Asian Journal of Andrology最新文献_第7页

Characterization of the protein expression and localization of hnRNP family members during murine spermatogenesis. 小鼠精子发生过程中hnRNP家族成员蛋白表达和定位的研究。

IF 2.9 2区医学

Asian Journal of Andrology Pub Date : 2023-05-01 DOI: 10.4103/aja202273

Xiao-Li Wang, Jin-Mei Li, Shui-Qiao Yuan

引用次数: 2

Clinical significance of distally located periurethral calcification in patients with lower urinary tract symptoms of benign prostate hyperplasia. 下尿路良性前列腺增生患者尿道周围远端钙化的临床意义。

IF 2.9 2区医学

Asian Journal of Andrology Pub Date : 2023-05-01 DOI: 10.4103/aja202245

Seong Hyeon Yu, Do Gyeong Lim, Sun-Ouck Kim

{"title":"Clinical significance of distally located periurethral calcification in patients with lower urinary tract symptoms of benign prostate hyperplasia.","authors":"Seong Hyeon Yu, Do Gyeong Lim, Sun-Ouck Kim","doi":"10.4103/aja202245","DOIUrl":"https://doi.org/10.4103/aja202245","url":null,"abstract":"This study evaluated the association of periurethral calcification (PUC) with uroflowmetric parameters and symptom severity in male patients with lower urinary tract symptoms (LUTS) of benign prostatic hyperplasia (BPH). The data were collected from a prospectively maintained database of 1321 men with LUTS of BPH who visited Chonnam National University Hospital (Gwang-ju, Korea) from January 2015 to December 2019. PUC severity and location were evaluated on the midsagittal plane during transrectal ultrasonography. Relationships among age, prostate-related parameters, International Prostate Symptom Score (IPSS), and uroflowmetric parameters were assessed. Among the 1321 patients in this study, 530 (40.1%) had PUC. Patients with PUC had significantly higher IPSS (mean ± standard deviation [s.d.]: 15.1 ± 8.7 vs 13.1 ± 7.9; P < 0.001) and lower peak flow rate (Qmax; mean ± s.d.: 12.4 ± 6.6 ml s-1 vs 14.7 ± 13.3 ml s-1; P < 0.001), compared with patients who did not have PUC. Analyses according to PUC severity revealed that patients with severe PUC had higher prostate-specific antigen (PSA) level (P = 0.009), higher total IPSS (P < 0.001), lower Qmax (P = 0.002), and smaller prostate volume (P < 0.001), compared with patients who had non-severe (mild or moderate) PUC. Multivariate analysis showed that distal PUC was independently associated with high total IPSS (P = 0.02), voiding symptom score (P = 0.04), and storage symptom score (P = 0.023), and low Qmax (P = 0.015). In conclusion, PUC was significantly associated with worse LUTS parameters in terms of IPSS and Qmax. Furthermore, distally located PUC was independently associated with worse LUTS of BPH in men.","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 3","pages":"361-365"},"PeriodicalIF":2.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cc/e6/AJA-25-361.PMC10226498.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9542406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetically predicted insomnia causally increases the risk of erectile dysfunction. 基因预测的失眠会增加勃起功能障碍的风险。

IF 2.9 2区医学

Asian Journal of Andrology Pub Date : 2023-05-01 DOI: 10.4103/aja202261

Yang Xiong, Fu-Xun Zhang, Yang-Chang Zhang, Chang-Jing Wu, Feng Qin, Jiu-Hong Yuan

