Problemy tuberkuleza i boleznei legkikh最新文献_第3页

[The course of a process and the efficiency of treatment of pulmonary tuberculosis patients excreting Mycobacterium tuberculosis with extensive drug resistance to antituberculous drugs]. 【对抗结核药物广泛耐药的结核分枝杆菌排出肺结核患者的一个过程及治疗效果】。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

V Iu Mishin, O G Komissarova, V I Chukanov, A S Kononets

{"title":"[The course of a process and the efficiency of treatment of pulmonary tuberculosis patients excreting Mycobacterium tuberculosis with extensive drug resistance to antituberculous drugs].","authors":"V Iu Mishin, O G Komissarova, V I Chukanov, A S Kononets","doi":"","DOIUrl":"","url":null,"abstract":"Forty-one pulmonary tuberculosis patients (32 males and 9 females) excreting Mycobacterium tuberculosis (MBT) with extensive drug resistance to antituberculous drugs were examined. The process was first detected in 14.6% of the patients. At the previous stage of treatment, the vast majority of patients (85.4%) received antituberculous drugs. Fibrocavernous tuberculosis was a predominant form (73.1%). The acutely progressive course of the process was observed in 29.3% of patients. Lung destructive changes and bacterial excretion were revealed in all (100%) patients. Resistance to streptomycin, isoniazid, rifampicin, and fluoroquinolones was seen in all (100%) patients. The fact that in this cohort of patients the resistance of MBT to reserve drug, such as kanamycin, amikacin, and cycloserine, is observed at a rather high rate (from 58.5 to 73.1%) is concerned about. For evaluation of the efficiency of treatment, all the examinees were divided into 2 groups, which were equal in clinical and laboratory characteristics. Group 1 patients (n = 19) were given chemotherapy regimen 2b (in new cases of tuberculosis) and individual chemotherapy regimens. Collapse therapy was additionally used in the treatment of Group 2 patients (n = 22). After 3-month chemotherapy, negative sputum was established in 4 (9.8%) and 6 (14.6%) patients in Groups 1 and 2, respectively. Following 6-month therapy, MBT excretion ceased in 13 (31.7%) and 15 (36.6%) patients in Groups 1 and 2, respectively. After 3- and 6-month therapy, decay cavity closure occurred in 2 (4.8%) and 7 (17%) Group 1 patients and in 4 (9.8%) and 15 (36.6%) Group 2 patients, respectively (p < 0.05).","PeriodicalId":85348,"journal":{"name":"Problemy tuberkuleza i boleznei legkikh","volume":" 2","pages":"50-2"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28122115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Topical aspects of organization of tuberculosis monitoring at the level of a subject of the Russian Federation (in case of the Belgorod Region)]. [在俄罗斯联邦一级组织结核病监测的专题方面(在别尔哥罗德州)]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

T I Malykhina, A A Amel'chenko, I M Son, V M Kolomiets, E M Belilovskiĭ

引用次数: 0

[Detection of tuberculosis in Moscow adolescents]. 莫斯科青少年肺结核的检测。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

A F Meĭsner, E S Ovsiankina, L B Stakheeva

{"title":"[Detection of tuberculosis in Moscow adolescents].","authors":"A F Meĭsner, E S Ovsiankina, L B Stakheeva","doi":"","DOIUrl":"","url":null,"abstract":"Retrospective analysis of the data available in the reporting form 0-89/y-[cyrillic letter: see text] and information analytical tables for Moscow tuberculosis monitoring) over 7 years on all notified new cases of tuberculosis among 15-17-year-old children has indicated that it is necessary to change the procedure for detecting tuberculosis for this age group of children in order to improve the early diagnosis of the disease. The Mantoux test is likely to be rather effective in examining adolescent schoolchildren and students from secondary specialized establishments and ineffective among unorganized young people and in migrants' families. Planned fluorography is of rather informative value in all the groups under study if there is a timely referral for examination. The authors consider whether it is worth making a tuberculosis 2 TE PPD-L in organized collective bodies (schools, colleges, etc.). Other groups of children may undergo only digital small-dose fluorography. Unorganized children above 10 years of age who lack annual Mantoux test results must be referred for digital small-dose fluorography. Refusal to undergo fluorography is justifiable only if there is no tuberculin sensitivity or evident symptoms of intoxication. In the megapolis, due to uncontrolled migration, a lawmaker must consolidate the statute on that mandatory control should be exercised over 15-17-year-old adolescents who must undergo fluorography during their each visit to a health care facility, on entering an educational establishment, or on employment. On consulting a physician, the adolescent who has undergone fluorography 6 months before must have it again.","PeriodicalId":85348,"journal":{"name":"Problemy tuberkuleza i boleznei legkikh","volume":" 1","pages":"40-5"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28015677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Immunological parameters in the assessment of the activity of a specific process in Mycobacterium tuberculosis-infected children and patients with intrathoracic lymphatic tuberculosis]. [评价结核分枝杆菌感染儿童和胸内淋巴结核患者特定过程活性的免疫学参数]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

