Autoimmunity最新文献_第5页

Correction. 修正。

IF 3.3 4区医学

Autoimmunity Pub Date : 2024-12-01 Epub Date: 2024-12-02 DOI: 10.1080/08916934.2024.2435720

引用次数: 0

Identification of TXN and F5 as novel diagnostic gene biomarkers of the severe asthma based on bioinformatics and machine learning analysis. 基于生物信息学和机器学习分析，确定 TXN 和 F5 为重症哮喘的新型诊断基因生物标记物。

IF 3.3 4区医学

Autoimmunity Pub Date : 2024-12-01 Epub Date: 2024-11-12 DOI: 10.1080/08916934.2024.2427085

Lu Shou, Haidong He, Yi Wei, Xianrong Xu, Wenmin Wang, Jisheng Zheng

{"title":"Identification of TXN and F5 as novel diagnostic gene biomarkers of the severe asthma based on bioinformatics and machine learning analysis.","authors":"Lu Shou, Haidong He, Yi Wei, Xianrong Xu, Wenmin Wang, Jisheng Zheng","doi":"10.1080/08916934.2024.2427085","DOIUrl":"https://doi.org/10.1080/08916934.2024.2427085","url":null,"abstract":"Asthma poses a major threat to human health. The aim of this study was to identify genetic markers of severe asthma and analyze the relationship between key genes and immune infiltration. Differentially expressed genes (DEGs) were first screened by downloading the training set GSE69683 and validation set GSE137268 from the GEO dataset. SVM-RFE analysis and the LASSO regression model were used to screen key genes, and CIBERSORT was used to assess immune infiltration in the samples. A total of 20 DEGs were identified in this study, mainly enriched for lymph node-like receptors, b-cell receptors, and neutrophil extracellular trap pathway. Comparative validation set GSE137268 identified thioredoxin (TXN) and coagulation factor V (F5) were identified as diagnostic markers of severe asthma. CIBERSORT analysis revealed that TXN and F5 are associated with multiple immune cell infiltrates. In addition, we identified miRNA and TF at the transcriptional level that may regulate F5 and TXN, and found that several commonly used drugs may exert therapeutic effects by targeting F5 and TXN. Taken together, TXN and F5 may be key genes in the development of severe asthma and are associated with immune infiltration. Our study can help to better understand the pathogenesis of asthma and provide new ideas for clinical treatment.","PeriodicalId":8688,"journal":{"name":"Autoimmunity","volume":"57 1","pages":"2427085"},"PeriodicalIF":3.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astragaloside IV promotes the pyroptosis of airway smooth muscle cells in childhood asthma by suppressing HMGB1/RAGE axis to inactivate NF-κb pathway. 黄芪皂苷 IV 通过抑制 HMGB1/RAGE 轴，使 NF-κb 通路失活，从而促进儿童哮喘患者气道平滑肌细胞的热休克。

IF 3.3 4区医学

Autoimmunity Pub Date : 2024-12-01 Epub Date: 2024-08-04 DOI: 10.1080/08916934.2024.2387100

Huahong Zhang, Jun Zhang, Hangli Pan, Ke Yang, Chongwei Hu

{"title":"Astragaloside IV promotes the pyroptosis of airway smooth muscle cells in childhood asthma by suppressing HMGB1/RAGE axis to inactivate NF-κb pathway.","authors":"Huahong Zhang, Jun Zhang, Hangli Pan, Ke Yang, Chongwei Hu","doi":"10.1080/08916934.2024.2387100","DOIUrl":"10.1080/08916934.2024.2387100","url":null,"abstract":"Childhood asthma, a common chronic childhood disease, leads to high mortality and morbidity in the world. Airway smooth muscle cells (ASMCs) is a group of multifunctional cells that has been found to be correlated with the pathogenesis of asthma. Astragaloside IV (AS-IV) is a compound extracted from Astragalus membranaceus, which has the anti-asthmatic effect. However, the role of molecular mechanisms regulated by AS-IV in the biological processes of ASMCs in asthma remains unclear. Our current study aims to investigate the downstream molecular mechanism of AS-IV in modulating the aberrant proliferation and pyroptosis of ASMCs in asthma. At first, we determined that the viability of ASMCs could be efficiently suppressed by AS-IV treatment (200 μM). Moreover, AS-IV promoted the pyroptosis and suppressed PDGF-BB-induced aberrant proliferation. Through mechanism investigation, we confirmed that AS-IV could suppress high mobility group box 1 (HMGB1) expression and prevent it from entering the cytoplasm. Subsequently, AS-IV blocked the interaction between HMGB1 and advanced glycosylation end product-specific receptor (RAGE) to inactivate NF-κB pathway. Finally, in vivo experiments demonstrated that AS-IV treatment can alleviate the lung inflammation in asthma mice. Collectively, AS-IV alleviates asthma and suppresses the pyroptosis of AMSCs through blocking HMGB1/RAGE axis to inactivate NF-κB pathway.","PeriodicalId":8688,"journal":{"name":"Autoimmunity","volume":"57 1","pages":"2387100"},"PeriodicalIF":3.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TMEM164 promotes ferroptosis by selectively mediating ATG5-dependent autophagosome formation to inhibit the progression of LUAD. TMEM164 通过选择性地介导 ATG5 依赖性自噬体的形成来促进铁变态反应，从而抑制 LUAD 的进展。

