Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)最新文献_第4页

Immunologic effectiveness of maraviroc- and raltegravir-containing regimens (R+M+) versus raltegravir-based regimens that do not include maraviroc (R+M-). 含马拉韦洛克和雷替格拉韦方案(R+M+)与不含马拉韦洛克的基于雷替格拉韦方案(R+M-)的免疫有效性比较

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-05-01 Epub Date: 2012-01-13 DOI: 10.1177/1545109711424967

Tony Antoniou, Graham Smith, Desheng Su, Janet M Raboud, Derek Lee, Colin Kovacs, Jason Brunetta, David Fletcher, Fred Crouzat, Mona Loutfy

{"title":"Immunologic effectiveness of maraviroc- and raltegravir-containing regimens (R+M+) versus raltegravir-based regimens that do not include maraviroc (R+M-).","authors":"Tony Antoniou, Graham Smith, Desheng Su, Janet M Raboud, Derek Lee, Colin Kovacs, Jason Brunetta, David Fletcher, Fred Crouzat, Mona Loutfy","doi":"10.1177/1545109711424967","DOIUrl":"https://doi.org/10.1177/1545109711424967","url":null,"abstract":"Objective: To compare the immunologic effectiveness of raltegravir-maraviroc (R+M+)-based regimens with raltegravir-based regimens that do not include maraviroc (R+M-) in treatment-experienced patients in clinical practice.Methods: We conducted a retrospective study of treatment-experienced HIV-infected adults receiving either R+M+- or R+M--based therapy. Longitudinal CD4 counts were analyzed using a linear mixed model.Results: One hundred and fifty-six patients were included in the analysis, of whom 32 were receiving R+M+ and 124 R+M-. Mean baseline CD4 counts in patients on R+M+ and R+M- were 463.8 and 442.3 cells/mm(3), respectively (P = .67). In multivariable mixed models, a baseline viral load ≥50 copies/mL was significantly associated with CD4 change during follow-up (P < .0001). No difference between R+M+ and R+M- was observed during follow-up (P = .81).Conclusion: CD4 cell recovery was similar among patients receiving either R+M+- or R+M--based therapy during a 24-month period of follow-up.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 3","pages":"192-7"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711424967","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30387745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Knowledge and practice of post-exposure prophylaxis (PEP) against HIV infection among health care providers in a tertiary hospital in Nigeria. 尼日利亚一家三级医院医护人员接触后预防艾滋病毒感染的知识和做法。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-05-01 Epub Date: 2011-04-21 DOI: 10.1177/1545109711401409

Rotimi S Owolabi, Peter Alabi, Samuel Ajayi, Olusoji Daniel, Adeniyi Ogundiran, Tanimola M Akande, And Tunde Onafowokan

{"title":"Knowledge and practice of post-exposure prophylaxis (PEP) against HIV infection among health care providers in a tertiary hospital in Nigeria.","authors":"Rotimi S Owolabi, Peter Alabi, Samuel Ajayi, Olusoji Daniel, Adeniyi Ogundiran, Tanimola M Akande, And Tunde Onafowokan","doi":"10.1177/1545109711401409","DOIUrl":"https://doi.org/10.1177/1545109711401409","url":null,"abstract":"Objective: To assess the knowledge and practice of post exposure prophylaxis (PEP) against HIV infection among health care providers in University of Abuja Teaching Hospital (UATH).Methods: A cross-sectional survey conducted on 230 health care providers in UATH.Results: Majority (97.0%) of the respondents have heard about PEP, but only a few (30.9%) of them could correctly identify the drugs used and duration of PEP. A third of respondents have had one form of accidental exposure or the other. HIV test was carried out in about two-thirds (64.8%) of the source patients. Thirteen (28.3%) of the source patients were HIV-positive. Of the 13 respondents that were exposed to HIV-positive patients, only 3 (23.1%) received PEP, and these three completed PEP, while majority, 10/13 (76.9%) did not receive PEP in spite of their exposure to HIV-positive sources.Conclusion: The study shows that the knowledge and practice of PEP among health care providers are very poor.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 3","pages":"179-83"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711401409","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29831640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

Reducing waiting time at a Nigerian HIV treatment clinic: opinions from and the satisfaction of people living with HIV/AIDS. 缩短尼日利亚艾滋病毒治疗诊所的等待时间:来自艾滋病毒/艾滋病感染者的意见和满意度。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-05-01 Epub Date: 2011-04-26 DOI: 10.1177/1545109711402214

Samuel Anu Olowookere, Akinola Ayoola Fatiregun, Modupe Martha-Alice Ladipo, Yetunde Adebisi Akenova

引用次数: 21

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-05-01 Epub Date: 2012-03-19 DOI: 10.1177/1545109712436723

Jean B Nachega, Chelsea Morroni, José M Zuniga, Renslow Sherer, Chris Beyrer, Suniti Solomon, Mauro Schechter, Jürgen Rockstroh

