Arrhythmia & Electrophysiology Review最新文献

Brugada Phenocopies: A Review of Mechanisms, Clinical Implications and Prognostic Considerations. Brugada表型：机制、临床意义和预后考虑的综述。

IF 4.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-09-23 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2026.16

Marta Lorente-Ros, Álvaro Lorente-Ros, Mohammad S Husain, Travis Hong, Jessica Sweeney, Adrian Baranchuk, Susan O'Donoghue

{"title":"Brugada Phenocopies: A Review of Mechanisms, Clinical Implications and Prognostic Considerations.","authors":"Marta Lorente-Ros, Álvaro Lorente-Ros, Mohammad S Husain, Travis Hong, Jessica Sweeney, Adrian Baranchuk, Susan O'Donoghue","doi":"10.15420/aer.2026.16","DOIUrl":"https://doi.org/10.15420/aer.2026.16","url":null,"abstract":"Brugada phenocopy (BrP) is a clinical entity characterised by an identical ECG pattern to that of Brugada syndrome, albeit in the absence of congenital sodium channel dysfunction. In BrP, diagnosis is based on the presence of an identifiable underlying trigger that elicits the typical ECG pattern and non-reproducible electrical changes associated with the administration of sodium channel blockers. Although a wide variety of conditions can elicit BrP, the underlying electrophysiological mechanisms leading to the ECG changes are incompletely understood. Experimental models mimicking phenocopy-inducing conditions and integrative evidence of genetic and environmentally modulated mechanisms of sodium channel dysfunction are imperative to gain insights into the mechanisms behind BrP. In this review, we summarise current literature on BrP and describe aetiologies and reproducibility, diagnostic and therapeutic approaches, prognostic implications and emerging evidence on the pathophysiological mechanisms behind the spectrum of phenotypes of sodium channel dysfunction that can help understand the phenomenon of BrP.","PeriodicalId":8412,"journal":{"name":"Arrhythmia & Electrophysiology Review","volume":"15 ","pages":"e31"},"PeriodicalIF":4.3,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Post-heart Transplant Atrial Fibrillation. 心脏移植后心房颤动的处理。

IF 4.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-09-22 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2025.45

Merna Abdou, Aaron A Sifuentes, Ghazaleh Goldar, Ran Lee, Supriya Shore

{"title":"Management of Post-heart Transplant Atrial Fibrillation.","authors":"Merna Abdou, Aaron A Sifuentes, Ghazaleh Goldar, Ran Lee, Supriya Shore","doi":"10.15420/aer.2025.45","DOIUrl":"https://doi.org/10.15420/aer.2025.45","url":null,"abstract":"AF is the most common atrial arrhythmia encountered after orthotopic heart transplantation, with distinct pathophysiology and clinical implications. While early postoperative AF is typically transient, late-onset AF is increasingly recognised as a marker of graft dysfunction, rejection or vasculopathy. Risk factors include advanced recipient age, prolonged ischaemic time and immunosuppressive therapy. The denervated status of the transplanted heart alters typical electrophysiology, complicating diagnosis and management. Management requires individualised strategies balancing rate versus rhythm control, careful drug interaction monitoring and thromboembolic risk assessment. Emerging evidence supports catheter ablation in select cases, although data remain limited. Immunosuppressants, particularly calcineurin inhibitors and azathioprine, may increase AF susceptibility. Given the lack of transplant-specific AF guidelines, a multidisciplinary approach is essential. Improved understanding of AF in orthotopic heart transplantation is critical to optimising graft longevity and patient survival. Future studies are needed to guide evidence-based management and surveillance.","PeriodicalId":8412,"journal":{"name":"Arrhythmia & Electrophysiology Review","volume":"15 ","pages":"e30"},"PeriodicalIF":4.3,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arterial Supply to the Atrioventricular Node: Anatomical Variability and Clinical Implications. 房室结的动脉供应：解剖变异和临床意义。

IF 4.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-09-01 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2026.22

Tomokazu Kawashima

引用次数: 0

Objective Assessment of Pathological ECG Waveforms Using Gender-specific Normal Waveform Distributions. 目的利用性别正态波形分布评价病理性心电波形。

IF 4.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-08-24 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2025.51

