Problemy tuberkuleza i boleznei legkikh最新文献_第3页

[Deaths of patients with tuberculosis in combination with HIV infection from various causes, other than tuberculosis]. [结核病以外的各种原因导致的结核病合并艾滋病毒感染患者死亡人数]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

N V Eĭsmont

{"title":"[Deaths of patients with tuberculosis in combination with HIV infection from various causes, other than tuberculosis].","authors":"N V Eĭsmont","doi":"","DOIUrl":"","url":null,"abstract":"The structure of tuberculosis patients with HIV infection who died from any causes, other than tuberculosis, in the Sverdlovsk Region in 2000-2006 did not differ from that of patients with concurrent pathology who died from tuberculosis. The general health care facilities had revealed tuberculosis during life in most patients who died from terminal-stage HIV infection; at death these patients had endstage HIV infection which tuberculosis joined to 4 years or more after HIV infection registration. A fatal outcome in 88.1% of the patients died from the terminal stage of HIV infection was observed within the first year after tuberculosis detection, in half the cases the background disease being generalized tuberculosis at autopsy; every two patients discharged microorganisms during life, drug resistance in the causative agent of tuberculosis was found in every three patients. Half the patients who died from other causes, other than HIV infection and tuberculosis lost their life within the first year after registration of the tuberculous process. Lifetime bacterial discharge was recorded in half the patients; drug resistance of Mycobacterium tuberculosis has developed a third of the patients with comorbidity who died from other causes, other than tuberculosis and HIV infection. The volume of lifetime specialized care for HIV infection to deceased patients with comorbidity had been inadequate. The importance of the problem of notification of cases, when the autopsy background disease was tuberculosis in comorbidity patients not included into the regional tuberculosis morbidity and mortality statistics, will increase with further development of the epidemics of tuberculosis and HIV infection to the Svedlovsk Region.","PeriodicalId":85348,"journal":{"name":"Problemy tuberkuleza i boleznei legkikh","volume":" 4","pages":"54-9"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28232221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Obstructive uropathy in nephrotuberculosis and the results of its surgical correction]. [肾结核梗阻性尿路病变及其手术矫正的结果]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

A A Volkov, O N Zuban'

引用次数: 0

[The effectiveness and safety of accessory treatment with vobenzyme in patients with community-acquired pneumonia]. [vobase辅助治疗社区获得性肺炎的有效性和安全性]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

E I Shmelev, I E Stepanian, A S Zaĭtseva, L B Sokolova, L A Mazaeva, N F Tumanova, Iu I Sternin

引用次数: 0

[Retrosternal lymphotropic chemotherapy and pneumoperitoneum in the treatment of drug-resistant destructive pulmonary tuberculosis]. [胸骨后淋巴细胞化疗联合气腹术治疗耐药破坏性肺结核]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

B S Kibrik, A V Zakharov, V M Lobanovskiĭ

{"title":"[Retrosternal lymphotropic chemotherapy and pneumoperitoneum in the treatment of drug-resistant destructive pulmonary tuberculosis].","authors":"B S Kibrik, A V Zakharov, V M Lobanovskiĭ","doi":"","DOIUrl":"","url":null,"abstract":"The efficiency of combined treatment with retrosternal lymphotropic administration of drugs and pneumoperitoneum was comparatively analyzed in 148 new cases of destructive pulmonary tuberculosis. Both methods were applied during combined chemotherapy in a study group of 48 patients. In Group 2 (n = 54), lymphotropic procedure was employed alone during standard chemotherapy; in Group 3 (n = 46), only pneumoperitoneum was used in combination of chemotherapy. In 40 patients, pulmonary tuberculosis was acutely progressive. Drug resistance was identified in 81.7%, including multidrug resistance in 27.7%. With the combined use of retrosternal lymphotropic therapy and pneumoperitoneum, bacterial excretion ceased in 96.2% of new cases of drug-resistant tuberculosis; decay cavity resolved in 80.8%. The proposed therapeutic technology used in patients with persistent bacterial excretion and decay cavities after ineffective 4-9-month treatment could achieve abacillation in 90.9% of patients and resolve decay cavities in 77.3%. Retrosternal drug injection reduces a risk for complications due to bronchial tuberculosis involvement when pneumoperitoneum is applied.","PeriodicalId":85348,"journal":{"name":"Problemy tuberkuleza i boleznei legkikh","volume":" 5","pages":"21-6"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28275892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Assessment of a risk for postoperative infectious complications in patients with fibrocarvous pulmonary tuberculosis]. 纤维纤维性肺结核术后感染并发症的风险评估。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

A V El'kin, O T Titarenko, D S Esmedliaeva, M E D'iakova, N P Alekseeva, T L Perova

