Asian Journal of Pharmacy and Technology最新文献_第7页

Synthesis of Zinc Oxide Nano particles from Moringa Tree leaves by Green Method and also check its Antibacterial activity against Gram Positive and Gram Negative Bacteria 用绿法合成辣木叶氧化锌纳米颗粒，并对其对革兰氏阳性菌和革兰氏阴性菌的抑菌活性进行研究

Asian Journal of Pharmacy and Technology Pub Date : 2022-08-10 DOI: 10.52711/2231-5713.2022.00035

S. Sehar, Mohsin Ali Khan, Amiza Amiza, Touqir Hussain, M. Zahid, Moazina Mobeen, Imran Raza, Minnatullah Minnatullah

引用次数: 0

A QBD Approach in Chemometric assisted Method Development of Telmisartan and Amlodipine besylate by UV-VIS Spectrophotometry 紫外-可见分光光度法测定替米沙坦和苯磺酸氨氯地平的QBD方法

Asian Journal of Pharmacy and Technology Pub Date : 2022-08-10 DOI: 10.52711/2231-5713.2022.00036

G. Dyade, Pooja Garad, Pallavi Jadhav

引用次数: 0

Formulation Optimization and Evaluation of Push Pull Osmotic Pump Tablet of Vildagliptin 维格列汀推拉式渗透泵片处方优化及评价

Asian Journal of Pharmacy and Technology Pub Date : 2022-08-10 DOI: 10.52711/2231-5713.2022.00034

B. M. M., Ashwini V. Patil, Ubhale R. J., Barhate S. D., M. Nasir

{"title":"Formulation Optimization and Evaluation of Push Pull Osmotic Pump Tablet of Vildagliptin","authors":"B. M. M., Ashwini V. Patil, Ubhale R. J., Barhate S. D., M. Nasir","doi":"10.52711/2231-5713.2022.00034","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00034","url":null,"abstract":"Purpose- The present study was to develop an oral push-pull osmotic pump tablet of vildagliptin, DPP-IV inhibitor drug; which is BCS class I drug. Method- The tablets were prepared by the wet granulation method using polyox and osmotic agent NaCl. The granules were compressed into bilayered tablet by conventional compression machine. The bilayered core osmotic tablets were coated with cellulose acetate in a conventional pan coating. In-vitro dissolution was evaluated using USP dissolution apparatus II in 0.1 N HCl pH 1.2 buffers for 2 hrs and phosphate buffer pH 7.5 for 22 hrs respectively. The formulated optimized batch VP1 were kept to stability studies for 3 months. Result- The formulated optimized batch VP1 of PPOP tablet shows 2hrs lag time with zero order release kinetic. In –vitro drug release was obtained 91.45 % up to 22hrs respectively. Polyox in push-pull layer along with osmotic agent and cellulose acetate controlled the drug release pattern from formulated PPOP tablet. No significant changes were observed upto the period of 3 months of storage during stability study. Conclusion- The PPOP tablet of vildagliptin was able to deliver the drug in controlled pattern over a long period of time by the process of osmosis. Conventional compression and pan coating method can be used to prepare PPOP tablet successfully.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83232857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The mRNA Vaccine Heralds a New Era in Vaccinology mRNA疫苗预示着疫苗学的新时代

Asian Journal of Pharmacy and Technology Pub Date : 2022-08-10 DOI: 10.52711/2231-5713.2022.00042

