{"title":"Clinical Characteristics and Short Term Outcome of Multi-Vessel Coronary Artery Disease Patients Presented with AMI- Single Center Experience","authors":"Sheeren Mohammed Khaled","doi":"10.1016/j.atherosclerosissup.2020.01.005","DOIUrl":"10.1016/j.atherosclerosissup.2020.01.005","url":null,"abstract":"","PeriodicalId":8592,"journal":{"name":"Atherosclerosis. Supplements","volume":"41 ","pages":"Page e2"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.atherosclerosissup.2020.01.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47103940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahmoud S. Eisa, Mohamed A. Oraby, Ahmed H. Abdel Moneim, Ahmed S. Salem
{"title":"Correlation Between Epicardial Fat Thickness Assessed by Echocardiography and Coronary Artery Disease Severity in Patients Attending Suez Canal University Hospital","authors":"Mahmoud S. Eisa, Mohamed A. Oraby, Ahmed H. Abdel Moneim, Ahmed S. Salem","doi":"10.1016/j.atherosclerosissup.2020.01.007","DOIUrl":"10.1016/j.atherosclerosissup.2020.01.007","url":null,"abstract":"","PeriodicalId":8592,"journal":{"name":"Atherosclerosis. Supplements","volume":"41 ","pages":"Page e2"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.atherosclerosissup.2020.01.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46715837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashraf Reda , Ashraf Ahmed Abdulmaged , Ahmed Hassan Zaid
{"title":"Serum Bilirubin as Predictor of Infarct-Related Artery Patency, and In-Hospital Outcomes for ST- Elevation Myocardial Infarction and In-Hospital Outcomes Following Percutaneous Coronary Intervention","authors":"Ashraf Reda , Ashraf Ahmed Abdulmaged , Ahmed Hassan Zaid","doi":"10.1016/j.atherosclerosissup.2020.01.010","DOIUrl":"10.1016/j.atherosclerosissup.2020.01.010","url":null,"abstract":"","PeriodicalId":8592,"journal":{"name":"Atherosclerosis. Supplements","volume":"41 ","pages":"Page e3"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.atherosclerosissup.2020.01.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41260482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashraf Reda , Ahmed Shawky Elserafy , Elsayed Farag , Tamer Mostafa , Nabil Farag , Atef Elbahry , Osama Sanad , Ahmed Bendary , Ahmed Elkersh , Ihab Attia , Morad Beshay , Mohammed Selim , Hazem Khamis
{"title":"Egyptian Association of Vascular Biology and Atherosclerosis (EAVA) consensus on the usage of pro protein convertase subtilisin/kexin type 9 (PCSK9) inhibitors","authors":"Ashraf Reda , Ahmed Shawky Elserafy , Elsayed Farag , Tamer Mostafa , Nabil Farag , Atef Elbahry , Osama Sanad , Ahmed Bendary , Ahmed Elkersh , Ihab Attia , Morad Beshay , Mohammed Selim , Hazem Khamis","doi":"10.1016/j.atherosclerosissup.2020.01.002","DOIUrl":"10.1016/j.atherosclerosissup.2020.01.002","url":null,"abstract":"","PeriodicalId":8592,"journal":{"name":"Atherosclerosis. Supplements","volume":"41 ","pages":"Page e1"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.atherosclerosissup.2020.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49130640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alaa M. Abou El Soud, Hanan M. Kamal, Ahmed Tageldein Abdellah, Ahmed H. Abdel Moniem
{"title":"Cardiovascular Predictors of Stroke in Patients with Sinus Rhythm Versus Patients with Atrial Fibrillation in Suez Canal University Hospital","authors":"Alaa M. Abou El Soud, Hanan M. Kamal, Ahmed Tageldein Abdellah, Ahmed H. Abdel Moniem","doi":"10.1016/j.atherosclerosissup.2020.01.004","DOIUrl":"10.1016/j.atherosclerosissup.2020.01.004","url":null,"abstract":"","PeriodicalId":8592,"journal":{"name":"Atherosclerosis. Supplements","volume":"41 ","pages":"Page e1"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.atherosclerosissup.2020.01.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45745785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roman N. Rodionov , Natalia Jarzebska , Alfred Schneider , Annett Rexin , Jan Sradnick , Silke Brilloff , Jens Martens-Lobenhoffer , Stefanie M. Bode-Böger , Vladimir Todorov , Christian Hugo , Norbert Weiss , Bernd Hohenstein
{"title":"ADMA elevation does not exacerbate development of diabetic nephropathy in mice with streptozotocin-induced diabetes mellitus","authors":"Roman N. Rodionov , Natalia Jarzebska , Alfred Schneider , Annett Rexin , Jan Sradnick , Silke Brilloff , Jens Martens-Lobenhoffer , Stefanie M. Bode-Böger , Vladimir Todorov , Christian Hugo , Norbert Weiss , Bernd Hohenstein","doi":"10.1016/j.atherosclerosissup.2019.08.040","DOIUrl":"10.1016/j.atherosclerosissup.2019.08.040","url":null,"abstract":"<div><h3>Background and aims</h3><p>Cardiovascular disease is nowadays the major cause of mortality and morbidity worldwide. The risk of developing cardiovascular disease is significantly increased in patients with diabetic nephropathy. It has been suggested that asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthases (NOS), may play an important role in the pathogenesis of diabetic nephropathy. ADMA is mainly metabolized by dimethylarginine dimethylaminohydrolase 1 (DDAH1). The goal of this study was to test the hypothesis that elevation of systemic ADMA levels by knocking out DDAH1 would exacerbate functional and structural glomerular abnormalities in a murine model of diabetic nephropathy.</p></div><div><h3>Methods</h3><p>Streptozotocin (STZ) was used to induce diabetes in adult DDAH1 knock-out and wild type mice. Healthy mice served as controls. Mice were sacrificed after 20 weeks of diabetes. Plasma ADMA levels were assessed by isotope-dilution tandem mass spectrometry and albumin by ELISA. Kidneys were used for FACS analysis and were also stained for markers of inflammation, cell proliferation, glomerular cells and cell matrix.</p></div><div><h3>Results</h3><p>STZ led to development of diabetes mellitus in all injected animals. Deficiency of DDAH1 led to a significant increase in plasma ADMA levels in healthy and diabetic mice. The diabetic state itself did not influence systemic ADMA levels. Diabetic mice of both genotypes developed albuminuria and had increased glomerulosclerosis index. There were no changes in desmin expression, glomerular cell proliferation rate, matrix expansion and expression of Mac-2 antigen in the diabetic mice of both genotypes as compared to the healthy ones.</p></div><div><h3>Conclusions</h3><p>In summary, STZ-induced diabetes led to the development of early features of diabetic nephropathy. Deficiency of DDAH1 and subsequent increase in systemic ADMA levels did not exacerbate these changes, indicating that ADMA is not the major mediator of diabetic nephropathy in this experiment model.</p></div>","PeriodicalId":8592,"journal":{"name":"Atherosclerosis. Supplements","volume":"40 ","pages":"Pages 100-105"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.atherosclerosissup.2019.08.040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78130712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}