Journal of anti-aging medicine最新文献

{"title":"Study Design of the Saku Control Obesity Program (SCOP)","authors":"Shaw Watanabe, A. Morita, N. Aiba, M. Miyachi, S. Sasaki, M. Morioka, Masahiko Noda, T. Takebayashi, M. Kimira","doi":"10.3793/JAAM.4.70","DOIUrl":"https://doi.org/10.3793/JAAM.4.70","url":null,"abstract":"BACKGROUND: The increasing number of patients with metabolic syndrome and resultant diabetes mellitus, hypertension, hyperlipidemia, and other lifestyle-related diseases are an urgent focus of the Ministry of Health, Labor and Welfare. Because obesity is a common basis of these diseases, the control of obesity is an important aim. METHODS: A cognitive-behavioral treatment is being employed in a randomized intervention trial at the Saku Health Dock Center. 976 people whose BMI in upper quintile were identified from the health checkup database, and 235 people participated in the Saku Control Obesity Program (SCOP). Various biomarkers (including lipokines and single nucleotide polymorphism SNPs), physical activity, personality type (measured by the NEO-FFI), and dietary habits and dietary intake behavior (measured by the SQ-DHQ) will be measured to clarify the multiple factors influencing obesity. Each participant will use a diary to record body weight, body fat, number of steps, physical activity energy expenditure (PAEE), and success in achieving the established plan; a dietary record and appropriate equipment are also provided. At 1, 3, 6, 9, and 12 months, each participant will be interviewed by a doctor and dietician and receive individual education regarding physical activity. Follow-up will occur 1 and 2 years after baseline measurements. RESULTS: A total of 116 men (52.9 ± 6.6 years) and 119 women (54.4 ± 6.5 years) are participating in the study. Average body weight (± SD) was 86.4 ± 11.8 kg in males and 75.2 ± 9.5 in females. BMI was 30.4 ± 3.5 in males and 31.1 ± 3.1 in females. Waist and visceral fat area were 101.5 ± 8.7 cm and 159 ± 54 cm2 in males and 103.7 ± 8.3 cm and 130 ± 47 cm2 in females, respectively. PAEE was 271 ± 127 kcal in males and 246 ± 102 kcal in females. Basal metabolic rate, measured in one-tenth of the participants, was 1659 ± 226 kcal in males and 1477 ± 210 kcal in females. CONCLUSION: The purpose of this study is to evaluate the effectiveness of a cognitive-behavioral treatment designed to help obese patients lose weight and to maintain their weight losses over time. SCOP has been started with a good participation rate.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"22 1","pages":"70-73"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82171777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A double-blind, randomized controlled trial (RCT) of L-carnitine and conjugated linoleic acid-based health food with health claims","authors":"Y. Yonei, Yoko Takahashi, Miwako Watanabe, T. Yoshioka","doi":"10.3793/JAAM.4.19","DOIUrl":"https://doi.org/10.3793/JAAM.4.19","url":null,"abstract":"In the present study, we investigated the physical effect of health food (supplement) which contains L-carnitine (200mg) and conjugated linoleic acid (700mg) for 8 weeks with a double-blind, randomized controlled non-crossover design. Overweight individuals (17 males and 18 females; age: 48.3±6.6yrs; BMI: 25.5±2.6) were assigned to either Study Group (n=18) or Control Group (n=17). A small increase in serum levels of HbAlc (3.3%) and CRP (35.3%) was noted in the Study Group (p<0.05), and a significant increase in urinary isoprostane production rate (38.9%) and its creatinine -adjusted value (isoprostane/CRE) (44.4%), which is a marker for damage of fatty acids by free radicals. No effect was observed for indicators related to body composition and lipid metabolism. The results showed a significant improvement for the following subjective symptoms: “Easily break into a sweat”, “Irritability”, “Easily angered”, “Sense of tension”, however, “Early satiety” exacerbated. The sole parameter we found a significant intergroup difference in rate of change was in urinary isoprostane production rate and its creatinine-corrected value, and the score obtained in the questionnaire for “Easily angered”. In conclusion, these findings suggest that the consumption of the test compounds with L-carnitine and conjugated linoleic acid can reduce some mental symptoms; however, the efficacy on QOL was equivocal. As unfavorable phenomenon, elevation of HbAlc, CRP and urinary isoprostane were observed during the study.