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The clinical usefulness of routine MRI assessment. 常规MRI评估的临床应用价值。
International MS journal Pub Date : 2011-05-01
Dl Arnold, L Stone
{"title":"The clinical usefulness of routine MRI assessment.","authors":"Dl Arnold,&nbsp;L Stone","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Although the diagnostic value of magnetic resonance imaging (MRI) in multiple sclerosis (MS) is widely accepted, the clinical usefulness of routine MRI for monitoring the evolution of patients with MS is less widely accepted. It is not uncommon for clinicians to say that they treat the patient, not the MRI. In this review, we highlight some of the evidence that routine MRI surveillance of patients with MS provides important information about disease activity that is not evident clinically, and that this information can help with prognosis and management decisions. Specific recommendations for MRI surveillance of MS patients are provided.</p>","PeriodicalId":86075,"journal":{"name":"International MS journal","volume":"17 2","pages":"58-62"},"PeriodicalIF":0.0,"publicationDate":"2011-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29950620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epstein-Barr Virus and MS. eb病毒和多发性硬化症。
International MS journal Pub Date : 2011-05-01
G Giovannoni
{"title":"Epstein-Barr Virus and MS.","authors":"G Giovannoni","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Epstein-Barr virus (EBV) infection, particularly symptomatic infection, is closely associated with multiple sclerosis (MS). The strength of this association, the interaction of EBV infection with genetic risk factors and emerging immunological data have resulted in some investigators arguing that this association may be causative. Causation, however, is a complex science and more extensive and definitive data is required to convince the wider community that EBV is the pivotal factor in the complex causal pathway that ultimately leads to the development of MS.</p>","PeriodicalId":86075,"journal":{"name":"International MS journal","volume":"17 2","pages":"44-9"},"PeriodicalIF":0.0,"publicationDate":"2011-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29950637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
American academy of neurology annual meeting. 美国神经病学学会年会。
International MS journal Pub Date : 2011-05-01
Ernest Willoughby
{"title":"American academy of neurology annual meeting.","authors":"Ernest Willoughby","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The American Academy of Neurology (AAN) Annual Meeting was held in Toronto, Canada from 10 to 17 April, 2010. As usual, multiple sclerosis (MS) featured prominently with about 450 poster and platform presentations on various aspects. Highlights were presentations on the controversial theory of venous obstruction as a cause of MS and updates on promising oral treatments, particularly fingolimod, cladribine and teriflumomide.</p>","PeriodicalId":86075,"journal":{"name":"International MS journal","volume":"17 2","pages":"69-70"},"PeriodicalIF":0.0,"publicationDate":"2011-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29950622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Psychosis as the Initial Presentation of MS: A Case Report. 急性精神病作为多发性硬化症的初始表现:一个病例报告。
International MS journal Pub Date : 2011-05-01
A Aggarwal, Dd Sharma, R Kumar, Rc Sharma
{"title":"Acute Psychosis as the Initial Presentation of MS: A Case Report.","authors":"A Aggarwal,&nbsp;Dd Sharma,&nbsp;R Kumar,&nbsp;Rc Sharma","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Psychiatric disorders have been commonly recognized to be associated with multiple sclerosis (MS) during the course of the illness or as a result of the side effects of the drugs used for its management. There have been reports of MS patirents, presenting initially with pure psychiatric symptoms. Amongst these, atypical psychosis has been infrequently reported to be a feature of MS; presentation with typical features of acute psychosis associated with stress appears to be very rare. Hence, this should always prompt for consideration of other diagnoses, including functional psychosis. Nonetheless, as illustrated by the following case report, acute onset of demyelinating diseases with the clinical phenotype of acute psychosis associated with stress may.</p>","PeriodicalId":86075,"journal":{"name":"International MS journal","volume":"17 2","pages":"54-7"},"PeriodicalIF":0.0,"publicationDate":"2011-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29950640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical usefulness of cerebrospinal fluid evaluation. 脑脊液评价的临床价值。
International MS journal Pub Date : 2010-01-01
S Fredrikson
{"title":"Clinical usefulness of cerebrospinal fluid evaluation.","authors":"S Fredrikson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The importance of analysis of cerebrospinal fluid (CSF), especially oligoclonal IgG bands, in the diagnosis of multiple sclerosis (MS) and its predictive value in patients with clinically isolated syndromes has recently been evaluated and confirmed in several studies. Despite the focus on magnetic imaging techniques in modern MS diagnostic criteria, evaluation of CSF is of great usefulness both as a diagnostic and predictive tool.</p>","PeriodicalId":86075,"journal":{"name":"International MS journal","volume":"17 1","pages":"24-7"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29150448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Historical figure: dr joseph babinski(1857 to 1932). 历史人物:约瑟夫·巴宾斯基博士(1857 - 1932)。
International MS journal Pub Date : 2010-01-01
H Dechy
{"title":"Historical figure: dr joseph babinski(1857 to 1932).","authors":"H Dechy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Each time a patient is examined somewhere, one looks for Babinskis sign. It is recorded in medical files all over the world, but because the history of medicine is only minimally taught, Babinski remains virtually unknown. At times he is thought to be Russian, some write his name with a Y; the reflex he discovered is sometimes abbreviated as Bab or, less frequently, as BBK. The essence of Babinskis success was in creating an original approach to the evaluation of the patient, based on a meticulous clinical exam, looking for those abnormal reflexes or signs which he described, often in the face of considerable criticism.</p>","PeriodicalId":86075,"journal":{"name":"International MS journal","volume":"17 1","pages":"19-23"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29150447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosing Depression in MS in the Face of Overlapping Symptoms. 面对重叠症状诊断多发性硬化症抑郁症