S N Efremova, I F Dovgaliuk, I Ia Sakharova

{"title":"[Immunological parameters in the assessment of the activity of a specific process in Mycobacterium tuberculosis-infected children and patients with intrathoracic lymphatic tuberculosis].","authors":"S N Efremova, I F Dovgaliuk, I Ia Sakharova","doi":"","DOIUrl":"","url":null,"abstract":"The data of a comprehensive study of 86 children aged 6 to 14 years, who were examined and treated at the Research Institute of Phthisiology for various manifestations of tuberculous infection: 25.6% with infected Mycobacterium tuberculosis with varying specific sensitization; 34.9% with minor forms of intrathoracic lymphatic tuberculosis (ITLT), 39.5% with disseminated processes into the intrathoracic lymph nodes, are analysed. Of the greatest informative value in the determination of the activity of tuberculous infection are RM V, VI, VII, and VIII dilutions in combination with immunological parameters of specific immunity: blast transpormation reaction (BTR) to PPD, a complex of serological reactions, IL-8, and lysosomal cationic test (LCT). Most children with ITLT showed a significant cellular response to PPD in the BTR test. It should be noted that on admission to the clinic, neutrophilic granulocytes were functionally inadequate in all the children as shown by LCT. The currently available immunological tests used in combination with the existing methods in the diagnosis of ITLT adequately evaluate the activity of tuberculous infection in children.","PeriodicalId":85348,"journal":{"name":"Problemy tuberkuleza i boleznei legkikh","volume":" 1","pages":"48-51"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28015679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A case of extrapulmonary multiple organ tuberculosis]. [肺外多器官结核1例]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

L V Burukhina, A A Shurygin, I P Koriukina, A E Shirinkina, N A Barmina, A R Khuseĭn, T A Poriadina

引用次数: 0

[Retrosternal lymphotropic chemotherapy and pneumoperitoneum in the treatment of drug-resistant destructive pulmonary tuberculosis]. [胸骨后淋巴细胞化疗联合气腹术治疗耐药破坏性肺结核]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

B S Kibrik, A V Zakharov, V M Lobanovskiĭ

{"title":"[Retrosternal lymphotropic chemotherapy and pneumoperitoneum in the treatment of drug-resistant destructive pulmonary tuberculosis].","authors":"B S Kibrik, A V Zakharov, V M Lobanovskiĭ","doi":"","DOIUrl":"","url":null,"abstract":"The efficiency of combined treatment with retrosternal lymphotropic administration of drugs and pneumoperitoneum was comparatively analyzed in 148 new cases of destructive pulmonary tuberculosis. Both methods were applied during combined chemotherapy in a study group of 48 patients. In Group 2 (n = 54), lymphotropic procedure was employed alone during standard chemotherapy; in Group 3 (n = 46), only pneumoperitoneum was used in combination of chemotherapy. In 40 patients, pulmonary tuberculosis was acutely progressive. Drug resistance was identified in 81.7%, including multidrug resistance in 27.7%. With the combined use of retrosternal lymphotropic therapy and pneumoperitoneum, bacterial excretion ceased in 96.2% of new cases of drug-resistant tuberculosis; decay cavity resolved in 80.8%. The proposed therapeutic technology used in patients with persistent bacterial excretion and decay cavities after ineffective 4-9-month treatment could achieve abacillation in 90.9% of patients and resolve decay cavities in 77.3%. Retrosternal drug injection reduces a risk for complications due to bronchial tuberculosis involvement when pneumoperitoneum is applied.","PeriodicalId":85348,"journal":{"name":"Problemy tuberkuleza i boleznei legkikh","volume":" 5","pages":"21-6"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28275892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Assessment of a risk for postoperative infectious complications in patients with fibrocarvous pulmonary tuberculosis]. 纤维纤维性肺结核术后感染并发症的风险评估。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

