The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology最新文献_第2页

Morphomolecular neuronal phenotypes in the neocortex reflect phylogenetic relationships among certain mammalian orders. 新皮层的形态分子神经元表型反映了某些哺乳动物目之间的系统发育关系。

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Pub Date : 2005-11-01 DOI: 10.1002/ar.a.20252

Patrick R Hof, Chet C Sherwood

{"title":"Morphomolecular neuronal phenotypes in the neocortex reflect phylogenetic relationships among certain mammalian orders.","authors":"Patrick R Hof, Chet C Sherwood","doi":"10.1002/ar.a.20252","DOIUrl":"https://doi.org/10.1002/ar.a.20252","url":null,"abstract":"The cytoarchitecture of the cerebral cortex in mammals has been traditionally investigated using Nissl, Golgi, or myelin stains and there are few comparative studies on the relationships between neuronal morphology and neurochemical specialization. Most available studies on neuronal subtypes identified by their molecular and morphologic characteristics have been performed in species commonly used in laboratory research such as the rat, mouse, cat, and macaque monkey, as well as in autopsic human brain specimens. A number of cellular markers, such as neurotransmitters, structural proteins, and calcium-buffering proteins, display a highly specific distribution in distinct classes of neocortical neurons in a large number of mammalian species. In this article, we present an overview of the morphologic characteristics and distribution of three calcium-binding proteins, parvalbumin, calbindin, and calretinin, and of a component of the neuronal cytoskeleton, nonphosphorylated neurofilament protein in the neocortex of various species, representative of the major subdivisions of mammals. The distribution of these neurochemical markers defined several species- and order-specific patterns that permit assessment of the degree to which neuronal morphomolecular specialization, as well as the regional and laminar distribution of distinct cell types in the neocortex, represents derived or ancestral features. In spite of the remarkable diversity in morphologic and cellular organization that occurred during mammalian neocortical evolution, such patterns identified several associations among taxa that closely match their phylogenetic relationships.","PeriodicalId":85633,"journal":{"name":"The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology","volume":"287 1","pages":"1153-63"},"PeriodicalIF":0.0,"publicationDate":"2005-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.a.20252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25625566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55

Anatomical analysis of an aye-aye brain (Daubentonia madagascariensis, primates: Prosimii) combining histology, structural magnetic resonance imaging, and diffusion-tensor imaging. 结合组织学、结构磁共振成像和弥散张量成像对一只猕猴脑的解剖分析(Daubentonia madagascar，灵长类:Prosimii)。

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Pub Date : 2005-11-01 DOI: 10.1002/ar.a.20264

Jason A Kaufman, Eric T Ahrens, David H Laidlaw, Song Zhang, John M Allman

{"title":"Anatomical analysis of an aye-aye brain (Daubentonia madagascariensis, primates: Prosimii) combining histology, structural magnetic resonance imaging, and diffusion-tensor imaging.","authors":"Jason A Kaufman, Eric T Ahrens, David H Laidlaw, Song Zhang, John M Allman","doi":"10.1002/ar.a.20264","DOIUrl":"https://doi.org/10.1002/ar.a.20264","url":null,"abstract":"This report presents initial results of a multimodal analysis of tissue volume and microstructure in the brain of an aye-aye (Daubentonia madagascariensis). The left hemisphere of an aye-aye brain was scanned using T2-weighted structural magnetic resonance imaging (MRI) and diffusion-tensor imaging (DTI) prior to histological processing and staining for Nissl substance and myelinated fibers. The objectives of the experiment were to estimate the volume of gross brain regions for comparison with published data on other prosimians and to validate DTI data on fiber anisotropy with histological measurements of fiber spread. Measurements of brain structure volumes in the specimen are consistent with those reported in the literature: the aye-aye has a very large brain for its body size, a reduced volume of visual structures (V1 and LGN), and an increased volume of the olfactory lobe. This trade-off between visual and olfactory reliance is likely a reflection of the nocturnal extractive foraging behavior practiced by Daubentonia. Additionally, frontal cortex volume is large in the aye-aye, a feature that may also be related to its complex foraging behavior and sensorimotor demands. Analysis of DTI data in the anterior cingulum bundle demonstrates a strong correlation between fiber spread as measured from histological sections and fiber spread as measured from DTI. These results represent the first quantitative comparison of DTI data and fiber-stained histology in the brain.","PeriodicalId":85633,"journal":{"name":"The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology","volume":"287 1","pages":"1026-37"},"PeriodicalIF":0.0,"publicationDate":"2005-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.a.20264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25645324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 59

Diversity of mammalian photoreceptor properties: adaptations to habitat and lifestyle? 哺乳动物光感受器特性的多样性:对栖息地和生活方式的适应?

