Bangladesh Medical Journal最新文献

{"title":"An Eleven Months Old Infant with Very Early Onset Inflammatory Bowel Diseases (IBD): A Rare Case Report","authors":"N. Ahamed, M. Khadga, Wahiduzzaman Majumder, Md Rukunuzzaman","doi":"10.3329/bmj.v50i2.61220","DOIUrl":"https://doi.org/10.3329/bmj.v50i2.61220","url":null,"abstract":"Inflammatory bowel disease (IBD) in pediatric cases has been seen rapidly increasing in number over the last decade. Now a days four types of pediatric IBD has been identified: less than ten years of age - early onset IBD, less than six years of age - very early onset IBD, less than two years of age- infantile IBD and less than twenty eight days of age - neonatal onset IBD. Young children presented with more aggressive clinical features and severity is more than the older children and adults. Early onset disease presenting in children may have a monogenic basis. Infantile IBD or neonatal IBD having the high rates to affect the first-degree relatives and there is very high chance to develop resistance against immunosuppressive treatment. Very early onset IBD (VEO-IBD) most commonly presenting per rectal bleeding with or without mucous stools, isolated colonic disease, perianal involvement, skin lesions, whereas early onset IBD (EO-IBD) commonly presented with abdominal pain and weight loss. A thorough history, physical examination, biochemical markers, endoscopic evaluation with macroscop and microscopic findings are the only way to reach the diagnosis. The treatment of VEO-IBD is the same as that given to the adolescents and adults with IBD (eg, anti-inflammatory agents, immunomodulators, biologics, antibiotics, and surgical approaches). Here, we report a rare case of very early onset IBD of a 11 months old male infant, who presented with the complaints of blood and mucus mixed loose watery stool for 10 days, having similar episodes for last five months. He was mildly pale, and had thrombocytosis with raised C reactive protein (CRP), features of colitis in stool routine microscopic test. The diagnosis was confirmed by colonoscopy and histopathology study, which showed features of Crohn’s colitis. He was treated by anti-inflammatory drugs (steroid and mesalazine) with a significant improvement in a short time.\u0000Bangladesh Med J. 2021 May; 50(2) : 45-49","PeriodicalId":8711,"journal":{"name":"Bangladesh Medical Journal","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75932062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Serum Zinc and Copper Level in Psoriatic and Non-Psoriatic Individual","authors":"Shawana Haque, M. Mahmud, R. B. Habib","doi":"10.3329/bmj.v50i2.61176","DOIUrl":"https://doi.org/10.3329/bmj.v50i2.61176","url":null,"abstract":"Psoriasis is a common chronic inflammatory disease of skin and multiple organs of body. The exact etiology of psoriasis is not yet certain. It is assumed that trace elements may have some role in pathogenesis of psoriasis. They can act as co-enzymes for metabolism and can act as antioxidants against free radicals. Therefore they can participate in epidermal proliferation and inflammatory process of psoriasis. This study aimed to evaluate the relation between psoriasis and trace elements namely zinc and copper. This study was conducted on 40 diagnosed cases of psoriasis and 40 non psoriatic individuals in the department of Dermatology and Venereology in Bangabandhu Sheikh Mujib Medical University, Dhaka. Biochemical analyses of serum copper and zinc were analyzed and compared statistically with cases and healthy controls. Serum zinc level was significantly lower and serum copper level was significantly higher in patient with psoriasis compared to control (p= < 0.001). Individuals with moderate to severe psoriasis had significantly lower zinc levels and significantly higher copper levels than patients with mild psoriasis, according to Psoriasis area and Severity Index Score (p= < 0.05). Correction of serum zinc and copper level could be beneficial for psoriasis patients.