Die Pharmazie. Beihefte最新文献_第4页

Analysis and management of drug related problems on a nephrology ward from a pharmacist's point of view. 从药师角度分析肾内科病房药物相关问题及处理。

Die Pharmazie. Beihefte Pub Date : 2019-10-01 DOI: 10.1691/ph.2019.9568

E. Dvořáčková, J. Rychlíčková, P. Pávek, M. Hojný, J. Vlček

{"title":"Analysis and management of drug related problems on a nephrology ward from a pharmacist's point of view.","authors":"E. Dvořáčková, J. Rychlíčková, P. Pávek, M. Hojný, J. Vlček","doi":"10.1691/ph.2019.9568","DOIUrl":"https://doi.org/10.1691/ph.2019.9568","url":null,"abstract":"The main goal of the study was to determine the incidence and the character of drug related problems (DRPs) identified in chronic kidney disease patients by the clinical pharmacist at the nephrology department. As secondary objective, the aim was to identify the frequency and character of DRPs of selected high risk drugs in medication reviews. The clinical pharmacist reviewed patients' medication records and made drug therapy-related recommendations to physicians. The clinical pharmacists' interventions were categorized using an adaptation of the Pharmaceutical Care Network Europe. During the study period (January 2016 - June 2018) the clinical pharmacist performed 1192 interventions in 1870 adult patients admitted to the Nephrology Department. The most frequent DRP was untreated indication 324 (27.18%) of all interventions, and incorrect dose 248 (20.81%). Anti-infectives were identified as the drug category with the highest frequency of interventions. Almost 93% of all interventions were accepted by the attending physicians. Still within the second objectives, underdosing was observed as the most frequent problem for renally excreted drugs. It was found that an incorrect dose is a very frequent issue at the nephrology department. Surprisingly, the main problem was underdosing. In the category of renally excreted drugs, underdosing was observed in antithrombotics and antivirals. The above- mentioned results prove the need of a clinical pharmacist, preferably in sense of maximizing of the treatment effect and improving the care of patients.","PeriodicalId":86039,"journal":{"name":"Die Pharmazie. Beihefte","volume":"15 1","pages":"625-629"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75234579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Prophylactic effect of rikkunshito, an herbal medicine, for chemotherapy-induced nausea in thoracic cancer patients receiving carboplatin-based chemotherapy. 对接受卡铂为基础的化疗的胸腺癌患者化疗引起的恶心的预防作用，一种草药。

Die Pharmazie. Beihefte Pub Date : 2019-10-01 DOI: 10.1691/ph.2019.9497

C. Hirose, H. Iihara, N. Funaguchi, J. Endo, F. Ito, K. Yanase, D. Kaito, Y. Sasaki, T. Gomyo, C. Sakai, Y. Ohno, A. Suzuki

{"title":"Prophylactic effect of rikkunshito, an herbal medicine, for chemotherapy-induced nausea in thoracic cancer patients receiving carboplatin-based chemotherapy.","authors":"C. Hirose, H. Iihara, N. Funaguchi, J. Endo, F. Ito, K. Yanase, D. Kaito, Y. Sasaki, T. Gomyo, C. Sakai, Y. Ohno, A. Suzuki","doi":"10.1691/ph.2019.9497","DOIUrl":"https://doi.org/10.1691/ph.2019.9497","url":null,"abstract":"Rikkunshito has been shown to improve upper gastrointestinal symptoms and anorexia. The aim of this study was to evaluate whether rikkunshito improves chemotherapy-induced nausea in thoracic cancer patients receiving carboplatin (CBDCA)-based chemotherapy. A retrospective before-and-after comparison study was conducted in patients with thoracic cancer receiving the first cycle of CBDCA-based chemotherapy. Among 61 eligible patients, 34 received standard antiemetic therapy with a combination of 5-hydroxytryptamine-3 receptor antagonist and dexamethasone from September 2012 and June 2013 (standard group), while the other 27 received the standard antiemetic therapy plus oral rikkunshito from July 2013 and December 2014 (rikkunshito group). The rates of no nausea showed no significant difference between the standard and rikkunshito group (Overall phase: 64.7 % for standard group vs 74.1 % for rikkunshito group, p = 0.579). Subgroup analysis indicated that, in female patients, the rates of no nausea in rikkunshito groups was significantly higher than in standard group (overall phase: 44.4 % vs 100 %, p = 0.034). Rikkunshito did not demonstrate an additional prophylactic effect on standard antiemetic therapy for nausea in patients with thoracic cancer receiving CBDCA-based chemotherapy, but showed a prophylactic effect of nausea in female patients.","PeriodicalId":86039,"journal":{"name":"Die Pharmazie. Beihefte","volume":"s1-6 1","pages":"620-624"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85977476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Community pharmacy-level factors associated with medical and nursing home facility collaboration in Japan. 日本社区药房层面与医疗和养老院设施合作相关的因素。