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"22 1","pages":"19-27"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82673498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effect of α Gel embedded Mattresses as Bedding on the Mind and Body","authors":"Y. Yonei, Yoko Takahashi, A. Shionoiri, Shino Inada","doi":"10.3793/JAAM.4.11","DOIUrl":"https://doi.org/10.3793/JAAM.4.11","url":null,"abstract":"We conducted an open parallel comparison study between Groups to evaluate the possible influence on mental and physical conditions of using a mattress and pillow in which a gel was embedded for 4 weeks. The study subjects consisted of 41 Japanese healthy adult volunteers with high total scores (7 or more) of Pittsburgh Sleep Quality Index and of both sexes aged between 35 to 57 (42.8±5.5) years old. They were divided into 2 groups; the Control Group consisting of 21 subjects and the Study Group consisting of 20 subjects. In the Study Group, DHEA-s (-9.8%) and the creatinine-corrected urinary 8-OHdG (-16.7%) was significantly decreased, and cortisol (27.7%) significantly increased. Of the physical symptoms, “Blurry eyes”, “Lethargy”, and “Coughing and sputum” significantly improved in the Study Group compared with control. Of the mental conditions, “No feeling of happiness”, “Shallow sleep” and “Difficulty falling asleep” significantly improved in the Study Group. For Lifestyle, only the Study Group was affected. Specifically, the “Frequency of alcohol intake” significantly increased along with the “Sleeping hours” (p<0.05). For the survey which entailed using the Pittsburgh Sleep Quality Index, the Study Group showed a significant improvement in “Quality of sleep” (p<0.01). “Sleeping hours” (p<0.05), and “Difficulty staying awake during the day” (p<0.05). Total score decreased from 9.30±2.36 to 6.05±2.80 (p<0.001). These data indicates that the use of a mattress and pillow in which a gel is embedded for four weeks should improve one's quality of sleep and some physical and mental symptoms for healthy adult males and females.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"2 1","pages":"11-18"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90751460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dioxin exposure and type 2 diabetes mellitus: Case control study","authors":"Shaw Watanabe, M. Morioka, T. Hirai, S. Mizuno","doi":"10.3793/JAAM.4.51","DOIUrl":"https://doi.org/10.3793/JAAM.4.51","url":null,"abstract":"OBJECTIVES: Relationship between dioxin exposure and diabetes mellitus (DM) has been in debate. Our cross-sectional study suggested that low-level dioxin exposure may cause type 2 diabetes in a general population. A case control study was performed to confirm the risk of dioxins. DESIGN and METHODS: 60 DM patients and 60 controls were selected for the case control study to detect the risk of dioxins for type 2 diabetes mellitus. After performing 75 g GTT, 56 DM, 12 IGT and 49 Control were grouped. In addition to the routine physical examination, questionnaire for life habits, past illness, family history and others were performed. 70 ml blood was collected for hematological and biochemical test, and measurement of 7 polychlorodibenzo-p-dioxins (PCDD), 10 polychloro-dibenzofurans (PCDF), and 12 coplanar polychlorobiphenyl (PCB). Concentration of dioxin congeners and their TEQ were used for regression factor analysis and logistic regression analysis to detect the risk of dioxins by SPSS. RESULTS: Total blood dioxin level was 23.4 ± 11.2 in Control, 30.8 ± 11.5 in IGT and 33.7 ± 13.7 pg TEQ/g lipid in DM. Logistic regression analysis revealed that family history (OR=20.4) and 4 of 5 dioxin factors (OR=2.2-2.8) had significant odds ratio. Crude congener concentration and their TEQ yielded the similar results. Other variables did not show significant odds ratio. Adverse effects of dioxins on TNFalpha, NEFA, adiponectin, and leptin were found. CONCLUSION: DM and IGT patients showed higher dioxin level compared to Control. Logistic regression analysis revealed that the exposure to both PCB and PCDD/PCDF showed significant effect.