Ketaki Shinde, Sonam Bendre, Niraj Kale, Suhit S. Gilda

{"title":"The mRNA Vaccine Heralds a New Era in Vaccinology","authors":"Ketaki Shinde, Sonam Bendre, Niraj Kale, Suhit S. Gilda","doi":"10.52711/2231-5713.2022.00042","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00042","url":null,"abstract":"Vaccination has had a significant impact on infectious diseases control. However, there are still a number of infectious diseases for which an effective vaccine has yet to be developed. There has been a lot of interest in RNA-based technologies for the creation of therapeutic vaccines over the last two decades. The adaptability of mRNA vaccines, as well as their potential to trigger cellular and humoral responses, are among their benefits. Furthermore, because of their intricate interaction with pattern recognition receptors (PRRs), mRNAs have inherent adjuvant qualities. This identification can be advantageous in terms of stimulating antigen-presenting cells (APCs) or harmful in terms of limiting mRNA translation indirectly. We highlight how numerous innate response mechanisms are triggered by mRNA molecules, and how each element, from the 5' cap to the poly-A tail, interferes with innate/adaptive immune responses. mRNA vaccines have the ability to be developed quickly and to be a strong tool in the fight against infectious illnesses. This article provides a thorough overview of mRNA vaccines, including recommendations for future mRNA vaccine development, as well as safety concerns and personalised vaccines. We focused on mRNA delivery and immunological activation, both which have important role for successful mRNA vaccination.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78734105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Review: Health Benefits of Herbal Plants in Nutraceuticals 草本植物在营养药品中的健康益处综述

Asian Journal of Pharmacy and Technology Pub Date : 2022-08-10 DOI: 10.52711/2231-5713.2022.00045

A. Anamika, Vandita Chauhan, A. Nautiyal

{"title":"A Review: Health Benefits of Herbal Plants in Nutraceuticals","authors":"A. Anamika, Vandita Chauhan, A. Nautiyal","doi":"10.52711/2231-5713.2022.00045","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00045","url":null,"abstract":"The term \"Nutraceutical\" comes from \"nutrition\" and \"pharmaceutical\". It is defined as a diet or part of a diet that provides health benefits of nutritious foods and helps prevent many diseases. Lifestyles have changed dramatically in the last 50 years as a result of urbanization, industrialization speed, and rapid change. These things have changed people's habits and forced them to eat fast, junk food. These habits directly affect our aspect of healthy eating and gradually reduce the amount and quality of nutrients. As a result of these changed eating habits, the population has increased the incidence of malnutrition, dementia and degenerative diseases. In recent years, people have become more concerned about health and health care. Nutraceuticals play an important role in boosting the immune system without damaging the body's natural immune system. Nutraceuticals are found in dietary supplements that offer additional health benefits also called medical diets, designer foods, active foods, and dietary supplements. Active foods are used to enhance certain bodily functions to prevent or treat infections. The medicinal plant contains many types of active phytochemicals that have therapeutic properties that address various health problems. This review explores the information available in the literature regarding health benefits of nutraceuticals and many other herbal plants. So here, an attempt is made to highlights the significance or importance of nutraceuticals and herbal plants with respect to health diseases and many other problems related to health. Therefore, the future nutraceutical program focuses on specific diagnostic models, clinical studies in humans, understanding the exact mechanism of action that is useful in the prevention and treatment of diseases. Nutraceuticals has demonstrated health benefits and immunity which should be taken as recommended.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72857072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An Overview on Mini Tablets Mini平板电脑概述

Asian Journal of Pharmacy and Technology Pub Date : 2022-08-10 DOI: 10.52711/2231-5713.2022.00043

Shubhangi Kodag, Swaranjali Gaikwad, Sunayana Mali, A. Mali

引用次数: 0

Potential of naturally occurring Mucoadhesive polymer in Vaginal infection 天然黏附聚合物在阴道感染中的潜在作用

Asian Journal of Pharmacy and Technology Pub Date : 2022-08-10 DOI: 10.52711/2231-5713.2022.00041

Ishwar Singh, Jatin Sharma, I. Kumar, Shivali Singla, Amitabh B Chaudhary, Sunny Dhiman

引用次数: 0

Design and Evaluation of Solid Lipid Microparticles of Curcumin for the Treatment of Alzheimer’s Disease 姜黄素固体脂质微粒治疗阿尔茨海默病的设计与评价

Asian Journal of Pharmacy and Technology Pub Date : 2022-08-10 DOI: 10.52711/2231-5713.2022.00032

