Asian Journal of Chemistry最新文献

{"title":"Assessment and Mitigation Strategies for Heavy Metals and Bacterial Contamination in Badshahpur Lake, Gurugram, India","authors":"Pooja Dua, A. Chauhan, Anuj Ranjan, Ritu Chauhan, Amita G. Dimri, T. Jindal","doi":"10.14233/ajchem.2024.31640","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31640","url":null,"abstract":"This study aims to assess the microbial load and heavy metals contamination in water samples from Badshahpur lake situated in Gurugram city, India across three zones. A total of 132 water samples were collected: 47 from zone 1, 40 from zone 2 and 45 from zone 3. The microbial load was quantified as total bacterial count (TBC) and concentrations of heavy metals viz. cadmium (Cd), copper (Cu), lead (Pb), chromium (Cr), arsenic (As), mercury (Hg), tin (Sn) and methyl mercury (MM) were measured using ICP-OES. In zone 1, TBC ranged from 5.2 × 103 to 3.7 × 109 CFU/mL, with the highest microbial load at IEWS-A11. Cadmium level was recorded higher at 0.044 mg/L at IEWS-A21 and copper concentrations reached 0.091 mg/L at IEWS-A18. Lead and chromium were also detected, with concerning levels of 0.039 mg/L and 0.031 mg/L, respectively. Zone 2 showed TBC from 4.0 × 104 to 6.7 × 108 CFU/mL, with significant heavy metal concentrations, particularly copper at 0.088 mg/L and cadmium at 0.038 mg/L. Zone 3 exhibited TBC ranging from 4.0 × 103 to 5.1 × 108 CFU/mL, with the highest cadmium concentration of 0.046 mg/L at IEWS-C25 and copper at 0.086 mg/L at IEWS-C12. Among all bacteria tested, the ubiquitous presence of E. coli across all zones indicates widespread faecal contamination. The results emphasize the areas with significant levels of heavy metal pollution, highlighting the importance of consistent monitoring of water quality, improved water treatment methods, and enhanced sanitation infrastructure to reduce health hazards and safeguard the stability of the environment.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141802650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, In silico Study and Cytotoxicity Evaluation of Some Newly Synthesized Stilbene Derivatives","authors":"Dimple Pirgal, S. Karki, Sujeet Kumar, Basavraj Metikurki","doi":"10.14233/ajchem.2024.31942","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31942","url":null,"abstract":"A series of 12 stilbene derivatives (23-34) were synthesized by reacting benzyl-triphenylphosphonium chlorides (9-14) and hydrochloride salt of 3,5-disubstituted-4-hydroxybenzaldehydes (21-22). The synthesized molecules were tested against the human breast cancer cell line MCF7 by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in 10% Dulbecco’s modified Eagle Medium (DMEM). Compound 23 exhibited significant cytotoxicity, with 1.11% viability at a concentration of 200 µM, compared to the reference standard resveratrol (15.14%) and 5-fluorouracil (51.86%). All the synthesized derivatives demonstrated equipotency to 5-fluorouracil (5-FU) at all the tested concentrations. The docking study was conducted on the tyrosine-protein kinase/Janus Kinase 2(JAK2) receptor using Autodock Vina. The results of the docking study suggest that, with the exception of compounds 29 (-6.7 kcal/mol) and 32 (-7.1 kcal/mol), most of the synthesized derivatives have exhibited glide scores greater than the standard resveratrol (-7.8 kcal/mol). This implies that these compounds 23-34 have a strong binding affinity to the JAK2 receptor, which is relevant in the context of cancer research, as JAK2 is associated with various signaling pathways involved in cell proliferation and survival.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"27 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141802752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified QuEChERS-LC-MS/MS Method for Forensic Quantification and Validation of Acyclovir and Amantadine from Biological Matrices","authors":"Priyanka Gopi, Chintan Singh, Majji Sai Sudha Rani, R. K. Sarin, Prateek Pandya","doi":"10.14233/ajchem.2024.31691","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31691","url":null,"abstract":"Antiviral drugs exhibit various toxic effects such as teratogenicity, carcinogenicity and surprisingly neurotoxic effects that mimics that of drugs of abuse as indicated by the in silico toxicological studies performed and corroborated with published literature. Despite extensive studies on antiviral drugs, their forensic implications regarding individual toxicity, drug interactions, overdose and abuse have been overlooked. Consequently, there is a critical need to develop an analytical strategy for forensic detection of these antivirals. In this study, a simple and selective LC-MS/MS method is developed to determine toxic antivirals acyclovir and amantadine in urine, saliva and gastric fluid. The modified QuEChERS extraction was followed by chromatography on a C18 column with a gradient mobile phase of 5 mM ammonium formate and 0.1% formic acid in methanol. Detection was performed using a triple quadrupole tandem mass spectrometer. The validation of method, adhering to SWGTOX guidelines, demonstrated excellent linearity, precision and accuracy, covering a linear range of 5-200 ng/mL for both drugs. The limit of detection ranged from 14 to 20 ng/mL and the limit of quantification ranged from 40 to 63 ng/mL for acyclovir and amantadine. Finally, the validated method was successfully applied to the forensic detection of antiviral drugs in gastric lavage, exhibiting robustness and reproducibility.