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"82 3-4 1","pages":"51-56"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77846689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double Blind Study of Health Claims for Food Containing Extract of Kabanoanatake (Charga: Fuscoporia obliqua) (RCT: randomized controlled trial)","authors":"Y. Yonei, Yoko Takahashi, K. Matsushita, Miwako Watanabe, T. Yoshioka","doi":"10.3793/JAAM.4.1","DOIUrl":"https://doi.org/10.3793/JAAM.4.1","url":null,"abstract":"We investigated the health claims of food containing Kabanoanatake (Charga: Fuscoporia obliqua) in terms of general body function in a double blind study using three Groups, control, Charga 5ml Group and Charga 15ml Group, each of which consisted of 20 subjects totaling 60 healthy adult volunteers (male: 23; female; 37, age: 45.7±6.9 years).For the Charga 5ml Group, systolic blood pressure (-3.72 %, p=0.046) and diastolic blood pressure (-3.47 %, p=0.018) were significantly lowered, while triglyceride (36.01 %, p=0.050) was increased. Also, slight changes were observed in total body water (-0.70 %, p=0.036), total body muscle (-0.69 %, p=0.034), fat-free mass (-0.72 %, p=0.022), total skeletal muscle (-1.35 %, p=0.005), basal metabolism (-0.60 %, p=0.013), HbAlc (1.57 %, p=0.034) and Cl (-1.19 %, p=0.019). Among oxidization stress markers, lipid peroxide (-7.89 %, p=0.006) was significantly improved. For mental and physical symptoms, significant improvements were observed in “Cold skin” (p=0.008) and “Inability to sleep because of worries” (p=0.008), while no parameter showed any aggravation. The Charga 15ml Group showed a significant improvement in the score for “loss of motivation” (p=0.042) for physical and mental symptoms. Apart from this, a slight but significant change was observed in Cl (-1.18 %, p=0.016), while aggravation was noted for “frequent urination” (p=0.049).The parameters which showed a dose-dependent change in terms of administration of Charga were from the blood test (lowering of fasting insulin level), physical symptoms on the common interview sheet on aging and the QOL (improved score in “stiff shoulders”), mental symptoms (an improvement in the scores for “loss of motivation”, “daily life is not enjoyable”, “pessimism” and “feeling of anxiety for no special reason”. While “weight loss; thin” and “Easily breaking into a sweat” showed a slight increases in their respective scores, the increase in the score for “frequent urination” was comparatively remarkable. There was no significant change in immune activity using the number of NK cells as a benchmark parameter. In conclusion, taking the balance between parameters that showed effects and aggravation into consideration, the preferability of two doses of Charga 5ml or 15ml/day seemed equivocal. As unfavorable phenomenon, frequent urination and mild elevation of γ-GTP and triglyceride were observed during the study.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"31 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72998287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Necessity of obesity control for preventing life-style related diseases","authors":"Shaw Watanabe, M. Morioka","doi":"10.3793/JAAM.4.74","DOIUrl":"https://doi.org/10.3793/JAAM.4.74","url":null,"abstract":"growing proportion of youth. Such obesity is a major risk factor of metabolic syndrome and following diabetes mellitus, hypertension and other life-style related diseases.1) Effective primary prevention programs are urgently needed to address this public health issue. Few studies have been conducted to intervene on these environmental influences for obesity prevention interventions. The Pound of Prevention study (POP) was the first weight gain primary prevention trial in adults in the USA.2) Five key behaviors were targeted: 1) increase fruit intake, 2)increase vegetable intake, 3)increase physical activity especially walking, 4) increase frequency of self-weighing, and 5) decrease dietary fat intake. After three years, weight gain did not differ by treatment group. However, the intervention was successful in increasing the frequency of self-weighing and healthy weight control behaviors. Results of the POP study are encouraging and suggest several ways to improve the efficacy of a low intensity weight gain prevention program. The Ministry of Health, Labour and Welfare distributed the guideline for eating habit and physical activity in 1999 and 2006, respectively,3,4) but the prevalence of obesity and diabetes mellitus has continuously increasing.5) In 2006, seven academic associations decided the criteria of metabolic syndrome and nationwide primary prevention is planned by implementing it to the mass screening program.6) However, the proposed education method by the guideline is not yet evaluated by epidemiological program. It is necessary to show the efficacy of the intervention to control obesity. So, we planned to do the intervention study by the cognitive behavior alteration method through dietary