Die Pharmazie. Beihefte Pub Date : 2019-10-01 DOI: 10.1691/ph.2019.9489

Y. Ino, A. Shimauchi, T. Tachi, Y. Noguchi, C. Sakai, K. Iguchi, A. Kano, H. Teramachi

{"title":"Community pharmacy-level factors associated with medical and nursing home facility collaboration in Japan.","authors":"Y. Ino, A. Shimauchi, T. Tachi, Y. Noguchi, C. Sakai, K. Iguchi, A. Kano, H. Teramachi","doi":"10.1691/ph.2019.9489","DOIUrl":"https://doi.org/10.1691/ph.2019.9489","url":null,"abstract":"The aim of this study was to clarify the community pharmacy-level factors related to experiences of and attitudes toward collaboration with medical and nursing home care facilities. We conducted a postal questionnaire survey of all pharmacies in Gifu, Japan, assessing the experiences and attitudes of supervising pharmacists regarding the following activities related to collaboration between medical facilities and nursing home care facilities: regional care meetings/service adjustment meetings, case discussion conferences, joint workshops/continuing education conferences, community service, information sharing through medical cooperation networks, and pharmacists accompanying physicians on home care visits. The factors significantly related to inter-professional collaboration were the family pharmacist guidance fee and the number of patients offered pharmaceutical care through cooperation with other medical facilities. Items on attitudes toward collaborating with other medical facilities showed similar results. Overall, policies that support inter-professional collaboration to create a foundation, establish mechanisms to facilitate collaboration, and identify collaborative activities that can be carried out at each pharmacy should be developed.","PeriodicalId":86039,"journal":{"name":"Die Pharmazie. Beihefte","volume":"13 1","pages":"630-638"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81622571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Ephrin type-A receptor 2 on tumor-derived exosomes enhances angiogenesis through the activation of MAPK signaling. 肿瘤源性外泌体上的Ephrin - a型受体2通过激活MAPK信号通路促进血管生成。

Die Pharmazie. Beihefte Pub Date : 2019-10-01 DOI: 10.1691/ph.2019.9474

T. Yamashita, H. Kamada, S. Kanasaki, K. Nagano, M. Inoue, K. Higashisaka, Y. Yoshioka, Y. Tsutsumi, S. Tsunoda

引用次数: 7

Preparation, characterization and antimicrobial activity of inclusion complexes of Myristica fragrans Hott. essential oil in β-cyclodextrins. 香肉豆蔻包合物的制备、表征及抗菌活性研究。β-环糊精中的精油。

