Dynamic medicine : DM最新文献

{"title":"Femoral artery remodeling after aerobic exercise training without weight loss in women.","authors":"Manning J Sabatier,&nbsp;Earl H Schwark,&nbsp;Richard Lewis,&nbsp;Gloria Sloan,&nbsp;Joseph Cannon,&nbsp;Kevin McCully","doi":"10.1186/1476-5918-7-13","DOIUrl":"https://doi.org/10.1186/1476-5918-7-13","url":null,"abstract":"<p><strong>Background: </strong>It is currently unclear whether reductions in adiposity mediate the improvements in vascular health that occur with aerobic exercise. The purpose of this longitudinal study of 13 healthy women (33 +/- 4 years old) was to determine whether 14 weeks of aerobic exercise would alter functional measures of vascular health, namely resting aortic pulse wave velocity (aPWV, an index of arterial stiffness), femoral artery diameter (D(FA)), and femoral artery blood flow (BF(FA)) independent of changes in adiposity.</p><p><strong>Methods: </strong>Aerobic fitness was assessed as VO2peak normalized to fat-free mass, and adiposity (percent body fat) was determined by dual energy x-ray absorptiometry. Serum concentrations of proteins associated with risk for cardiovascular disease, including C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1), and leptin, were also measured. Subjects cycled for 50 minutes, 3 times per week.</p><p><strong>Results: </strong>Aerobic fitness normalized to fat-free mass increased 6% (P = 0.03) whereas adiposity did not change. Resting D(FA) increased 12% (P < 0.001) and resting shear rate decreased 28% (P = 0.007). Aortic PWV, and serum sICAM-1, CRP and leptin did not change with training.</p><p><strong>Conclusion: </strong>Significant reductions in adiposity were not necessary for aerobic exercise training to bring about improvements in aerobic fitness and arterial remodeling. Peripheral arterial remodeling occurred without changes in central arterial stiffness or markers of inflammation.</p>","PeriodicalId":84611,"journal":{"name":"Dynamic medicine : DM","volume":"7 ","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2008-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1476-5918-7-13","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27660936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical influence of TKA designs with varying radii on bilateral TKA patients during sit-to-stand.","authors":"He Wang,&nbsp;Kathy J Simpson,&nbsp;Samatchai Chamnongkich,&nbsp;Tracy Kinsey,&nbsp;Ormonde M Mahoney","doi":"10.1186/1476-5918-7-12","DOIUrl":"https://doi.org/10.1186/1476-5918-7-12","url":null,"abstract":"<p><strong>Background: </strong>Compared to the design of a traditional multi-radius (MR) total knee arthroplasty (TKA), the single-radius (SR) implant investigated has a fixed flexion/extension center of rotation. The biomechanical effectiveness of an SR for functional daily activities, i.e., sit-to-stand, is not well understood. The purpose of the study was to compare the biomechanics underlying functional performance of the sit-to-stand (STS) movement between the limbs containing an MR and an SR TKA of bilateral TKA participants.</p><p><strong>Methods: </strong>Sagittal plane kinematics and kinetics, and EMG data for selected knee flexor and extensor muscles were analyzed for eight bilateral TKA patients, each with an SR and an MR TKA implant.</p><p><strong>Results: </strong>Compared to the MR limb, the SR limb demonstrated greater peak antero-posterior (AP) ground reaction force, higher AP ground reaction impulse, less vastus lateralis and semitendinosus EMG during the forward-thrust phase of the STS movement. No significant difference of knee extensor moment was found between the two knees.</p><p><strong>Conclusion: </strong>Some GRF and EMG differences were evident between the MR and SR limbs during STS movement. Compensatory adaptations may be used to perform the STS.</p>","PeriodicalId":84611,"journal":{"name":"Dynamic medicine : DM","volume":"7 ","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2008-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1476-5918-7-12","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27594004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The oxygen delivery response to acute hypoxia during incremental knee extension exercise differs in active and trained males.","authors":"Michael D Kennedy,&nbsp;Darren Er Warburton,&nbsp;Carol A Boliek,&nbsp;Ben Ta Esch,&nbsp;Jessica M Scott,&nbsp;Mark J Haykowsky","doi":"10.1186/1476-5918-7-11","DOIUrl":"https://doi.org/10.1186/1476-5918-7-11","url":null,"abstract":"<p><strong>Background: </strong>It is well known that hypoxic exercise in healthy individuals increases limb blood flow, leg oxygen extraction and limb vascular conductance during knee extension exercise. However, the effect of hypoxia on cardiac output, and total vascular conductance is less clear. Furthermore, the oxygen delivery response to hypoxic exercise in well trained individuals is not well known. Therefore our aim was to determine the cardiac output (Doppler echocardiography), vascular conductance, limb blood flow (Doppler echocardiography) and muscle oxygenation response during hypoxic knee extension in normally active and endurance-trained males.