Krzysztof Piotr Malinowski, Klaudia Proniewska, Peter M van Dam

{"title":"Objective Assessment of Pathological ECG Waveforms Using Gender-specific Normal Waveform Distributions.","authors":"Krzysztof Piotr Malinowski, Klaudia Proniewska, Peter M van Dam","doi":"10.15420/aer.2025.51","DOIUrl":"10.15420/aer.2025.51","url":null,"abstract":"Introduction: The objective definition of the normal ECG waveform is difficult, even 121 years after Einthoven's invention of the ECG. Consequently, ECG evaluation is primarily focused on interval measurements. For the waveforms, many rules and exceptions apply, making the interpretation of the ECG waveforms an art. In this study, a novel method is proposed that compares ECG waveforms with a distribution of normal ECG waveforms (WaveECG) and vectorcardiographic-derived positions of the electrical activity (PathECG) in order to determine the pathological status of the ECG.Methods: Human-annotated ECGs from the PhysioNet PTB-XL Diagnostic ECG database were used. ECGs classified as normal were used to create gender-specific distributions of the normal WaveECG and PathECG. The similarity between the evaluated ECG and the distributions was then quantified. Logistic regression was used to examine the potential of PathECG and WaveECG in the prediction of an abnormal ECG waveform. The independent China Physiological Signal Challenge database was used for validation.Results: A total of 14,381 ECGs were used to construct the distribution of the normal WaveECG and PathECG and to fit the model, and 6,320 independent ECGs were used for validation. The QRS model performance had an area under the receiver operating characteristic curve of 82.1% (95% CI [80.3-84%]) for male patients and 86.1% (95% CI [84.7-87.6%]) for female patients. The area under the receiver operating characteristic curve of the P wave model was 65.4% (95% CI [62.8-68.0%]) for female patients and 66.8% (95% CI [63.9-69.6%]) for male patients.Conclusion: An abnormal ECG can be detected in an explainable and visually understandable way by comparing the ECG to the distribution of normal ECGs. This method might significantly support the less experienced ECG reader in identifying patients requiring cardiac care.","PeriodicalId":8412,"journal":{"name":"Arrhythmia & Electrophysiology Review","volume":"15 ","pages":"e28"},"PeriodicalIF":4.3,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13573016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Burden of Post-ablation Atrial Fibrillation Recurrence in East Asia: A Systematic Literature Review. 东亚地区房颤消融后复发的临床负担：系统文献综述。

IF 4.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-07-20 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2025.64

Jie Liu, Hao Liu, Dan Yu, Tingyin Chen, Zhaoxin Qian, Yuting Chen, Wendong Chen, Ruizheng Shi

{"title":"Clinical Burden of Post-ablation Atrial Fibrillation Recurrence in East Asia: A Systematic Literature Review.","authors":"Jie Liu, Hao Liu, Dan Yu, Tingyin Chen, Zhaoxin Qian, Yuting Chen, Wendong Chen, Ruizheng Shi","doi":"10.15420/aer.2025.64","DOIUrl":"10.15420/aer.2025.64","url":null,"abstract":"Aim: This study aimed to systematically review and synthesise existing real-world evidence on the clinical characteristics and outcomes of patients with post-ablation AF recurrence in east Asia.Methods: Following the PRISMA guidelines, main Chinese- and English-language databases were searched for observational studies published from 2019 to 2024. Inclusion criteria targeted East Asian patients aged ≥18 years with post-ablation AF recurrence. Two independent reviewers conducted study selection, data extraction and quality assessment using the Newcastle-Ottawa Scale. Meta-analyses were performed using a random effects model to synthesise the extracted data.Results: A total of 68 studies involving 28,750 patients were included. Paroxysmal AF accounted for about half of the population (53.4%; 95% CI [47.8-58.9]). Common comorbidities included hypertension (52.6%; 95% CI [50.2-55.0]), coronary artery disease (17.2%; 95% CI [12.9-22.5]) and diabetes (16.8%; 95% CI [14.9-18.8]). The AF recurrence rates after repeat ablation (21.4%; 95% CI [16.6-27.1]) and antiarrhythmic drug therapy (19.6%; 95% CI [18.0-21.2]) were similar. Recurrence was higher in patients with late recurrence (32.6%; 95% CI [26.9-38.8]) than those with early recurrence (21.5%; 95% CI [17.9-25.6]). The pooled 3-year incidence of major events included heart failure hospitalisation (3.2%; 95% CI [2.8-3.6]), ischaemic stroke (1.2%; 95% CI [0.9-1.7]) and cardiovascular-related death (0.3%; 95% CI [0.1-0.5]).Conclusion: Post-ablation AF recurrence in East Asia imposes a considerable disease burden with high recurrence rates even after repeated ablation or antiarrhythmic drug therapy. The presence of prevalent comorbidities and measurable risks of morbidity and mortality further contribute to the long-term clinical and economic burdens of AF.","PeriodicalId":8412,"journal":{"name":"Arrhythmia & Electrophysiology Review","volume":"15 ","pages":"e27"},"PeriodicalIF":4.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13425645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Confirming Dissociated Pulmonary Vein Activity after Pulmonary Vein Isolation While Still in Atrial Fibrillation: Are We Scooping the Moon in the Water? 房颤患者在肺静脉隔离后确认游离肺静脉活动：我们是在水中捞月亮吗？

