Asthma research and practice最新文献_第7页

Asthma: epidemiology of disease control in Latin America - short review. 哮喘:拉丁美洲疾病控制的流行病学-简短回顾。

Asthma research and practice Pub Date : 2017-05-11 eCollection Date: 2017-01-01 DOI: 10.1186/s40733-017-0032-3

Dirceu Solé, Carolina Sanchez Aranda, Gustavo Falbo Wandalsen

{"title":"Asthma: epidemiology of disease control in Latin America - short review.","authors":"Dirceu Solé, Carolina Sanchez Aranda, Gustavo Falbo Wandalsen","doi":"10.1186/s40733-017-0032-3","DOIUrl":"https://doi.org/10.1186/s40733-017-0032-3","url":null,"abstract":"Asthma is reported as one of the most common chronic diseases in childhood, impairing the quality of life of patients and their families and incurring high costs to the healthcare system and society. Despite the development of new drugs and the availability of international treatment guidelines, asthma is still poorly controlled, especially in Latin America. Original and review articles on asthma control or epidemiology with high levels of evidence have been selected for analysis among those published in PubMed referenced journals during the last 20 years, using the following keywords: \"asthma control\" combined with \"Latin America\", \" epidemiology\", \"prevalence\", \"burden\", \"mortality\", \"treatment and unmet needs\", \"children\", \"adolescents\", and \"infants\". There was a high prevalence and severity of asthma during the period analyzed, especially in children and adolescents. Wheezing in infants was a significant reason for seeking medical care in Latin American health centers. Moreover, the frequent use of quick-relief bronchodilators and oral corticosteroids by these patients indicates the lack of a policy for providing better care for asthmatic patients, as well as poor asthma control. Among adults, studies document poor treatment and control of the disease, as revealed by low adherence to routine anti-inflammatory medications and high rates of emergency care visits and hospitalization. In conclusion, although rare, studies on asthma control in Latin America repeatedly show that patients are inadequately controlled and frequently overestimate their degree of asthma control according to the criteria used by international asthma treatment guidelines. Additional education for doctors and patients is essential for adequate control of this illness, and therefore also for reduction of the individual and social burden of asthma.","PeriodicalId":8572,"journal":{"name":"Asthma research and practice","volume":"3 ","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2017-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40733-017-0032-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34998287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Asthma in the elderly: a double-blind, placebo-controlled study of the effect of montelukast. 老年人哮喘:孟鲁司特效果的双盲、安慰剂对照研究。

Asthma research and practice Pub Date : 2017-04-17 eCollection Date: 2017-01-01 DOI: 10.1186/s40733-017-0031-4

Michele Columbo

{"title":"Asthma in the elderly: a double-blind, placebo-controlled study of the effect of montelukast.","authors":"Michele Columbo","doi":"10.1186/s40733-017-0031-4","DOIUrl":"https://doi.org/10.1186/s40733-017-0031-4","url":null,"abstract":"Background: Little is known about asthma in the elderly as most studies of this condition have not included this patient group. It is unclear whether leukotriene antagonists benefit older asthmatics. We studied the effect of adding montelukast to the asthma treatment of elderly subjects.Methods: Twenty-five subjects 65 years old and older with asthma were evaluated at week 0, 1, 5, 9, 13, and 17. Each subject received montelukast 10 mg and placebo each for 8 weeks in a cross-over design.Results: Montelukast for 4 or 8 weeks did not significantly affect ACT, daily symptom scores, number of puffs of albuterol, spirometric values, peripheral blood eosinophils, or serum IgE vs. baseline or placebo. Similar results were obtained when analyzing subgroups of patients with lower ACT, lower FEV1, and higher eosinophils.Conclusions: In this study of elderly asthmatics, montelukast had no effect on asthma symptoms, number of puffs of albuterol, spirometric values, peripheral blood eosinophils or serum IgE. These results will require confirmation in larger patient cohorts and in patients with uncontrolled asthmatic symptoms.","PeriodicalId":8572,"journal":{"name":"Asthma research and practice","volume":"3 ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2017-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40733-017-0031-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34931791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Gender-specific determinants of asthma among U.S. adults. 美国成年人哮喘的性别特异性决定因素

Asthma research and practice Pub Date : 2017-01-24 eCollection Date: 2017-01-01 DOI: 10.1186/s40733-017-0030-5

