发布求助
文献互助 智能选刊 最新文献

Asian Journal of Organic & Medicinal Chemistry最新文献

筛选
英文 中文
Use of Crumb Rubber as Replacement Over Aggregate in Concrete 橡胶屑在混凝土中替代骨料的应用
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.7-1-sp4.pp93-96
{"title":"Use of Crumb Rubber as Replacement Over Aggregate in Concrete","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp93-96","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp93-96","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83063787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Isoniazid: An Exploratory Review 异烟肼:一项探索性综述
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.ajomc-p373
V. Saini, A. Goyal, Ajay Kumar
{"title":"Isoniazid: An Exploratory Review","authors":"V. Saini, A. Goyal, Ajay Kumar","doi":"10.14233/ajomc.2022.ajomc-p373","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p373","url":null,"abstract":"Isoniazid (INH) is one of the most successful tuberculosis medications in the market today. In particular, isoniazid is used as a prophylaxis medication to avoid resurgence of illness in those who have underlying Mycobacterium tuberculosis (MTB) infection. The mode of action of isoniazid is complicated and incorporates a number of distinct aspects in which various biomolecular routes are impacted, including mycolic acid production. Catalase-peroxidase (KatG) activates the prodrug isoniazid and enzymes such as β-ketoacyl ACP synthase (KasA) and enoyl acyl carrier protein (ACP) reductase target the active isoniazid products. Various genes in diverse biochemical networks and pathways are involved in the physiological mechanisms of isoniazid resistance. Isoniazid resistance is the most common of all clinical drug-resistant isolates, with incidence in some areas of up to 20 to 30%. In this review article, several existing components that may influence to the complexities of isoniazid function including mechanism of action, resistance mechanisms in MTB, along with their history, different synthetic procedures, uses, dosage forms, side effects, adverse drug reactions, physico-chemical characteristics, ADME properties, contraindications as well as future perspectives are discussed. Studies of pharmacokinetics have found that the cause of the drug mediated hepatotoxicity is possible by metabolism of isoniazid. Because of inter-individual heterogeneity of polymorphism that affect isoniazid metabolism rates, customized medicines may be required in various populations to prevent hepatotoxicity. The isoniazid multidrug combination treatment which would proved to be effective tuberculosis treatment in future. Further exploration is needed for better comprehension of pathogenesis mechanism of Mycobacterium tuberculosis (MTB) and drug resistance studies are required for building up better therapeutics and diagnostic against tuberculosis.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83331553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Hardnessforal-7075 Thixoformed upto Recrystallization Temperatures 触变成形al-7075在再结晶温度下的硬度比较
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.7-1-sp4.pp227-229
{"title":"Comparison of Hardnessforal-7075 Thixoformed upto Recrystallization Temperatures","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp227-229","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp227-229","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83823731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review Paper on Advanced Technologies Used in Retrofitting 改造中应用的先进技术综述
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.7-1-sp4.pp76-78
{"title":"Review Paper on Advanced Technologies Used in Retrofitting","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp76-78","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp76-78","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78348297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review Paper on Abrasive Water Jet Machining 磨料水射流加工研究进展
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.7-1-sp4.pp205-209
{"title":"A Review Paper on Abrasive Water Jet Machining","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp205-209","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp205-209","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74464417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review on Seismic Evaluation of RC Building 钢筋混凝土建筑抗震评价研究进展
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.7-1-sp4.pp79-82
{"title":"A Review on Seismic Evaluation of RC Building","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp79-82","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp79-82","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75417242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of in silico ADMET Properties and Molecular Docking Study of SubstitutedThiadiazole for Screening of Antibacterial and Antifungal Activities against Protein TargetsHelicobacter pylori α-Carbonic Anhydrase and Trypanosoma brucei Pteridine Reductase 对幽门螺杆菌α-碳酸酐酶和布氏锥虫翼啶还原酶抑菌和抗真菌活性的分子对接研究
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.ajomc-p363
Nitin J. Deshmukh, L. Soni
{"title":"Prediction of in silico ADMET Properties and Molecular Docking Study of Substituted\u0000Thiadiazole for Screening of Antibacterial and Antifungal Activities against Protein Targets\u0000Helicobacter pylori α-Carbonic Anhydrase and Trypanosoma brucei Pteridine Reductase","authors":"Nitin J. Deshmukh, L. Soni","doi":"10.14233/ajomc.2022.ajomc-p363","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p363","url":null,"abstract":"The aim of this work was to evaluate the physico-chemical, pharmacokinetic parameters (absorption, distribution, metabolism, excretion and toxicity) and pharmacodynamic parameters (bioactivity and adverse reactions) of substituted thiadiazole by means of in silico computational prediction. Online softwares such as Pre-ADMET, Molinspiration and rule of five were used for the analysis. Substituted thiadiazole fits the characteristics of drug-likeness, pharmacokinetic properties appropriate to the predicted patterns and activities within the scope for the treatment of infection in the stomach or duodenum (first part of the small intestine), gastritis and trypanosomiasis. Therefore, in silico results allow us to conclude that substituted thiadiazole is predicted to be a potential future drug candidate, due to its relevant Drug-likeness profile, bioavailability, excellent liposolubility and adequate pharmacokinetics, including at the level of CNS, penetrating the blood-brain barrier. Molecular docking studies have also been performed to screen the antibacterial and antifungal activities of the 50 designed compounds against protein targets Helicobacter pylori α-carbonic anhydrase (PDB: 5TUO) and Trypanosoma brucei Pteridine Reductase (PTR1) (PDB: 4WCD) respectively. Among all the compounds C11 exhibited the most significant affinity score against Helicobacter pylori α-carbonic anhydrase and C37 exhibited the most significant affinity score against Trypanosoma brucei pteridine reductase (PTR1) best significant hydrogen bonds interaction at the active site of protein.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75870779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review on the Behaviour of Tubular Section and Conventional Section 管状截面与常规截面性能研究进展
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.7-1-sp4.pp20-23
{"title":"A Review on the Behaviour of Tubular Section and Conventional Section","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp20-23","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp20-23","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75035282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plastic Bottles Applicability for Local Construction: A Survey 塑料瓶在地方施工中的适用性调查
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.7-1-sp4.pp1-4
{"title":"Plastic Bottles Applicability for Local Construction: A Survey","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp1-4","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp1-4","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78168094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding the Make-or-buy Decision Strategy: A Brief Communication 理解“决定还是购买”的决策策略:一个简短的交流
Asian Journal of Organic & Medicinal Chemistry Pub Date : 2022-01-01 DOI: 10.14233/ajomc.2022.7-1-sp4.pp248-250
{"title":"Understanding the Make-or-buy Decision Strategy: A Brief Communication","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp248-250","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp248-250","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86994268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信