Bangladesh Pharmaceutical Journal最新文献

{"title":"New Drug Approvals Vol. 25(1)","authors":"M. A. Hossain","doi":"10.3329/bpj.v25i1.57969","DOIUrl":"https://doi.org/10.3329/bpj.v25i1.57969","url":null,"abstract":"Abstract not available \u0000Bangladesh Pharmaceutical Journal 25(1): 115-117, 2022 (January)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88247310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Health News Vol. 25(1)","authors":"M. A. Hossain","doi":"10.3329/bpj.v25i1.57971","DOIUrl":"https://doi.org/10.3329/bpj.v25i1.57971","url":null,"abstract":"Abstract not available \u0000Bangladesh Pharmaceutical Journal 25(1): 121-124, 2022 (January)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79756132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro Analysis Provides New Insights into the Pharmacological Actions of Methanol Extract of Seeds of Tamarindus indica L. and its Kupchan Fractions","authors":"Sharmeen Asad, F. Kabir, Safaet Alam, Fahmida Tasnim Richi, Irin Pervin Anny, M. Nesa, M. Rashid","doi":"10.3329/bpj.v25i1.57835","DOIUrl":"https://doi.org/10.3329/bpj.v25i1.57835","url":null,"abstract":"Tamarind or Tamarindus indica L. is a multipurpose plant distributed throughout the tropics including Bangladesh. The present study was conducted to establish the preliminary antioxidant, antimicrobial, anti-inflammatory and thrombolytic activities of methanol extract of T. indica seeds along with its Kupchan fractions. To evaluate the antioxidant properties, the total phenolic content of T. indica was determined and expressed in gallic acid equivalent (GAE). Alongside, DPPH free radical scavenging assay was performed to ensure the antioxidant properties of the seeds where the methanolic crude extract revealed the maximum activity having IC50 value of 9.43 μg/ml. In the antimicrobial assay by disk diffusion method, only non-polar fractions of the extract showed mild antimicrobial activity against the test organisms tested while the polar crude methanol extract exhibited the maximum inhibition (58.16%, p < 0.001) of hypotonic solution-induced erythrocyte rupture in anti-inflammatory investigation among all the partitionates. During evaluation of thrombolytic activity in terms of percent of clot lysis, the methanol soluble fraction exhibited the highest percent of thrombolysis (23.5%) as compared to the reference standard, streptokinase (64.25%). The findings of the current study rationalize some of the traditional uses of T. indica and preliminarily ascertain its bioactive potential, which may act as a base for phytochemical and mechanism-based pharmacological studies of the plant in future.\u0000Bangladesh Pharmaceutical Journal 25(1): 9-15, 2022 (January)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89822624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Antioxidant, Antimicrobial, Cytotoxicity and Thrombolytic Potential of Erythrina fusca Lour Grown in Bangladesh","authors":"A. Anjum, Md. Zakir Sultan, Mohammad Abdullah Al Mansur, C. Hasan, M. Rashid","doi":"10.3329/bpj.v25i1.57834","DOIUrl":"https://doi.org/10.3329/bpj.v25i1.57834","url":null,"abstract":"The current study was conducted to assess the antioxidant, antimicrobial, cytotoxicity and thrombolytic potential of the leaves and stem bark of Erythrina fusca Lour grown in Bangladesh. For the assessment of antioxidant properties, DPPH scavenging and phosphomolybdenum assays were used. In the DPPH free radical scavenging assay, the chloroform soluble fraction of a methanol extract of leaves of E. fusca exhibited the highest free radical scavenging activity with an IC50 value of 5.5 ± 0.60 μg/ml, while the reference standard (ascorbic acid) showed an IC50 value of 5.8 ± 0.18 μg/ml. All the test samples and the standard BHT demonstrated good linear relationship in the phosphomolybdenum assay. It was observed that the test samples contained considerable number of bioactive compounds including total phenolics in the aqueous soluble fraction of the leaves giving the highest 94.02 ± 1.004 GAE/100g of dried sample. All test samples exhibited moderate antimicrobial activity against 13 Gram-positive and Gram-negative bacterial strains and 3 fungi, where the chloroform soluble fraction of the stem bark demonstrated the highest inhibition of growth with zone of inhibition of 19.3 ± 0.21 mm against Bacillus cereus. All the test samples displayed cytotoxic activity against brine shrimp nauplii having significant LC50 and LC90 values. The chloroform soluble materials demonstrated highest lethality with LC50 value of 1.55 ± 0.30 μg/ml and LC90 65.68 ± 0.23 μg/ml. On the other hand, the carbon tetrachloride soluble fraction of the stem bark showed the highest clot lysis (22.75 ± 0.59%) as compared to that (66.77 ± 0.61%) revealed by reference standard, streptokinase. The findings of this study revealed that the leaves and stem bark of E. fusca growing in Bangladesh possesses bioactive compounds but further studies are required to purify and identify them.