Rebecca Greenblatt, Omar Mansour, Edward Zhao, Michelle Ross, Blanca E Himes

{"title":"Gender-specific determinants of asthma among U.S. adults.","authors":"Rebecca Greenblatt, Omar Mansour, Edward Zhao, Michelle Ross, Blanca E Himes","doi":"10.1186/s40733-017-0030-5","DOIUrl":"10.1186/s40733-017-0030-5","url":null,"abstract":"Background: Asthma, a chronic respiratory disease affecting over 18.7 million American adults, has marked disparities by gender, race/ethnicity and socioeconomic status. Our goal was to identify gender-specific demographic and socioeconomic determinants of asthma prevalence among U.S. adults using data from the Behavioral Risk Factors Surveillance System (BRFSS) and the National Health and Nutrition Examination Survey (NHANES).Methods: Gender-specific regression analyses were performed to model the relationship between asthma prevalence with age, race/ethnicity, income, education level, smoking status, and body mass index (BMI), while taking into account the study designs.Results: Based on BRFSS data from 1,003,894 respondents, weighted asthma prevalence was 6.2% in males and 10.6% in females. Asthma prevalence among grade 2 obese and grade 3 obese vs. not overweight or obese women was 2.5 and 3.5 times higher, respectively, while that in men was 1.7 and 2.4 times higher; asthma prevalence among current vs. never smoker women was 1.4 times higher, while that in men was 1.1 times higher. Similar results were obtained with NHANES data from 13,364 respondents: asthma prevalence among grade 2 obese and grade 3 obese vs. not overweight or obese respondents was 2.0 and 3.3 times higher for women, though there was no significant difference for men; asthma prevalence among current vs. never smokers was 1.8 times higher for women and not significantly different in men. Asthma prevalence by race/ethnicity and income levels did not differ considerably between men and women.Conclusions: Our results underscore the importance of obesity and smoking as modifiable asthma risk factors that most strongly affect women.","PeriodicalId":8572,"journal":{"name":"Asthma research and practice","volume":"3 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2017-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40733-017-0030-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49079978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Asthma costs and social impact. 哮喘成本和社会影响

Asthma research and practice Pub Date : 2017-01-06 eCollection Date: 2017-01-01 DOI: 10.1186/s40733-016-0029-3

Carlos Nunes, Ana Margarida Pereira, Mário Morais-Almeida

{"title":"Asthma costs and social impact.","authors":"Carlos Nunes, Ana Margarida Pereira, Mário Morais-Almeida","doi":"10.1186/s40733-016-0029-3","DOIUrl":"10.1186/s40733-016-0029-3","url":null,"abstract":"In recent decades, both asthma prevalence and incidence have been increasing worldwide, not only due to the genetic background, but mainly because of the effect of a wide number of environmental and lifestyle risk factors. In many countries noncommunicable diseases, like asthma, are not yet considered a healthcare priority. This review will analyze and discuss disparities in asthma management in several countries and regions, such as access to healthcare human resources and medications, due to limited financial capacity to develop strategies to control and prevent this chronic disease. This review tries to explore the social and economic burden of asthma impact on society. Although asthma is generally accepted as a costly illness, the total costs to society (direct, indirect and intangible asthma costs) are difficult to estimate, mainly due to different disease definitions and characterizations but also to the use of different methodologies to assess the asthma socio-economic impact in different societies. The asthma costs are very variables from country to country, however we can estimate that a mean cost per patient per year, including all asthmatics (intermittent, mild, moderate and severe asthma) in Europe is $USD 1,900, which seems lower than USA, estimated mean $USD 3,100.","PeriodicalId":8572,"journal":{"name":"Asthma research and practice","volume":" ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49417322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preacutionary labelling of cross-reactive foods: The case of rapeseed. 交叉反应食品的预先标签：油菜籽案例。

Asthma research and practice Pub Date : 2016-11-01 eCollection Date: 2016-01-01 DOI: 10.1186/s40733-016-0028-4