</p><p><strong>Methods: </strong>Ten normally active and nine endurance-trained males (VO2max = 46.1 and 65.5 mL/kg/min, respectively) performed 2 leg knee extension at 25, 50, 75 and 100% of their maximum intensity in both normoxic and hypoxic conditions (FIO2 = 15%; randomized order). Results were analyzed with a 2-way mixed model ANOVA (group x intensity).</p><p><strong>Results: </strong>The main finding was that in normally active individuals hypoxic sub-maximal exercise (25 - 75% of maximum intensity) brought about a 3 fold increase in limb blood flow but decreased stroke volume compared to normoxia. In the trained group there were no significant changes in stroke volume, cardiac output and limb blood flow at sub-maximal intensities (compared to normoxia). During maximal intensity hypoxic exercise limb blood flow increased approximately 300 mL/min compared to maximal intensity normoxic exercise.</p><p><strong>Conclusion: </strong>Cardiorespiratory fitness likely influences the oxygen delivery response to hypoxic exercise both at a systemic and limb level. The increase in limb blood flow during maximal exercise in hypoxia (both active and trained individuals) suggests a hypoxic stimulus that is not present in normoxic conditions.</p>","PeriodicalId":84611,"journal":{"name":"Dynamic medicine : DM","volume":"7 ","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2008-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1476-5918-7-11","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27594186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring of pre-frontal oxygen status in helicopter pilots using near-infrared spectrophotometers.","authors":"Azusa Kikukawa,&nbsp;Asao Kobayashi,&nbsp;Yoshinori Miyamoto","doi":"10.1186/1476-5918-7-10","DOIUrl":"https://doi.org/10.1186/1476-5918-7-10","url":null,"abstract":"<p><strong>Background: </strong>There are few in-flight studies of cognition-related cerebral oxygen status in helicopter pilots.</p><p><strong>Methods: </strong>Four male helicopter pilots volunteered for nine sorties during visual flight in a BK117 and UH-60J. The pilots' pre-frontal oxy-hemoglobin (O2Hb) and deoxy-hemoglobin (HHb) concentration were continuously monitored from the right/left sections of the forehead using near-infrared spectrophotometers with a consideration of motion artifacts.</p><p><strong>Results: </strong>The concentration of O2Hb progressively increased (13.98 micromol*L-1 as a maximum increased concentration) in both the right/left sections of the forehead from the basal level during the heightened cognitive demand of helicopter flight. There was comparatively little change (4.32 micromol*L-1 as a maximum increased concentration) in HHb concentration during measurement of helicopter flight. HHb changes were apparently not affected by a heightened cognitive demand of helicopter pilots.</p><p><strong>Conclusion: </strong>These results demonstrate that near-infrared spectroscopy, especially O2Hb measurements, provides a sensitive method for the monitoring of cognitive demand (maneuvers) in helicopter pilots.</p>","PeriodicalId":84611,"journal":{"name":"Dynamic medicine : DM","volume":"7 ","pages":"10"},"PeriodicalIF":0.0,"publicationDate":"2008-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1476-5918-7-10","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27525799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patellofemoral pain syndrome (PFPS): a systematic review of anatomy and potential risk factors.","authors":"Gregory R Waryasz,&nbsp;Ann Y McDermott","doi":"10.1186/1476-5918-7-9","DOIUrl":"https://doi.org/10.1186/1476-5918-7-9","url":null,"abstract":"<p><strong>Background: </strong>Patellofemoral Pain Syndrome (PFPS), a common cause of anterior knee pain, is successfully treated in over 2/3 of patients through rehabilitation protocols designed to reduce pain and return function to the individual. Applying preventive medicine strategies, the majority of cases of PFPS may be avoided if a pre-diagnosis can be made by clinician or certified athletic trainer testing the current researched potential risk factors during a Preparticipation Screening Evaluation (PPSE). We provide a detailed and comprehensive review of the soft tissue, arterial system, and innervation to the patellofemoral joint in order to supply the clinician with the knowledge required to assess the anatomy and make recommendations to patients identified as potentially at risk. The purpose of this article is to review knee anatomy and the literature regarding potential risk factors associated with patellofemoral pain syndrome and prehabilitation strategies. A comprehensive review of knee anatomy will present the relationships of arterial collateralization, innervations, and soft tissue alignment to the possible multifactoral mechanism involved in PFPS, while attempting to advocate future use of different treatments aimed at non-soft tissue causes of PFPS.