\u0000Bangladesh Med J. 2021 May; 50(2) : 28-31","PeriodicalId":8711,"journal":{"name":"Bangladesh Medical Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89429236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obituary news Vol.50(1)","authors":"K. Halim","doi":"10.3329/bmj.v50i2.61221","DOIUrl":"https://doi.org/10.3329/bmj.v50i2.61221","url":null,"abstract":"Abstract not available\u0000Bangladesh Med J. 2021 May; 50(2) : 50-52","PeriodicalId":8711,"journal":{"name":"Bangladesh Medical Journal","volume":"296 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74953961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obituary News September-2020 Vol.49(3)","authors":"K. Halim","doi":"10.3329/bmj.v49i3.56083","DOIUrl":"https://doi.org/10.3329/bmj.v49i3.56083","url":null,"abstract":"Abstract not available \u0000Bangladesh Med J. 2020 Sept; 49(3) : 57-63","PeriodicalId":8711,"journal":{"name":"Bangladesh Medical Journal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74333295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"‘Crush Programme’ as Part of Combined Control Programme for Culex Mosquito in Both North and South Dhaka City Corporation","authors":"Abul Masud Md Nurul Karim, Tamanna Afroz, K. Halim, Masuma Begum, Tarique Mehedi Parvez","doi":"10.3329/bmj.v49i3.56082","DOIUrl":"https://doi.org/10.3329/bmj.v49i3.56082","url":null,"abstract":"Abstract not available\u0000Bangladesh Med J. 2020 Sept; 49(3) : 53-56","PeriodicalId":8711,"journal":{"name":"Bangladesh Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83005120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinico-Histopathological Consistency in Dermatological Diseases","authors":"M. Mahmud, Md Abdullah Al Mamun, S. C. Hazra, R. B. Habib, M. Chowdhury","doi":"10.3329/bmj.v49i3.56078","DOIUrl":"https://doi.org/10.3329/bmj.v49i3.56078","url":null,"abstract":"Skin biopsy for histopathology is the most reliable investigation for diagnosis of skin diseases. The main purpose of skin biopsy is to confirm clinical diagnosis but dermatologists usually looking for the concordance with histopathological report. The aim of the study was to observe the consistency of clinical and histopathological diagnosis of skin diseases. An observational study was conducted on 630 patients that undertaken skin biopsy and that was performed at the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University from January 2018 to January 2019. Patients who were advised for biopsy by outpatient and inpatient department and the biopsy was done accordingly was included in the study. Finally the inclusion was confirmed when the histopathological report was available. Demographic information, clinical diagnosis, type of biopsy procedure, types of specimen taken and send for histopathological procedure and the histopathological diagnosis was noted in data collection sheet. Histopathological diagnosis and its correlation with clinical diagnosis was assessed for consistency and it was the main outcome measure of the study. The mean age of patients on whom biopsy was performed was 35.14 ±16.57 years and the age range was 5-82 years. Male patients outnumbered female and the male to female ratio was 1.15: 1. Three types of biopsy were performed among them incisional biopsy was the commonest type (93.5%). In most of the cases collected specimen was skin 94.76%, others type of specimens were mucous membrane 2.6%, nail matrix 1.9% and 0.6% specimen was hair follicle. Among the cases 71.43% was diagnosed clinically. The common clinical diagnosis in which biopsy was done was psoriasis and its types 17.77%, lichen planus and its variants 14.12%, the connective tissue diseases 6.19% and infectious diseases 5.39%.  In 79.52% cases histopathological diagnosis was done and 68.22% diagnosis was consistent with the clinical diagnosis. The maximum clinico-pathological concordance was found in vesiculo-bullous disease 93.33%. Then connective tissue diseases 79.48%, vasculitides 75% and lichenoid diseases 73.56%. Skin biopsy is a conclusive tool to overcome diagnostic dilemmas in dermatological diseases. The clinico-pathological concordance is assumed lower than the expectation of dermatologists but the collective efforts of dermatologists and pathologists can improve the capacity of diagnosis of biopsy samples. \u0000Bangladesh Med J. 2020 Sept; 49(3) : 29-34","PeriodicalId":8711,"journal":{"name":"Bangladesh Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79464543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic Chiasmatic Hypothalamic Glioma Presented as with Panhypopituitarism with Bilateral Primary Optic Atrophy","authors":"Asm Al Amin, Shanta Afrin, S. Biswas, Wahida Rahman, Md. Nazmul Hasan","doi":"10.3329/bmj.v49i3.56081","DOIUrl":"https://doi.org/10.3329/bmj.v49i3.56081","url":null,"abstract":"Optic chiasmatic hypothalamic gliomas are among common primary neoplasm of the optic nerve. It presents with decreased vision as well as features of hypopituitarism due to infiltration of the hypothalamus. In this case report, a young man presented with loss of libido, increased thirst, gradual loss of vision, bilateral optic atrophy and visual field defect. The MRI of sellar and paraseller region showed optic chiasmaticglioma with hypothalamic extension and biochemical parameter showed panhypopituitarism.  