IF 3.3 4区医学

Autoimmunity Pub Date : 2024-12-01 Epub Date: 2024-10-11 DOI: 10.1080/08916934.2024.2410192

Yongxiang Su, Lintao Li, Junhai Chen, Chao Gao

{"title":"TMEM164 promotes ferroptosis by selectively mediating ATG5-dependent autophagosome formation to inhibit the progression of LUAD.","authors":"Yongxiang Su, Lintao Li, Junhai Chen, Chao Gao","doi":"10.1080/08916934.2024.2410192","DOIUrl":"10.1080/08916934.2024.2410192","url":null,"abstract":"The study focuses on lung adenocarcinoma (LUAD), a predominant type of lung cancer. Despite advancements in diagnostics and molecular therapies, treatment remains challenging due to its low five-year survival rate. This study aims to investigate the role of the transmembrane protein TMEM164 in ferroptosis and anti-tumor immunity in LUAD, and to evaluate its potential as a therapeutic target. Through cellular experiments (such as QPCR, WB, CCK-8, EdU, Transwell, flow cytometry, CO-IP) and animal model experiments (including HE staining and IHC analysis), the relationship between TMEM164 expression and LUAD progression was explored, with particular attention to its mechanisms in ferroptosis and autophagy. The results show that TMEM164 expression is downregulated in LUAD and is associated with poor prognosis. Increasing TMEM164 expression significantly inhibits cell proliferation, migration, and invasion, while promoting an autophagy process dependent on ATG5 for autophagosome formation, thus facilitating ferroptosis. In mouse models, high TMEM164 expression combined with anti-PD-1 antibodies demonstrated synergistic anti-tumor effects. These findings highlight the critical role of TMEM164 in LUAD, suggesting that modulating TMEM164 expression could open new avenues for LUAD treatment.","PeriodicalId":8688,"journal":{"name":"Autoimmunity","volume":"57 1","pages":"2410192"},"PeriodicalIF":3.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating interleukin-27 is associated with the risk of chronic periodontitis and allergic rhinitis: A Mendelian randomization analysis. 循环白细胞介素-27与慢性牙周炎和过敏性鼻炎的风险有关：孟德尔随机分析

IF 3.5 4区医学

Autoimmunity Pub Date : 2024-12-01 Epub Date: 2024-06-03 DOI: 10.1080/08916934.2024.2358070

Nan Jiang, JingLi Zhao, ChuHuan Zhou, XinRong Nan

{"title":"Circulating interleukin-27 is associated with the risk of chronic periodontitis and allergic rhinitis: A Mendelian randomization analysis.","authors":"Nan Jiang, JingLi Zhao, ChuHuan Zhou, XinRong Nan","doi":"10.1080/08916934.2024.2358070","DOIUrl":"10.1080/08916934.2024.2358070","url":null,"abstract":"Background: Chronic periodontitis (CP) and allergic rhinitis (AR) have attracted wide attention as global public health problems with high incidence. Recent studies have shown that circulating interleukin-27 (IL-27) is associated with the risk of CP and AR. The aim of this study is to analyze the causal effect between them using Mendelian randomization (MR).Methods: Bidirectional MR analyses were performed with the use of publicly available genome-wide association study (GWAS) data. Summary data on circulating IL-27, CP, and AR published in genome-wide association studies were collected. Instrumental variables (IV) were extracted using assumptions of correlation, independence and exclusivity as criteria. Inverse variance weighting (IVW) was used as the main method, combined with weighted median method (WM) and MR-Egger and other MR Analysis methods for causal inference of exposure and outcome. Cochran's Q and MR-Egger intercept were used for sensitivity analysis.Results: The IVW study showed a causal effect between increased circulating IL-27 levels and increased risk of CP (OR = 1.14, 95%CI = 1.02-1.26, p = .020). Similarly, the increase of circulating IL-27 level had a causal effect on the decreased risk of AR (OR = 0.88, 95%CI = 0.80-0.97, p = .012). In addition, IVW study found that there was a causal between the increased risk of CP and circulating IL-27 level (OR = 1.05, 95%CI = 1.01-1.10, p = .016). However, there was no significant causal relationship between the risk of AR and circulating IL-27 levels (OR = 0.97, 95%CI = 0.91-1.02, p = .209). no significant heterogeneity or horizontal pleiotropy was found in sensitivity analysis.Conclusions: There is a causal effect between circulating IL-27 level and CP, AR, which will help to find new ideas and methods for the diagnosis and treatment of CP and AR.","PeriodicalId":8688,"journal":{"name":"Autoimmunity","volume":"57 1","pages":"2358070"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice. 系统性红斑狼疮易感小鼠接受卡介苗挑战后的部分长期临床症状改善