IF 4.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-07-06 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2026.21

Simon Salim, Ying-Chieh Liao, Shih-Ann Chen

引用次数: 0

Catheter Ablation as an Early Rhythm-control Strategy in Patients with Atrial Fibrillation and Heart Failure. 导管消融作为心房颤动和心力衰竭患者的早期心律控制策略。

IF 4.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-06-30 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2026.03

Mutaz Alkalbani, Chirag Sandesara

引用次数: 0

Prevalence and Discrimination of On-going Fibrillation in Isolated Pulmonary Vein in Non-paroxysmal AF Ablation. 非阵发性房颤消融中孤立肺静脉持续颤动的患病率和鉴别。

IF 4.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-06-16 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2025.68

Ling-Cong Kong, Tian Shuang, Jian-Feng Huang, Hai-Feng Wang, Zhi-Guo Zou, Xin-Hua Wang

{"title":"Prevalence and Discrimination of On-going Fibrillation in Isolated Pulmonary Vein in Non-paroxysmal AF Ablation.","authors":"Ling-Cong Kong, Tian Shuang, Jian-Feng Huang, Hai-Feng Wang, Zhi-Guo Zou, Xin-Hua Wang","doi":"10.15420/aer.2025.68","DOIUrl":"10.15420/aer.2025.68","url":null,"abstract":"Background: It is unclear whether on-going fibrillation in isolated pulmonary veins (OFIP) may coexist with AF in patients undergoing ablation for non-paroxysmal AF (PAF). This study explored the prevalence of OFIP in non-PAF ablation with the aim of developing an algorithm to distinguish between OFIP and isolation failure, thereby minimising excessive ablation.Methods: Non-PAF patients undergoing first-time ablation were divided into a retrospective induction cohort (IC; n=300) and a prospective validation cohort (VC; n=263). In the case of on-going pulmonary vein (PV) fibrillation after ablation, the completeness of PV isolation was assessed based on the change in PV potential and after additional ablation.Results: Among 563 patients, 20 (3.55%) had OFIP (9 in the IC; 11 in the VC). No significant predictors of OFIP were identified in terms of baseline characteristics or procedural factors. Based on three right-sided, five left-sided and one bilateral case of OFIP in the IC, the disappearance of PV potential (either spontaneous or mechanical bumping-induced) or a combination of bipolar voltage reduction >80%, local activation time later than PV recordings and no response to carina ablation were adopted as major criteria in the algorithm to discriminate between OFIP and isolation failure. Among the 20 patients in the VC with on-going PV fibrillation, the algorithm identified true OFIP in 11, false OFIP in three and true incomplete PV isolation in six. The sensitivity, specificity and positive and negative predictive values of the algorithm were 100%, 66.7%, 78.6% and 100%, respectively.Conclusion: The rate of OFIP was not negligible in non-PAF patients undergoing ablation procedures to achieve efficient and safe PV isolation. A novel four-step algorithm was developed to discriminate OFIP from isolation failure, with good predictive value.","PeriodicalId":8412,"journal":{"name":"Arrhythmia & Electrophysiology Review","volume":"15 ","pages":"e24"},"PeriodicalIF":4.3,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T Wave Oversensing in Left Bundle Branch Optimised CRT. 左束支优化CRT中T波过感。

IF 4.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-06-05 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2025.52

Nadiya Johal, Badrinathan Chandrasekaran, Paul Foley

引用次数: 0

Idiopathic Ventricular Arrhythmias: Map Meticulously, Ablate Sparingly. 特发性室性心律失常：仔细测绘，谨慎消融。

IF 4.3

Arrhythmia & Electrophysiology Review Pub Date : 2026-06-05 eCollection Date: 2026-01-01 DOI: 10.15420/aer.2026.07

Roy M John

引用次数: 0