Arrhythmia & Electrophysiology Review最新文献

Conduction System Pacing Leads: Lumenless versus Stylet-driven Technologies in Contemporary Practice. 传导系统起搏导联：当代实践中的无光与风格驱动技术。

IF 3.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-03-27 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2026.15.s1

Amr Abdin

{"title":"Conduction System Pacing Leads: Lumenless versus Stylet-driven Technologies in Contemporary Practice.","authors":"Amr Abdin","doi":"10.15420/aer.2026.15.s1","DOIUrl":"https://doi.org/10.15420/aer.2026.15.s1","url":null,"abstract":"Conduction system pacing (CSP), including His bundle pacing and left bundle branch area pacing (LBBAP), has emerged as a physiological alternative to right ventricular pacing and an evolving modality for cardiac resynchronisation therapy. As clinical adoption expands, lead technology has become central to procedural success, electrical performance, and long-term safety. Historically, CSP has relied on lumenless leads (LLL), while stylet-driven leads (SDL) are increasingly used, particularly for LBBAP. Current evidence indicates that CSP procedures are feasible, reproducible, and show positive trends in outcomes for both bradycardia and heart failure patients, with both LLL and SDL achieving high implant success and comparable pacing parameters. However, differences in mechanical design may influence implantation technique, complication profiles, and long-term durability. Although observational studies and registries support the safety and effectiveness of both lead types, long-term data on lead fracture, extractability, and device-specific performance remain limited. At present, no clear superiority of one platform over the other can be established. Lead selection should therefore be individualised, guided by anatomy, operator experience and device-specific evidence, while further prospective studies are needed to optimise CSP lead design and long-term outcomes.","PeriodicalId":8412,"journal":{"name":"Arrhythmia & Electrophysiology Review","volume":"15 ","pages":"1-7"},"PeriodicalIF":3.3,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atrial Cardiomyopathy and Atrial Fibrillation in Different Heart Failure Substrates. 不同心衰基质的心房心肌病和心房颤动。

IF 3.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-03-11 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2025.53

Bharat K Kantharia, Lingling Wu, Mohit M Hulsurkar, Kaveh Karimzad, Arti N Shah, Bharat Narasimhan, Xander Ht Wehrens, Dominik Linz, Jordi Heijman

{"title":"Atrial Cardiomyopathy and Atrial Fibrillation in Different Heart Failure Substrates.","authors":"Bharat K Kantharia, Lingling Wu, Mohit M Hulsurkar, Kaveh Karimzad, Arti N Shah, Bharat Narasimhan, Xander Ht Wehrens, Dominik Linz, Jordi Heijman","doi":"10.15420/aer.2025.53","DOIUrl":"https://doi.org/10.15420/aer.2025.53","url":null,"abstract":"The incidences of AF and heart failure (HF) have been progressively increasing worldwide. These conditions exhibit a strong interdependence, with each exacerbating the other. HF is currently classified based on left ventricular ejection fraction (EF) as HF with reduced, mid-range or preserved EF (HFrEF, HFmrEF or HFpEF, respectively). Atrial cardiomyopathy, also known as atriopathy, involves structural, architectural, contractile, or electrophysiological alterations in the atria, driven by diverse mechanisms stemming from risk factors and comorbidities, including diabetes, hypertension, ischaemic and valvular heart diseases, hypertrophic and dilated cardiomyopathies, as well as various forms of HF. Emerging evidence also implicates infiltrative cardiomyopathies (e.g. cardiac amyloidosis), certain cancers, and chemotherapeutic agents in promoting both AF and HF. This review summarises key basic and translational science findings, along with their potential clinical applications, that connect shared pathophysiological substrates between HF and atrial cardiomyopathy.","PeriodicalId":8412,"journal":{"name":"Arrhythmia & Electrophysiology Review","volume":"15 ","pages":"e11"},"PeriodicalIF":3.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitral Annular Disjunction and Coalescing Myths in Cardiology. 心脏病学中的二尖瓣环分离和合并神话。

IF 3.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-03-05 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2025.89

Demosthenes G Katritsis, Robert H Anderson

引用次数: 0

The Biophysics of Radiofrequency Ablation and Factors Affecting Lesion Size. 射频消融的生物物理学及影响病灶大小的因素。

IF 3.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-03-03 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2025.66

