Asian Journal of Pharmaceutical and Clinical Research最新文献

{"title":"COMPARATIVE ROLE OF ULTRASOUND AND COMPUTED TOMOGRAPHY IN DIAGNOSIS OF NONTRAUMATIC RIGHT ILIAC FOSSA PAIN IN PATIENTS ABOVE 50 YEARS OF AGE ADMITTED IN A TERTIARY-CARE HOSPITAL","authors":"PRASUN DAS, Sudipta Basu, Malay Karmakar, Srijak Bhattacharyya","doi":"10.22159/ajpcr.2024v17i7.50971","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.50971","url":null,"abstract":"Objectives: The objective of the study was to evaluate and compare the role of ultrasonography (USG) and computed tomography (CT) in diagnosing non-traumatic right iliac fossa (RIF) pain in the geriatric population. More specifically, to evaluate the diagnostic accuracy parameters of both imaging modalities after enumerating the relevant etiologies. The ultimate aim is to assess the diagnostic accuracy variables of USG in diagnosing non-traumatic RIF pain in the elderly, taking computed tomography as the gold standard of investigation.\u0000Methods: Fifty patients in the elderly age group with non-traumatic RIF pain were evaluated consecutively by USG, followed by a CT scan.\u0000Results: Overall, in detecting non-traumatic RIF pain in our study, sonography was found to have sensitivity, specificity, positive predictive value, and negative predictive value of 35.14%, 23.07%, 56.52%, and 11.1% with respect to a CT scan. It also reveals that in diagnosing the different etiologies of RIF pain, the findings of the USG have a weakly positive correlation with the findings of the CT scan. It also reveals that, on comparison between CT and USG, we found a statistically significant difference in diagnosing RIF pain in this study population.\u0000Conclusions: We therefore conclude that ultrasound may be used as an initial imaging investigation as the majority of cases of non-traumatic RIF pain come in the acute stage and emergency ultrasound comes into play due to its easy use and more availability. However, we must do a CT scan after that to narrow down the differential diagnoses in this age group.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A STUDY OF VISUAL OUTCOME AND COMPLICATIONS OF SCLERAL-FIXATED INTRAOCULAR LENS","authors":"Kamlesh Najukram, Rajesh B Lanje, Sreelakshmi Gotekar, Pillai","doi":"10.22159/ajpcr.2024v17i7.50926","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.50926","url":null,"abstract":"Objectives: Objectives of this study are to find indications for the scleral-fixated intraocular lens, to measure visual acuity in patients with scleral-fixated intraocular lens postoperatively and also to note the complications of scleral-fixated intraocular lens intra and postoperatively.\u0000Materials and Methods: The study includes 36 eyes of 36 aphakic patients presenting to Ophthalmology department between November 2019 and April 2021 after obtaining Institutional Ethical Committee Clearance. Informed and written consent were obtained from each patient included in the study. Goldmann applanation tonometer was used to record IOP for all cases preoperatively. Detailed ophthalmic examination was done on slit-lamp biomicroscope and best corrected visual acuity was recorded. Keratometry was done using an autorefractokeratometer. The axial length of the eye was calculated with the help of A scan biometry in aphakic mode. IOL power was then calculated with the SRK T formula using 118.2 as A constant for SFIOL. Patients underwent anterior vitrectomy followed by scleral fixation intraocular lens implantation by Gabor’s technique after the detailed preoperative examination. The postoperative examination was done on day 1, day 7, at 1 month, and at 3 months, and the findings were noted.\u0000Result: Out of 36, 25 (69%) patients were having surgical aphakia due to complications of cataract surgery. 5 (14%) patients were having aphakia due to trauma to the eye and 6 (17%) patients were having spontaneous dislocation of lens. Good visual outcome was observed postoperatively. Improvement in BCVA to 6/18 or more was observed in all 36 (100%) patients at the end of 1 month. Corneal edema, AC flare, vitreous hemorrhage, and increase in intraocular pressure were some of the complications that were noted in the immediate postoperative period. However, all the complications had resolved at the end of 1 month.\u0000Conclusion: From this study, we can conclude that combined anterior vitrectomy and scleral-fixated sutured PCIOL implantation is an effective and safe procedure to correct aphakia in eyes without adequate capsular support. It provides excellent visual outcome with less postoperative complications. Furthermore, it is a superior alternative to ACIOLs and iris-fixated IOLs as it decreases the complications such as bullous keratopathy, UGH syndrome, iritis, and CME.