IF 3.3 4区医学

Autoimmunity Pub Date : 2024-12-01 Epub Date: 2024-07-21 DOI: 10.1080/08916934.2024.2380465

Valentina P Mora, Francisco B Quero, Tays Troncoso-Bravo, Claudia Orellana, Patricia Pereira, Juan P Mackern-Oberti, Samanta C Funes, Jorge A Soto, Karen Bohmwald, Susan M Bueno, Alexis M Kalergis

{"title":"Partial long-term clinical improvement after a BCG challenge in systemic lupus erythematosus-prone mice.","authors":"Valentina P Mora, Francisco B Quero, Tays Troncoso-Bravo, Claudia Orellana, Patricia Pereira, Juan P Mackern-Oberti, Samanta C Funes, Jorge A Soto, Karen Bohmwald, Susan M Bueno, Alexis M Kalergis","doi":"10.1080/08916934.2024.2380465","DOIUrl":"https://doi.org/10.1080/08916934.2024.2380465","url":null,"abstract":"Systemic Lupus Erythematosus (SLE) is an autoimmune disorder that causes a breakdown of immune tolerance. Current treatments mainly involve general immunosuppression, increasing the risk of infections. On the other hand, Bacillus Calmette-Guérin (BCG) has been investigated as a potential therapy for autoimmune diseases in recent years, prompting an ongoing investigation. This study aimed to evaluate the effect of BCG vaccination on early and late clinical presentation of SLE in a murine disease model. MRL/MPJ-Faslpr mice were immunized with BCG or treated with PBS as a control. The progress of the disease was evaluated at 27 days post-immunization (dpi) (early) and 56 dpi (late). Clinical parameters and proteinuria were monitored. Blood samples were collected for measurement of antinuclear antibodies (ANAs), anti-double-stranded DNA (anti-dsDNA), and cytokine determination was performed using ELISA. Samples collected from mice were analyzed by flow cytometry and histopathology. We observed a clinical improvement in BCG-treated mice, reduced proteinuria in the latter stages of the disease, and decreased TNF-α. However, BCG did not elicit significant changes in ANAs, anti-dsDNA, histopathological scores, or immune cell infiltration. BCG was only partially beneficial in an SLE mouse model, and further research is needed to determine whether the immunity induced by this vaccine can counteract lupus's autoimmune response.","PeriodicalId":8688,"journal":{"name":"Autoimmunity","volume":"57 1","pages":"2380465"},"PeriodicalIF":3.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of NLRP3 inflammasome in type 2 inflammation related diseases. NLRP3 炎症小体在 2 型炎症相关疾病中的作用。

IF 3.5 4区医学

Autoimmunity Pub Date : 2024-12-01 Epub Date: 2024-02-08 DOI: 10.1080/08916934.2024.2310269

Shenming Xu, Dan Wang, Lina Tan, Jianyun Lu

引用次数: 0

Effects of autoimmune abnormalities on fertility and placental morphology in mice. 自身免疫异常对小鼠生育能力和胎盘形态的影响

IF 3.5 4区医学

Autoimmunity Pub Date : 2024-12-01 Epub Date: 2024-02-22 DOI: 10.1080/08916934.2024.2319209

Risa Yamanaka, Osamu Ichii, Teppei Nakamura, Yuki Otani, Takashi Namaba, Yasuhiro Kon