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Pub Date : 2005-11-01 DOI: 10.1002/ar.a.20262

Leo Peichl

{"title":"Diversity of mammalian photoreceptor properties: adaptations to habitat and lifestyle?","authors":"Leo Peichl","doi":"10.1002/ar.a.20262","DOIUrl":"https://doi.org/10.1002/ar.a.20262","url":null,"abstract":"All mammalian retinae contain rod photoreceptors for low-light vision and cone photoreceptors for daylight and color vision. Most nonprimate mammals have dichromatic color vision based on two cone types with spectrally different visual pigments: a short-wavelength-sensitive (S-)cone and a long-wavelength-sensitive (L-)cone. Superimposed on this basic similarity, there are remarkable differences between species. This article reviews some striking examples. The density ratio of cones to rods ranges from 1:200 in the most nocturnal to 20:1 in a few diurnal species. In some species, the proportion of the spectral cone types and their distribution across the retina deviate from the pattern found in most mammals, including a complete absence of S-cones. Depending on species, the spectral sensitivity of the L-cone pigment may peak in the green, yellow, or orange, and that of the S-cone pigment in the blue, violet, or near-ultraviolet. While exclusive expression of one pigment per cone is the rule, some species feature coexpression of the L- and S-pigment in a significant proportion of their cones. It is widely assumed that all these variations represent adaptations to specific visual needs associated with particular habitats and lifestyles. However, in many cases we have not yet identified the adaptive value of a given photoreceptor arrangement. Comparative anatomy is a fruitful approach to explore the range of possible arrangements within the blueprint of the mammalian retina and to identify species with particularly interesting or puzzling patterns that deserve further scrutiny with physiological and behavioral assays.","PeriodicalId":85633,"journal":{"name":"The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology","volume":"287 1","pages":"1001-12"},"PeriodicalIF":0.0,"publicationDate":"2005-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.a.20262","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25618024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 331

Comparative anatomy of the facial motor nucleus in mammals, with an analysis of neuron numbers in primates. 哺乳动物面部运动核的比较解剖学，以及灵长类动物神经元数量的分析。

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Pub Date : 2005-11-01 DOI: 10.1002/ar.a.20259

Chet C Sherwood

{"title":"Comparative anatomy of the facial motor nucleus in mammals, with an analysis of neuron numbers in primates.","authors":"Chet C Sherwood","doi":"10.1002/ar.a.20259","DOIUrl":"https://doi.org/10.1002/ar.a.20259","url":null,"abstract":"The facial motor nucleus (VII) contains motoneurons that innervate the facial muscles of expression. In this review, the comparative anatomy of this brainstem nucleus is examined. Several aspects of the anatomical organization of the VII appear to be common across mammals, such as the distribution of neuron types, general topography of muscle representation, and afferent connections from the midbrain and brainstem. Phylogenetic specializations are apparent in the proportion of neurons allocated to the representation of subsets of muscles and the degree of differentiation among subnuclei. These interspecific differences may be related to the elaboration of certain facial muscles in the context of socioecological adaptations such as whisking behavior, sound localization, vocalization, and facial expression. Furthermore, current evidence indicates that direct descending corticomotoneuron projections in the VII are present only in catarrhine primates, suggesting that this connectivity is an important substrate for the evolution of enhanced mobility and flexibility in facial expression. Data are also presented from a stereologic analysis of VII neuron numbers in 18 primate species and a scandentian. Using phylogenetic comparative statistics, it is shown that there is not a correlation between group size and VII neuron number (adjusted for medulla volume) among primates. Great apes and humans, however, display moderately more VII neurons that expected for their medulla size.","PeriodicalId":85633,"journal":{"name":"The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology","volume":"287 1","pages":"1067-79"},"PeriodicalIF":0.0,"publicationDate":"2005-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.a.20259","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25618027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 80

Developmentally regulated expression of Shh and Ihh in the developing mouse cranial base: comparison with Sox9 expression. 发育中的小鼠颅底Shh和Ihh的发育调控表达:与Sox9表达的比较

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Pub Date : 2005-10-01 DOI: 10.1002/ar.a.20231