\u0000Bangladesh Pharmaceutical Journal 25(1): 1-8, 2022 (January)","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88484602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of Aptamers That Bind to the Multivalent Aminoglycoside Amikacin","authors":"A. Alam, Y. Miura, T. Tsukahara","doi":"10.20944/preprints202108.0493.v1","DOIUrl":"https://doi.org/10.20944/preprints202108.0493.v1","url":null,"abstract":"Increased awareness of the multiple roles of RNA molecules has led to the realization that, in addition to their structural and functional roles, RNAs can be drug targets for small molecular therapy. The aim of this study was to identify multivalent amikacin specific RNA aptamers that can be a new target sites for aminoglycoside antibiotics, including amikacin using the systemic evolution of ligands by exponential enrichment (SELEX) method. Amikacin, a member of the aminoglycoside group of antibiotics, binds to specific sites in bacterial 16S ribosomal RNAs (rRNAs) and interferes with protein synthesis, leading to cell death. Here, we used the SELEX method to isolate high affinity RNA fragments (aptamers) that bind to amikacin. After five rounds of SELEX selection, in which a linear N25 DNA template was used for the first selection cycle, the resulting RNA was cloned and sequenced. Among the 38 clones generated, five groups of sequences (groups A through E) containing nine conserved motifs were identified. The sequences of groups A and B were almost identical, indicating that the selected RNA was enriched. Subsequently, the Basic Local Alignment Search Tool program was used to search for the conserved motifs in bacterial 16S rRNA sequences. Strikingly, no sequence homology was observed, suggesting that the conserved sequences (motifs) identified in this study may be novel target sites for amikacin.","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86093746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Drug Approvals Vol 24(2)","authors":"Akbar Hossain","doi":"10.3329/BPJ.V24I2.54768","DOIUrl":"https://doi.org/10.3329/BPJ.V24I2.54768","url":null,"abstract":"Abstract not available \u0000Bangladesh Pharmaceutical Journal 24(2): 195-197, 2021","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73106280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude, Perception of Biological Science and Healthcare Professional Students to Complementary and Alternative Medicine Health Belief and Practice in Southeastern Region of Bangladesh: A Comparative Study","authors":"A. Reza, Nahid Sikdar, Mst Samima Nasrin, Atiar Rahman, A. R. Tareq, A. Alam, Sanjida Sharmin, M. Sayeed","doi":"10.3329/BPJ.V24I2.54714","DOIUrl":"https://doi.org/10.3329/BPJ.V24I2.54714","url":null,"abstract":"The health professionals require scientific knowledge to advise their patients on complementary and alternative medicines (CAM). Previously, several studies were conducted regarding the CAM perception, attitude and use on health care professionals only; in contrast, our study encompasses both students of health care professionals and other disciplines. The aim of this study was to compare the attitudes and perception about CAM practices between students of biological sciences (Biochemistry and Molecular Biology, Microbiology and Botany) and health care professionals (Pharmacy and medical students) in public and private universities located in the southeastern region in Bangladesh. The questionnaire-based study conducted on 332 systematically sampled students (four private and one public universities) located in the southeastern region in Bangladesh. The cross-sectional study was conducted from March to July, 2018. All students showed a positive attitude towards CAM use. Herbal medicine, homeopathy, nutritional supplements followed by hypnosis, massage, spiritual healing, and meditation were the most commonly known and used CAM modalities. Most of the students (40.7%) believed that the integration of CAM and conventional medicine should be essential in health care setting. The major obstacles for CAM use are patient interest (48.2%) and lack of physician interest (43.4%). In addition, 36.7% students believed that CAM practices should be included in their school’s curriculum. Moreover, 39.5% students assumed that CAM knowledge is important to their daily life. Biological sciences and healthcare professional students of Bangladesh showed positive perception on CAM uses. \u0000Bangladesh Pharmaceutical Journal 24(2): 159-167, 2021","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79782341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro and In vivo Investigations Provide New Insights into Bioactivities of Blumea clarkei Hook.f. Leaves","authors":"Farzana Kabir, Asif Uj Jaman, Rizia Azad Rumpa, Tabassum Jannat, Safaet Alam, Tanoy Saha, Ashraful Islam, Mahfuza Afroz Soma","doi":"10.3329/BPJ.V24I2.54713","DOIUrl":"https://doi.org/10.3329/BPJ.V24I2.54713","url":null,"abstract":"As there is a resurgence of interest in plants as promising sources of new active pharmaceutical constituents, the present study has been designed to establish the preliminary biological activities of Blumea clarkei Hook.f. leaves. Here, the crude methanol extract of the leaves along with its organic and aqueous soluble fractions were subjected to different in vitro and in vivo assays. The ethyl acetate soluble fraction exhibited the highest total phenolic content (71.59 mg of GAE/gm of extract) and DPPH free radical scavenging (IC50 value 19.25 μg/ml) whereas another polar fraction; the aqueous soluble extractive showed the maximum cytotoxicity (LC50 value of 18.60 μg/ml) in the brine shrimp lethality assay. In membrane stabilizing activity evaluation, the inhibition of hypotonic solution and heat induced hemolysis