</p><p><strong>Methods: </strong>A systematic database search of English language PubMed, SportDiscus, Ovid MEDLINE, Web of Science, LexisNexis, and EBM reviews, plus hand searching the reference lists of these retrieved articles was performed to determine possible risk factors for patellofemoral pain syndrome.</p><p><strong>Results: </strong>Positive potential risk factors identified included: weakness in functional testing; gastrocnemius, hamstring, quadriceps or iliotibial band tightness; generalized ligamentous laxity; deficient hamstring or quadriceps strength; hip musculature weakness; an excessive quadriceps (Q) angle; patellar compression or tilting; and an abnormal VMO/VL reflex timing. An evidence-based medicine model was utilized to report evaluation criteria to determine the at-risk individuals, then a defined prehabilitation program was proposed that begins with a dynamic warm-up followed by stretches, power and multi-joint exercises, and culminates with isolation exercises. The prehabilitation program is performed at lower intensity level ranges and can be conducted 3 days per week in conjunction with general strength training. Based on an objective one repetition maximum (1RM) test which determines the amount an individual can lift in good form through a full range of motion, prehabilitation exercises are performed at 50-60% intensity.</p><p><strong>Conclusion: </strong>To reduce the likelihood of developing PFPS, any individual, especially those with positive potential risk factors, can perform the proposed prehabilitation program.</p>","PeriodicalId":84611,"journal":{"name":"Dynamic medicine : DM","volume":" ","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2008-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1476-5918-7-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40539312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A school-curriculum-based exercise intervention program for two years in pre-pubertal girls does not influence hip structure.","authors":"Gayani Alwis, Christian Linden, Susanna Stenevi-Lundgren, Henrik G Ahlborg, Magnus Dencker, Jack Besjakov, Per Gardsell, Magnus K Karlsson","doi":"10.1186/1476-5918-7-8","DOIUrl":"10.1186/1476-5918-7-8","url":null,"abstract":"<p><strong>Background: </strong>It is known that physical activity during growth has a positive influence on bone mineral accrual, and is thus possibly one strategy to prevent osteoporosis. However, as bone geometry, independent of areal bone mineral density (aBMD), influences fracture risk, this study aimed to evaluate whether hip structure in pre-pubertal girls is also affected by a two-year exercise intervention program.</p><p><strong>Methods: </strong>Forty-two girls aged 7-9 years in a school-curriculum-based exercise intervention program comprising 40 minutes of general physical activity per school day (200 minutes per week) were compared with 43 age-matched girls who participated in the general Swedish physical education curriculum comprising a mean of 60 minutes per week. The hip was scanned by dual energy X-ray absorptiometry (DXA) and the hip structural analysis (HSA) software was applied to evaluate bone mineral content (BMC, g), areal bone mineral density (aBMD, g/cm2), periosteal diameter, cross-sectional area (CSA, cm2), section modulus (Z, cm3) and cross-sectional moment of inertia (CSMI, cm4) of the femoral neck (FN). Annual changes were compared. Subjective duration of physical activity was estimated by questionnaire and objective level of everyday physical activity at follow-up by means of accelerometers worn for four consecutive days. All children remained at Tanner stage 1 throughout the study. Group comparisons were made by independent student's t-test between means and analyses of covariance (ANCOVA).</p><p><strong>Results: </strong>At baseline, the two groups did not differ with regard to age, anthropometrics or bone parameters. No between-group differences were observed for annual changes in the FN variables measured.</p><p><strong>Conclusion: </strong>A two-year school-based moderately intense general exercise program for 7-9-year-old pre-pubertal girls does not influence structural changes in the FN.