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Systematic Investigation of Lanthanoid Transition Heavy Metal Acetates as Electron Staining Reagents for Protein Molecules in Biological Transmission Electron Microscopy. 系统研究生物透射电子显微镜中作为蛋白质分子电子染色试剂的镧系过渡重金属乙酸盐。
IF 2.8
Reviews in clinical gerontology Pub Date : 2022-04-01 DOI: 10.1017/S1431927622000411
Noriyuki Ishii
{"title":"Systematic Investigation of Lanthanoid Transition Heavy Metal Acetates as Electron Staining Reagents for Protein Molecules in Biological Transmission Electron Microscopy.","authors":"Noriyuki Ishii","doi":"10.1017/S1431927622000411","DOIUrl":"10.1017/S1431927622000411","url":null,"abstract":"<p><p>Cryo-electron microscopy, widely used for high-resolution protein structure determination, does not require staining. Yet negative staining with heavy metal salts such as uranyl acetate has been in persistent demand since the 1950s due to its image contrasting capabilities at room temperature with a common electron microscope. However, uranium compounds are nuclear fuel materials and are tightly controlled worldwide. Acetates of each lanthanoid series elements except promethium are prepared at the same concentration (2%(w/v)) and used as a model on horse spleen ferritin for electron microscopic analysis to systematically evaluate their effectiveness as electron staining reagents for the protein. Analysis shows that the triacetates of samarium and europium, followed by gadolinium and erbium, and then lanthanum and neodymium could function as electron staining reagents. Thulium-triacetate precipitates thin plate-like crystals and may be used for selecting better imaging fields. Of the 14 lanthanoid-triacetates examined, about half are viable alternatives to uranyl acetate as an electron staining reagent for ferritin, and there appears an optimal range in ionic sizes for promising lanthanoids. This is the first systematic investigation of lanthanoid transition heavy metal triacetates from the viewpoint of lanthanoid contraction, using density distribution histograms of electron micrographs as an indicator for comparison with uranyl acetate.</p>","PeriodicalId":85413,"journal":{"name":"Reviews in clinical gerontology","volume":"5 1","pages":"1-10"},"PeriodicalIF":2.8,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79011991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does cognitive reserve moderate the association between mood and cognition? A systematic review 认知储备是否调节情绪和认知之间的联系?系统回顾
Reviews in clinical gerontology Pub Date : 2015-08-01 DOI: 10.1017/S0959259815000155
C. Opdebeeck, C. Quinn, S. Nelis, L. Clare
{"title":"Does cognitive reserve moderate the association between mood and cognition? A systematic review","authors":"C. Opdebeeck, C. Quinn, S. Nelis, L. Clare","doi":"10.1017/S0959259815000155","DOIUrl":"https://doi.org/10.1017/S0959259815000155","url":null,"abstract":"This research was funded by a Bangor University, School of Psychology PhD scholarship awarded to Carol Opdebeeck.","PeriodicalId":85413,"journal":{"name":"Reviews in clinical gerontology","volume":"32 1","pages":"181-193"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S0959259815000155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57030692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Non-pharmacological management of sexual behaviours that challenge in dementia 痴呆患者性行为的非药物管理
Reviews in clinical gerontology Pub Date : 2015-08-01 DOI: 10.1017/S0959259815000167
H. Thornton, Rosslyn Offord
{"title":"Non-pharmacological management of sexual behaviours that challenge in dementia","authors":"H. Thornton, Rosslyn Offord","doi":"10.1017/S0959259815000167","DOIUrl":"https://doi.org/10.1017/S0959259815000167","url":null,"abstract":"A literature search was conducted to identify and evaluate non-pharmacological interventions available for people living with dementia, who present with sexual behaviours that challenge. A lack of research implementing and evaluating clinical interventions was identified, and the search was broadened to include discussion papers relating to sexuality and dementia. This included work both with couples affected by dementia at home, and with staff in institutional care settings. The papers identified come from a range of countries, with wide variation in care settings and practices. Literature suggests sexual behaviours that challenge in dementia are best understood within the broader context of behavioural and psychological symptoms of dementia (BPSD). There is a consensus highlighting the importance of training staff to recognize the sexual needs of people with dementia and to develop clear policy and guidelines to support staff in managing potential challenges. Few authors attempted to include the perspectives of either care partners or the person with dementia.","PeriodicalId":85413,"journal":{"name":"Reviews in clinical gerontology","volume":"25 1","pages":"194-201"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S0959259815000167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57030734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pain in older people with frailty 身体虚弱的老年人的疼痛
Reviews in clinical gerontology Pub Date : 2015-08-01 DOI: 10.1017/S0959259815000143
L. Brown, John B. Young, A. Clegg, Anne Heaven