{"title":"Genetically predicted insomnia causally increases the risk of erectile dysfunction.","authors":"Yang Xiong, Fu-Xun Zhang, Yang-Chang Zhang, Chang-Jing Wu, Feng Qin, Jiu-Hong Yuan","doi":"10.4103/aja202261","DOIUrl":"https://doi.org/10.4103/aja202261","url":null,"abstract":"Sleep has attracted extensive attention due to its significance in health. However, its association with erectile dysfunction (ED) is insufficiently investigated. To investigate the potential causal links between sleep traits (insomnia, sleep duration, and chronotype) and ED, this study was performed. The single-nucleotide polymorphisms (SNPs) associated with insomnia, sleep duration, and chronotype were retrieved from previous genome-wide association studies (GWAS). A conventional two-sample Mendelian randomization (MR) was used to estimate the causal links between sleep traits and ED. The summary statistics of ED were from individuals of European ancestry (6175 cases vs 217 630 controls). As shown by the random effect inverse-variance-weighting (IVW) estimator, genetically predicted insomnia was causally associated with a 1.15-fold risk of ED (95% confidence interval: 1.07–1.23, P < 0.001). Sleep duration and morningness were not causally associated with ED, as indicated by the IVW (all P > 0.05). These findings were consistent with the results of sensitivity analyses. Based on genetic data, this study provides causal evidence that genetically predicted insomnia increases the risk of ED, whereas sleep duration and chronotype do not.","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 3","pages":"421-425"},"PeriodicalIF":2.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c2/6e/AJA-25-421.PMC10226508.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9912852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Transrectal ultrasound examination of prostate cancer guided by fusion imaging of multiparametric MRI and TRUS: avoiding unnecessary mpMRI-guided targeted biopsy. 多参数MRI与TRUS融合成像引导下的前列腺癌经直肠超声检查:避免不必要的mpmri引导下的靶向活检。

IF 2.9 2区医学

Asian Journal of Andrology Pub Date : 2023-05-01 DOI: 10.4103/aja202276

Guang Xu, Jun-Heng Li, Li-Hua Xiang, Bin Yang, Yun-Chao Chen, Yi-Kang Sun, Bing-Hui Zhao, Jian Wu, Li-Ping Sun, Hui-Xiong Xu

{"title":"Transrectal ultrasound examination of prostate cancer guided by fusion imaging of multiparametric MRI and TRUS: avoiding unnecessary mpMRI-guided targeted biopsy.","authors":"Guang Xu, Jun-Heng Li, Li-Hua Xiang, Bin Yang, Yun-Chao Chen, Yi-Kang Sun, Bing-Hui Zhao, Jian Wu, Li-Ping Sun, Hui-Xiong Xu","doi":"10.4103/aja202276","DOIUrl":"https://doi.org/10.4103/aja202276","url":null,"abstract":"The purpose of this study was to explore transrectal ultrasound (TRUS) findings of prostate cancer (PCa) guided by multiparametric magnetic resonance imaging (mpMRI) and to improve the Prostate Imaging Reporting and Data System (PI-RADS) system for avoiding unnecessary mpMRI-guided targeted biopsy (TB). From January 2018 to October 2019, fusion mpMRI and TRUS-guided biopsies were performed in 162 consecutive patients. The study included 188 suspicious lesions on mpMRI in 156 patients, all of whom underwent mpMRI-TRUS fusion imaging-guided TB and 12-core transperineal systematic biopsy (SB). Univariate analyses were performed to investigate the relationship between TRUS features and PCa. Then, logistic regression analysis with generalized estimating equations was performed to determine the independent predictors of PCa and obtain the fitted probability of PCa. The detection rates of PCa based on TB alone, SB alone, and combined SB and TB were 55.9% (105 of 188), 52.6% (82 of 156), and 62.8% (98 of 156), respectively. The significant predictors of PCa on TRUS were hypoechogenicity (odds ratio [OR]: 9.595, P = 0.002), taller-than-wide shape (OR: 3.539, P = 0.022), asymmetric vascular structures (OR: 3.728, P = 0.031), close proximity to capsule (OR: 3.473, P = 0.040), and irregular margins (OR: 3.843, P = 0.041). We propose subgrouping PI-RADS score 3 into categories 3a, 3b, 3c, and 3d based on different numbers of TRUS predictors, as the creation of PI-RADS 3a (no suspicious ultrasound features) could avoid 16.7% of mpMRI-guided TBs. Risk stratification of PCa with mpMRI-TRUS fusion imaging-directed ultrasound features could avoid unnecessary mpMRI-TBs.","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 3","pages":"410-415"},"PeriodicalIF":2.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bb/15/AJA-25-410.PMC10226505.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9913364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Note: PlncRNA-1 induces apoptosis through the Her-2 pathway in prostate cancer cells. 注:PlncRNA-1通过Her-2通路诱导前列腺癌细胞凋亡。