We diagnosed this patient as a case of Optic chiasmatic hypothalamic gliomas (OCHGS) with panhypopituitarism with partial cranial diabetes insipidus with bilateral primary optic atrophy.The patient underwent surgery after adequate hormonal treatment but died due to post-operative complications \u0000Bangladesh Med J. 2020 Sept; 49(3) : 49-52","PeriodicalId":8711,"journal":{"name":"Bangladesh Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90782726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Concentration of 25-Hydroxy Vitamin D in Chronic Liver Disease and its’ Correlation with Severity","authors":"Fannana Ahmed, Pinaki Paul, Anwarul Kabi, Rashedul Hasan","doi":"10.3329/bmj.v49i3.56079","DOIUrl":"https://doi.org/10.3329/bmj.v49i3.56079","url":null,"abstract":"Chronic Liver Disease (CLD) is a common disease all over the world and the major biological factors are Hepatitis B virus (HBV) and Hepatitis C virus (HCV) in Bangladesh and Alcoholic liver disease in the western world. Life expectancy of CLD patient is increasing now a days by available modern treatment; but the long term complications are now evident. Hepatic osteodystrophy is one of the most common complication which is associated with vitamin D deficiency. Vitamin D undergoes hepatic 25-hydroxylation, but as the hepatic parenchyma is jeopardized so the metabolic activation of this vitamin is impaired. The aim of the study was to measure the concentration of 25-hydroxy vitamin D 25(OH) D in CLD patient in different etiology and to find out the relationship of level of 25(OH) D in different stages of the disease according to Child-Pugh classification. This cross sectional study was carried out in the Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka during the period of April 2015 to March 2016. Patients attending the Gastroenterology Department with cirrhosis of liver and who fulfilled the inclusion criteria were initially enrolled for the study. Study objectives were explained and informed consent was taken from patients prior to record their clinical history, examination findings and initial investigation reports in the standard data sheet. The diagnosis of liver cirrhosis was made by combination of clinical features, blood profile and trans abdominal ultrasonography (T. USG). Endoscopy of the upper GIT was also done to see the presence of oesophageal or gastric varices which is a sign of increase portal pressure. Stages of CLD were assessed by Child-Pugh scoring system and level of 25(OH) D was measured from blood with the help of the Department of Bio-chemistry. Data was collected using a structured data sheet and analyzed by SPSS. Out of 85 patients, male-female ratio was 3:1 and mean age was 53.0 ± 10.7 year within the range of 25-70 years. Most of the patients had acites 92.9% and anorexia 90.6%; where four-fifth patients had weight loss and more than one third had Jaundice. Nearly half of the patients had abdominal pain and 42.4% had melaena. Four-fifth patients had history of blood transfusion and most of them had H/O hospitalization 94.8%, anaemia (97.6%) and Splenomegaly 92.9%. More than half (52.9%) of patients had bone pain; where jaundice 61.2% and Leukonychia 61.2% were detected in equal number of patients. Mean  vitamin 25(OH) D was 16.29 ± 7.96 in 69 HBV patients and 20.14 ± 9.76 in 16 HCV patients. In this study, 28.2% patients were in child Pugh A, 36.4% in child Pugh B and 32.9% in child Pugh C stages. Mean  vitamin 25(OH) D were 27.12 ± 6.11, 15.97 ± 5.40 and 9.57 ± 1.I5 in Child-pugh A, Child-pugh B and Child-pugh C stages respectively. Mean vitamin 25(OH) D was observed at decreased level as the changes of stage from lower to higher. Vitamin D deficiency was highly prevalent