{"title":"The supramolecular chemistry of protein cages and viruses","authors":"Y. H. Lau","doi":"10.1071/ch23102","DOIUrl":"https://doi.org/10.1071/ch23102","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85706088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Perspectives and opinions from scientific leaders on the evolution of data-independent acquisition for quantitative proteomics and novel biological applications","authors":"C. Hunter, J. Bons, B. Schilling","doi":"10.1071/ch23039","DOIUrl":"https://doi.org/10.1071/ch23039","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91296983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of amphoteric surfactants on the dispersibility of TiO2 nanoparticles and experimental study of enhanced oil recovery","authors":"Zhangkun Ren, Lipei Fu, Xinxin Qiu, Wenzheng Chen, Wenzhe Si, Qianli Ma, Minglu Shao, Lifeng Chen, Menglin Wang, Kaili Liao","doi":"10.1071/ch23080","DOIUrl":"https://doi.org/10.1071/ch23080","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84642936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Navigating natural product-related patents in Australia and beyond","authors":"Claire Gregg, Michael Caine","doi":"10.1071/ch22254","DOIUrl":"https://doi.org/10.1071/ch22254","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88294137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel G. Anstis, Jessica Liyu, Emma K. Davison, J. Sperry
{"title":"Alkaloids from the entheogenic plant Peganum harmala","authors":"Daniel G. Anstis, Jessica Liyu, Emma K. Davison, J. Sperry","doi":"10.1071/ch23038","DOIUrl":"https://doi.org/10.1071/ch23038","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76759333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Majbrit Frøsig-Jørgensen, Jing Ji, Declan M. Gorman, Meng-Wei Kan, David J. Craik
{"title":"Discovery and optimisation of conotoxin Vc1.1 and analogues with analgesic properties","authors":"Majbrit Frøsig-Jørgensen, Jing Ji, Declan M. Gorman, Meng-Wei Kan, David J. Craik","doi":"10.1071/ch23155","DOIUrl":"https://doi.org/10.1071/ch23155","url":null,"abstract":"A specimen of the marine cone snail Conus victoriae collected from a beach in Broome, Western Australia, by a group from The University of Melbourne led to the discovery of the α-conotoxin Vc1.1, which was found to have analgesic activity in rodents. The discovery of this venom-derived peptide led to a series of structural, mechanistic and pharmacological studies directed towards the development of a new analgesic for neuropathic pain by groups in Australia and internationally. Solid-phase peptide synthesis played an important role in developing structure–activity relationships. Studies in a rat model of neuropathic pain showed that a cyclic analogue of the peptide, cVc1.1, had comparable analgesic activity with that of gabapentin, one of the foremost clinically used drugs for neuropathic pain, with cVc1.1 delivered orally at a 120-fold lower dose than gabapentin. Originally, Vc1.1 was believed to act primarily through nicotinic acetylcholine receptors, but evidence for a mechanism mediated through γ-aminobutyric acid B (GABAB) receptors later emerged. Efforts to optimise the binding and pharmacological properties of analogues of Vc1.1 revealed that the affinity towards either receptor can be modulated by sequence mutations, disulfide bond modifications and backbone cyclisation. This Account describes the discovery, structure, chemistry and pharmacology of Vc1.1, with a focus on studies carried out in Australian laboratories.","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135953869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Celebrating RACI and Academy of Science awards 2022–23","authors":"Curt Wentrup","doi":"10.1071/ch23183","DOIUrl":"https://doi.org/10.1071/ch23183","url":null,"abstract":"BiographiesGo To >>TopConflicts of interestReferences Curt Wentrup graduated Candidatus Scientiarum under K. A. Jensen, University of Copenhagen and PhD at the Australian National University with W. D. Crow, undertook post-doctorates with Hans Dahn (Univeristé de Lausanne), W. M. Jones (Gainesville) and Maitland Jones Jr (Princeton), became Maître-Assistant and Privat-Docent at Lausanne and Professor at Universität Marburg before returning to The University of Queensland as Chair of Organic Chemistry in 1985. He received a DSc from Copenhagen, an honorary doctorate from Pau, France, a Fellowship of the Australian Academy of Science, and the Australian Centenary, Craig, Birch and Leighton Medals. As emeritus professor, he continues research in organic, physical and historical chemistry.","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136258308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Walker, Glenn A Pullella, M. Piggott, P. Duggan
{"title":"Introduction to the chemistry and pharmacology of psychedelic drugs","authors":"S. Walker, Glenn A Pullella, M. Piggott, P. Duggan","doi":"10.1071/ch23050","DOIUrl":"https://doi.org/10.1071/ch23050","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74777055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kinitra L. Hutchinson, B. Z. Poliquit, Andrew J. Clulow, P. Burn, I. Gentle, P. Shaw
{"title":"Correlating vapour uptake with the luminescence quenching of poly(dendrimer)s for the detection of nitro group-containing explosives","authors":"Kinitra L. Hutchinson, B. Z. Poliquit, Andrew J. Clulow, P. Burn, I. Gentle, P. Shaw","doi":"10.1071/ch23131","DOIUrl":"https://doi.org/10.1071/ch23131","url":null,"abstract":"","PeriodicalId":8575,"journal":{"name":"Australian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73887564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}