IF 2.9 2区医学

Asian Journal of Andrology Pub Date : 2023-05-01 DOI: 10.4103/aja202318

Qing Yang, Zi-Lian Cui, Qin Wang, Xun-Bo Jin, Yong Zhao, Mu-Wen Wang, Wei Song, Hua-Wei Qu, Wei-Ting Kang

引用次数: 0

Biallelic mutations in WDR12 are associated with male infertility with tapered-head sperm. WDR12双等位基因突变与锥形头精子男性不育有关。

IF 2.9 2区医学

Asian Journal of Andrology Pub Date : 2023-05-01 DOI: 10.4103/aja202269

Juan Hua, Lan Guo, Yao Yao, Wen Hu, Yang-Yang Wan, Bo Xu

{"title":"Biallelic mutations in WDR12 are associated with male infertility with tapered-head sperm.","authors":"Juan Hua, Lan Guo, Yao Yao, Wen Hu, Yang-Yang Wan, Bo Xu","doi":"10.4103/aja202269","DOIUrl":"https://doi.org/10.4103/aja202269","url":null,"abstract":"Teratozoospermia is a rare disease associated with male infertility. Several recurrent genetic mutations have been reported to be associated with abnormal sperm morphology, but the genetic basis of tapered-head sperm is not well understood. In this study, whole-exome sequencing (WES) identified a homozygous WD repeat domain 12 (WDR12; p.Ser162Ala/c.484T>G) variant in an infertile patient with tapered-head spermatozoa from a consanguineous Chinese family. Bioinformatic analysis predicted this mutation to be a pathogenic variant. To verify the effect of this variant, we analyzed WDR12 protein expression in spermatozoa of the patient and a control individual, as well as in the 293T cell line, by Western blot analysis, and found that WDR12 expression was significantly downregulated. To understand the role of normal WDR12, we evaluated its mRNA and protein expression in mice at different ages. We observed that WDR12 expression was increased in pachytene spermatocytes, with intense staining visible in round spermatid nuclei. Based on these results, the data suggest that the rare biallelic pathogenic missense variant (p.Ser162Ala/c.484T>G) in the WDR12 gene is associated with tapered-head spermatozoa. In addition, after intracytoplasmic sperm injection (ICSI), a successful pregnancy was achieved. This finding indicates that infertility associated with this WDR12 homozygous mutation can be overcome by ICSI. The present results may provide novel insights into understanding the molecular mechanisms of male infertility.","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 3","pages":"398-403"},"PeriodicalIF":2.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d4/b5/AJA-25-398.PMC10226492.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9594902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Association between semen collection time and semen parameters: an observational study. 精液采集时间与精液参数之间的关系:一项观察性研究。

IF 2.9 2区医学

Asian Journal of Andrology Pub Date : 2023-05-01 DOI: 10.4103/aja202268

Shun Bai, Xian-Chao Dou, Hao-Lin Qi, Yan-Song Zhu, Yin-Tao Zhang, Yi-Xun Liu, Xue-Chun Hu, Cheng Cao, Xian-Hong Tong, Bo Xu, Li-Min Wu, Xiao-Hua Jiang

{"title":"Association between semen collection time and semen parameters: an observational study.","authors":"Shun Bai, Xian-Chao Dou, Hao-Lin Qi, Yan-Song Zhu, Yin-Tao Zhang, Yi-Xun Liu, Xue-Chun Hu, Cheng Cao, Xian-Hong Tong, Bo Xu, Li-Min Wu, Xiao-Hua Jiang","doi":"10.4103/aja202268","DOIUrl":"https://doi.org/10.4103/aja202268","url":null,"abstract":"The process of semen collection plays a key role in the quality of semen specimens. However, the association between semen collection time and semen quality is still unclear. In this study, ejaculates by masturbation from 746 subfertile men or healthy men who underwent semen analysis were examined. The median (interquartile range) semen collection time for all participants was 7.0 (5.0-11.0) min, and the median time taken for semen collection was lower in healthy men than that in subfertile men (6.0 min vs 7.0 min). An increase in the time required to produce semen samples was associated with poorer semen quality. Among those undergoing assisted reproductive technology (ART), the miscarriage rate was positively correlated with the semen collection time. After adjusting for confounders, the highest quartile (Q4) of collection time was negatively associated with semen volume and sperm concentration. A longer time to produce semen samples (Q3 and Q4) was negatively correlated with progressive and total sperm motility. In addition, there was a significant negative linear association between the semen collection time and the sperm morphology. Higher risks of asthenozoospermia (adjusted odds ratio [OR] = 2.06, 95% confidence interval [CI]: 1.31-3.25, P = 0.002) and teratozoospermia (adjusted OR = 1.98, 95% CI: 1.10-3.55, P = 0.02) were observed in Q3 than those in Q1. Our results indicate that a higher risk of abnormal semen parameter values was associated with an increase in time for semen collection, which may be related to male fertility through its association with semen quality.","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 3","pages":"339-344"},"PeriodicalIF":2.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/89/1b/AJA-25-339.PMC10226501.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9912876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutathione S-transferase genetic polymorphisms and fluoride-induced reproductive toxicity in men with idiopathic infertility. 特发性不育症男性谷胱甘肽s -转移酶遗传多态性和氟化物诱导的生殖毒性。