Aarti Bhati, Sanjeev Kumar, Renu Chaudhary, Sarvesh Kumar, Alimuddin Saifi

{"title":"Design and Evaluation of Solid Lipid Microparticles of Curcumin for the Treatment of Alzheimer’s Disease","authors":"Aarti Bhati, Sanjeev Kumar, Renu Chaudhary, Sarvesh Kumar, Alimuddin Saifi","doi":"10.52711/2231-5713.2022.00032","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00032","url":null,"abstract":"A solid lipid Microparticle reaches to the target site at controlled rate and show controlled release for better therapeutic result. This drug delivery system are prepare to obtained prolonged sustained or controlled drug delivery, to improves bioavailability, to enhance stability and to reduce toxic effects follows with target drug at specific site. The solid lipid micro particles of curcumin were prepared in a view to achieve high permeability of curcumin in brain through blood-brain-barrier. The solid lipid microspheres are prepared by hot melts microencapsulation technique was used to formulate solid lipid microspheres. Twelve formulations were prepared by varying concentration of surfactants (span 20, span 60, span 80 and Tween 80). The developed formulation were subjected to various parameter such as the particle size, % entrapment efficiency, production yield, % cumulative release, percentage yield and drug loading. Based upon highest entrapment efficiency, drug release and % cumulative release the F3 formulation was considered as the best formulation. The prepared microsphere were subjected to different evaluation parameter such as melting point, thin layer chromatography, solubility, FTIR, compatibility study and In-vitro drug release. The developed formulation shows spherical and smooth surface. The % drug release of F3 formulation was found to be 86.23% after 12 hr.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83799567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-Vitro, In-Vivo Evaluation of Floating Tablets of Clarithromycin. 克拉霉素漂浮片的体外、体内评价。

Asian Journal of Pharmacy and Technology Pub Date : 2022-08-10 DOI: 10.52711/2231-5713.2022.00037

Manojkumar Patil, A. Mali, S. Mali

{"title":"In-Vitro, In-Vivo Evaluation of Floating Tablets of Clarithromycin.","authors":"Manojkumar Patil, A. Mali, S. Mali","doi":"10.52711/2231-5713.2022.00037","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00037","url":null,"abstract":"The main purpose of this research work was to design and process optimization of oral floating drug delivery system of Clarithromycin floating tablets by using the hydrophilic polymer Hydroxylpropyl methyl cellulose and gas generating agent sodium bicarbonate and citric acid. A 32 randomized full factorial design was used to study. In this design 2 factors were evaluated, each at 3 levels and experimental trials were performed at all 9 possible combinations. The independent and dependent variables are selected for optimization study. The radio-labelled floating tablets were prepared by adding barium sulphate in the optimized formulations for in- vivo radiographic study. The Results of multiple regression analysis indicated that both factors X1 and X2 significantly affected on the dependent parameters. The formulation was optimized on the basis of floating ability and in-vitro drug release. It should be concluded that as the time increases, the swelling index was increased, because weight gain by tablet was increased proportionally with rate of hydration. In-vivo radiographic studies of the optimized formulations were performed using New Zeal Albino rabbits by X-ray imaging technique. The in-vivo X-ray imaging and radiographic studies clearly indicated that the prepared optimized floating tablets were retained in the rabbit stomach over a prolonged period of time and had good in-vivo performance. Radiological evidences suggest that the formulated floating tablets of antibiotics were well floated more than 6 h in rabbit stomach.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90293688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of Oxiconazole Topical Emulgel Formulation for the Treatment of Skin Infections 奥昔康唑外用乳状剂治疗皮肤感染的配方优化

Asian Journal of Pharmacy and Technology Pub Date : 2022-08-10 DOI: 10.52711/2231-5713.2022.00038

B. Hemalatha, T. P. Priya, K. Manasa, Ch. Greeshmika, P. Kavya, Shaik Sayeeda Sarah, K. Padmalatha

引用次数: 2