Die Pharmazie. Beihefte Pub Date : 2019-10-01 DOI: 10.1691/ph.2019.9061

Jin Wang, Hai-hong Zhang, Feng Liu, Yu-ping Zhang, Yong-ming Zhao

{"title":"Preparation, characterization and antimicrobial activity of inclusion complexes of Myristica fragrans Hott. essential oil in β-cyclodextrins.","authors":"Jin Wang, Hai-hong Zhang, Feng Liu, Yu-ping Zhang, Yong-ming Zhao","doi":"10.1691/ph.2019.9061","DOIUrl":"https://doi.org/10.1691/ph.2019.9061","url":null,"abstract":"Inclusion complexes of essential oils with cyclodextrins are an effective way to improve stability and solubility, and turn liquid materials into easy to handle powders. In this work, an essential oil of Myristica fragrans Hott. (MFEO), already used in the food and cosmetics industries, was formulated with beta-cyclodextrins (β-CD) using a co-precipitation method. The orthogonal array scheme was adapted for the optimization of preparation process. DSC and FT-IR spectroscopy analysis indicated the successful formation of MFEO/β-CD inclusion complexes, which improved the thermal stability of MFEO. Furthermore, comparing the antimicrobial activity of MFEO/β-CD inclusion complexes and free essential oil against Staphyloccocus aureus, Staphyloccocus epidermidis, Escherichia coli, Klebsiella pneumoniae, yeast Saccharomyces cerevisiae and Bacillus subtilis, it was found that the antimicrobial effect was enhanced after the formation of inclusion complexes. This study demonstrates the potential for the use of MFEO/β-CD inclusion complexes in the treatment of bacterial infection.","PeriodicalId":86039,"journal":{"name":"Die Pharmazie. Beihefte","volume":"37 1","pages":"590-594"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72888414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effect of acetazolamide on lithium reabsorption and lithium-induced GSK3β phosphorylation in rat kidney. 乙酰唑胺对大鼠肾锂重吸收及锂诱导的GSK3β磷酸化的影响。

Die Pharmazie. Beihefte Pub Date : 2019-10-01 DOI: 10.1691/ph.2019.9060

Y. Uwai, M. Tsuduki, T. Kawasaki, T. Nabekura

{"title":"Effect of acetazolamide on lithium reabsorption and lithium-induced GSK3β phosphorylation in rat kidney.","authors":"Y. Uwai, M. Tsuduki, T. Kawasaki, T. Nabekura","doi":"10.1691/ph.2019.9060","DOIUrl":"https://doi.org/10.1691/ph.2019.9060","url":null,"abstract":"Lithium promotes the phosphorylation of glycogen synthase kinase-3β (GSK3β), and this reaction protects against acute kidney injury mediated by renal apoptosis. Lithium is considered to be reabsorbed by sodium-phosphate cotransporters and sodium-proton exchanger NHE3. This study evaluated the relation between the lithium reabsorption and the phosphorylation of GSK3β, by using acetazolamide, an NHE3 inhibitor. In rats infused with lithium chloride, the plasma concentration of lithium was 4.77 mEq/l, and the renal clearance of lithium and its fractional excretion were calculated to be 2.29 ml/min/kg and 0.405, respectively. Coadministration of acetazolamide decreased creatinine clearance and the reabsorption rate of lithium, increased the fractional excretion of lithium, and did not affect its plasma concentration. Western blot analysis exhibited the facilitation of GSK3β phosphorylation in the kidney cortex by lithium infusion, and acetazolamide inhibited the lithium-induced phosphorylation of GSK3β. Lithium did not affect GSK3β phosphorylation in the liver and did not affect Akt in the kidney cortex and liver. These data show that lithium reabsorption contributes to GSK3β phosphorylation in the kidney cortex.","PeriodicalId":86039,"journal":{"name":"Die Pharmazie. Beihefte","volume":"6 1","pages":"611-613"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88202545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PI3K-AKT-mTOR signaling pathway: the intersection of allergic asthma and cataract. PI3K-AKT-mTOR信号通路:过敏性哮喘与白内障的交叉。

Die Pharmazie. Beihefte Pub Date : 2019-10-01 DOI: 10.1691/ph.2019.9080

Yang Zhao, Xiangsheng Li, Zhenzhen Xu, Lifang Hao, Yanfen Zhang, Zhongcheng Liu

引用次数: 8

Geniposide protects against ox-LDL-induced foam cell formation through inhibition of MAPKs and NF-kB signaling pathways. 京尼平苷通过抑制MAPKs和NF-kB信号通路来防止ox- ldl诱导的泡沫细胞形成。

