{"title":"[Mortality in past centuries].","authors":"P Stephan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>\"Mortality and life expectancy over a time period of 300 years were studied for a relatively large village population [in Germany]. From synchronous and diachronous comparisons of the data concerning different social classes of this village (subdivided according to their sex and age, social rank, number of children/family and birth rank, registration of orphans, half-orphans, illegitimate children as well as progeny of old parents and children with a high inbreeding degree, and interpretation of causes of death) significant differences in mortality were deduced.\" (SUMMARY IN ENG)</p>","PeriodicalId":84273,"journal":{"name":"Biologisches Zentralblatt","volume":"112 1","pages":"28-81"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22037049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mutability of genes depends on their functional state - a hypothesis.","authors":"V I Korogodin, V L Korogodin, C Fajszi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new point of view is formulated on the main dogma of genetics - the undirectedcharacter of mutagenesis. In the study of spontaneous mutability in adenine auxotrophic strains of the yeast, Saccharomyces, it was shown that when diminishing the adenine concentration in the medium, the transition from repression to derepression of the adenine biosynthesis system is accompanied by a 1.5-2 orders of magnitude increase in the spontaneous mutation rate in the ade2 gene. At the same time the mutation rate of suppressor genes varies very little. On this ground the following hypothesis is proposed: active genes mutate much more often than repressed ones. Some consequences of this hypothesis are discussed.</p>","PeriodicalId":84273,"journal":{"name":"Biologisches Zentralblatt","volume":"109 ","pages":"447-51"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36525167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I Hansmann, F Beermann, E Hummler, B Pabst, F Theuring
{"title":"MECHANISMS OF NONDISJUNCTION AND IMPLICATIONS FOR TESTING ANEUGENS.","authors":"I Hansmann, F Beermann, E Hummler, B Pabst, F Theuring","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>THE HUMAN SPECIES IS AFFECTED BY A HIGH FREQUENCY OF CONSTITUTIONAL ANEUPLOIDY WHICH IS MAINLY DERIVED FROM NONDISJUNCTION DURING PARENTAL MEIOSIS AND PREFERENTIALLY DURING MATERNAL MEIOSIS I. IN UNRAVELLING THE MECHANISMS INVOLVED WE STUDIED VARIOUS CONDITIONS CAUSING AND ASSOCIATED WITH NONDISJUNCTION IN OOCYTES FROM DJUNGARIAN HAMSTERS. CONSIDERING OUR OBSERVATIONS WE SUGGEST THAT THE ORDERLY SEGREGATION OF CHROMOSOMES AT MEIOSIS APPEARS TO RESULT FROM A CASCADE OF DIFFERENTIATION PROCESSES REQUIRING THE INTERACTION OF AN EXTRA-, TRANS- AND INTRACELLULAR SIGNALLING. FAILURES MAY OCCUR AT ANY LEVEL ALTERING E.G.: (1) THE CONTROL OF FOLLICULAR MATURATION/FUNCTION (OR GENERALLY THE FUNCTION OF THE SOMATIC COMPARTMENT WITHIN THE GONADS) (2) THE SIGNALLING BETWEEN SOMA AND MEIOCYTE (3) THE FUNCTION OF THE CYTOPLASM AND CYTOPLASMIC ORGANELLES SUCH AS THE SPINDLE AND MITOCHONDRIA (BEERMANN ET AL. 1988) (3) THE RATE OF MEIOSIS (5) CHROMOSOME BEHAVIOR AND THEIR INTERACTION WITH MICROTUBULI. NONDISJUNCTION APPEARS TO BE ONE CONSEQUENCE OF A DISTURBED CONTROL OF MEIOCYTE PROLIFERATION. THE CAUSES MIGHT, IN ANALOGY, BE AS DIVERSE AS THOSE LEADING TO NEOPLASTIC GROWTH OF SOMATIC CELLS. NOTWITHSTANDING THE NECESSITY FOR SIMPLIFICATION IN MUTAGENICITY TESTING ONE HAS TO REMIND THAT THE MAJORITY OF TRISOMIES ORIGINATE FROM A MEIOSIS I ERROR. SO FAR WE CAN NOT BE SURE THAT SOMATIC CELL TESTING MAY INDICATE PUTATIVE EVENTS DURING THE ABOVE DESCRIBED COMPLICATED INTERACTIVE MATURATION PROCESS OF GERM CELLS.</p>","PeriodicalId":84273,"journal":{"name":"Biologisches Zentralblatt","volume":"108 4","pages":"323-31"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36527225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chromosomal aberrations induced by the restriction endonucleases Alu I and Bam HI: Comparison with X-rays.","authors":"G Obe, C Johannes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dose-effect relationships for the frequencies of polycentric chromosomes inducedby the restriction endonucleases Alu I and Bam HI and by X-rays in Chinese hamster ovary (CHO) cells were analyzed and compared. 1 Gy of X-rays produce the same frequency of polycentric chromosomes as 2 units Alu I and 7.9 units Bam HI.</p>","PeriodicalId":84273,"journal":{"name":"Biologisches Zentralblatt","volume":"106 2","pages":"175-90"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36529038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[What are the causes of reduced fertility in human populations in former centuries?].","authors":"P Stephan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84273,"journal":{"name":"Biologisches Zentralblatt","volume":"106 1","pages":"21-32"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22035263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Mutagenicity testing with Drosophila as a method for detecting potential carcinogens].","authors":"E Vogel, F H Sobels","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84273,"journal":{"name":"Biologisches Zentralblatt","volume":"95 4","pages":"405-13"},"PeriodicalIF":0.0,"publicationDate":"1976-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22024299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The energy levels in some anaerobic breathing processes.","authors":"A RIPPEL-BALDES","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84273,"journal":{"name":"Biologisches Zentralblatt","volume":"67 1-2","pages":"60-4"},"PeriodicalIF":0.0,"publicationDate":"1948-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27784756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Physiological differences between green and frosted clans of Abistaceen.","authors":"T SCHMUCKER","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84273,"journal":{"name":"Biologisches Zentralblatt","volume":"67 1-2","pages":"65-71"},"PeriodicalIF":0.0,"publicationDate":"1948-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27784757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The influence of the ice age on European bird life.","authors":"G STEINBACHER","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":84273,"journal":{"name":"Biologisches Zentralblatt","volume":"67 9-10","pages":"444-56"},"PeriodicalIF":0.0,"publicationDate":"1948-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27139596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}