Alexander P Bates, Waqas Ullah

引用次数: 0

Spatial Autocorrelation Dimension (D_i ) for the Characterisation of Atrial Fibrillatory Dynamics. 表征心房颤动动力学的空间自相关维数（Di）。

IF 3.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-03-03 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2024.06

Kathryn D Tiver, Dhani Dharmaprani, Anand N Ganesan

{"title":"Spatial Autocorrelation Dimension (Di ) for the Characterisation of Atrial Fibrillatory Dynamics.","authors":"Kathryn D Tiver, Dhani Dharmaprani, Anand N Ganesan","doi":"10.15420/aer.2024.06","DOIUrl":"10.15420/aer.2024.06","url":null,"abstract":"AF may be considered as a state of spatiotemporal disorder. As such, the behaviour of well-studied disordered systems in nature could be used to understand and predict AF dynamics. In this paper we review the scientific basis of a novel means of quantifying disorder in AF, namely spatial autocorrelation dimension (Di ), which reflects the ratio of system size to spatial synchronisation, and relate it to the clinical entity of AF. In disordered systems, system size and spatial synchronisation determine behaviour; similarly, atrial size is a key determinant of clinical outcomes in AF, and spatial synchronisation may be quantified using the self-similarity of nearby electrograms with increasing distance. The advantage of this approach over the established paradigms of AF dynamics is that it allows AF to be studied according to the principles of disordered systems, ubiquitous across nature. It permits us to emerge from limitations imposed by the traditional theories of understanding AF, which have led to stagnant clinical outcomes in recent decades.","PeriodicalId":8412,"journal":{"name":"Arrhythmia & Electrophysiology Review","volume":"15 ","pages":"e07"},"PeriodicalIF":3.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147462680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward a Prospective Definition of Atrial Fibrillation-induced Cardiomyopathy. 心房颤动性心肌病的前瞻性定义。

IF 3.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-03-03 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2025.65

Nikhil Ahluwalia, Shohreh Honarbakhsh, Ross J Hunter, Steffen Petersen, Guy Lloyd, Richard J Schilling

{"title":"Toward a Prospective Definition of Atrial Fibrillation-induced Cardiomyopathy.","authors":"Nikhil Ahluwalia, Shohreh Honarbakhsh, Ross J Hunter, Steffen Petersen, Guy Lloyd, Richard J Schilling","doi":"10.15420/aer.2025.65","DOIUrl":"10.15420/aer.2025.65","url":null,"abstract":"AF can mediate left ventricular systolic dysfunction (LVSD) through a tachycardia-mediated cardiomyopathic process that may reverse with rate control alone. However, additional mechanisms contribute to AF-induced cardiomyopathy (AIC) that require rhythm control therapies. AIC can currently only be diagnosed retrospectively, as these component mechanisms are difficult to distinguish from each other and from other causes of LVSD prospectively. This narrative review considers the different potential mechanisms through which AF can impair ventricular function: rapid ventricular rate; irregularity of the ventricular rhythm; and impaired atrial contraction. How these features may exploit underlying structural vulnerability are considered and additional imaging-based parameters such as late gadolinium enhancement on cardiac MRI and contractile reserve during stress echocardiography are discussed. The limitations of existing parameters are discussed and a novel, non-parametric marker of ventricular rate with consideration of the inherent irregularity of AF - the Restitution Threshold Index (RTI) - is reviewed. Integrating RTI with these imaging-based measures may enhance clinical decision-making by more accurately identifying patients who would benefit from timely rhythm control. Further prospective validation is essential to develop accessible tools and an open-access RTI calculator has been made available (https://restitutionthreshold.com) to facilitate reproducibility and wider application.","PeriodicalId":8412,"journal":{"name":"Arrhythmia & Electrophysiology Review","volume":"15 ","pages":"e09"},"PeriodicalIF":3.3,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147462685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Latest Advances and Ongoing Challenges in Pulsed Field Ablation. 脉冲场烧蚀的最新进展和持续挑战。

IF 3.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-02-24 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2025.32

Sara Vázquez-Calvo, Vladimir Poletaev, Atul Verma

引用次数: 0

When ICDs Do Not Deliver: The Unseen Burden of Untreated Arrhythmias. 当icd不交付：未治疗心律失常的看不见的负担。

IF 3.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-02-18 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2025.59