in pa","PeriodicalId":8711,"journal":{"name":"Bangladesh Medical Journal","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82922341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Imaging (MRI) Evaluation of Sellar Region Tumors with Histopathological Correlation","authors":"S. Yiasmeen, Abul Masud Md Nurul Karim, M. Begum, Syeda Ireen Parvin, F. Akter, Golam Rahman Dulal","doi":"10.3329/bmj.v49i3.56074","DOIUrl":"https://doi.org/10.3329/bmj.v49i3.56074","url":null,"abstract":"MRI is a complex, rapidly evolving modality which has assumed an increasingly important role in the diagnosis of Sellar region tumors. It is now the preferred modality for the definitive evaluation and follow-up of the most sellar region tumors. Using different pulse sequence small lesion can be detected even without contrast. Gd-DTPA provides valuable information in MR imaging sellar region tumors, particularly in pre-operative evaluation. This study was conducted to elucidate the accuracy of MRI in pre-operative evaluation of sellar region tumors and its validity by determining sensitivity, specificity, positive and negative predictive value with histopathological correlation. This cross sectional observational study was carried out in the department of radiology and imaging in collaboration with department of Neurosurgery, Dhaka Medical college Hospital, Dhaka during the period of January 2008 to April 2009. MRI of brain was done on 42 patients referred for evaluation of sellar region tumors. The following result and observation were obtained. The age range of the patient was 20 to 80 years. The mean age (HSE) was 34.31(+2.80). Maximum patients were in age group 20-30 years and male-female ratio was 1.8:1. Most sellar region tumor located in the intrasellar with suprasellar extension. Out of 42 patients 37 (88%) patients were truly diagnosed by MRI as sellar region tumors. The sensitivity of MRI to diagnosed macro adenoma was 81.25%, specificity 80.76%, positive predictive value 72.2%, negative predictive value 87.5%, accuracy 80.95%. This study finds that MRI is a valid imaging modality in the diagnosis of pituitary adenoma and sellar region tumor. \u0000Bangladesh Med J. 2020 Sept; 49(3) : 1-10","PeriodicalId":8711,"journal":{"name":"Bangladesh Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83525186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation of Campylobacter Species in the Stool of Under Five Children With Acute Diarrhea in a Tertiary Care Hospital of Bangladesh","authors":"Suborna Dey, R. Das, M. Haque, P. Das, S. Das, F. Habib, Sultana Mehnaz Rahman Chowdhury, Mohammed Mirazur Rahman, Sakib Aman, Md Nazmul Hasan","doi":"10.3329/bmj.v49i3.56075","DOIUrl":"https://doi.org/10.3329/bmj.v49i3.56075","url":null,"abstract":"Campylobacter species is the main etiology of gastroenteritis due to bacteria.  To determine prevalence of Campylobacter species in stool of children less than five years of age with acute diarrhoea, this observational study was conducted in the Department of Microbiology, Sylhet M A G Osmani Medical College, Sylhet from January to December, 2017. Stool samples were collected from 162 under-five children with acute diarrhoea admitted in the Department of Paediatrics. Isolation of Campylobacter species were done by stool culture. About two third of the children were male (65.4%) and more than one fourth of the affected children (26.65%) were in age group 6-12 months. Campylobacter species was isolated in 24 (15%) sample and among them, Campylobacter jejuni were 22 (91.7%) and Campylobacter coli were 2 (8.3%). Isolation rate of Campylobacter species did not differ significantly between age group of 6-12 months and  above 12 months (p=0.211) of age;  male and female children (p=0.288); among socioeconomic status (p=0.673) and between residential status (p=0.108). Isolation rate of Campylobacter species are frequent among under five children with acute diarrhea and most of the children came from low socioeconomic background and were male. However, a large multicenter study needs to be conducted to generate more evidence regarding the issue. \u0000Bangladesh Med J. 2020 Sept; 49(3) : 11-16","PeriodicalId":8711,"journal":{"name":"Bangladesh Medical Journal","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87176864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}