Topics in HIV medicine : a publication of the International AIDS Society, USA最新文献_第8页

Changing trends in bacterial infections: Staphylococcus aureus, bacterial pneumonia, Clostridium difficile. 细菌感染的变化趋势:金黄色葡萄球菌，细菌性肺炎，艰难梭菌。

Topics in HIV medicine : a publication of the International AIDS Society, USA Pub Date : 2007-06-01

John G Bartlett

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Recent efforts in biomedical prevention of HIV. 最近在艾滋病毒生物医学预防方面的努力。

Topics in HIV medicine : a publication of the International AIDS Society, USA Pub Date : 2007-06-01

Raphael J Landovitz

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Advances in antiretroviral therapy. 抗逆转录病毒治疗的进展。

Topics in HIV medicine : a publication of the International AIDS Society, USA Pub Date : 2007-04-01

Joyce Jones, Barbara Taylor, Timothy J Wilkin, Scott M Hammer

{"title":"Advances in antiretroviral therapy.","authors":"Joyce Jones, Barbara Taylor, Timothy J Wilkin, Scott M Hammer","doi":"","DOIUrl":"","url":null,"abstract":"The 14th Conference on Retroviruses and Opportunistic Infections provided a forum for presentation of state-of-the-art research on antiretroviral therapy. This year's conference marked the first public presentation of phase III trials of the lead compounds in 2 new drug classes: maraviroc (a CCR5 inhibitor) and raltegravir (an HIV-1 integrase inhibitor). These agents are likely to be approved by the US Food and Drug Administration this year and should provide major new options for treatment-experienced patients with multidrug resistant virus. Other dominant themes of the conference were the impressive number of presentations describing outcomes of antiretroviral therapy programs in resource-limited settings and new information on mechanisms of drug resistance. Among the latter, the importance of drug resistance mutations occurring in the RNase H and connection domains of the HIV-1 reverse transcriptase was of special note. In addition, substantial new information was presented on other new antiretroviral agents, studies in treatment-naive patients, antiretroviral therapy strategies, prevention of mother-to-child transmission, predictors of clinical response to therapy, and antiretroviral pharmacokinetics. Research in antiretroviral therapy remains dynamic and advances in the field continue to improve our ability to maintain long-term control of HIV-1 replication in infected persons.","PeriodicalId":85800,"journal":{"name":"Topics in HIV medicine : a publication of the International AIDS Society, USA","volume":"15 2","pages":"48-82"},"PeriodicalIF":0.0,"publicationDate":"2007-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26709744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Complications of HIV disease and therapy. 艾滋病的并发症和治疗。

Topics in HIV medicine : a publication of the International AIDS Society, USA Pub Date : 2007-04-01

Judith S Currier, Diane V Havlir

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Neurologic complications of HIV disease and their treatment. 艾滋病的神经系统并发症及其治疗。

Topics in HIV medicine : a publication of the International AIDS Society, USA Pub Date : 2007-04-01

Scott Letendre, Beau Ances, Sarah Gibson, Ronald J Ellis

{"title":"Neurologic complications of HIV disease and their treatment.","authors":"Scott Letendre, Beau Ances, Sarah Gibson, Ronald J Ellis","doi":"","DOIUrl":"","url":null,"abstract":"Important new information regarding neurologic complications of HIV disease was presented at the 2007 Conference on Retroviruses and Opportunistic Infections. In addition to presentations on pathogenesis and treatment of neurologic complications, the conference included findings that have implications for the management of HIV disease outside the nervous system. Key findings included that the distribution of antiretrovirals into the central nervous system may influence the effectiveness of treatment outside this protected compartment; that postponing initiation of therapy until blood CD4+ counts fall to 300 cells/mm3 may increase the risk for HIV-associated neurocognitive impairment but interruption of antiretroviral therapy in individuals with high CD4+ counts may have neuropsychologic benefits; that substantial changes, including macrophage activation and neuronal injury can occur shortly after HIV transmission; that HIV can influence neural progenitor cells to decrease neuronal differentiation; that newer neuroimaging technologies, such as diffusion tensor imaging and blood oxygen level-dependent functional magnetic resonance imaging can identify important effects of HIV on the brain such as alterations in cerebral oxygen consumption; that serotonin reuptake inhibitors and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors may reduce HIV RNA levels in cerebral spinal fluid; and that erythropoietin and the non-immunosuppressive immunophilin ligand, GPI-1046, may improve HIV-associated injury of peripheral nerves. The conference also included an important focus on JC virus encephalitis (also known as progressive multifocal leukoencephalopathy).","PeriodicalId":85800,"journal":{"name":"Topics in HIV medicine : a publication of the International AIDS Society, USA","volume":"15 2","pages":"32-9"},"PeriodicalIF":0.0,"publicationDate":"2007-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26709743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV epidemiology and prevention interventions. 艾滋病毒流行病学和预防干预措施。

Topics in HIV medicine : a publication of the International AIDS Society, USA Pub Date : 2007-04-01

Susan Buchbinder

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Basic science highlights. 基础科学亮点。

Topics in HIV medicine : a publication of the International AIDS Society, USA Pub Date : 2007-04-01

Mario Stevenson

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Review on structured treatment interruptions (STIs). 结构化治疗中断(STIs)综述。

Topics in HIV medicine : a publication of the International AIDS Society, USA Pub Date : 2007-02-01

Bernard Hirschel

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HIV infection in women: perinatal issues and cervical cancer surveillance. 妇女感染艾滋病毒:围产期问题和宫颈癌监测。

Topics in HIV medicine : a publication of the International AIDS Society, USA Pub Date : 2007-02-01

Carmen D Zorrilla

{"title":"HIV infection in women: perinatal issues and cervical cancer surveillance.","authors":"Carmen D Zorrilla","doi":"","DOIUrl":"","url":null,"abstract":"Issues of HIV infection in women include perinatal care to prevent mother-child transmission and screening for cervical dysplasia. Antiretroviral therapy has been very successful in reducing perinatal transmission rates. Ongoing issues in this setting include absense of relevant pharmacokinetics data for new drugs and formulations, implementation of new resistance testing guidelines, and recent apparently conflicting findings on the potential role of protease inhibitor treatment in preterm delivery. Recent findings also include a similar low transmission rate with vaginal delivery and emergency cesarean delivery versus elective cesarean delivery in women on antiretroviral therapy with HIV viral load of less than 1000 copies/mL, and a low rate of postpartum morbidity in women undergoing elective cesarean delivery. Recent changes in recommendations for cervical cancer screening in the general population should not be applied to HIV-infected women. However, the recent finding that HIV-infected women with CD4+ cell counts greater than 500/ul do not have a greater rate of squamous intraepithelial lesions than women without HIV infection suggests that the former can be followed less frequently if they have normal Pap tests. This article summarizes a presentation on HIV infection in women made by Carmen D. Zorrilla, MD, at the 9th Annual Ryan White CARE Act Clinical Update in Washington, DC, in August 2006. The original presentation is available as a Webcast at www.iasusa.org.","PeriodicalId":85800,"journal":{"name":"Topics in HIV medicine : a publication of the International AIDS Society, USA","volume":"15 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26242249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV testing: rationale for changing recommendations. 艾滋病毒检测:改变建议的理由。

Topics in HIV medicine : a publication of the International AIDS Society, USA Pub Date : 2007-02-01

Robert S Janssen

引用次数: 0