Vaccine weekly最新文献_第2页

Vaccination efforts lauded in Brazil. 巴西赞扬疫苗接种工作。

Vaccine weekly Pub Date : 1994-12-19

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Women's issues. Worldwide they face greatest HIV risk. 女性的问题。在世界范围内，他们面临着最大的艾滋病毒风险。

Vaccine weekly Pub Date : 1994-12-12

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Thai volunteers test HIV vaccine. 泰国志愿者测试艾滋病毒疫苗。

Vaccine weekly Pub Date : 1994-12-12

{"title":"Thai volunteers test HIV vaccine.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"A group of 30 Thai volunteers received their final injections in a multi-national test of what doctors believe is a promising experimental AIDS vaccine. Dr. Prapan Panupark, director of the project in Thailand, said he was encouraged by initial results of the test conducted on 25 males and five females. The study of the experimental vaccine, known as the United Biomedical Inc. synthetic monovalent HIV-1 peptide, involved healthy volunteers aged from 21 to 48. Prapan told a press conference that participants received their first injections on June 6, 1994, another on July 4, 1994, and their final shot November 28, 1994. He said similar tests are taking place in Brazil and Uganda, which, like Thailand, have been hard-hit by HIV. One month after the second injection, Prapan said, blood tests revealed that out of 24 volunteers receiving the vaccine, 10 had developed immunity. \"We are happy that immunity developed in 10 cases out of 24, or over 40%,\" he said. \"We are happy because in similar tests in other countries, such as the US and Australia, only about 20% of the volunteers developed immunity.\" He said the volunteers will have their blood tested three more times to determine their levels of immunity. According to recently released figures, 3902 people have died of AIDS in Thailand in the past decade. Another 5215 patients are suffering from advanced AIDS in Thailand, while an estimated 600,000 people are believed to be HIV-positive.","PeriodicalId":85829,"journal":{"name":"Vaccine weekly","volume":" ","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"1994-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22039116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Epidemiology / vaccine efficacy trials. "HIV Incidence in Adults in Northern Thailand". 流行病学/疫苗功效试验。“泰国北部成人艾滋病毒发病率”。

Vaccine weekly Pub Date : 1994-10-10

C Khamboonruang, C Beyrer, C Natpatan, S Eiumtrakol, D Celentano, K E Nelson

{"title":"Epidemiology / vaccine efficacy trials. \"HIV Incidence in Adults in Northern Thailand\".","authors":"C Khamboonruang, C Beyrer, C Natpatan, S Eiumtrakol, D Celentano, K E Nelson","doi":"","DOIUrl":"","url":null,"abstract":"Unlabelled: According to an abstract submitted by the authors to the X International Conference on AIDS, held August 7-12, 1994, in Yokohama, Japan, \"Objective: To measure the HIV-1 incidence, follow-up rates and high risk behaviors in cohorts of seronegative adults in northern Thailand.Methods: We screened cohorts of female commercial sex workers (CSWs), male STD clinic patients, Royal Thai Army (RTA) conscripts, and discharged RTA conscripts at baseline and q3 to 6 months for HIV infection by ELISA and WB and did interviews for high risk behavior, medical history, and STD cultures.Results: Of 1068 CSWs, 409 (38.3%) were HIV positive, and 396 HIV negative were enrolled in the study; follow-up at 6 months was 70.7% and 19 seroconverted, for an incidence of 12.8/100 person years. Of 1031 male STD patients, 164 (15.9%) were HIV positive, and 264 HIV negative (30.4%) were enrolled; follow-up at 6 months was 91.9% and 6 seroconverted, for an incidence of 4.92/100 person years. Of 969 RTA conscripts, 12.4% were HIV positive at baseline and 90% were followed at 6 months; 3 of 778 seroconverted, for an incidence of 0.87/100 person years. (Previous RTA cohorts have had an incidence of 3.4%/year). Among 380 men discharged from RTA, follow-up at 9 months was 81.8% and the incidence was 5.2/100 person years. Sample sizes required to show an HIV vaccine efficacy of 60%, with a power-.90, alpha-.05 varies from CSUs 644, STD patients 1456 to ex-RTA-1306.Conclusions: Several populations in northern Thailand appear to have sufficiently high HIV-1 incidence and adequate follow-up for HIV vaccine efficacy trials and other preventive intervention trials.","PeriodicalId":85829,"journal":{"name":"Vaccine weekly","volume":" ","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"1994-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22037719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Contraceptive vaccines. Birth-control vaccine feasible, but more work needed. 避孕疫苗。控制生育的疫苗是可行的，但需要做更多的工作。

Vaccine weekly Pub Date : 1994-09-26

引用次数: 0