{"title":"Pain in older people with frailty","authors":"L. Brown, John B. Young, A. Clegg, Anne Heaven","doi":"10.1017/S0959259815000143","DOIUrl":"https://doi.org/10.1017/S0959259815000143","url":null,"abstract":"In this review we identified cohort and cross-sectional studies which assessed pain in community-dwelling older people (> 65 years) reliably characterised as frail. Secondly, we considered biologically plausible mechanisms which may alter pain perception, or contribute to, or exacerbate pain in an older person with frailty. Thirdly, we considered specific implications of pain management for this group of people. From the limited data from the seven included studies, it would appear that the presence of pain is higher in older people with frailty compared to people characterised as pre-frail or not frail. Thus, older people reporting pain are more likely to be frail. However, a lack of prospective data precludes inferences about the direction of the relationship: that is whether pain or frailty is the antecedent. Further research is needed to understand the direction of the relationship, and to identify appropriate pain management strategies for older people with frailty.","PeriodicalId":85413,"journal":{"name":"Reviews in clinical gerontology","volume":"1 1","pages":"159-171"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S0959259815000143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57030625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Fear of falling assessments in older people with dementia 老年痴呆症患者害怕评估下降
Reviews in clinical gerontology Pub Date : 2015-05-01 DOI: 10.1017/S0959259815000106
Chantel Cox, M. Vassallo
{"title":"Fear of falling assessments in older people with dementia","authors":"Chantel Cox, M. Vassallo","doi":"10.1017/S0959259815000106","DOIUrl":"https://doi.org/10.1017/S0959259815000106","url":null,"abstract":"Fear of falling (FoF) is a common condition in older age. However, there is a paucity of research on its prevalence, impact and treatment in older people with dementia. People with dementia have an increased risk of falls which present a significant threat to their independence, as well as having a significant economic impact on health and social services. This review outlines the key issues in relation to FoF, current guidelines and assessment tools and their use for people with dementia. Further research needs to be completed in both addressing the specific assessment barriers that people with dementia may face regarding the use of current FoF tools, with further exploration surrounding the individual's experience of FoF and how this may be impacting upon their quality of life and functionality. Until a well-validated method has been developed, clinicians need to utilize available tools as guidelines, seek the assistance of proxies at all stages of the care journey, and use clinical judgement to assess FoF in patients with dementia.","PeriodicalId":85413,"journal":{"name":"Reviews in clinical gerontology","volume":"25 1","pages":"98-106"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S0959259815000106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57030551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Ageing, exercise and the chemistry of inflammation 衰老，运动和炎症的化学反应
Reviews in clinical gerontology Pub Date : 2015-05-01 DOI: 10.1017/S0959259815000088
S. Allen
{"title":"Ageing, exercise and the chemistry of inflammation","authors":"S. Allen","doi":"10.1017/S0959259815000088","DOIUrl":"https://doi.org/10.1017/S0959259815000088","url":null,"abstract":"Exercise has a complex influence on the biochemical markers of inflammation that includes suppression of pro-inflammatory cytokines and promotion of anti-inflammatory cytokines. The magnitude of this effect is large for prolonged activity at high work rates. People who are able to perform regular mild–moderate exercise have lower baseline pro-inflammatory cytokine levels that appear to be associated with a number of health benefits, including reduced all-cause mortality. These effects extend into old age. Interleukin-6 (IL-6), a pleiotropic myokine released by active muscle cells, appears to play a central role in these observed phenomena, though the mechanisms of action are intricate and incompletely understood. The minimum threshold of the exercise–cytokine dose–response, if any, has not been clearly characterized. Therefore, the potential to influence cytokine activity and reduce age-associated inflammation in very aged or frail people able to perform only very low levels of physical activity is unknown.","PeriodicalId":85413,"journal":{"name":"Reviews in clinical gerontology","volume":"25 1","pages":"73-80"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S0959259815000088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57030531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Transport, driving and ageing 交通、驾驶和老龄化
Reviews in clinical gerontology Pub Date : 2015-05-01 DOI: 10.1017/S095925981500009X
D. O’Neill
{"title":"Transport, driving and ageing","authors":"D. O’Neill","doi":"10.1017/S095925981500009X","DOIUrl":"https://doi.org/10.1017/S095925981500009X","url":null,"abstract":"Transport is the invisible glue that holds our lives together, an under-recognized contributor to economic, social and personal well-being. In public health terms, the medical profession had previously allowed itself to focus almost exclusively on the downsides of transport. However, the research basis for transport, driving and ageing is steadily evolving and has important academic and practical considerations for gerontologists and geriatricians. For gerontologists, teasing out the critical role of transport in the health and well-being of older people is an imperative, as well as the key challenges inherent in transitioning from driving to not driving. The safe crash record of a group with significant multi-morbidity allows us to focus on the remarkable strategic and adaptive skills of older people. From a policy perspective, strictures on older drivers are an exemplar of institutionalized ageism. For geriatricians, a key challenge is to develop strategies for including transportation in our clinical assessments, formulating effective strategies for assessment of medical fitness to drive, incorporating enabling techniques, giving due consideration to ethical and legal aspects, and developing and promoting multi-modality and alternative transportation options.","PeriodicalId":85413,"journal":{"name":"Reviews in clinical gerontology","volume":"25 1","pages":"147-158"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S095925981500009X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57030540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Subcutaneous fluid and drug delivery: safe, efficient and inexpensive 皮下液体和药物输送:安全、有效和廉价