International MS journal Pub Date : 2010-01-01
Sb Patten
{"title":"Diagnosing Depression in MS in the Face of Overlapping Symptoms.","authors":"Sb Patten","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Depression is an important problem in multiple sclerosis (MS), but the diagnosis is challenging since symptoms of depression overlap with those of MS. In the past, the main strategy has been to remove physical symptoms from scales assessing depressive symptoms in MS, but these attempts have not been successful. Depression and overlapping MS symptoms may actually share pathophysiological mechanisms, so the strategy of attempting to exclude such symptoms may be fundamentally flawed. Current diagnostic criteria provide a pragmatic solution, but it may be possible to develop improved definitions.</p>","PeriodicalId":86075,"journal":{"name":"International MS journal","volume":"17 1","pages":"3-5"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29150444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of Routine Neuropsychological Assessment for Early Identificationof Cognitive Impairment in MS. 常规神经心理学评估在早期识别多发性硬化症认知功能障碍中的应用。
International MS journal Pub Date : 2010-01-01
M Hoogs, S Morrow, Rhb Benedict
{"title":"Utility of Routine Neuropsychological Assessment for Early Identificationof Cognitive Impairment in MS.","authors":"M Hoogs,&nbsp;S Morrow,&nbsp;Rhb Benedict","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In addition to physical disability, multiple sclerosis (MS) is increasingly recognized for its association with neuropsychological (NP) impairment, including cognitive deficits and disorders of mood and affect. NP impairment can occur as early as the first demyelinating episode. Often insidious in nature, NP impairment has a significant impact on a wide range of quality-of-life measures including vocational status, social functioning, and instrumental activities of daily living. Objective, performance-based measures of NP status are important but underutilized tools used to evaluate and quantify deficits. These NP tests help clinicians make treatment decisions and assist in monitoring clinical status over time. Additionally, there is growing interest in developing improved screening measures to indicate when referral for NP testing is advised. This article reviews research findings pertaining to screening and monitoring NP status in MS as well as the clinical meaning of NP impairment.</p>","PeriodicalId":86075,"journal":{"name":"International MS journal","volume":"17 1","pages":"6-11"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29150445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cyclophosphamide Treatment of MS: Current Therapeutic Approaches and Treatment Regimens. 环磷酰胺治疗多发性硬化症:目前的治疗方法和治疗方案。
International MS journal Pub Date : 2010-01-01
As Elkhalifa, Hl Weiner
{"title":"Cyclophosphamide Treatment of MS: Current Therapeutic Approaches and Treatment Regimens.","authors":"As Elkhalifa,&nbsp;Hl Weiner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immunosuppression and immunotherapy have developed as the primary mode of therapy for multiple sclerosis (MS) and are most effective in active, relapsing stages of the disease. Cyclophosphamide has been used in the treatment of MS for over 40 years. The effectiveness of cyclophosphamide and its ability to stabilize MS patients has been suggested in many studies. Cyclophosphamide has selective effects on the immune response, including the suppression of Th1/Th17 responses and the enhancement of cells secreting anti-inflammatory cytokines such as interleukin (IL) IL-4, IL-10 and TGF-b. Different regimens have been developed fosssssssssr the use of cyclophosphamide in MS, from intermittent outpatient pulse therapy that is analogous to protocols used in lupus nephritis, to very high-dose inpatient regimens. Cyclophosphamide has also been used to treat paediatric MS. Like most immunomodulatory drugs, cyclophosphamide has limited, if any efficacy in primary progressive MS, or stages of secondary progressive MS with slow clinical deterioration, in the absence of relapses or inflammatory changes (gadolinium enhancement) on magnetic resonance imaging. Cyclophosphamide is used in relapsing or actively progressive MS as second-line therapy in patients unresponsive to interferon beta or glatiramer acetate who are not candidates for natalizumab.</p>","PeriodicalId":86075,"journal":{"name":"International MS journal","volume":"17 1","pages":"12-8"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29150446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing fatigue: clinical correlates, assessment procedures and therapeutic strategies. 管理疲劳:临床相关性，评估程序和治疗策略。
International MS journal Pub Date : 2010-01-01
Ik Penner, P Calabrese
{"title":"Managing fatigue: clinical correlates, assessment procedures and therapeutic strategies.","authors":"Ik Penner,&nbsp;P Calabrese","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The majority of patients with Multiple Sclerosis (MS) experience fatigue and for many susabjects concerned it is the most disabling symptom. Fatigue is most prominent in the afternoon and may be aggravated by heat. It has a tremendous negative impact on quality of life and is often one of the major reasons for early retirement and unemployment. Against further assumptions, fatigue can occur at all stages and is often present at the onset of the disease. Reliable assessment however, is difficult as it is a subjectively perceived lack of physical and/or mental energy interfering with intended activities and has to be differentiated from depression, consequences of sleep disorders, cognitive decline, and side-effects of medication. Moreover, fatigue is not directly related to overall disease evolution, to disability levels or localized lesions, although an association with dysfunction of fronto-thalamo-basal-ganglia circuits seems likely. Several therapeutic approaches including pharmacological as well as non-pharmacological strategies are available but an evidence-based specific gold-standard for the treatment of fatigue is still missing.</p>","PeriodicalId":86075,"journal":{"name":"International MS journal","volume":"17 1","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29149862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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