Antibiotics and Chemotherapy最新文献

{"title":"Biapenem: Clinical and Microbiological Characteristics and the Place of The New Carbapenem In The Treatment of Severe Infections In The Hospital. Clinical Pharmacologists' Point of View","authors":"S. Yakovlev, M. Suvorova","doi":"10.37489/0235-2990-2022-67-5-6-81-91","DOIUrl":"https://doi.org/10.37489/0235-2990-2022-67-5-6-81-91","url":null,"abstract":"","PeriodicalId":8471,"journal":{"name":"Antibiotics and Chemotherapy","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76183003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Сharacterization of Neisseria meningitidis Serogroup W in St. Petersburg","authors":"E. Martens, L. I. Zhelezova, V. Gostev, D. Likholetova, S. Zakharenko","doi":"10.37489/0235-2990-2022-67-5-6-14-18","DOIUrl":"https://doi.org/10.37489/0235-2990-2022-67-5-6-14-18","url":null,"abstract":"The study included 14 isolates of Neisseria meningitidis s erogroup W, isolated from patients with generalized forms of me- ningococcal infection aged 0–17 years at the Pediatric Research and Clinical Center for Infectious Diseases during the period from 2009 to 2020, as well as from carriers. The isolates from carriers (17–18 years old) were isolated in 2016–2019. The isolates were identified by MALDI-TOF mass spectrometry using a Microflex LT mass spectrometer (Bruker Daltonics, Germany). Whole genome sequencing of N.meningitidis was carried out on the basis of the Miseq Illumina platform; it was established that they belong to ST11 (cc11) sequence type. The results of the whole genome sequencing of the studied meningococci showed that there are 2 groups of the subcluster belonging to the Hajj cluster in St. Petersburg. In addition, they show close affinity with meningococci of the Anglo-French and Swedish clusters of the Hajj line.","PeriodicalId":8471,"journal":{"name":"Antibiotics and Chemotherapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87074120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic Sensitivity of Neisseria meningitidis Isolated From Patients with Generalized Forms of Meningococcal Infection and From Healthy Carriers","authors":"E. Martens, L. I. Zhelezova, V. Gostev, D. Likholetova, D. Gladin","doi":"10.37489/0235-2990-2022-67-5-6-19-24","DOIUrl":"https://doi.org/10.37489/0235-2990-2022-67-5-6-19-24","url":null,"abstract":"","PeriodicalId":8471,"journal":{"name":"Antibiotics and Chemotherapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83483061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenetic Therapy in Patients with Recurrent Herpetic Infection","authors":"A. R. Shogenova, A. A. Kodzokova, I. A. Kushkhova, I. A. Mudrenova, D. A. Tkhazaplizheva, M. A. Atabaeva, A. A. Atmurzaev, Z. A. Kambachokova, A. A. Kambachokova","doi":"10.37489/0235-2990-2022-67-5-6-25-29","DOIUrl":"https://doi.org/10.37489/0235-2990-2022-67-5-6-25-29","url":null,"abstract":"When treating patients with recurrent herpesvirus infection, it is necessary to use combination therapy, which involves the use of both chemotherapy and immunotropic drugs. Simultaneous use of drugs with different mechanisms of action allows to achieve greater efficiency than the use of monotherapy. The effectiveness of Cycloferon, an interferon inducer, which has an anti-inflammatory and immunomodulatory effect in combination therapy in patients with labial herpes, has been established. An accelerated elevation of rashes was observed against the background of the use of Cycloferon in combination therapy with acyclic nucleosides (Acyclovir); the severity of general intoxication syndrome, subjective symp-toms (pain, itching, burning), and signs of inflammation (edema, hyperemia) decreased by half compared with the control group. Also, an increase in the duration of remission by 2–2.5 times was observed in patients taking Cycloferon. High efficiency, good tolerance by patients, as well as the possibility of using it with the main antiviral chemotherapy drugs indicate the advisability of including Cycloferon in the combination therapy in patients with recurrent herpes infection.","PeriodicalId":8471,"journal":{"name":"Antibiotics and Chemotherapy","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87230052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiological Characteristics in Causative Agents of Infectious Complications in Cancer Patients","authors":"Ю. Куцевалова, Д. А. Розенко, Ю. Козель, В. В. Семянников, Т. В. Аушева, В. Пустовая, Е. А. Марыков, А. И. Алавердян, Д. А. Гусак, А. В. Микутин, Д. И. Мирошниченко, А. Г. Анисимова, Л. Г. Боронина, O. Kutsevalova, Dmitri A. Rozenko, Y. Kozel, Vasily V. Semyannikov, Tatiana V. Ausheva, I. V. Pustovaya, E. A. Marykov, Artem I. Alaverdyan, Darya A. Gusak, Andrey V. Mikutin, D. I. Miroshnichenko, A. G. Anisimova, L. Boronina","doi":"10.37489/0235-2990-2022-67-5-6-30-38","DOIUrl":"https://doi.org/10.37489/0235-2990-2022-67-5-6-30-38","url":null,"abstract":"Background. Infectious complications are the most frequent and severe among all complications in cancer patients. The development of fungal-bacterial infections is particularly difficult. The aim was to develop an etiological descrip-tion for the causative agents of infectious complications in oncological patients. Materials and methods. The study was conducted from January, 2020 to December (inclusive both dates), 2021. 