IF 2.9 2区医学

Asian Journal of Andrology Pub Date : 2023-05-01 DOI: 10.4103/aja202271

Jun He, Yi Mu, Miao Liu, Bang-Wei Che, Wen-Jun Zhang, Ke-Hang Chen, Kai-Fa Tang

{"title":"Glutathione S-transferase genetic polymorphisms and fluoride-induced reproductive toxicity in men with idiopathic infertility.","authors":"Jun He, Yi Mu, Miao Liu, Bang-Wei Che, Wen-Jun Zhang, Ke-Hang Chen, Kai-Fa Tang","doi":"10.4103/aja202271","DOIUrl":"https://doi.org/10.4103/aja202271","url":null,"abstract":"Male infertility caused by idiopathic oligoasthenospermia (OAT) is known as idiopathic male infertility. Glutathione S-transferase (GST) and fluoride may play important roles in idiopathic male infertility, but their effects are still unknown. Our study examined the relationship between GST polymorphisms and fluoride-induced toxicity in idiopathic male infertility and determined the underlying mechanism. Sperm, blood, and urine samples were collected from 560 males. Fluoride levels were measured by a highly selective electrode method, and GST genotypes were identified using polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP). Semen parameters, DNA fragmentation index (DFI), mitochondrial membrane potential (MMP), and oxidative stress (OS) biomarkers were statistically assessed at the P < 0.05 level. Compared with healthy fertile group, semen parameters, fluoride levels, OS biomarkers, sex hormone levels, and MMP and DFI levels were lower in the idiopathic male infertility group. For glutathione S-transferase M1 (GSTM1[-]) and glutathione S-transferase T1 (GSTT1[-]) or glutathione S-transferase P1 (GSTP1) mutant genotypes, levels of semen fluoride, OS, MMP, and DFI were considerably higher, and the mean levels of sperm parameters and testosterone were statistically significant in GSTM1(+), GSTT1(+), and GSTP1 wild-type genotypes. Both semen and blood fluoride levels were associated with oxidative stress in idiopathic male infertility patients. Elevated fluoride in semen with the genotypes listed above was linked to reproductive quality in idiopathic male infertility patients. In conclusion, GST polymorphisms and fluorine may have an indicative relationship between reproductive quality and sex hormone levels, and OS participates in the development of idiopathic male infertility.","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 3","pages":"404-409"},"PeriodicalIF":2.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/62/AJA-25-404.PMC10226502.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9912877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel homozygous frameshift variant in DNAH8 causes multiple morphological abnormalities of the sperm flagella in a consanguineous Pakistani family. 在巴基斯坦的一个近亲家庭中，一种新的DNAH8纯合子移码变异导致精子鞭毛的多种形态异常。

IF 2.9 2区医学

Asian Journal of Andrology Pub Date : 2023-05-01 DOI: 10.4103/aja202274

Sobia Dil, Asad Khan, Ahsanullah Unar, Meng-Lei Yang, Imtiaz Ali, Aurang Zeb, Huan Zhang, Jian-Teng Zhou, Muhammad Zubair, Khalid Khan, Shun Bai, Qing-Hua Shi

