Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale最新文献_第8页

[Adverse drug reaction - Definitions, risk factors and pharmacovigilance]. [药物不良反应-定义、危险因素和药物警戒]。

Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale Pub Date : 2015-12-10 DOI: 10.1024/0040-5930/a000735

S. Krähenbühl

引用次数: 1

[Adverse drug events of older patients presenting in the emergency department]. [急诊科老年患者的药物不良事件]。

Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale Pub Date : 2015-12-10 DOI: 10.1024/0040-5930/a000736

A. Malinovska, R. Bingisser, C. Nickel

{"title":"[Adverse drug events of older patients presenting in the emergency department].","authors":"A. Malinovska, R. Bingisser, C. Nickel","doi":"10.1024/0040-5930/a000736","DOIUrl":"https://doi.org/10.1024/0040-5930/a000736","url":null,"abstract":"The effect of medication is always a balance between their beneficial effects and any adverse reactions they might elicit. The main risk for adverse drug events {ADEs) is polypharmacy, which is the simultaneous use of multiple drugs.This often applies to older patients, who suffer from multiple diseases and therefore take multiple medications. Thus, itis not surprising, that ADEs are frequention older patients and account up to 16% of emergency visits. It is still under discussion, whether age is an independent risk factor for ADEs. However, there are some age-related changes in the pharmacokinetic and pharmacodynamics properties of many drugs, which may influence the highly fragile balance between benefit and harm in older patients. Though there are multiple risk factors for and causes of ADEs, it could be shown that a lot of ADEs are preventable and even predictable: Budnitz eta/. showed that almost two thirds of emergency hospitalisations occur due to four medication classes: warfarin, oral antiplatelet agents, insulin and oral hypoglycaemic agents. Nevertheless, only 40-60% ofA DEs are recognized in the emergency department. This might be explained by the broad clinical symptoms, ranging from bleeding due to anticoagulants to the more nonspecific symptom of weakness due to hyponatraemia secondary to thiazide diuretics. Detecting and avoiding ADEs could be aided by using lists such as Beers criteria or STOPP/FART which list medications which are potentially inappropriate for older patients.","PeriodicalId":87030,"journal":{"name":"Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale","volume":"10 1","pages":"673-7"},"PeriodicalIF":0.0,"publicationDate":"2015-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78905015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

[5-0xoproline (pyroglutamic acid) acidosis and acetaminophen- a differential diagnosis in high anion gap metabolic acidosis]. [5-脯氨酸(焦谷氨酸)酸中毒和对乙酰氨基酚-高阴离子间隙代谢性酸中毒的鉴别诊断]。

Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale Pub Date : 2015-12-10 DOI: 10.1024/0040-5930/a000745

S. Weiler, R. Bellmann, G. Kullak-Ublick

{"title":"[5-0xoproline (pyroglutamic acid) acidosis and acetaminophen- a differential diagnosis in high anion gap metabolic acidosis].","authors":"S. Weiler, R. Bellmann, G. Kullak-Ublick","doi":"10.1024/0040-5930/a000745","DOIUrl":"https://doi.org/10.1024/0040-5930/a000745","url":null,"abstract":"Rare cases of high anion gap metabolic acidosis during long-term paracetamol administration in therapeutic doses with causative 5-oxoproline (pyroglutamic acid} accumulation have been reported. Other concomitant risk factors such as malnutrition, alcohol abuse, renal or hepatic dysfunction, comedication with flue/oxacillin, vigabatrin, netilmicin or sepsis have been described. The etiology seems to be a drug-induced reversible inhibition of glutathione synthetase or 5-oxoprolinase leading to elevated serum and urine levels of 5-oxoproline. Other more frequent differential diagnoses, such as intoxications, ketoacidosis or lactic acidosis should be excluded. Causative substances should be stopped. 5-oxoproline concentrations in urine can be quantified to establish the diagnosis. Adverse drug reactions, which are not listed or insufficiently described in the respective Swiss product information, should be reported to the regional pharmacovigilance centres for early signal detection. 5-0 xoproline acidosis will be integrated as a potential adverse drug reaction in the Swiss product information for paracetamol.","PeriodicalId":87030,"journal":{"name":"Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale","volume":"27 1","pages":"737-41"},"PeriodicalIF":0.0,"publicationDate":"2015-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88129586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

