140","url":null,"abstract":"Severe acute respiratory syndrome (SARS) is a viral respiratory illness caused by a novel coronavirus (SARS - CoV), which emerged as a pandemic in 2003. The mechanism of the immune reaction initiated by SARS - CoV still remains unclear. Here we aimed to describe the genetic patterns of high - resolution HLA - A, - B, - C, - DRB1, and - DQB1, loci in recovered SARS patients from Beijing and examine the association between HLA genes and susceptibility or resistance to SARS. A total of 70 recovered Chinese Han SARS patients were recruited to donate convalescent plasma in 2003. HLA high - resolution typing was carried out using sequence based typing (SBT). Allele frequencies were calculated by direct counting, and were compared with the frequencies of HLA alleles of donors recruited by the China Marrow Donor Program between 2002 and 2015 using Fisher's exact test. Significance of association was defined according to the Bonferroni method for multiple comparisons. We observed 20, 35, 21, 25, and 17 alleles respectively at HLA - A, - B, - C, - DRB1, and - DQB1 loci among the 70 recovered patients. We identified 12 alleles (HLA - A*02:10, - A*02:93, - A*03:02, - B*08:01, - B*15:152, - B*37:01, - DRB1*10:01, - DRB1*11:03, - DRB1*14:10, - DRB1*14:12, - DRB1*15:02, and - DQB1*05:10) showing a nominal association with SARS ( P <0.05), but none remained significant after Bonferroni correction. The study suggests that high - resolution HLA alleles are unlikely to contribute significantly to the susceptibility or resistance to SARS - CoV infection in the northern Chinese population.","PeriodicalId":87226,"journal":{"name":"Blood and genomics","volume":"384 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78448867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of thromboelastography in clinical emergency trauma patients 血栓弹性成像在临床急诊创伤患者中的作用

Blood and genomics Pub Date : 2019-01-01 DOI: 10.46701/apjbg.2019012019108

F. Geng, Xiaoxi Liu, P. Fang, Haiying Hu, Xiaoqiong Deng, Wen Wang, Yin Li, Y. Lai, X. Zhong

引用次数: 0