A V El'kin, O T Titarenko, D S Esmedliaeva, M E D'iakova, N P Alekseeva, T L Perova

引用次数: 0

[Detection of mutations in codon 306 of the embB gene for molecular genetic characterization of clinical Mycobacterium tuberculosis strains]. [临床结核分枝杆菌菌株embB基因306密码子突变的分子遗传学检测]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

M V Afanas'ev, A D Borovskaia, E N Il'ina, T G Smirnova, E E Larionova, A V Kuz'min, S N Andreevskaia, L N Chernousova, V M Govorun

{"title":"[Detection of mutations in codon 306 of the embB gene for molecular genetic characterization of clinical Mycobacterium tuberculosis strains].","authors":"M V Afanas'ev, A D Borovskaia, E N Il'ina, T G Smirnova, E E Larionova, A V Kuz'min, S N Andreevskaia, L N Chernousova, V M Govorun","doi":"","DOIUrl":"","url":null,"abstract":"A total of 254 Mycobacterium tuberculosis strains were used in the study. Among them, there were 183 ethambutol (EMB)-resistant strains, 13 multidrug resistant ones, but EMB-sensitive, and 39 strains sensitive to rifampicin (RIF), isoniazid (INZ), and EMB. All the strains were analyzed for genetic changes in three loci: embB306, rpoB, and katG/inhA promoter, which were associated with the formation of resistance to EMB, RIF, and INZ, respectively. The Mycobacterium tuberculosis strains were obtained from pulmonary tuberculosis patients living in the Central Region of the Russian Federation. Resistance to RIF, INZ, and EMB was revealed by the absolute concentration test. The inhibitory concentration (IC) of EMB was determined for all the strains. Genetic changes in the above loci were estimated by mini-sequencing, followed by mass-spectrometry recording MALDI-TOF products. The relative low frequency of embB306 mutations was observed among the EMB-resistant strains (about 41.5%). Mutations in codon 306 were detected only in strains with EMB IC > or = 2 mg/L. A statistical significant association was found between the frequency of embB306 mutations and the multidrug resistant phenotype. A combination of these mutations with the traditional genetic markers of multidrug resistance may be used for the more effective detection of multidrug-resistant strains.","PeriodicalId":85348,"journal":{"name":"Problemy tuberkuleza i boleznei legkikh","volume":" 5","pages":"48-53"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28276998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[In vitro interferon-gamma induction in whole blood samples is a test for tuberculous infection in children and adolescents]. [体外干扰素γ诱导全血样本是儿童和青少年结核感染的一种检测方法]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

L I Mordovskaia, M A Vladimirskiĭ, V A Aksenova, E E Efremov, G I Ignashenkova, T N Vlasik

{"title":"[In vitro interferon-gamma induction in whole blood samples is a test for tuberculous infection in children and adolescents].","authors":"L I Mordovskaia, M A Vladimirskiĭ, V A Aksenova, E E Efremov, G I Ignashenkova, T N Vlasik","doi":"","DOIUrl":"","url":null,"abstract":"By applying the interferon-gamma (IFN-gamma) induction technique in the whole blood samples exposed to short-term (22-24-hour) incubation in the presence of Mycobacterium tuberculosis antigens--PPD tuberculin and specific recombinant ESAT-6 lacking in the cells of vaccine BCG and other non-tuberculous mycobacteria, the authors studied the groups of children and adolescents with a negative Mantoux test (n = 31), with postvaccine BCG allergy (n = 40), as well as patients with primary tuberculous infection (n = 84) and those with pulmonary tuberculosis (n = 44). Patients with primary tuberculous infection and a high sensitivity (94%) and a high specificity (97%) may be differentiated from children and adolescents with postvaccinal allergy when the recombinant ESAT-6 antigen and the critical IFN-gamma level (greater than 70 pg/ml) detectable in the plasma samples after incubation with the antigen. It has been also shown that in adolescents with local forms of pulmonary tuberculosis specific IFN-gamma induction may be suppressed in number of cases, which is ascribed to decreased specific immunity.","PeriodicalId":85348,"journal":{"name":"Problemy tuberkuleza i boleznei legkikh","volume":" 6","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40000433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Continuous professional education of physicians in childhood and adolescence tuberculosis]. [儿童和青少年结核病医师的持续专业教育]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

P P Sel'tsovskiĭ, A S Svistunova

引用次数: 0