[Side effects and interactions of frequently used cardiovascular drugs]. [常用心血管药物的副作用和相互作用]。

Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale Pub Date : 2015-12-10 DOI: 10.1024/0040-5930/a000740

T. Dieterle

引用次数: 5

[Understanding and reducing the risk of adverse drug reactions in pediatric patients]. [了解和降低儿科患者药物不良反应的风险]。

Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale Pub Date : 2015-12-10 DOI: 10.1024/0040-5930/a000737

V. Gotta, J. N. van den Anker, M. Pfister

引用次数: 0

[ Preventing adverse drug events using clinical decision support systems]. [使用临床决策支持系统预防药物不良事件]。

Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale Pub Date : 2015-12-10 DOI: 10.1024/0040-5930/a000739

A. R. Salili, F. Hammann, A. Taegtmeyer

引用次数: 2

[ Drug allergies: clinical presentation and red flags]. [药物过敏:临床表现和危险信号]。

Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale Pub Date : 2015-12-10 DOI: 10.1024/0040-5930/a000743

K. Scherer Hofmeier, A. Bircher

引用次数: 2

[Sleep apnea]. (睡眠呼吸暂停)。

Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale Pub Date : 2013-04-03 DOI: 10.1007/978-3-540-68706-1_1677

T. Hess, E. Russi

引用次数: 0

[Sonographic diagnosis of gestational trophoblastic disease in early pregnancy]. 妊娠早期妊娠滋养细胞疾病的超声诊断

Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale Pub Date : 2008-11-01 DOI: 10.1024/0040-5930.65.11.657

E. Visca, C. Vökt, S. Tercanli

{"title":"[Sonographic diagnosis of gestational trophoblastic disease in early pregnancy].","authors":"E. Visca, C. Vökt, S. Tercanli","doi":"10.1024/0040-5930.65.11.657","DOIUrl":"https://doi.org/10.1024/0040-5930.65.11.657","url":null,"abstract":"Gestational trophoblastic disease (GTD) is classified as a metastatic or non-metastatic lesion, furthermore, villous GTD is distinguished from non-villous GTD. Because of their higher incidence and their risk of persistent gestational trophoblastic neoplasia (pGTN), early diagnosis of molar pregnancies is of clinical importance. Advances in ultrasound (US) technology and frequent application of transvaginal sonography in early pregnancy have changed the clinical and pathological presentation of molar pregnancies. Based on US imaging and histopathological examination of products of conception, the majority of cases are diagnosed in early pregnancy, either as incidental findings or in women presenting with symptoms of miscarriage. Molar pregnancies have characteristic sonographic features which are more pronounced as pregnancy advances. In early pregnancy, overall US detection rates for molar pregnancies range between 34-56% depending on gestational age, sonographic features, histologic morphology, apparative equipment, and operator expertise. There also seems to be an intrinsic limit to US detection rates based on histomorphometric features of the hydropic villi. Thus, in early pregnancy, lack of typical sonographic features does not exclude molar pregnancy. If a condition predisposing for pGTN is not recognized at the time of evacuation, prognosis is worse. With increasing demand for medical management of miscarriages and abortions, when products of conception are usually not submitted for histological examination, sonographic assessment of the chorion is mandatory. In the case of suspicious findings, surgical management and histological examination are indicated.","PeriodicalId":87030,"journal":{"name":"Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale","volume":"18 1","pages":"657-61"},"PeriodicalIF":0.0,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78840077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

[Club drugs]. 俱乐部毒品。

Therapeutische Umschau und medizinische Bibliographie. Revue therapeutique et bibliographie medicale Pub Date : 2007-01-01 DOI: 10.4135/9781483349985.n112

C. Senn, A. Bücheli, M. Schaub, R. Stohler

引用次数: 0