change and physical activity under the support of the Ministry of Health, Labor and Welfare. The result of the current study will provide important information on the effectiveness of a broad-reaching weight-gain prevention program. It will also provide unique data about whether changing these environmental influences will have an impact on preventing weight gain. The incorporation of a stronger environmental component to support the behavioral recommendations and their implementation by individuals should also strengthen the intervention’s effectiveness on body weight and behavior changes.7) The pilot data provided useful planning information on intervention and measurement protocols. The current literature supports stronger and more specific behavioral recommendations to prevent weight gain. Cognitive behavioral modification approaches for improving people’s intrinsic motivation for weight loss and maintenance. Positive support, rewarding or praising, and modeling desired eating and exercise behaviors are important. Psychological and genetic (single nucleotide polymorphism) variables are also important to build so-called tailor-made nutrition or health education. In addition to the dietary intake and physical activity, eating behavior is another ","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"50 1","pages":"74-75"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80962842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetics of an Equol Supplement in Humans","authors":"Shaw Watanabe, Naoto Otaki, M. Uehara, Kazuharu Suzuki, T. Ueno, Shigeto Uchiyama, S. Mizuno","doi":"10.3793/JAAM.4.57","DOIUrl":"https://doi.org/10.3793/JAAM.4.57","url":null,"abstract":"Equol, a metabolite of daidzein, is considered to be the most effective estrogen modifier in the human body. The production of equol depends on an individual's intestinal flora, however, so an equol supplement has been developed for nonproducers. To examine the pharmacokinetics in humans of a newly developed equol supplement made from fermented soy germ by Lactococcus sp. Equol supplements were given to 18 adults (20-22 yr) in three doses (one 10-mg dose, one 30-mg dose, or three 10-mg doses per day) to investigate the pharmacokinetics and physiological effects. Equol reached a peak in plasma at 30 or 60 min after supplement intake, and the average plasma half-life was 83 min. Plasma concentrations of equol were always higher in females than in males. Less than 5% of the highest plasma concentration remained in the plasma after 2 days. Up to 56% of the orally administered equol was excreted in urine within 1 day. This short-term, high-dose equol exposure yielded no observable adverse effect in both feeling and biochemical markers. For equol nonproducers, this newly developed equol supplement may yield more beneficial effects of isoflavones.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"14 1","pages":"57-62"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89256231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Personality (NEO-Five Factor Inventory) with Eating Behaviors and Physical Activity Levels in Obese Subjects in the Saku Control Obesity Program (SCOP)","authors":"Yumi Ohmori, Nozomu Suzuki, A. Morita, N. Aiba, M. Miyachi, Shaw Watanabe, Y. Kikuchi, M. Kimira","doi":"10.3793/JAAM.4.43","DOIUrl":"https://doi.org/10.3793/JAAM.4.43","url":null,"abstract":"BACKGROUND: Obesity is one of the most common risks for lifestyle-related diseases, but the personality of individuals in relation to obesity has not been well studied. We investigated the association of personality traits with physical activity levels and eating behaviors in obese subjects. METHOD: The subjects were 116 males and 119 females in the Saku Control Obesity Program SCOP study. The influence of personality on obesity was analyzed using a questionnaire from the NEO-FFI. We analyzed the association of physical activity level (measured with an accelerometer) and eating behavior (assessed by a questionnaire) among the three classes (low, average, high) of scores within five personality domains. RESULTS: Scores in the Neuroticism and Agreeableness domains of females were significantly higher than those of males. There were significant differences among the three classes of Neuroticism and Agreeableness with regard to physical activity levels. Eating behavior was associated with the Neuroticism and Openness domains. The scales of bad eating behavior related to obesity were positively correlated with scores in the Neuroticism domain in both males and females. In males the scale of all categories of eating behavior increased as scores in the Openness domain rose; in females the scale of “perception of constitution and weight” decreased as Openness scores rose. CONCLUSION: Personality determined by NEO-FFI was related to physical activity level and eating behavior. In particular, the Neuroticism domain had great effects on these parameters.