were revealed maximum by the DCM (30.64%) and aqueous soluble fraction (39.15%), respectively while the crude methanol extract exhibited the highest thrombolytic potential (30.47% clot lysis). The central analgesic activity of the crude extract significantly increased the latent response time in tail-immersion method (p<0.001) at doses 200 and 400 mg/kg of body weight after 90 minutes of administration when compared to the control group. In acetic acid-induced writhing method, the plant extract showed prominent peripheral analgesia (p<0.001) with 47.54% and 65.57% inhibition at 200- and 400-mg/kg of body weight, respectively. In addition, a dose dependent hypoglycemic and antidiarrheal activities were also observed by the crude extract. \u0000Bangladesh Pharmaceutical Journal 24(2): 149-158, 2021","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73082586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Effects of Superdisintegrants on Immediate Release Tablet of Linagliptin, a DDP-4 Inhibitor","authors":"Tanoy Saha, Mahbubul Alam, Dilshad Noor Lira, A. S. Rouf","doi":"10.3329/BPJ.V24I2.54715","DOIUrl":"https://doi.org/10.3329/BPJ.V24I2.54715","url":null,"abstract":"The study aimed to develop and evaluate an immediate-release tablet dosage form of Linagliptin. Different concentrations (ranges 5-10%) of super-disintegrants, Croscarmellose sodium (CCS), and Sodium starch glycolate (SSG) were used to prepare nine tablet dosage forms (F1 to F9) through the direct compression method. The compatibility of the formulations was evaluated by FTIR to reveal any possible drug-excipient interactions and it was proved to be compatible with all formulations. Precompression (bulk density, tapped density, Carr’s index, Hausner’s ratio, and angle of repose) and post-compression parameters (weight variation, hardness, thickness, and friability) were analyzed for all tablets and the results were found satisfactory as well as within limits as per USP guidelines. All the formulated batches (F1 to F9) exhibited disintegration of tablets within 2 minutes, where formulation F9 represented the lowest disintegration time (51±3 sec) which was also found significantly better than the marketed product (310±5 sec). In terms of drug dissolution, 90% of drug release was observed for all nine formulations within 45 minutes and formulation F9 (5% CCS and 5% SSG) illustrated the rapid and highest dissolution rate compared to the marketed one’s, 100% drug release at 20 minutes and 91.77 % drug release at 30 minutes successively. The respective data sets of drug release were mathematically fitted to several kinetic models and for all formulations, drug release pattern obeyed first-order kinetics amongst those, formulation F2 (r2= 0.98), F4 (r2= 0.99), F5 (r2= 0.98), and F9 (r2= 0.97) were found to be best fitted in this kinetic norm. Based on disintegration time and dissolution data comparison to a brand leader market product, F9 was experienced as the best formulation. Furthermore, it was observed that if SSG and CCS were combined, then these two parameters were more improved compared to their separate uses. Thus, incorporation of the optimum amount of super-disintegrants in a formulation showed rapid swelling, faster disintegration as well as ease of dissolution of tablet dosage forms. \u0000Bangladesh Pharmaceutical Journal 24(2): 168-179, 2021","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91411656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free Radical Scavenging, Membrane Stabilizing and Thrombolytic Potentials of the Leaves of Quisqualis indica (L.)","authors":"F. Ahmed, F. Aktar, M. Rashid, M. S. Rahman","doi":"10.3329/BPJ.V24I2.54707","DOIUrl":"https://doi.org/10.3329/BPJ.V24I2.54707","url":null,"abstract":"Bangladesh is a land of thousands of plants which might provide a scope to obtain therapeutically important natural drugs. Systematic screening of plants is very vital to fulfill this goal. Quisqualis indica (L.) is a vine and it belongs to the Combretaceae family. It grows all over the Bangladesh. It has some local uses to treat headache, skin disease, diarrhea, fever, cough, etc. In order to assess its biological potential, the leaves of the plant were collected and subjected to methanol extraction followed by fractionating into petroleum ether, carbon tetrachloride, chloroform and aqueous soluble materials. Primary free radical scavenging power of the extractives was evaluated using the radicals generated by DPPH and H2O2. Methanol crude extract as well as aqueous and chloroform fractions showed noticeable radical scavenging potential. Besides, these extracts had higher level of phenolics. The membrane stabilizing potential of the extractives was estimated based on the prevention of hemolysis of RBC prompted by hypotonic solution as well as heat. The aqueous fraction showed the highest level of membrane stabilizing potential indicating its primary anti-inflammatory ability. The extractives were also subjected to thrombolytic study. Mild thrombolytic ability was displayed by them compared to the standard. Further studies are required to explore bioactive compounds. \u0000Bangladesh Pharmaceutical Journal 24(2): 99-104, 2021","PeriodicalId":8695,"journal":{"name":"Bangladesh Pharmaceutical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87276888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}