Xuguang Nie, Keijo Luukko, Inger Hals Kvinnsland, Päivi Kettunen

{"title":"Developmentally regulated expression of Shh and Ihh in the developing mouse cranial base: comparison with Sox9 expression.","authors":"Xuguang Nie, Keijo Luukko, Inger Hals Kvinnsland, Päivi Kettunen","doi":"10.1002/ar.a.20231","DOIUrl":"https://doi.org/10.1002/ar.a.20231","url":null,"abstract":"The cranial base, located between the cranial vault and the facial bones, plays an important role in integrated craniofacial development and growth. Transgenic Shh and Sox9-deficient mice show similar defects in cranial base patterning. Therefore, in order to examine potential interactions of Shh, Ihh, another member of the Hh family, and Sox9 during cranial base development and growth, we investigated their cellular mRNA expression domains in the embryonic (E) and early postnatal (PN) cranial base from E10 to PN5 using sectional radioactive 35-S in situ hybridization. Of the Hhs, Shh was observed in the foregut epithelium and the notochord, while Sox9 showed broad expression in the loose mesenchyme of the cranial base area during E10-E11. Subsequently, from E12 onward, all genes were observed in the developing cranial base, and after birth the genes were prominently colocalized in the prehypertrophic chondrocytes of the synchondroses. Collectively, these data suggest that Hh-Sox9 auto- and paracrine signaling interactions may provide a critical mechanism for regulating the patterning of the cranial base as well as for its development and growth.","PeriodicalId":85633,"journal":{"name":"The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology","volume":"286 2","pages":"891-8"},"PeriodicalIF":0.0,"publicationDate":"2005-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.a.20231","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25287273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Vitamin A storage in hepatic stellate cells in the regenerating rat liver: with special reference to zonal heterogeneity. 再生大鼠肝星状细胞中维生素A的储存:特别参考地带性异质性。

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Pub Date : 2005-10-01 DOI: 10.1002/ar.a.20230

Nobuyo Higashi, Mitsuru Sato, Naosuke Kojima, Toshiaki Irie, Koichi Kawamura, Ayako Mabuchi, Haruki Senoo

{"title":"Vitamin A storage in hepatic stellate cells in the regenerating rat liver: with special reference to zonal heterogeneity.","authors":"Nobuyo Higashi, Mitsuru Sato, Naosuke Kojima, Toshiaki Irie, Koichi Kawamura, Ayako Mabuchi, Haruki Senoo","doi":"10.1002/ar.a.20230","DOIUrl":"https://doi.org/10.1002/ar.a.20230","url":null,"abstract":"Under physiological conditions, hepatic stellate cells (HSCs) within liver lobules store about 80% of the total body vitamin A in lipid droplets in their cytoplasm, and these cells show zonal heterogeneity in terms of vitamin A-storing capacity. Vitamin A is essential for the growth and differentiation of cells, and it is well known that liver cells including HSCs show a remarkable growth capacity after partial hepatectomy (PHx). However, the status of vitamin A storage in HSCs in the liver regeneration is not yet known. Therefore, we conducted the present study to examine vitamin A storage in these cells during liver regeneration. Morphometry at the electron microscopic level, fluorescence microscopy for vitamin A autofluorescence, and immunofluorescence microscopy for desmin and alpha-smooth muscle actin (alpha-SMA) were performed on sections of liver from male Wistar strain rats at various times after the animal had been subjected to 70% PHx. The mean area of vitamin A-storing lipid droplets per HSC gradually decreased toward 3 days after PHx, and then returned to normal within 14 days after it. However, the heterogeneity of vitamin A-storing lipid droplet area per HSC within the hepatic lobule disappeared after PHx and did not return to normal by 14 days thereafter, even though the liver volume had returned to normal. These results suggest that HSCs alter their vitamin A-storing capacity during liver regeneration and that the recovery of vitamin A homeostasis requires a much longer time than that for liver volume.","PeriodicalId":85633,"journal":{"name":"The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology","volume":"286 2","pages":"899-907"},"PeriodicalIF":0.0,"publicationDate":"2005-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.a.20230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25236598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Software system for three-dimensional volumetric reconstruction of histological sections: a case study for the snake chondrocranium. 组织切片三维体积重建的软件系统:蛇软骨头盖骨的案例研究。

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Pub Date : 2005-10-01 DOI: 10.1002/ar.a.20227