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"302 1","pages":"43-50"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73174545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Aging with Minerals in Male Japanese Adults","authors":"H. Yasuda, Kazuya Yoshida, Hiroshi Tagai, Katsumi Fukuchi, R. Tokuda, Toyoharu Tsutsui, Y. Yonei","doi":"10.3793/JAAM.4.38","DOIUrl":"https://doi.org/10.3793/JAAM.4.38","url":null,"abstract":"including essential minerals and toxic metals in over 1500 male Japanese adults aged 20-60 years. Several minerals were found to be significantly and positively or inversely correlated to aging. The most age-correlated element was mercury (Hg) with the highest regression coefficient of r = 0.417, followed by boron (B) (r = 0.189), potassium (K) (r = 0.186), arsenic (As) (r = 0.178), selenium (Se) (r = 0.153) and sodium (Na) (r = 0.131) with the p-value of p <0.0000 for every element. Using the regression equation of Age = 13.9 Log Hg – 12.5 obtained, a 10-fold increase in mercury level was estimated to associate with a 13.9-year increment in aging. The most inverse-correlated mineral to aging was calcium (Ca) (r = -0.207), followed by magnesium (Mg) (r = -0.174), cupper (Cu) (r = -0.147), and zinc (r = -0.105; p < 0.0001). 000These findings suggest that some minerals contribute to aging and higher dietary mercury intake may be associated with acceleration of aging. Dietary intake of the competitive minerals against mercury, such as calcium, magnesium, cupper and zinc, may be useful for controlling aging in Japanese.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"26 1","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78368120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA polymorphism of obese people in Saku Control Obesity Program (SCOP)","authors":"Kouich Yamada, J. Takezawa, A. Morita, Y. Matsumura, Shaw Watanabe","doi":"10.3793/JAAM.4.63","DOIUrl":"https://doi.org/10.3793/JAAM.4.63","url":null,"abstract":"BACKGROUND: Various genes related to fat-, sugar-or energy-metabolism are suspected that their polymorphisms (SNPs) are susceptible to development of obesity and other metabolic syndromes. Although many lines of evidences are accumulated, inspections as to their relation are still insufficient. Here, we assembled 235 obese people in Saku Control Obesity Program (SCOP), and are going to investigate the association between those SNPs, body mass index (BMI) and other clinical parameters. METHODS: 235 subjects, whose BMI belonged in upper quintile (over 28.3), are recruited from examinees for periodic medical checkup in the Health Dock of Saku Central Hospital (Nagano, Japan). Genotyping for the SNPs were conducted using the PCR-PFLP method from peripheral venous blood. The frequencies of the SNPs in UCP1 (-3826A/G), UCP2 (Ala55Val), UCP3 (-55C/T), PPARγ2 (Pro12Ala), adiponectin (Ile164Thr), leptin receptor (LEPR, Arg109Lys), calpain 10 (SNP43), β2AR (Arg16Gly, Gln27Glu), β3AR (Trp64Arg) were analyzed and associations between those SNPs, body mass index (BMI) and other clinical parameters were investigated. The frequency was compared with those in HapMap Project or in Nansei Cohort.. RESULTS: Frequencies of above SNPs in SCOP were not different from those of healthy people in Nansei Cohort or HapMapProject, except for adiponectin Ile164Thr. SNPs of UCPs or β2, β3AR genes, often reported their association with BMI, were not confirmed in obese subjects in SCOP. We found significant association in the LEPR Arg109Lys in woman; Lys/Lys minor homozygotes had higher levels of leptin, TNF-α, C-peptide, insulin, triglyceride and fasting serum glucose, and also, the genotype showed a trend of higher values of HbA1c, BMI, body fat mass and waist circumference. CONCLUSION: Adipocytokines, such as leptin and adiponectin, may play an important role in the development of metabolic syndrome, and they would be influenced by polymorphism of UCP or β2, β3AR genes.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"30 1","pages":"63-69"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74741398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}