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[Therapeutic strategies in Parkinson's disease]. [帕金森病的治疗策略]。
Archivos de neurobiologia Pub Date : 1991-11-01
I Shoulson
{"title":"[Therapeutic strategies in Parkinson's disease].","authors":"I Shoulson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12852158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of a controlled low-protein diet on the pharmacological response to levodopa and on the plasma levels of L-dopa and amino acids in patients with Parkinson's disease]. [控制低蛋白饮食对帕金森病患者左旋多巴药理学反应及血浆左旋多巴和氨基酸水平的影响]。
Archivos de neurobiologia Pub Date : 1991-11-01
G Sanchís, M A Mena, R Martín del Río, B Morales, M J Casarejo, M J de Yébenes, C Tabernero, A Jiménez, J G de Yébenes
{"title":"[Effect of a controlled low-protein diet on the pharmacological response to levodopa and on the plasma levels of L-dopa and amino acids in patients with Parkinson's disease].","authors":"G Sanchís,&nbsp;M A Mena,&nbsp;R Martín del Río,&nbsp;B Morales,&nbsp;M J Casarejo,&nbsp;M J de Yébenes,&nbsp;C Tabernero,&nbsp;A Jiménez,&nbsp;J G de Yébenes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Levodopa is the treatment of choice in Parkinson's disease, but a high percentage of patients develop complications in the response, including fluctuations, after some years of treatment. Although the origin of fluctuations is unknown, these could be, at least partly, attributed to pharmacokinetic factors. Aromatic aminoacids interfere in the absorption and brain penetration of levodopa, and lowering protein intake improves the quality of the response. The continuation of a low-protein diet is difficult for some patients. In this way, to know if these diet effects are noticeable in an acute period would be interesting, in order to select groups of patients who were susceptible to improve with this treatment. In this report we have studied the acute effect of a low protein diet on the pharmacological response to levodopa, and the plasmatic levels of L-Dopa, 3-OM-Dopa and large neutral aminoacids. Protein restriction improves clinical response to levodopa, although the mechanisms of this improvement remain unknown.</p>","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Therapeutic advances in Parkinson disease. Symposium of the XLII annual meeting of the Spanish Neurological Society. December 1990]. 帕金森病的治疗进展。西班牙神经学学会第二十二届年会专题讨论会。1990年12月)。
Archivos de neurobiologia Pub Date : 1991-11-01
{"title":"[Therapeutic advances in Parkinson disease. Symposium of the XLII annual meeting of the Spanish Neurological Society. December 1990].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12852270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Anatomo-functional basis for Parkinson's disease]. 【帕金森病的解剖学功能基础】。
Archivos de neurobiologia Pub Date : 1991-11-01
J A Obeso, M R Luquín, J Artieda, M T Herrero, M A Pastor, J Guridi
{"title":"[Anatomo-functional basis for Parkinson's disease].","authors":"J A Obeso,&nbsp;M R Luquín,&nbsp;J Artieda,&nbsp;M T Herrero,&nbsp;M A Pastor,&nbsp;J Guridi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Optimization of the treatment of Parkinson's disease using dopamine agonists]. 【多巴胺激动剂治疗帕金森病的优化】。
Archivos de neurobiologia Pub Date : 1991-11-01
U K Rinne
{"title":"[Optimization of the treatment of Parkinson's disease using dopamine agonists].","authors":"U K Rinne","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12852273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cognitive deterioration in Parkinson's disease]. [帕金森氏症的认知衰退]。
Archivos de neurobiologia Pub Date : 1991-11-01
J Vilert Barnet, A Jarne Esparcia, M Aguilar Barbera
{"title":"[Cognitive deterioration in Parkinson's disease].","authors":"J Vilert Barnet,&nbsp;A Jarne Esparcia,&nbsp;M Aguilar Barbera","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this study is to contrast a sampling of 20 patients diagnosed as suffering from \"Idiopathic Parkinson's Disease\" (mean age, 54; schooling, 8.5 years; length of disease, 6.07 years) with a healthy control group, in order to detect possible correlation between intellectual impairment and depression in the individuals affected by Parkinsonism. An integrated battery of neuropsychological testing (PIEN-Test Barcelona. Peña, 1990) was used, in conjunction with \"Beck's Depression Inventory\". The results show significant differences in the following areas: expressive language, complex language comprehension, motor coordination, complex visuospatial factors, verbal memory and WAIS-type intelligence factors. Discriminant analysis was performed to select the most discriminating variables. The results were as follows, beginning with the most discriminating factor: motor coordination, complex comprehension, complex visuospatial factors, math skills and an overall slowing down. The patients with the highest depression levels were found to have the greatest impairment in mental control/attention and complex comprehension.</p>","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Search for the cause of Parkinson's disease]. [寻找帕金森氏症的病因]。
Archivos de neurobiologia Pub Date : 1991-11-01
J W Langston
{"title":"[Search for the cause of Parkinson's disease].","authors":"J W Langston","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pergolide in Parkinson's disease]. [培高利特治疗帕金森病]。
Archivos de neurobiologia Pub Date : 1991-11-01
D Parkes
{"title":"[Pergolide in Parkinson's disease].","authors":"D Parkes","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Parkinson's disease: advances in the decade of the brain]. [帕金森病:大脑十年的进展]。
Archivos de neurobiologia Pub Date : 1991-11-01
E Tolosa, J Chacón
{"title":"[Parkinson's disease: advances in the decade of the brain].","authors":"E Tolosa,&nbsp;J Chacón","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12973392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Focal dystonias and facial hemispasm: treatment with botulinum A toxin]. 局灶性肌张力障碍和面部半痉挛:肉毒杆菌A毒素治疗。
Archivos de neurobiologia Pub Date : 1991-09-01
R Astarloa, B Morales, V Sánchez, N Peñafiel, J Rábano, J Oliván, J García de Yébenes
{"title":"[Focal dystonias and facial hemispasm: treatment with botulinum A toxin].","authors":"R Astarloa,&nbsp;B Morales,&nbsp;V Sánchez,&nbsp;N Peñafiel,&nbsp;J Rábano,&nbsp;J Oliván,&nbsp;J García de Yébenes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report the results of the treatment of 80 patients with various idiopathic focal dystonia and essential hemifacial spasm with Botulinum A toxin. A statistically significant improvement was obtained in our 34 patients with blepharospasm, 19 patients with hemifacial spasm, 59% of 22 patients with cervical dystonia and 60% of 5 patients with hand dystonia. Mean duration of the benefit of each injection was 15.3, 16.3, 7.6 and 8.7 weeks respectively. Adverse effects were local and transient. We concluded that botulinum A toxin is a safe and effective therapy for patients with focal dystonia and hemifacial spasm.</p>","PeriodicalId":8654,"journal":{"name":"Archivos de neurobiologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12966000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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