Clarice Hofstadler-Deiques, Marcelo Walter, Fábio Mierlo, Rodrigo Ruduit

{"title":"Software system for three-dimensional volumetric reconstruction of histological sections: a case study for the snake chondrocranium.","authors":"Clarice Hofstadler-Deiques, Marcelo Walter, Fábio Mierlo, Rodrigo Ruduit","doi":"10.1002/ar.a.20227","DOIUrl":"https://doi.org/10.1002/ar.a.20227","url":null,"abstract":"Volumetric digital computer-assisted reconstruction of histological sections is an attractive possibility for developmental studies. Commercial solutions are very expensive for many educational institutions. Therefore, we developed a software system for three-dimensional reconstruction of anatomical virtual models. The input data for the system are the digitized images from the histological samples of the chondrocranium of two crotalines, Bothrops jararaca and Crotalus durissus terrificus, and one colubrid, Philodryas olfersii, using a stereomicroscope connected to a digital camera. These images are then manually registered and segmented. We use computer graphics visualization algorithms such as marching cubes and ray casting to generate three-dimensional visualizations of the volumes. The results show that the digital reconstruction is as good as the manual reconstruction with the advantages of speed of reconstruction, accuracy, and flexibility to handle and study the volume. Compared with commercial options, our system has approximately the same features, and it is available free for the scientific community.","PeriodicalId":85633,"journal":{"name":"The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology","volume":"286 2","pages":"938-44"},"PeriodicalIF":0.0,"publicationDate":"2005-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.a.20227","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25261311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Different levels of the neuronal nitric oxide synthase isoform modulate the rate of osteoclastic differentiation of TIB-71 and CRL-2278 RAW 264.7 murine cell clones. 不同水平的神经元一氧化氮合酶异构体调节TIB-71和CRL-2278 RAW 264.7小鼠细胞克隆的破骨分化率。

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Pub Date : 2005-10-01 DOI: 10.1002/ar.a.20239

Vanessa Nicolin, Cristina Ponti, Paola Narducci, Vittorio Grill, Roberta Bortul, Marina Zweyer, Mauro Vaccarezza, Giorgio Zauli

{"title":"Different levels of the neuronal nitric oxide synthase isoform modulate the rate of osteoclastic differentiation of TIB-71 and CRL-2278 RAW 264.7 murine cell clones.","authors":"Vanessa Nicolin, Cristina Ponti, Paola Narducci, Vittorio Grill, Roberta Bortul, Marina Zweyer, Mauro Vaccarezza, Giorgio Zauli","doi":"10.1002/ar.a.20239","DOIUrl":"https://doi.org/10.1002/ar.a.20239","url":null,"abstract":"It has been clearly established that osteoclasts, which play a crucial role in bone resorption, differentiate from hematopoietic cells belonging to the monocyte/macrophage lineage in the presence of macrophage-colony stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL). We have here investigated the M-CSF- and RANKL-induced osteoclastic differentiation of two distinct clones of the murine monocytic/macrophagic RAW 264.7 cell line, known as TIB-71 and CRL-2278, the latter cell clone being defective for the expression of the inducible nitric oxide synthase isoform in response to interferon-gamma or lipopolysaccharide. CRL-2278 cells demonstrated a more rapid osteoclastic differentiation than TIB-71 cells, as documented by morphology, tartrate-resistant acid phosphatase positivity, and bone resorption activity. The enhanced osteoclastic differentiation of CRL-2278 was accompanied by a higher rate of cells in the S/G2-M phases of cell cycle as compared to TIB-71. The analysis of nitric oxide synthase (NOS) isoforms clearly demonstrated that only neuronal NOS was detectable at high levels in CRL-2278 but not in TIB cells under all tested conditions. Moreover, the broad inhibitor of NOS activity L-NAME significantly inhibited osteoclastic differentiation of CRL-2278 cells. Altogether, these results demonstrate that a basal constitutive neuronal NOS activity positively affects the RANKL/M-CSF-related osteoclastic differentiation.","PeriodicalId":85633,"journal":{"name":"The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology","volume":"286 2","pages":"945-54"},"PeriodicalIF":0.0,"publicationDate":"2005-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.a.20239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24993116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Development of the articular cavity in the rat temporomandibular joint with special reference to the behavior of endothelial cells and macrophages. 大鼠颞下颌关节腔的发育与内皮细胞和巨噬细胞的行为有关。

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Pub Date : 2005-10-01 DOI: 10.1002/ar.a.20228