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"41 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"D-π-A based Diaminomalenonitrile Imine Compounds as Sensors: From Ion Recognition to Logic Arithmetic Applications","authors":"Wasseem Akbar, Bashir Ahmed, E. G. Naz, Purvee Bhardwaj, Imtiaz Ahmad Shah, M. A. Kaloo","doi":"10.14233/ajchem.2024.31914","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31914","url":null,"abstract":"In this review article, exciting highlights on highly π-conjugated (π-D-A) 2,3-diaminomaleonitrile (DAMN) based imines or Schiff base chemosensors have been reviewed and discussed. Owing to the typical free -NH2 anion recognition site and 1,2-ethylenediamine based chelating structure, both anion and cation sensing has been achieved with such designed molecules. It has been found that ion interactions strongly alter the electronic push-pull and hence intramolecular charge transfer (ICT) properties across the molecular system. So far such molecular recognition strategy has successfully detected ions like F–, CN– and Cu+2 in aqueous as well as non-aqueous media. Importantly, recognition is usually reversible and changes are clearly perceived through naked eyes. In this work, various sensing aspects like mechanism of interaction, type of recognition, sensitivity, reversibility, binding constants and spectral changes (absorption and emission) have been thoroughly discussed. Herein, the designed and fabricated sensor reports have been arranged in systematic order since 2010 so that the reader gets complete and trending picture of how the developments have taken place in the area of this research. In last, essential shortcomings and future challenges existing with the current approaches have also been highlighted.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"51 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141805162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Characterization of Color Tunable Europium(III) and Terbium(III) Co-Doped LaSrAl3O7 Nanocrystalline Phosphors: A Photoluminescent Synergy","authors":"D. Dhaterwal, M. Matoria, A. Dalal, Surender Kumar, Sonika Singh","doi":"10.14233/ajchem.2024.32115","DOIUrl":"https://doi.org/10.14233/ajchem.2024.32115","url":null,"abstract":"Color tunable La0.99-xEuxTb0.01SrAl3O7 (x = 0.01-0.07 mol) luminous nanocrystalline materials were synthesized using an affordable, simple, streamlined and self-propagating, urea-assisted solution combustion synthesis route. The X-ray powder diffraction pattern of optimized La0.95Eu0.04Tb0.01SrAl3O7 co-doped phosphor sintered at 900 ºC revealed the formation of single phased phosphor having tetragonal crystalline structure with P421m (113) space group. The field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) micrographs revealed agglomerates featuring spherical-shaped porous nanoparticles with interconnect boundaries and smooth surface. The basic composition was determined via scrutiny of energy dispersive X-ray (EDAX) spectrum. Observations of diffuse reflectance spectroscopy were analyzed to determine the optical band gap values of synthesized Eu3+/Tb3+ co-doped LaSrAl3O7 nanocrystalline luminescent materials. To explore how dopant concentration affected the luminous intensity of phosphors, a thorough examination of the photoluminescence excitation and emission spectra of La0.99-xEuxTb0.01SrAl3O7 (x = 0.01-0.07 mol) was executed. The analysis of luminescence spectra demonstrated that Tb3+ efficiently sensitized the Eu3+ ion. The critical distance (Rc) was calculated to be 5.576 Å and it emerged that non-radiant energy loss occurrence i.e. concentration quenching observed after x = 0.04 mol (Eu3+) doping in La0.99-xEuxTb0.01SrAl3O7 (x = 0.01-0.07 mol) co-doped phosphors was induced by the dipole-quadrupole (d-q) interactions. Moreover, colorimetric attributes including Commission International de I'Eclairage 1931 color coordinates (x, y), color purity and correlated color temperature were obtained by utilization their emission data. The derived nanophosphor materials photometric traits enable new design opportunities for upgraded luminous materials that can be utilized in field emission displays, diverse luminous sources, photonic appliances, phosphor converted light emitting diodes, full-color displays and numerous lighting devices.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"38 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141804108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Synthesis of Novel Quinazolin-4(3H)-One Appended 1,2,4-Oxadiazoles as Antimicrobial Agents","authors":"Nagaraju Myakala, Kotaiah Kandula, Nagamani Rayala, Satheesh Kuna, Vishnu Thumma, A. Bhavani","doi":"10.14233/ajchem.2024.31907","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31907","url":null,"abstract":"A novel series of hybrid heterocycles having quinazolinone based 1,2,4-oxadiazoles scaffold with methylamino linkage were obtained in two synthetic pathways. In method I, quinazolinone based ester reacted with amidoximes and gave the corresponding hybrid products in poor yields. To reduce the duration of reaction time and increase the yields of the products, dehydrochlorination reaction of 6-aminoquinazolinone was carried out with 5-chloromethyl-1,2,4-oxadiazoles in other synthetic method, which furnished the products in good to excellent yields. The synthesized 1,2,4-oxadiazole hybrids were characterized using spectroscopic techniques and also screened for their antimicrobial activity against bacteria and fungi, among which chloro-substituted analogues 6d and 6e presented potent activity against all strains whereas other analogues proven to have moderate activities.