Alessandro Fiocchi, Lamia Dahdah, Carla Riccardi, Oscar Mazzina, Vincenzo Fierro

{"title":"Preacutionary labelling of cross-reactive foods: The case of rapeseed.","authors":"Alessandro Fiocchi, Lamia Dahdah, Carla Riccardi, Oscar Mazzina, Vincenzo Fierro","doi":"10.1186/s40733-016-0028-4","DOIUrl":"10.1186/s40733-016-0028-4","url":null,"abstract":"Food allergic individuals are exposed to unnecessary dietary restrictions due to precautionary food allergy labelling (PFAL). Two forms of PFAL exist: type I identifies the possible presence of allergenic contaminaion in foods ('may content…'), type II indicates as potentially dangerous ingredients or contaminants that do no belong to official list of food allergens. PFAL type II is based on the fear of cross-reactivity with foods belonging to that list. PFAL type II is less known, but may be tempting for the legal offices of food companies, for clinicians in a 'defensive medicine' key, and even for legislators. We identify here a case of PFAL type II, allergy to rapeseed (belonging to the family of Brassicaceae). Increasingly used for their nutritional and nutraceutic value in asthma prevention, rapeseed has been indicated by regulatory authorities in Canada and Europe as potential cross-reactor with mustard. In this review, we provide the elements for a risk assessment of cross-reactivity of rapeseed/mustard allergy in the general population both clinically and from the point of view of the molecular allergy. Three findings emerge: 1. Allergic reactions to rapeseed are exceptional 2. The allergens identified in rapeseed and mustard are similar, but not identical 3. Reactions to rapeseed have never been described in mustard-allergic patients. On the ground of existing evidence, a precautionary labeling for rapeseed as potentially dangerous for patients allergic to mustard is not justified. In the interest of patients with multiple food allergy, PFAL type II must be avoided.","PeriodicalId":8572,"journal":{"name":"Asthma research and practice","volume":"2 1","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65749234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asthma phenotypes: the intriguing selective intervention with Montelukast 哮喘表型:孟鲁司特的有趣的选择性干预

Asthma research and practice Pub Date : 2016-08-12 DOI: 10.1186/s40733-016-0026-6

C. Marcello, Lombardi Carlo

引用次数: 20

The management of asthmatic smokers 哮喘吸烟者的管理

Asthma research and practice Pub Date : 2016-06-20 DOI: 10.1186/s40733-016-0025-7

J. Chatkin, Cynthia Rocha Dullius

引用次数: 42

Potential of molecular based diagnostics and its impact on allergen immunotherapy 分子诊断的潜力及其对过敏原免疫治疗的影响

Asthma research and practice Pub Date : 2016-06-02 DOI: 10.1186/s40733-016-0024-8

G. Melioli, E. Savi, M. Crivellaro, G. Passalacqua

引用次数: 7

A qualitative evaluation of the implementation of guidelines and a support tool for asthma management in primary care 对初级保健中哮喘管理指南实施情况的定性评价和支持工具

Asthma research and practice Pub Date : 2016-05-04 DOI: 10.1186/s40733-016-0023-9

K. Watkins, C. Fisher, Jila Misaghian, C. Schneider, R. Clifford

引用次数: 19

Child maltreatment and pediatric asthma: a review of the literature. 虐待儿童与小儿哮喘：文献综述。

Asthma research and practice Pub Date : 2016-04-11 eCollection Date: 2016-01-01 DOI: 10.1186/s40733-016-0022-x

Hannah M C Schreier, Edith Chen, Gregory E Miller

{"title":"Child maltreatment and pediatric asthma: a review of the literature.","authors":"Hannah M C Schreier, Edith Chen, Gregory E Miller","doi":"10.1186/s40733-016-0022-x","DOIUrl":"10.1186/s40733-016-0022-x","url":null,"abstract":"Background: Child maltreatment is a common problem with known adverse consequences, yet its contributions to the development and course of pediatric asthma are only poorly understood.Main: This review first describes possible pathways connecting child maltreatment to pediatric asthma, including aspects of the physical home environment, health behaviors and disease management, and psychological consequences of child maltreatment. We subsequently review existing studies, which generally report an association between maltreatment experiences and asthma outcomes in childhood. However, this literature is in its early stages; there are only a handful studies, most of them rely on self-reports of both child maltreatment and asthma history, and none have investigated the physiological underpinnings of this association. Taken together, however, the studies are suggestive of child maltreatment playing a role in pediatric asthma incidence and expression that should be explored further.Conclusion: Existing data are sparse and do not allow for specific conclusions. However, the data are suggestive of child maltreatment influencing asthma risk and morbidity long before the adult years. Future research should focus on understanding how child maltreatment contributes to asthma disease risk and progression in this highly vulnerable population.","PeriodicalId":8572,"journal":{"name":"Asthma research and practice","volume":"2 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2016-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65749119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0