Akiko Suzuki, Kayoko Nozawa-Inoue, Nobuyuki Ikeda, Norio Amizuka, Kazuhiro Ono, Ritsuo Takagi, Takeyasu Maeda

{"title":"Development of the articular cavity in the rat temporomandibular joint with special reference to the behavior of endothelial cells and macrophages.","authors":"Akiko Suzuki, Kayoko Nozawa-Inoue, Nobuyuki Ikeda, Norio Amizuka, Kazuhiro Ono, Ritsuo Takagi, Takeyasu Maeda","doi":"10.1002/ar.a.20228","DOIUrl":"https://doi.org/10.1002/ar.a.20228","url":null,"abstract":"Previous developmental studies on the temporomandibular joint (TMJ) have proposed several hypotheses on the formation of its articular cavity. However, detailed information is meager. The present study examined the formation process of the articular cavity in the rat TMJ by immunocytochemistry for CD31, RECA-1, and ED1, which are useful cellular markers for endothelial cells and monocyte/macrophage lineages, respectively. The upper articular cavity formation had begun by embryonic day 21 (E21) and was completed at postnatal day 1 (P1) in advance of the lower cavitation; the latter took place from P1 to P3. The occurrence and distribution pattern of the CD31-, RECA-1-, and ED1-positive cells differed between the upper and lower articular cavity-forming areas: the ED1-positive cells exclusively occurred in the area of the prospective upper articular cavity prior to its formation, while no ED1-positive cell appeared in the lower cavity-forming area. In contrast, the CD31- and RECA-1-positive endothelial cells were restricted to the lower cavity-forming area (never the prospective upper cavity) at E19 and diminished thereafter. Throughout the cavity formation, we failed to find any apoptotic cells in the cavity formation area, indicating no involvement of apoptosis in the cavity formation in TMJ. The present findings on the behaviors of endothelial cells and ED1-positive cells show a possibility of different mechanism in the cavity formation between the upper and lower articular cavities in the rat TMJ. The appearance of ED1-reactive cells and temporal vascularization may play crucial roles in the upper and lower articular cavity formation, respectively.","PeriodicalId":85633,"journal":{"name":"The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology","volume":"286 2","pages":"908-16"},"PeriodicalIF":0.0,"publicationDate":"2005-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.a.20228","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25257919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Genes critical to vasculogenesis as defined by systematic analysis of vascular defects in knockout mice. 通过对敲除小鼠血管缺陷的系统分析确定的对血管发生至关重要的基因。

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Pub Date : 2005-10-01 DOI: 10.1002/ar.a.20232

W Scott Argraves, Christopher J Drake

{"title":"Genes critical to vasculogenesis as defined by systematic analysis of vascular defects in knockout mice.","authors":"W Scott Argraves, Christopher J Drake","doi":"10.1002/ar.a.20232","DOIUrl":"https://doi.org/10.1002/ar.a.20232","url":null,"abstract":"To identify genes important to the process of vasculogenesis, we evaluated embryonic vascular anomalies from 100 mouse knockout studies using a novel meta-analysis approach. By applying this method, termed approach for ranking of embryonic vascular anomalies (AREVA), rank scores were calculated for each knockout based on the occurrence of vascular defects during periods of vasculogenesis in specific embryonic regions. As a result, 12 genes (fibronectin, VEGFR-1/Flt-1, VEGFR-2/Flk-1, alpha 5 integrin, Tek/Tie2, VE-cadherin, VEGFA, connexin 45, ShcA, cytochrome P450 reductase, CD148/DEP-1, and EphrinB2) were determined to play critical roles in vasculogenesis. Functional categorization of these genes revealed the fundamental importance of VEGF signaling since 10 of the 12 genes (fibronectin, VEGFR-1/Flt-1, VEGFR-2/Flk-1, alpha 5 integrin, VE-cadherin, VEGFA, ShcA, cytochrome P450 reductase, CD148/DEP-1, and EphrinB2) relate to this pathway. Furthermore, the findings highlight a potential network for regulating VEGF signaling involving integration of fibronectin, EphrinB2, Tie2, and connexin 45 signaling pathways via the ShcA/Ras/Raf/Mek/Erk cascade. In addition to retrospective application of AREVA as done herein, AREVA can be used prospectively to determine the relevancy to vasculogenesis of newly inactivated genes.","PeriodicalId":85633,"journal":{"name":"The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology","volume":"286 2","pages":"875-84"},"PeriodicalIF":0.0,"publicationDate":"2005-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.a.20232","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25261313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 57