{"title":"HIV-related stigma, isolation, discrimination, and serostatus disclosure: a global survey of 2035 HIV-infected adults.","authors":"Jean B Nachega, Chelsea Morroni, José M Zuniga, Renslow Sherer, Chris Beyrer, Suniti Solomon, Mauro Schechter, Jürgen Rockstroh","doi":"10.1177/1545109712436723","DOIUrl":"https://doi.org/10.1177/1545109712436723","url":null,"abstract":"Background: Little is known globally about the perspectives of people living with HIV/AIDS (PLWHA) on perceived HIV-related stigma and its consequences.Methods: Cross-sectional study (January-March 2010) of perceived HIV-related stigma among PLWHA (N = 2035) using a standardized questionnaire.Findings: Thirty-seven percent of respondents reported loneliness as a result of their HIV status. Depression was reported by 27%. While 96% reported disclosing their HIV status to at least 1 person, 17% of patients who reported being in a long-term sexual relationship had not disclosed their status to their partner. Variables associated with perceived stigma were living in Asia-Pacific versus other regions (odds ratio [OR]: 2.77; 95% confidence interval [CI] 1.96-3.92); having experienced body/face changes; reported depression (OR: 1.25; 95% CI 1.11-1.38); and nondisclosure of HIV status (OR: 1.75; 95% CI 1.28-2.41).Conclusion: Thirty years into the HIV pandemic, perceived HIV stigma, isolation, and discrimination persist and are associated with loneliness and depression among PLWHA.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 3","pages":"172-8"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109712436723","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30514517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 95

Mobile phone communication and health system strengthening: a pilot study of telephonic warmline consultation in HIV care and support in South India. 移动电话通信和加强卫生系统:在印度南部开展艾滋病毒护理和支助方面电话热线咨询的试点研究。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-05-01 Epub Date: 2012-02-21 DOI: 10.1177/1545109711428010

G Manoharan, Shoba Dharmarajan, P K Ramalingam, Siju Mathew, Jacob C Varghese

{"title":"Mobile phone communication and health system strengthening: a pilot study of telephonic warmline consultation in HIV care and support in South India.","authors":"G Manoharan, Shoba Dharmarajan, P K Ramalingam, Siju Mathew, Jacob C Varghese","doi":"10.1177/1545109711428010","DOIUrl":"https://doi.org/10.1177/1545109711428010","url":null,"abstract":"Introduction: I-TECH India established a warmline pilot in the year 2008 to provide mobile-based technical support on clinical management to doctors caring for HIV patients in antiretroviral therapy (ART) centers.Methods: Warmline was piloted from May to August 2008. Standardized call records were analyzed. Statistical analyses were performed using SPSS.Results: The service was used by 38 doctors. The study demonstrated the frequency of calls and the nature of questions raised by them. Of the calls, 139 were new calls (90.3%) and 15 were follow-up calls. The average number of calls per day was 2.6 (SD 1.6). Of the total number, 81% of the calls were from high-volume centers. Most of the calls were related to ARV toxicities, ART initiation, and the management of opportunistic infections (OI).Conclusion: The South Indian warmline pilot demonstrated a potential model of ongoing technical assistance to ART doctors in times of need. AIDS-control organizations may consider expanding this model of expert distance-mentoring clinical support as a resource in India and other countries.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 3","pages":"184-7"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711428010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30478930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Further evidence that the expression of CD38 and HLA-DR(+) in CD8(+) lymphocytes does not correlate to disease progression in HIV-1 vertically infected children. 进一步的证据表明CD38和HLA-DR(+)在CD8(+)淋巴细胞中的表达与HIV-1垂直感染儿童的疾病进展无关。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-05-01 Epub Date: 2011-10-05 DOI: 10.1177/1545109711421642

Juliana Ribeiro Romeiro, Jorge Andrade Pinto, Maria Luiza Silva, Silvana Maria Eloi-Santos