{"title":"A novel homozygous frameshift variant in DNAH8 causes multiple morphological abnormalities of the sperm flagella in a consanguineous Pakistani family.","authors":"Sobia Dil, Asad Khan, Ahsanullah Unar, Meng-Lei Yang, Imtiaz Ali, Aurang Zeb, Huan Zhang, Jian-Teng Zhou, Muhammad Zubair, Khalid Khan, Shun Bai, Qing-Hua Shi","doi":"10.4103/aja202274","DOIUrl":"https://doi.org/10.4103/aja202274","url":null,"abstract":"Multiple morphological abnormalities of the sperm flagella (MMAF) is a severe form of asthenozoospermia categorized by immotile spermatozoa with abnormal flagella in ejaculate. Whole-exome sequencing (WES) is used to detect pathogenic variants in patients with MMAF. In this study, a novel homozygous frameshift variant (c.6158_6159insT) in dynein axonemal heavy chain 8 (DNAH8) from two infertile brothers with MMAF in a consanguineous Pakistani family was identified by WES. Reverse transcription-polymerase chain reaction (RT-PCR) confirmed DNAH8 mRNA decay in these patients with the DNAH8 mutation. Hematoxylin-eosin staining and transmission electron microscopy revealed highly divergent morphology and ultrastructure of sperm flagella in these patients. Furthermore, an immunofluorescence assay showed the absence of DNAH8 and a reduction in its associated protein DNAH17 in the patients' spermatozoa. Collectively, our study expands the phenotypic spectrum of patients with DNAH8-related MMAF worldwide.","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 3","pages":"350-355"},"PeriodicalIF":2.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fe/89/AJA-25-350.PMC10226489.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9534768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Outcomes of radical prostatectomy in a 20-year localized prostate cancer single institution series in China. 中国20年局部前列腺癌根治性前列腺切除术的结果

IF 2.9 2区医学

Asian Journal of Andrology Pub Date : 2023-05-01 DOI: 10.4103/aja202264

Xiao-Hao Ruan, Tsun Tsun Stacia Chun, Da Huang, Hoi-Lung Wong, Brian Sze-Ho Ho, Chiu-Fung Tsang, Terence Chun-Ting Lai, Ada Tsui-Lin Ng, Rong Na, James Hok-Leung Tsu

{"title":"Outcomes of radical prostatectomy in a 20-year localized prostate cancer single institution series in China.","authors":"Xiao-Hao Ruan, Tsun Tsun Stacia Chun, Da Huang, Hoi-Lung Wong, Brian Sze-Ho Ho, Chiu-Fung Tsang, Terence Chun-Ting Lai, Ada Tsui-Lin Ng, Rong Na, James Hok-Leung Tsu","doi":"10.4103/aja202264","DOIUrl":"https://doi.org/10.4103/aja202264","url":null,"abstract":"The long-term survival outcomes of radical prostatectomy (RP) in Chinese prostate cancer (PCa) patients are poorly understood. We conducted a single-center, retrospective analysis of patients undergoing RP to study the prognostic value of pathological and surgical information. From April 1998 to February 2022, 782 patients undergoing RP at Queen Mary Hospital of The University of Hong Kong (Hong Kong, China) were included in our study. Multivariable Cox regression analysis and Kaplan-Meier analysis with stratification were performed. The 5-year, 10-year, and 15-year overall survival (OS) rates were 96.6%, 86.8%, and 70.6%, respectively, while the 5-year, 10-year, and 15-year PCa-specific survival (PSS) rates were 99.7%, 98.6%, and 97.8%, respectively. Surgical International Society of Urological Pathology PCa grades (ISUP Grade Group) ≥4 was significantly associated with poorer PSS (hazard ratio [HR] = 8.52, 95% confidence interval [CI]: 1.42-51.25, P = 0.02). Pathological T3 stage was not significantly associated with PSS or OS in our cohort. Lymph node invasion and extracapsular extension might be associated with worse PSS (HR = 20.30, 95% CI: 1.22-336.38, P = 0.04; and HR = 7.29, 95% CI: 1.22-43.64, P = 0.03, respectively). Different surgical approaches (open, laparoscopic, or robotic-assisted) had similar outcomes in terms of PSS and OS. In conclusion, we report the longest timespan follow-up of Chinese PCa patients after RP with different approaches.","PeriodicalId":8483,"journal":{"name":"Asian Journal of Andrology","volume":"25 3","pages":"345-349"},"PeriodicalIF":2.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/32/da/AJA-25-345.PMC10226499.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9541153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0