Basic life sciences最新文献_第7页

A nucleosome model for the simulation of DNA strand break experiments. 模拟DNA链断裂实验的核小体模型。

Basic life sciences Pub Date : 1994-01-01 DOI: 10.1007/978-1-4757-9788-6_17

M Terrissol, E Pomplun

引用次数: 8

Monte Carlo approach in assessing damage in higher order structures of DNA. 用蒙特卡罗方法评估DNA高阶结构的损伤。

Basic life sciences Pub Date : 1994-01-01 DOI: 10.1007/978-1-4757-9788-6_16

A Chatterjee, J B Schmidt, W R Holley

{"title":"Monte Carlo approach in assessing damage in higher order structures of DNA.","authors":"A Chatterjee, J B Schmidt, W R Holley","doi":"10.1007/978-1-4757-9788-6_16","DOIUrl":"https://doi.org/10.1007/978-1-4757-9788-6_16","url":null,"abstract":"We have developed a computer monitor of nuclear DNA in the form of chromatin fibre. The fibres are modeled as a ideal solenoid consisting of twenty helical turns with six nucleosomes per turn. The chromatin model, in combination with are Monte Carlo theory of radiation damage induces by charged particles, based on general features of tack structure and stopping power theory, has been used to evaluate the influence of DNA structure on initial damage. An interesting has emerged from our calculations. Our calculated results predict the existence of strong spatial correlations in damage sites associated with the symmetries in the solenoidal model. We have calculated spectra of short fragments of double stranded DNA produced by multiple double strand breaks induced by both high and low LET radiation. The spectra exhibit peaks at multiples of approximately 85 base pairs (the nucleosome periodicity), and approximately 1000 base pairs (solenoid periodicity). Preliminary experiments to investigate the fragment distributions from irradiated DNA, made by B. Rydberg at Lawrence Berkeley Laboratory, confirm the existence of short DNA fragments and are in substantial agreement with the predictions of our theory.","PeriodicalId":8697,"journal":{"name":"Basic life sciences","volume":"63 ","pages":"225-35; discussion 235-41"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18758094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

A computational approach to the relationship between radiation induced double strand breaks and translocations. 辐射诱导双链断裂与易位关系的计算方法。

Basic life sciences Pub Date : 1994-01-01 DOI: 10.1007/978-1-4757-9788-6_18

W R Holley, A Chatterjee

引用次数: 3

Charged-particle transport in biomolecular media: the third generation. 生物分子介质中的带电粒子输运:第三代。

Basic life sciences Pub Date : 1994-01-01 DOI: 10.1007/978-1-4757-9788-6_7

M Zaider, A Fung, M Bardash

引用次数: 7

The ERabp gene family: structural and physiological analyses. ERabp基因家族:结构和生理分析。

Basic life sciences Pub Date : 1994-01-01 DOI: 10.1007/978-1-4757-9492-2_12

K Palme, T Hesse, C Garbers, C Simmons, D Söll

引用次数: 3

Monte Carlo track-structure calculations for aqueous solutions containing biomolecules. 含有生物分子的水溶液的蒙特卡罗轨迹结构计算。

Basic life sciences Pub Date : 1994-01-01 DOI: 10.1007/978-1-4757-9788-6_11

J E Turner, R N Hamm, R H Ritchie, W E Bolch

引用次数: 12

Comparison of various Monte Carlo track structure codes for energetic electrons in gaseous and liquid water. 气态和液态水中高能电子的各种蒙特卡罗轨道结构代码的比较。

Basic life sciences Pub Date : 1994-01-01 DOI: 10.1007/978-1-4757-9788-6_12

H Nikjoo, S Uehara

引用次数: 15

The modulating effects of antioxidants in rat embryos and Sertoli cells in culture. 抗氧化剂对大鼠胚胎和培养的支持细胞的调节作用。

Basic life sciences Pub Date : 1993-01-01 DOI: 10.1007/978-1-4615-2984-2_18

D Anderson, A J Francis

{"title":"The modulating effects of antioxidants in rat embryos and Sertoli cells in culture.","authors":"D Anderson, A J Francis","doi":"10.1007/978-1-4615-2984-2_18","DOIUrl":"https://doi.org/10.1007/978-1-4615-2984-2_18","url":null,"abstract":"The male and female reproductive systems are targets for the toxicity of a wide range of compounds. There is a paucity of information regarding the modulating effects of antioxidants in such systems. Enzymically generated oxygen radicals have been shown to be toxic and/or mutagenic in a variety of in vitro test systems. It is known that vitamins C and E can modify responses in such systems. Malformations and growth reductions have been observed in whole rat embryo cultures in this laboratory after treatment with the oxygen radical generating system of xanthine/xanthine oxidase. Groups of 9.5-day-old rat embryos were treated with this system with or without vitamin C or E. Vitamin C at the doses given totally abolished neural suture defects while vitamin E only partially did so. Vitamins C and E administered alone had no effect on the embryos. Germ cell detachment has been shown to occur in mixed cultures of Sertoli and germ cells in response to some known in vivo testicular toxins. Such cultures were also treated with the oxygen radical generating system of xanthine/xanthine oxidase. There was an increase in germ cell detachment with this treatment which was reduced by vitamin C but not by vitamin E at the doses administered. These findings would suggest that vitamin supplementation could protect somatic cells of reproductive systems against toxins that act through oxygen radical mechanisms.","PeriodicalId":8697,"journal":{"name":"Basic life sciences","volume":"61 ","pages":"189-200"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4615-2984-2_18","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19293041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Assessment of body fat: a comparison of techniques. 体脂评估:技术比较。

Basic life sciences Pub Date : 1993-01-01 DOI: 10.1007/978-1-4899-1268-8_11

S J Ryde, D W Thomas, J L Birks, P A Ali, N H Saunders, S al-Zeibak, W D Morgan

引用次数: 6

Accuracy of DXA-based body composition measurements for pediatric studies. 儿童研究中基于dxa的身体成分测量的准确性。

Basic life sciences Pub Date : 1993-01-01 DOI: 10.1007/978-1-4899-1268-8_34

K J Ellis, R J Shypailo, J A Pratt, W G Pond

引用次数: 16