{"title":"Further evidence that the expression of CD38 and HLA-DR(+) in CD8(+) lymphocytes does not correlate to disease progression in HIV-1 vertically infected children.","authors":"Juliana Ribeiro Romeiro, Jorge Andrade Pinto, Maria Luiza Silva, Silvana Maria Eloi-Santos","doi":"10.1177/1545109711421642","DOIUrl":"https://doi.org/10.1177/1545109711421642","url":null,"abstract":"Background: In adults, an increase in CD8(+)CD38(+) T cell levels is a strong indicator of disease progression in HIV infection. However, in children, data are conflicting. Slow-progressing children (SPC) provide an exceptional resource for the investigation and clarification of the immunological and virological mechanisms of natural control of HIV infection and can be used to investigate prognostic indicators of disease progression.Objectives: To investigate the immune activation status and T regulatory (Treg) cell levels in SPC.Study design: A cross-sectional study was carried out on 28 children 8 years old and older who were vertically infected with HIV. The children were stratified into 3 groups according to their clinical outcome: SPC (anti-retroviral-therapy-naïve; ≥8 years-old; CD4 ≥20%; viral load <25,000 copies), IF/VF (anti-retroviral-therapy but with no therapeutic response), and IS/VS (anti-retroviral therapy with good therapeutic response). Uninfected children (NI) were assessed as healthy control group.Results: A higher percentage of activated CD8(+) T cells were found in all HIV infected children, regardless of the evolution of disease. The activation of CD8(+) T cells was not associated with either viral load or the percentage of CD4(+) T cells. In addition, Treg cell levels did not show any correlation with the clinical outcome or the activation status of CD8(+) T cells.Conclusions: HIV-1-infected children presented an increased percentage of activated CD8(+) T cells and an unaltered percentage of Treg cells, regardless of their clinical evolution. Thus, these immunological parameters should not be used for prognostic evaluation.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 3","pages":"164-8"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711421642","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30187861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Preferences for rapid point-of-care HIV testing in primary care. 倾向于在初级保健中进行快速即时艾滋病毒检测。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-05-01 Epub Date: 2012-01-13 DOI: 10.1177/1545109711427605

Michael Schwandt, Eileen Nicolle, Sheila Dunn

{"title":"Preferences for rapid point-of-care HIV testing in primary care.","authors":"Michael Schwandt, Eileen Nicolle, Sheila Dunn","doi":"10.1177/1545109711427605","DOIUrl":"https://doi.org/10.1177/1545109711427605","url":null,"abstract":"Although the identification of individuals infected with HIV is an important element of treatment and prevention programs, many people living with HIV are unaware of their status. Thus, individuals are unable to benefit from treatment, and preventable HIV transmission continues to occur. Rapid point-of-care testing for HIV has been found to be preferred by patients in some contexts. However, few studies have examined preferences in primary care populations. This study investigates HIV testing preferences within an urban primary care clinic. Employing a cross-sectional design, data were collected on demographic characteristics, HIV risk factors, and testing history and preferences of participants. A total of 81% of participants stated that they would prefer rapid testing to standard testing, a finding that is consistent across demographic variables and risk factors examined. Increased availability of this modality may decrease barriers to HIV testing, with positive implications both for clinical management of HIV infection and prevention of HIV transmission.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 3","pages":"157-63"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711427605","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30387784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Brain abscesses in HIV-positive patients due to Pneumocystis jiroveci. 乙肝肺囊虫引起的hiv阳性患者脑脓肿。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-05-01 Epub Date: 2012-03-26 DOI: 10.1177/1545109712439625

Roy Nasnas, Marc Y Matta, Gilbert El Helou, Nathalie Rizk, Dolla Karam Sarkis, Ronald Moussa

引用次数: 3

Internal medicine and emergency medicine physicians lack accurate knowledge of current CDC HIV testing recommendations and infrequently offer HIV testing. 内科和急诊医生缺乏对当前疾病预防控制中心艾滋病毒检测建议的准确了解，很少提供艾滋病毒检测。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-03-01 Epub Date: 2012-02-14 DOI: 10.1177/1545109711430165

Mayar Al Mohajer, Michael Lyons, Eileen King, Jesse Pratt, Carl J Fichtenbaum

{"title":"Internal medicine and emergency medicine physicians lack accurate knowledge of current CDC HIV testing recommendations and infrequently offer HIV testing.","authors":"Mayar Al Mohajer, Michael Lyons, Eileen King, Jesse Pratt, Carl J Fichtenbaum","doi":"10.1177/1545109711430165","DOIUrl":"https://doi.org/10.1177/1545109711430165","url":null,"abstract":"Objectives: To evaluate the knowledge and attitudes of residents and attendings in emergency medicine (EM) and internal medicine (IM) about HIV.Methods: An electronic anonymous 41-question survey of IM and EM physicians at the University of Cincinnati Academic Health Center.Results: The survey was completed by 232 physicians (71.6%). EM residents were more likely to routinely offer HIV testing compared to IM residents (60.7% vs. 27.8%, P = 0.0009). Overall, there was no difference in offering HIV testing by sex (32% vs. 35.6%) or by residents versus attendings (33.8% vs. 33.3%). Only 70 physicians (30.9%) were aware of current CDC recommendations of HIV screening with attendings more knowledgeable than residents (41.7% vs. 26%, P = 0.017).Conclusion: EM and IM residents and attendings fail to offer HIV testing or assess for HIV transmission risk factors with sufficient frequency. There is also a gap in knowledge of the current CDC recommendations.","PeriodicalId":86092,"journal":{"name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","volume":"11 2","pages":"101-8"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1545109711430165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30462079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

A potential drug-herbal interaction between Ginkgo biloba and efavirenz. 银杏叶和依非韦伦之间潜在的药物-草药相互作用。

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Pub Date : 2012-03-01 Epub Date: 2012-02-09 DOI: 10.1177/1545109711435364

Mark Naccarato, Deborah Yoong, Kevin Gough

引用次数: 25