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"38 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141805311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triton X-100 Mediated Electron Transfer Reactions between Iron(III) Polypyridyl Complexes and Phenylsulfinylacetic Acids","authors":"R. J. E. Rathnakumari, C. Kavitha, J. J. S. Jaba Rose, P. Subramaniam, V. Vetriselvi","doi":"10.14233/ajchem.2024.31880","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31880","url":null,"abstract":"Oxidative decarboxylation of phenylsulfinylacetic acids (PSAAs) by iron(III) polypyridyl complexes in non-ionic surfactant Triton X-100 medium has been investigated spectrophotometrically. An initial intermediate formation between PSAA and [Fe(NN)3]3+ is confirmed from the observed Michaelis–Menten kinetics and fractional order dependence on PSAA. Applying the Hammett substituent constants to the overall rate constants obtained in TX-100 medium gives non-linear concave upward Hammett plots. A suitable mechanism involving the formation of diphenyl sulphone as product has been proposed. The observed increase in rate with increase in concentration of TX-100 at low concentration range, clearly shows that the reaction takes place in micellar medium and both the reactants are associated or incorporated into micellar phase.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"86 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141802489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanogold Supported Titania Loaded SBA-15: An Efficient Catalyst for Reduction of 4-Nitrophenol","authors":"Soumini Chandralayam, Sugunan Sankaran","doi":"10.14233/ajchem.2024.31767","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31767","url":null,"abstract":"Gold nanoparticles with an average particle size below 5 nm were effectively dispersed over titania loaded SBA-15. The nanogold supported systems were found to be highly effective in the liquid phase reduction of 4-nitrophenol to 4-aminophenol at room temperature (304 K) obeying pseudo-first-order kinetics. The highly effective catalyst with 3 wt.% Au incorporation to 20 wt.% Ti loaded SBA-15 (3Au/20Ti/SBA) showed a TON of 5.8 × 1021 molecules/g and a TOF of 6.5 × 1018 molecules/g/s in the reaction.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"82 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141802506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Isoniazid to 2-Pyrazolines: Synthesis, In silico Behaviour and Antimicrobial Activity","authors":"Geetha Birudala, Gurinderdeep Singh, S. A. R. Junaid Nayeem, S. Padmavathi, Srinivasa Rao Pingali, Vaishali, R. Dighe","doi":"10.14233/ajchem.2024.31666","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31666","url":null,"abstract":"This study explores the synthesis, in silico behaviour and antimicrobial activity of isoniazid derived 2-pyrazolines as potential drugs for tuberculosis and bacterial infections. The investigation encompasses the synthesis, computational studies for molecular behaviour and antimicrobial efficacy assessment. Incorporating established drugs like isoniazid is explored to enhance their pharmacological properties. The synthesized compounds were characterized by analytical techniques such as IR, NMR, mass spectral analysis and elemental analysis. Synthesized pyrazolines 4a-j were evaluated for in vitro antitubercular and antibacterial activities against various biological strains. In silico analysis provides valuable insights into ADMET descriptors, confirming good pharmacokinetic properties. This suggests these compounds as templates for developing new anti-mycobacterial agents, guiding the design of novel compounds with improved therapeutic potential.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"21 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141802968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinetic Modeling of Sodium Bicarbonate Pre-treatment of Corn Stalks for Increased Biogas Generation during Anaerobic Digestion: Viability and Fertilizer Potential","authors":"Md. Nurul Islam Siddique, Z. B. Khalid, Md. Zamri Bin Ibrahim, N. Ali, N. Rasit, Muhammad Syarifuddin Yahya, Sajal Kumar Adhikary","doi":"10.14233/ajchem.2024.31820","DOIUrl":"https://doi.org/10.14233/ajchem.2024.31820","url":null,"abstract":"Sustainability in terms of the economy and the environment is severely hampered by poor waste management in the industrial sectors and a lack of renewable energy sources to meet expanding energy demands. To address this issue, the influences of sodium bicarbonate treatment on biogas generation during the anaerobic fermentation of corn stalks were analyzed. The application of sodium bicarbonate (9%, w/w) resulted in a significantly higher generation of 14692 mL biogas with a production of 223 mL/g, which was 30% higher than the untreated sample biogas generation. Surprisingly, chemical oxygen demand elimination was boosted by a factor of ten. In addition, sodium bicarbonate stabilized the pH of fermented corn stalks. The Gompertz modeling, according to the findings, had a significant correlation coefficient (> 0.995) and fit the accumulative biogas production trends well. Sludge recapture from the fermented effluent was 0.08 m3 sludge/m3 wastewater. Sodium bicarbonate added to corn stalks may increased the cumulative methane production while lowering chemical oxygen demand (COD) levels.","PeriodicalId":8494,"journal":{"name":"Asian Journal of Chemistry","volume":"21 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141802976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}