{"title":"Effects of autoimmune abnormalities on fertility and placental morphology in mice.","authors":"Risa Yamanaka, Osamu Ichii, Teppei Nakamura, Yuki Otani, Takashi Namaba, Yasuhiro Kon","doi":"10.1080/08916934.2024.2319209","DOIUrl":"10.1080/08916934.2024.2319209","url":null,"abstract":"Autoimmune diseases (AIDs) alter the placental immune environment leading to fetal loss. This study investigated the effects of AIDs on pregnancy and the placenta in AID-prone MRL/MpJ-Faslpr/lpr mice and wild-type MRL/MpJ, which were mated with male MRL/MpJ and MRL/MpJ-Faslpr/lpr at five months and defined as moLpr and moMpJ, respectively. AID indices (spleen weight and serum autoantibody levels) and fertility status (number and size of fetuses, morphology, and comprehensive gene expression of placentas) were evaluated on gestational day 15.5. Both strains showed equivalent fertility, but moLpr showed lighter placentas and fetuses than moMpJ, and decreased fertility with AID severity. moLpr placentas had a higher number of T cells, higher expression of genes associated with T helper 2 and T follicular helper functions, and altered expression of genes (Krt15, Slc7a3, Sprr2a3) that significantly regulate pregnancy or immunity. The gene expression of T cell migration-associated chemokines (Ccl5, Cxcl9) was significantly increased in moLpr placentas, and CCL5 and CXCL9 were detected in moLpr placentas, particularly in T cells and placenta-component cells, respectively. Thus, AID altered placental morphofunction and fertility in mice; however, fertility was maintained at the examined time points. This study enhances our understanding of placental alterations and gestational risk due to AIDs.","PeriodicalId":8688,"journal":{"name":"Autoimmunity","volume":"57 1","pages":"2319209"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139929813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KISS-1 knockdown inhibits cell growth, migration, and invasion in HTR-8/SVneo cells by regulating the GRP54-mediated PI3K/AKT signaling pathway. 通过调节 GRP54 介导的 PI3K/AKT 信号通路，敲除 KISS-1 可抑制 HTR-8/SVneo 细胞的生长、迁移和侵袭。

IF 3.5 4区医学

Autoimmunity Pub Date : 2024-12-01 Epub Date: 2023-12-28 DOI: 10.1080/08916934.2023.2297564

Lingna Chen, Yuying Ruan, Liping Ni, Guiting Wang, Yajuan Gao, Jindi Zhang, Dingheng Li, Haiou Xu

{"title":"KISS-1 knockdown inhibits cell growth, migration, and invasion in HTR-8/SVneo cells by regulating the GRP54-mediated PI3K/AKT signaling pathway.","authors":"Lingna Chen, Yuying Ruan, Liping Ni, Guiting Wang, Yajuan Gao, Jindi Zhang, Dingheng Li, Haiou Xu","doi":"10.1080/08916934.2023.2297564","DOIUrl":"10.1080/08916934.2023.2297564","url":null,"abstract":"Recurrent spontaneous abortions (RSA) affect reproductive health and increase the risk of subsequent abortions. To investigate the role of KISS-1/GPR-54 signaling in RSA progression. Villus tissue was collected from RSA patients, and human trophoblastic HTR-8/SVneo cells were used. KISS-1 and GRP54 levels were detected using RT-qPCR and immunohistochemistry. Western blotting was performed to analyze ZO-1 and ZEB1 levels. Cell proliferation was determined via CCK-8 and cell clone formation assays. Transwell assays were performed to assess cell migration and invasion abilities. KISS-1 was down-regulated in the villus tissues of RSA patients. KISS-1 overexpression dramatically inhibited trophoblast proliferation, migration, and invasion. Mechanistically, ZEB1 expression was down-regulated, whereas ZO-1 expression was up-regulated, after KISS-1 overexpression. GPR54 silencing neutralized the effect of KISS-1 in HTR-8/SVneo cells. Additionally, KISS-1 overexpression inactivated the PI3K/AKT signaling pathway through GRP54. The KISS-1/GPR-54 signaling axis regulates RSA progression by regulating the PI3K/AKT signaling pathway.","PeriodicalId":8688,"journal":{"name":"Autoimmunity","volume":"57 1","pages":"2297564"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress in the construction of animal models of autoimmune thyroiditis. 构建自身免疫性甲状腺炎动物模型的研究进展。

IF 3.5 4区医学

Autoimmunity Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1080/08916934.2024.2317190

Ke Liu, Pei Zhang, Ling Zhou, Lin Han, Linhua Zhao, Xiaotong Yu

引用次数: 0