</p>","PeriodicalId":84611,"journal":{"name":"Dynamic medicine : DM","volume":"7 ","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2008-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2397397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27408860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percent body fat estimations in college men using field and laboratory methods: a three-compartment model approach.","authors":"Jordan R Moon, Sarah E Tobkin, Abbie E Smith, Michael D Roberts, Eric D Ryan, Vincent J Dalbo, Chris M Lockwood, Ashley A Walter, Joel T Cramer, Travis W Beck, Jeffrey R Stout","doi":"10.1186/1476-5918-7-7","DOIUrl":"10.1186/1476-5918-7-7","url":null,"abstract":"<p><strong>Background: </strong>Methods used to estimate percent body fat can be classified as a laboratory or field technique. However, the validity of these methods compared to multiple-compartment models has not been fully established. The purpose of this study was to determine the validity of field and laboratory methods for estimating percent fat (%fat) in healthy college-age men compared to the Siri three-compartment model (3C).</p><p><strong>Methods: </strong>Thirty-one Caucasian men (22.5 +/- 2.7 yrs; 175.6 +/- 6.3 cm; 76.4 +/- 10.3 kg) had their %fat estimated by bioelectrical impedance analysis (BIA) using the BodyGram computer program (BIA-AK) and population-specific equation (BIA-Lohman), near-infrared interactance (NIR) (Futrex(R) 6100/XL), four circumference-based military equations [Marine Corps (MC), Navy and Air Force (NAF), Army (A), and Friedl], air-displacement plethysmography (BP), and hydrostatic weighing (HW).</p><p><strong>Results: </strong>All circumference-based military equations (MC = 4.7% fat, NAF = 5.2% fat, A = 4.7% fat, Friedl = 4.7% fat) along with NIR (NIR = 5.1% fat) produced an unacceptable total error (TE). Both laboratory methods produced acceptable TE values (HW = 2.5% fat; BP = 2.7% fat). The BIA-AK, and BIA-Lohman field methods produced acceptable TE values (2.1% fat). A significant difference was observed for the MC and NAF equations compared to both the 3C model and HW (p < 0.006).</p><p><strong>Conclusion: </strong>Results indicate that the BP and HW are valid laboratory methods when compared to the 3C model to estimate %fat in college-age Caucasian men. When the use of a laboratory method is not feasible, BIA-AK, and BIA-Lohman are acceptable field methods to estimate %fat in this population.</p>","PeriodicalId":84611,"journal":{"name":"Dynamic medicine : DM","volume":"7 ","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2008-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27397111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The economic impact of ME/CFS: individual and societal costs.","authors":"Leonard A Jason,&nbsp;Mary C Benton,&nbsp;Lisa Valentine,&nbsp;Abra Johnson,&nbsp;Susan Torres-Harding","doi":"10.1186/1476-5918-7-6","DOIUrl":"https://doi.org/10.1186/1476-5918-7-6","url":null,"abstract":"<p><strong>Background: </strong>ME/CFS is characterized by debilitating fatigue in addition to other physical and cognitive symptoms. It is estimated to affect over 800,000 adults in the U.S. ME/CFS often results in diminished functionality and increased economic impact. The economic impact of an illness is generally divided into two categories: direct and indirect costs. Despite high prevalence rates and the disabling nature of the illness, few studies have examined the costs of ME/CFS at the individual and societal level. In fact, of the four studies examining the economic impact of ME/ME/CFS only two used a U. S. sample. The current study used community and tertiary samples to examine the direct costs of ME/CFS.</p><p><strong>Methods: </strong>Using archival data, Study 1 examined the direct cost of ME/CFS in a community-based sample in Chicago. Study 2 estimated the direct cost of ME/CFS in a tertiary sample in Chicago. Both Study 1 and Study 2 assessed direct costs using office visit costs, medical test costs, and medication costs.</p><p><strong>Results: </strong>For Study 1, the annual direct total cost per ME/CFS patient was estimated to be $2,342, with the total annual direct cost of ME/CFS to society being approximately $2 billion. In Study 2, the annual direct was estimated to be $8,675 per ME/CFS patient, with the total annual direct cost of ME/CFS to society being approximately $7 billion.</p><p><strong>Conclusion: </strong>Using ME/CFS prevalence data of 0.42 and indirect costs estimates from Reynolds et al. (2004), the direct and indirect cost of ME/CFS to society was estimated to be $18,677,912,000 for the community sample and $23,972,300,000 for the tertiary sample. These findings indicate that whether or not individuals are recruited from a community or tertiary sample, ME/CFS imposes substantial economic costs.