Die Pharmazie. Beihefte Pub Date : 2019-10-01 DOI: 10.1691/ph.2019.9506

Zhi-qiang Li, Xiu-ying Huang, Chun-yan Hu, Zhongsheng Zhu, Yang Chen, Min Gong

{"title":"Geniposide protects against ox-LDL-induced foam cell formation through inhibition of MAPKs and NF-kB signaling pathways.","authors":"Zhi-qiang Li, Xiu-ying Huang, Chun-yan Hu, Zhongsheng Zhu, Yang Chen, Min Gong","doi":"10.1691/ph.2019.9506","DOIUrl":"https://doi.org/10.1691/ph.2019.9506","url":null,"abstract":"Atherosclerosis (AS) is characterized by the significant accumulation of low-density lipoprotein (LDL)-cholesterol in macrophages that reside in the vessel wall and the resultant inflammatory response. Therefore, inhibition of LDL-induced inflammation is a promising interference for AS. Many traditional Chinese medicine prescriptions have been developed for AS treatment. Geniposide (GEN) is an iridoid glycoside mainly found in Gardenia jasminoides fruit. Although GEN has previously been shown to possess anti-atherosclerotic activities, its effects on the formation of macrophage-derived foam cells remain poorly characterized. In our current study, we demonstrated that GEN could significantly inhibit oxidized light-density lipoprotein (ox-LDL) induced macrophage foam cell formation and the expression of pro-inflammatory cytokines in a dose-dependent manner. In addition, treatment of GEN in bone-marrow derived macrophages repressed iNOS expression and NO expression. GEN could also alleviate ox-LDL-dependent up-regulation of CD36 expression by blocking the phosphorylation of p38 MAPK, ERK, JNK and NF-kB p65. The results of our current study demonstrate that GEN exhibits significant therapeutic effects against ox-LDA-induced foam cell formation and inflammation. Therefore, GEN is promising agent for treating AS.","PeriodicalId":86039,"journal":{"name":"Die Pharmazie. Beihefte","volume":"1 1","pages":"601-605"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73209829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Cepharanthine, a bisbenzylisoquinoline alkaloid, inhibits lipopolysaccharide-induced microglial activation. 头孢酞碱是一种双苄基异喹啉生物碱，可抑制脂多糖诱导的小胶质细胞活化。

Die Pharmazie. Beihefte Pub Date : 2019-10-01 DOI: 10.1691/ph.2019.9562

M. L. Chen, J. Gou, X. Meng, C. L. Chen, X. Liu

引用次数: 2

Interaction with St. John's wort due to exposure with blackcurrant aroma? How not to present a case report of an adverse event. 由于接触黑加仑的香气而与圣约翰草产生相互作用?如何不提交不良事件的病例报告。

Die Pharmazie. Beihefte Pub Date : 2019-10-01 DOI: 10.1691/ph.2019.9491

K. Kuchta, M. Thomsen, T. Scior, M. Schmidt

{"title":"Interaction with St. John's wort due to exposure with blackcurrant aroma? How not to present a case report of an adverse event.","authors":"K. Kuchta, M. Thomsen, T. Scior, M. Schmidt","doi":"10.1691/ph.2019.9491","DOIUrl":"https://doi.org/10.1691/ph.2019.9491","url":null,"abstract":"Background: Adverse events case reports are important for signal generation in pharmacovigilance. They require a thorough collation of the facts, otherwise they may lead to erroneous conclusions which may conceal other treatment-related causes of the observation. Methods: We describe a case report from the literature that arrives at an erroneous conclusion merely from taking insufficient care when collating and interpreting the facts: The authors of the case report confused blackcurrant (Ribes nigrum) with St. John's wort preparation (Hypericum perforatum) and erroneously assumed that the intake of a herbal preparation was responsible for a drop in serum levels of everolimus. Results: The clinical observations in this case report may actually reflect a potentially lethal situation emerging from the prescribed medication everolimus. St. John's wort preparations rich in hyperforin do in fact reproducibly lead to the decrease of blood levels of medications metabolized through cytochrome P450 subtype 3A4. However, a case report requires more care than just ascribing the blame to something seemingly well-known. Conclusion: The readers of this report might have profited more from the description of the risks of treating graft-versus-host disease with everolimus, and the action to be taken in case of potentially severe adverse reactions to everolimus.","PeriodicalId":86039,"journal":{"name":"Die Pharmazie. Beihefte","volume":"55 1","pages":"595-597"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81602541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0