Reviews in clinical gerontology Pub Date : 2015-05-01 DOI: 10.1017/S095925981500012X
Oscar Duems-Noriega, S. Ariño-Blasco
{"title":"Subcutaneous fluid and drug delivery: safe, efficient and inexpensive","authors":"Oscar Duems-Noriega, S. Ariño-Blasco","doi":"10.1017/S095925981500012X","DOIUrl":"https://doi.org/10.1017/S095925981500012X","url":null,"abstract":"Patients with difficult venous access or oral intolerance and clinical situations with inadequate response to oral therapy have generated the need for alternative routes of delivery for drugs and fluids. The purpose of this study was to conduct a systematic review examining the evidence for subcutaneous (SC) administration of drugs and/or fluids. We used a broad search strategy using electronic databases CINAHL, EMBASE, PubMed and Cochrane library, key terms and ‘Medical Subject Headings’ (MeSH) such as ‘subcutaneous route’, ‘hypodermoclysis’ and the name/group of the most used drugs via this route (e.g. ‘ketorolac, morphine, ceftriaxone’, ‘analgesics, opioids, antibiotics’). We conclude that the SC route is an effective alternative for rehydration in patients with mild–moderate dehydration and offers a number of potential advantages in appropriately selected scenarios. Experience of administering drugs by this route suggests that it is well tolerated and is associated with minimal side-effects.","PeriodicalId":85413,"journal":{"name":"Reviews in clinical gerontology","volume":"25 1","pages":"117-146"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S095925981500012X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57030609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Small intestinal bacterial overgrowth in older people 老年人的小肠细菌过度生长
Reviews in clinical gerontology Pub Date : 2015-05-01 DOI: 10.1017/S0959259815000118
S. Amer, H. Manzar
{"title":"Small intestinal bacterial overgrowth in older people","authors":"S. Amer, H. Manzar","doi":"10.1017/S0959259815000118","DOIUrl":"https://doi.org/10.1017/S0959259815000118","url":null,"abstract":"Small intestinal bacterial overgrowth (SIBO) is a condition in which non-native bacteria and/or native bacteria are present in increased numbers in the small bowel, resulting in excessive fermentation, inflammation or malabsorption. Patients with SIBO vary in presentation, from being only mildly symptomatic to suffering from chronic diarrhoea, weight loss and malabsorption. A number of diagnostic tests are currently available, with aspiration of the small intestinal fluid being the gold standard. Treatment encompasses a multimodal approach including treatment of the underlying disease, nutritional support and antibiotic therapy. In this review, we discuss the risk factors, clinical manifestations, diagnosis and treatment of SIBO in older people.","PeriodicalId":85413,"journal":{"name":"Reviews in clinical gerontology","volume":"25 1","pages":"81-85"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S0959259815000118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57030605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Hospital readmissions in frail older people 体弱老年人的再入院率
Reviews in clinical gerontology Pub Date : 2015-04-29 DOI: 10.1017/S0959259815000064
E. Craven, S. Conroy
{"title":"Hospital readmissions in frail older people","authors":"E. Craven, S. Conroy","doi":"10.1017/S0959259815000064","DOIUrl":"https://doi.org/10.1017/S0959259815000064","url":null,"abstract":"The majority of hospital in-patients are older people, and many of these are at increased risk of readmission, which can be an adverse outcome for the patient. Currently there is poor understanding as to how best to reduce the risk of readmission. We searched MEDLINE, EMBASE and the Cochrane library for high quality review articles about readmissions. Each review was quality assessed by two reviewers. Grouped data and evidence from original papers is cited with 95% confidence intervals when possible. Nine review studies of sufficient quality were included. Two addressed risk factors for readmission, which included: age, poor functional status prior to admission, length of stay during the index admission, depression, cognitive impairment, malnutrition, social support and social networks/support. The seven other reviews addressed interventions to reduce readmission, which included: discharge planning, post-discharge support, post-discharge case management, and nutritional supplementation. It is possible to identify older people at risk of readmission using well-established risk factors; discharge planning, post-discharge support and nutritional interventions appear to be effective in reducing readmission. Combined interventions appear to be more effective than isolated interventions.","PeriodicalId":85413,"journal":{"name":"Reviews in clinical gerontology","volume":"25 1","pages":"107-116"},"PeriodicalIF":0.0,"publicationDate":"2015-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/S0959259815000064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57030522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
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