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TO MONITOR THE ADVERSE DRUG REACTIONS ASSOCIATED WITH THE USE OF ANTIHYPERTENSIVE AGENTS IN A TERTIARY CARE HOSPITAL IN CENTRAL KERALA","authors":"Ashin T Senoj, Santosh Pillai, Sajit Varghese, Nisha Kurian, Jithin Yesudas, Jomon S John, Liya Roslin, Joseph","doi":"10.22159/ajpcr.2024v17i7.50010","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.50010","url":null,"abstract":"Objective: The objective of the study is to monitor the adverse drug reactions (ADRs) due to anti-hypertensive drugs prescribed in a tertiary care hospital.\u0000Methods: The study was conducted in the outpatient department of General Medicine of a tertiary care hospital in Kerala. The demographic details and suspected ADRs were collected from the patients and evaluated, and causality assessment was done.\u0000Results: More women developed ADRs compared to men due to the anti-hypertensive drug. The occurrence of adverse reactions was seen to be more in older patients over 50 years of age compared to younger individuals. The occurrence of ADR was more in patients using a combination of drugs (74.3%) rather than monotherapy. Calcium channel blockers were associated with more number of adverse reactions (62.5%) with amlodipine showing the maximum ADRs (64.8). The commonly seen ADR was edema. When the causality assessment was done, most were probable/likely followed by possible.\u0000Conclusion: This study shows that calcium channel blockers were the therapeutic class of drugs that caused the most number of ADRs, especially pedal edema; there was a higher frequency of ADRs to various antihypertensive drugs. Females and those more than 50 years old had shown a higher proportion of ADRs though not statistically significant. Furthermore, those individuals who took more drugs to treat hypertension also showed more ADRs. This study of adverse reactions toward antihypertensive medications will help physicians to choose a better option to treat their patients which will eventually help in patient satisfaction and medication safety.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141671062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-directed Learning for Medical Students","authors":"Vaishali Jain","doi":"10.22159/ajpcr.2024v17i7.51065","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.51065","url":null,"abstract":"“The integration of Competency-Based Medical Education (CBME) into the medical curriculum in 2019 marked a significant shift in medical education in India. This approach emphasizes the acquisition of specific competencies deemed essential for medical practice, thereby necessitating innovative pedagogical strategies to foster comprehensive learning among medical students. One such pivotal component introduced within the updated curriculum is self-directed learning (SDL), recognized as a vital means to cultivate lifelong learning skills and adaptability in medical professionals. Against this backdrop, the book on \"Self-directed Learning for Medical Students\" authored by Dr. Kailash Charokar, MS, MBA(HA), PGDHA, CMCL-FAIMER Fellow, NMC ACME; Dr. Vishnu Pal, PhD (Med Anatomy), NMC ACME; Dr. Yuganti Vaidya, MD(Anatomy), NMC ACME; and Dr. Tukaram Prabhu K, Msc. Medical Microbiology emerges as a timely useful resource. The contributors are experienced faculty members of the institutional medical education unit with special interest in Self-directed learning in CMBE (SDL Study Circle Team). The team has experience and supports the implementation of longitudinal educational project study in the different phases of undergraduate CBME MBBS Curriculum in the subject disciplines.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METABOLIC SYNDROME AND RISK OF CARDIOVASCULAR DISEASE WITH THYROID DISORDER","authors":"Ravi Shankar, Neha Sharma, Ajay Kumar, Raju Ram, Aparajita Kushwaha","doi":"10.22159/ajpcr.2024v17i7.51844","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.51844","url":null,"abstract":"Objectives: Metabolic syndrome (MetS) is the most widely used term for the aggregation of metabolic abnormalities, which leads to an increase in the risk of developing cardiovascular pathology. The prevalence of MetS is increasing all over the world with distinct evidence of high prevalence in India and other South Asian countries. Thyroid dysfunction, prominently subclinical hypothyroidism, has been observed more frequently in patients of MetS than in the general population.\u0000Methods: This cross-sectional, observational study was conducted among MetS patients in the general population and near and dear of patients (350) at the Pacific Institute of Medical Sciences, Udaipur. For the determination of gastric peptidases (ghrelin and obestatin), insulin was done by enzyme-linked immunosorbent assay. Thyroid hormones are determined by chemiluminescence.