引用次数: 0

[Detection of mutations in codon 306 of the embB gene for molecular genetic characterization of clinical Mycobacterium tuberculosis strains]. [临床结核分枝杆菌菌株embB基因306密码子突变的分子遗传学检测]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

M V Afanas'ev, A D Borovskaia, E N Il'ina, T G Smirnova, E E Larionova, A V Kuz'min, S N Andreevskaia, L N Chernousova, V M Govorun

{"title":"[Detection of mutations in codon 306 of the embB gene for molecular genetic characterization of clinical Mycobacterium tuberculosis strains].","authors":"M V Afanas'ev, A D Borovskaia, E N Il'ina, T G Smirnova, E E Larionova, A V Kuz'min, S N Andreevskaia, L N Chernousova, V M Govorun","doi":"","DOIUrl":"","url":null,"abstract":"A total of 254 Mycobacterium tuberculosis strains were used in the study. Among them, there were 183 ethambutol (EMB)-resistant strains, 13 multidrug resistant ones, but EMB-sensitive, and 39 strains sensitive to rifampicin (RIF), isoniazid (INZ), and EMB. All the strains were analyzed for genetic changes in three loci: embB306, rpoB, and katG/inhA promoter, which were associated with the formation of resistance to EMB, RIF, and INZ, respectively. The Mycobacterium tuberculosis strains were obtained from pulmonary tuberculosis patients living in the Central Region of the Russian Federation. Resistance to RIF, INZ, and EMB was revealed by the absolute concentration test. The inhibitory concentration (IC) of EMB was determined for all the strains. Genetic changes in the above loci were estimated by mini-sequencing, followed by mass-spectrometry recording MALDI-TOF products. The relative low frequency of embB306 mutations was observed among the EMB-resistant strains (about 41.5%). Mutations in codon 306 were detected only in strains with EMB IC > or = 2 mg/L. A statistical significant association was found between the frequency of embB306 mutations and the multidrug resistant phenotype. A combination of these mutations with the traditional genetic markers of multidrug resistance may be used for the more effective detection of multidrug-resistant strains.","PeriodicalId":85348,"journal":{"name":"Problemy tuberkuleza i boleznei legkikh","volume":" 5","pages":"48-53"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28276998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A case of extrapulmonary multiple organ tuberculosis]. [肺外多器官结核1例]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

L V Burukhina, A A Shurygin, I P Koriukina, A E Shirinkina, N A Barmina, A R Khuseĭn, T A Poriadina

引用次数: 0

[Tuberculosis hospitals in Russia: requirements, prospects for development]. [俄罗斯结核病医院:要求、发展前景]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

M V Shilova

引用次数: 0

[In vitro interferon-gamma induction in whole blood samples is a test for tuberculous infection in children and adolescents]. [体外干扰素γ诱导全血样本是儿童和青少年结核感染的一种检测方法]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

L I Mordovskaia, M A Vladimirskiĭ, V A Aksenova, E E Efremov, G I Ignashenkova, T N Vlasik

{"title":"[In vitro interferon-gamma induction in whole blood samples is a test for tuberculous infection in children and adolescents].","authors":"L I Mordovskaia, M A Vladimirskiĭ, V A Aksenova, E E Efremov, G I Ignashenkova, T N Vlasik","doi":"","DOIUrl":"","url":null,"abstract":"By applying the interferon-gamma (IFN-gamma) induction technique in the whole blood samples exposed to short-term (22-24-hour) incubation in the presence of Mycobacterium tuberculosis antigens--PPD tuberculin and specific recombinant ESAT-6 lacking in the cells of vaccine BCG and other non-tuberculous mycobacteria, the authors studied the groups of children and adolescents with a negative Mantoux test (n = 31), with postvaccine BCG allergy (n = 40), as well as patients with primary tuberculous infection (n = 84) and those with pulmonary tuberculosis (n = 44). Patients with primary tuberculous infection and a high sensitivity (94%) and a high specificity (97%) may be differentiated from children and adolescents with postvaccinal allergy when the recombinant ESAT-6 antigen and the critical IFN-gamma level (greater than 70 pg/ml) detectable in the plasma samples after incubation with the antigen. It has been also shown that in adolescents with local forms of pulmonary tuberculosis specific IFN-gamma induction may be suppressed in number of cases, which is ascribed to decreased specific immunity.","PeriodicalId":85348,"journal":{"name":"Problemy tuberkuleza i boleznei legkikh","volume":" 6","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40000433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Continuous professional education of physicians in childhood and adolescence tuberculosis]. [儿童和青少年结核病医师的持续专业教育]。

Problemy tuberkuleza i boleznei legkikh Pub Date : 2009-01-01

P P Sel'tsovskiĭ, A S Svistunova

引用次数: 0