Christopher Monkhouse, Charles Swerdlow, Robert Hauser, Ross J Hunter, Pier D Lambiase, Syed Ahsan

{"title":"When ICDs Do Not Deliver: The Unseen Burden of Untreated Arrhythmias.","authors":"Christopher Monkhouse, Charles Swerdlow, Robert Hauser, Ross J Hunter, Pier D Lambiase, Syed Ahsan","doi":"10.15420/aer.2025.59","DOIUrl":"https://doi.org/10.15420/aer.2025.59","url":null,"abstract":"ICDs are implanted to treat sudden arrhythmic death by treating episodes of ventricular arrhythmia (VA). Despite this primary function, patients can still die with a functioning ICD due to untreated VA. The purpose of this review is to examine the causes and implications of ICD failures in detection and therapy delivery during VA and assess post-mortem interrogation practices and literature. The literature, adverse event reports, and the authors' own internal data were reviewed to identify causes of ICD non-therapy. Signal-related, functional, algorithmic and myocardial undersensing were identified as contributors, along with episodes of failed defibrillation/cardioversion. Contemporary ICD programming prioritises specificity but may compromise sensitivity. Post-mortem interrogation is rare, under-utilised and has no standardisation, despite reports of ICD failure being the cause of death in up to 25% of cases. To conclude, failure to interrogate ICDs after death risks missing fatal undersensing. Systematic post-mortem analysis is proposed as the cardiac equivalent of aviation's black box, which is critical for learning and sudden arrhythmic death prevention.","PeriodicalId":8412,"journal":{"name":"Arrhythmia & Electrophysiology Review","volume":"15 ","pages":"e04"},"PeriodicalIF":3.3,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preserving Access After Lead Extraction in Venous Stenosis Using Snaring: The Cowboy Bridge Technique. 利用诱捕法保留静脉狭窄铅提取后的通道：牛桥技术。

IF 3.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-02-18 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2025.57

Elkin González Villegas, Panagiotis Mililis, Jesús Saldaña-García, Alejandra Barreto, José Carlos Romero Carmona, Athanasios Saplaouras, Konstantinos P Letsas, Michael Efremidis, Rafael Peinado Peinado

引用次数: 0

Impacts of Cardiac Dyssynchrony and Resynchronisation on Cellular Metabolism and Mitochondria: Current Understanding for Future Applications. 心脏非同步化和再同步化对细胞代谢和线粒体的影响：对未来应用的当前理解。

IF 3.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-02-16 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2025.69

Pawut Gumrai, Wanwarang Wongcharoen, Siriporn C Chattipakorn, Chanisa Thonusin, Nipon Chattipakorn

{"title":"Impacts of Cardiac Dyssynchrony and Resynchronisation on Cellular Metabolism and Mitochondria: Current Understanding for Future Applications.","authors":"Pawut Gumrai, Wanwarang Wongcharoen, Siriporn C Chattipakorn, Chanisa Thonusin, Nipon Chattipakorn","doi":"10.15420/aer.2025.69","DOIUrl":"https://doi.org/10.15420/aer.2025.69","url":null,"abstract":"Ventricular dyssynchrony serves as a cause of heart failure, resulting from impaired electrical conduction within the heart, commonly from bundle branch block or right ventricular pacing. It exceeds structural remodelling to cause significant cellular dysfunction, particularly in aberrant myocardial metabolism, alterations to myocardial oxygen consumption and cardiac efficiency, along with compromised mitochondrial activity. CRT is a therapeutic strategy that is used for the dyssynchronous ventricle by correcting electrical aberrance, while also improving cellular metabolic homeostasis, cardiac efficiency and mitochondrial function. This article provides a comprehensive review of the mechanisms responsible for ventricular dyssynchrony-induced cardiac remodelling and its reversal through cardiac resynchronisation therapy, focusing on the influence that these mechanisms exert on cellular metabolism and mitochondrial function. Additionally, it underscores the potential for risk assessment and individualised treatment targeting in dyssynchronous heart failure, using metabolic profiles, mitochondrial function indicators and metabolomic evaluation to enhance the efficacy of CRT and improve patient outcomes.","PeriodicalId":8412,"journal":{"name":"Arrhythmia & Electrophysiology Review","volume":"15 ","pages":"e03"},"PeriodicalIF":3.3,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0