\u0000Results: The key findings in this analysis are the significant negative correlation between insulin and ghrelin. This inverse relationship was observed in individuals without cardiovascular disease (CVD), suggesting that even in the absence of overt CVD, insulin may play a role in regulating ghrelin levels. This finding is particularly noteworthy given ghrelin’s role in appetite regulation and energy balance.\u0000Conclusion: The findings emphasize the need for a holistic approach to health assessment and management, considering individual factors such as age, sex, and the presence of underlying health conditions along with thyroid disorders.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141836655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CROSS-SECTIONAL STUDY TO ASSESS THE COMPLIANCE TO IRON FOLIC ACID TABLETS AMONG WOMEN ATTENDING ANTENATAL CLINIC","authors":"S. S, Santosh M. Biradar, Vinod S Kamble, S. B","doi":"10.22159/ajpcr.2024v17i7.50042","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.50042","url":null,"abstract":"Objective: As anemia is highly prevalent among pregnant women, the government of India took the initiative to start prophylactic iron folic acid tablets (IFA) to reduce its prevalence. Hence, this study was done with the objectives to assess compliance to IFA among antenatal women and to identify the associated factors.\u0000Methods: The present study was a cross-sectional study conducted among 100 women attending antenatal clinics. A pre-designed semi-structured questionnaire was used to collect the data. The data were analyzed for frequency, percentage, and Chi-square.\u0000Results: The compliance to IFA was found to be 46.15% and was significantly more in anemic pregnant women.\u0000Conclusion: The prevalence of compliance to IFA tablets was only 46.15%. Hence, counseling and awareness to be done about the importance of taking IFA tablets regularly during the antenatal period, so that compliance can be improved.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE STUDY BETWEEN EARLY AND LATE LAPAROSCOPIC CHOLECYSTECTOMY IN TREATMENT OF ACUTE CHOLECYSTITIS IN BUNDELKHAND REGION","authors":"Manoj Kumar, Ramesh Chandra Arun","doi":"10.22159/ajpcr.2024v17i7.51349","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.51349","url":null,"abstract":"Objectives: Laparoscopic cholecystectomy is considered the procedure of choice for patients presenting with acute cholecystitis. The following study is an attempt to compare the outcome and operative complications of early versus late laparoscopic cholecystectomy in patients presenting with acute cholecystitis in a tertiary care center in Banda district of bundelkhand region.\u0000Methods: The present study involved a review of case records of 80 patients with the clinical diagnosis of acute cholecystitis, admitted in the surgical wards of a tertiary care center of Banda district during the period from January 2023 to December 2023 who underwent laparoscopic cholecystectomy on an elective basis. Participants were divided into two groups, Group A (early laparoscopic cholecystectomy) and Group B (delayed laparoscopic cholecystectomy) containing 40 patients each. The hospital records of these patients were reviewed and analyzed.\u0000Results: The present study showed statistically significant differences in age distribution and duration of surgery. The average duration of surgery was 42.3±8.97 min in Group “A” and 53.5±9.87 min for Group “B.” Male-to-female ratio was 2:1. The rate of conversion was found to be 2.5% in Group “A” as compared to 10% in Group “B.” Post-operative complications such as wound infection and biliary leakage were more common in Group “B” in comparison of Group “A.”\u0000Conclusion: Early cholecystectomy can be considered a safe and better method of treatment for acute cholecystitis due to its shorter hospital stay, avoidance of readmission to hospital, and decreased overall costs of treatment which is a major economic benefit to both the patient and health care system in comparison of late cholecystectomy.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECT OF INTRAVENOUS LIGNOCAINE ON HEMODYNAMIC VARIABLES DURING INTRAOPERATIVE AND POST-OPERATIVE PERIOD","authors":"Sheetal Khandekar, Sanjiv Titler, Shyambaran, Rakesh Dr, Ravindra Singh","doi":"10.22159/ajpcr.2024v17i7.50823","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.50823","url":null,"abstract":"Objectives: The objective of this study was to assess the efficacy of intravenous lignocaine on hemodynamic variables during intraoperative and post-operative periods and in relieving post-operative pain in major abdominal surgery.