3662 hospitalized patients (men and women) aged from 1 to 85 years with clinical manifestations of an infection were examined. The traditional micro- biological method was used to clarify the etiology of the infectious process and to verify the pathogen. Phenotypic and real-time PCR methods were used for detection of carbapenemase and ESBL production. Results . The organs of the respiratory system, skin, soft tissues, and blood are most susceptible to infectious complications. In the etiology of infectious complications, the leading place is occupied by gram-negative bacteria. The conducted microbiological study made it possible to establish that resistance to cephalosporins and carbapenems in enterobacteria is realized through various resistance mechanisms. Extended-spectrum β -lactamases and carbapenemases are particularly rel- evant and concerning. Monitoring revealed the growth of carbapenemase-producing isolates of Klebsiella pneumoniae (34.9%), the spread of carbapenemase among Escherichia coli strains (5.1%), the increase in the spread of Acineto- bacter baumannii strains with the production of NDM groups (32.6%). Conclusion . Prescription of antibacterial drugs should be based only on the results of microbiological diagnostics. The current situation requires modern methods of microbiological diagnostics: the use of only up-to-date (periodically updated) criteria for determining sensitivity to antimicrobial drugs, as well as the introduction of phenotypic tests that provide reliable information without mo- lecular genetic methods. in","PeriodicalId":8471,"journal":{"name":"Antibiotics and Chemotherapy","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88882543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Antimicrobial Activity of a Pyrimidine Derivative Against Staphylococcus Aureus","authors":"A. Tsibizova, A. L. Yasinevskaya, I. Tyurenkov, A. Ozerov, O. Bashkina, M. Samotrueva","doi":"10.37489/0235-2990-2022-67-5-6-4-9","DOIUrl":"https://doi.org/10.37489/0235-2990-2022-67-5-6-4-9","url":null,"abstract":"","PeriodicalId":8471,"journal":{"name":"Antibiotics and Chemotherapy","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91269752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of The Anolyte Solution on Pathogenic Microflora","authors":"D. Kuklin, S. Styazhkina, M. K. Ivanova, V. V. Tikhonova, A. Bagautdinov, A. R. Gilimkhanova, A. I. Vakhitova","doi":"10.37489/0235-2990-2022-67-5-6-10-13","DOIUrl":"https://doi.org/10.37489/0235-2990-2022-67-5-6-10-13","url":null,"abstract":"","PeriodicalId":8471,"journal":{"name":"Antibiotics and Chemotherapy","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76513753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Antibacterial Activity of Extracts of Betula Pendula (Silver Birch) Bark Against Uropathogenic Microorganisms","authors":"Y. Chapurin, M. J. Mbarga, A. Senyagin, I. Podoprigora, Rehailia Manar","doi":"10.37489/0235-2990-2022-67-3-4-29-35","DOIUrl":"https://doi.org/10.37489/0235-2990-2022-67-3-4-29-35","url":null,"abstract":"The aim of this work was to evaluate the antibacterial activity of the aqueous and ethanolic extracts of Betula pendula (silver birch) bark against various microorganisms causing urinary tract infections.Material and methods. Aqueous and ethanol extracts of biologically active compounds from Betula pendula bark were tested against ten clinical uropathogenic strains (gram-positive bacteria — Kocuria rhizophila 1542, Staphylococcus simulans 5882, Enterococcus avium 1669, Enterococcus faecalis 5960, and Corynebacterium spp. 1638; gram-negative bacteria — Enterococcus cloacae, Morganella morganii 6392, Escherichia coli 1449, Seratia mansescens 6441, and Achromobacter xylosoxidans 4892). Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 25922 were used as reference standards for Gram-positive and Gram-negative microorganisms. The sensitivity of the experimental strains to the antibiotic was evaluated by the Kirby–Bauer disk diffusion method, while the antibacterial activity of the obtained extracts was evaluated using the agar diffusion method. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were also determined via the serial dilution method.Results. The bark of B.pendula contained 78.85% of dry matter. The volume yield of the aqueous (AE) and ethanol extract (EE) was 74.66% and 86.66% (v/v), respectively, while their mass yields were 6.59% and 10.65% (w/w). K.rizophilia 1542 and Corynebacterium spp. 1638 were the most resistant bacteria with a multidrug resistance index of 0.45. AE and EE were active against all microorganisms tested. MIC of AE ranged from 8 to 32 mg/ml, while MIC of EE ranged from 2 to 16 mg/ml.Conclusion. An aqueous extract of Betula pendula bark exhibits weak antimicrobial activity, while the ethanol extract exhibits a more pronounced antimicrobial activity, but has a bacteriostatic effect. ","PeriodicalId":8471,"journal":{"name":"Antibiotics and Chemotherapy","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89583473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccine Prophylaxis of Herpes Zoster In Rheumatic Diseases: Paradigm Revision and New Opportunities","authors":"G. Gridneva, B. Belov, E. Aronova","doi":"10.37489/0235-2990-2022-67-3-4-70-76","DOIUrl":"https://doi.org/10.37489/0235-2990-2022-67-3-4-70-76","url":null,"abstract":"Background. The issues of vaccination against the herpesvirus infection are still important in rheumatological practice.This infection often develops in patients receiving immunosuppressive treatment, especially Janus kinase inhibitors (a class-specific adverse reaction) and genetically engineered biologics.The aim of this review is to highlight the current state of the issue of vaccination against Herpes zoster (HZ).Materials and Methods. 37 publications (4 domestic, 33 foreign) were analyzed, in which the mechanisms of pathogenesisand clinical features of herpesvirus infection in patients with immunodeficiency, both with and without immunoinflammatory rheumatic diseases (IIRD), the frequency and variety of post-vaccination reactions, complications and exacerbations of the course of IIRD were considered.Results. There is currently a trend towards reassessment of the rheumatological community's opinion about HZ vaccination, including live vaccine. Literature data allow us to express optimism regarding the effective prevention of herpes zoster in patients who plan to take drugs, primarily from the group of Janus kinase inhibitors. The advantages of the adjuvant recombinant subunit vaccine (Shingrix®) include the possibility of its use against the background of treatment with antirheumatic drugs without significant restrictions, as well as no need to postpone the initiation of the necessary therapy.Conclusions. Publications on the issues of HZ vaccination are few. It is necessary to conduct carefully controlled studies on the efficacy and safety of antiherpetic vaccines with an emphasis on the post-vaccination course of IIRD in patients with rheumatological profile, including in the Russian Federation.","PeriodicalId":8471,"journal":{"name":"Antibiotics and Chemotherapy","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88107371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemorrhagic Fevers: Antiviral Effects and Molecular Targets of Biologically Active Polysaccharides and Lectins from Marine Aquatic Organisms","authors":"N. Besednova, T. Zaporozhets, B. Andryukov, S. Ermakova, T. Kuznetsova, S. Kryzhanovsky, M. Shchelkanov","doi":"10.37489/0235-2990-2022-67-3-4-53-69","DOIUrl":"https://doi.org/10.37489/0235-2990-2022-67-3-4-53-69","url":null,"abstract":"The search and creation of etiotropic drugs is one of the most important tasks of modern virology. This review examines the antiviral influence of certain natural substances (sulfated polysaccharides and lectins from marine hydrobionts) on the causative agents of hemorrhagic fevers. Such compounds can be used as an alternative to synthetic drugs due to their low toxicity, rare side effects, and the absence of virus resistance. In addition to a strong antiviral effect, polysaccharides and lectins possess anti-inflammatory, immunomodulatory, antioxidant, and antitoxic properties, which are important for the relief of numerous disorders caused by the pathogens of viral hemorrhagic fevers. The prospects of using these compounds as the basis for the creation of new drugs and biologically active food additives are considered in the final part of the review.","PeriodicalId":8471,"journal":{"name":"Antibiotics and Chemotherapy","volume":"os-34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87218530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}