</p>","PeriodicalId":84611,"journal":{"name":"Dynamic medicine : DM","volume":"7 ","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2008-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1476-5918-7-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27369790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescents with metabolic syndrome have a history of low aerobic fitness and physical activity levels.","authors":"Robert G McMurray,&nbsp;Shrikant I Bangdiwala,&nbsp;Joanne S Harrell,&nbsp;Leila D Amorim","doi":"10.1186/1476-5918-7-5","DOIUrl":"https://doi.org/10.1186/1476-5918-7-5","url":null,"abstract":"<p><strong>Purpose: </strong>Metabolic syndrome (MS) is a clustering of cardiovascular disease risk factors that identifies individuals with the highest risk for heart disease. Two factors that may influence the MS are physical activity and aerobic fitness. This study determined if adolescent with the MS had low levels of aerobic fitness and physical activity as children.</p><p><strong>Methods: </strong>This longitudinal, exploratory study had 389 participants: 51% girls, 84% Caucasian, 12% African American, 1% Hispanic, and 3% other races, from the State of North Carolina. Habitual physical activity (PA survey), aerobic fitness (VO2max), body mass index (BMI), blood pressure, and lipids obtained at 7-10 y of age were compared to their results obtained 7 y later at ages 14-17 y.</p><p><strong>Results: </strong>Eighteen adolescents (4.6%) developed 3 or more characteristics of the MS. Logistic regression, adjusting for BMI percentile, blood pressure, and cholesterol levels, found that adolescents with the MS were 6.08 (95%CI = 1.18-60.08) times more likely to have low aerobic fitness as children and 5.16 (95%CI = 1.06-49.66) times more likely to have low PA levels.</p><p><strong>Conclusion: </strong>Low levels of childhood physical activity and aerobic fitness are associated with the presence of the metabolic syndrome in adolescents. Thus, efforts need to begin early in childhood to increase exercise.</p>","PeriodicalId":84611,"journal":{"name":"Dynamic medicine : DM","volume":"7 ","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2008-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1476-5918-7-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27368922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of obesity on falls and quality of life.","authors":"Cecilie Fjeldstad,&nbsp;Anette S Fjeldstad,&nbsp;Luke S Acree,&nbsp;Kevin J Nickel,&nbsp;Andrew W Gardner","doi":"10.1186/1476-5918-7-4","DOIUrl":"https://doi.org/10.1186/1476-5918-7-4","url":null,"abstract":"<p><strong>Objective: </strong>To determine (1) whether obese older adults had higher prevalence of falls and ambulatory stumbling, impaired balance and lower health-related quality of life (HRQL) than their normal weight counterparts, and (2) whether the falls and balance measures were associated with HRQL in obese adults.</p><p><strong>Methods: </strong>Subjects who had a body mass index (BMI) greater than 30 kg/m2 were classified into an obese group (n = 128) while those with BMI between 18.5 and 24.9 kg/m2 were included into a normal weight group (n = 88). Functional tests were performed to assess balance, and questionnaires were administered to assess history of falls, ambulatory stumbling, and HRQL.</p><p><strong>Results: </strong>The obese group reported a higher prevalence of falls (27% vs. 15%), and ambulatory stumbling (32% vs. 14%) than the normal weight group. Furthermore, the obese group had lower HRQL, (p < or = 0.05) for physical function (63 +/- 27 vs. 75 +/- 26; mean +/- SD), role-physical (59 +/- 40 vs. 74 +/- 37), vitality (58 +/- 23 vs. 66 +/- 20), bodily pain (62 +/- 25 vs. 74 +/- 21) and general health (64 +/- 19 vs. 70 +/- 18). In the obese group, a history of falls was related (p < or = 0.05) to lower scores in 4 domains of HRQL, and ambulatory stumbling was related (p < or = 0.01) to 7 domains.</p><p><strong>Conclusion: </strong>In middle-aged and older adults, obesity was associated with a higher prevalence of falls and stumbling during ambulation, as well as lower values in multiple domains of HRQL. Furthermore, a history of falls and ambulatory stumbling were related to lower measures of HRQL in obese adults.</p>","PeriodicalId":84611,"journal":{"name":"Dynamic medicine : DM","volume":"7 ","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2008-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1476-5918-7-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27290178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}