\u0000Methods: To investigate the effects of lidocaine, we designed a double-blind study. We enrolled 100 patients of ASA Grade I or II slated for major abdominal procedures. Each participant received either lidocaine or a saline placebo intravenously. After surgery, we monitored their pain levels, vital signs, and any potential side effects.\u0000Results: Our study revealed clear differences in heart rate, blood pressure (both systolic and diastolic), and overall arterial pressure between the lidocaine and placebo groups. Notably, the lidocaine group experienced fewer side effects, such as nausea, vomiting, headache, and shivering, compared to the control group.\u0000Conclusion: Intravenous lidocaine reduces intraoperative and post-operative pulse rate and blood pressure in major abdominal surgery. It delays analgesic needs and lowers the incidence of nausea, vomiting, chills, and headache compared to controls.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141671209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OUTCOMES OF PRP INJECTION THERAPY IN SUBACROMIAL SPACE IN PARTIAL TEARS OF ROTATOR CUFF","authors":"HARMANPREET SINGH, SAHIL VERMA, KSHITIJ MEHTA, DALJINDER SINGH, DHARMINDER SINGH, GIRISH SAHNI, Simran","doi":"10.22159/ajpcr.2024v17i7.50682","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.50682","url":null,"abstract":"Objective: The aim of the study was to record the outcomes of the platelet-rich plasma (PRP) injection therapy in the subacromial area in cases of partial rotator cuff (RC) tears on controlling pain and improving shoulder mobility and performing daily activities with ease.\u0000Methods: The study was conducted in the Orthopedics branch of Government Medical College and Rajindra Hospital Patiala on a total of 50 patients (aged more than 20 years) who presented in the emergency and Outpatient Department with symptoms of anterolateral shoulder pain and decreased range of motion at shoulder joint, who had not responded to conservative management and physiotherapy measures for consecutive 3 months. The patients were subjected to magnetic resonance imaging of the affected shoulder and those who showed partial cuff tears were considered for the study. Every consenting patient was given a PRP injection by posterior approach into the subacromial space. Patients were then followed up subsequently after 1 month, 6 months, 12 months, and 24 months for resolution of symptoms and improved painless activities at the shoulder. The outcome was assessed based on Visual Analog Scale (VAS) system and constant shoulder scoring system.\u0000Results: Comparison of the patients before and after injection therapy revealed a significant difference in VAS and constant shoulder scale at all the follow-up times with maximum improvement at the longest follow-up period.\u0000Conclusion: Injection of PRP in subacromial space was found safe and effective in enhancing overall life quality with the betterment of symptoms in patients with anterolateral shoulder pain, and thus, improving efficiency of work, shoulder functioning in patients having partial RC tears irrespective of its cause with its beneficial effects more at long term.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ROLE OF POLIDOCANOL IN PERCUTANEOUS SCLEROTHERAPY IN TREATMENT OF ANEURYSMAL BONE CYST – A SINGLE-CENTER STUDY","authors":"PAVAN KUMAR BABU, S. S, AJAY RAIDU G, UMA SHANKAR","doi":"10.22159/ajpcr.2024v17i7.50704","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.50704","url":null,"abstract":"Objectives: To study the clinical and radiological outcomes in patients treated with 3% polidocanol as a sclerosing agent in percutaneous sclerotherapy for aneurysmal bone cyst (ABC).\u0000Methods: This is a single-centered retrospective study conducted in the Department of Orthopaedics at Kurnool Medical College with 23 patients from 2018 to 2021 over 3 years, where 3% polidocanol was used as a sclerosing agent in percutaneous sclerotherapy as a treatment option for ABC. Postoperatively, patients are evaluated based on clinical and radiological examinations.\u0000Results: Clinically, patients were compared to their own Visual Analog Score (VAS) at the time of healing to the VAS score during their first visit. The mean VAS during the first visit was 7.6. At the time of healing, there were only two patients who scored a score of 1 on the VAS. Radiologically, plain radiographs were observed for ossification. 20 (86.9%) patients achieved complete ossification, 2 (8.69%) patients could achieve partial ossification.\u0000Conclusion: With this study, we would like to present that percutaneous sclerotherapy with 3% polidocanol is effective both clinically and radiologically in the treatment of ABCs. Our institution has adopted sclerotherapy as part of salvage therapy and as the first line of treatment in treating ABC tumors.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141671606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}