Research in prostaglandins最新文献

Increased association of G-/? subunits to phospholipase C-?l in LTD 4 stimulated epithelial cells G-/?磷脂酶C-?l在lc4刺激的上皮细胞中表达

Research in prostaglandins Pub Date : 1999-12-01 DOI: 10.1016/S0090-6980(99)90350-7

C. Thodeti, J. Adolfsson, M. Juhas, A. Sjölander

引用次数: 0

The induction of cyclooxygenase-2 (COX-2) in intact human amnion tissue by interleukin-4. 白细胞介素-4诱导完整人羊膜组织环氧合酶-2 (COX-2)的表达。

Research in prostaglandins Pub Date : 1995-04-01 DOI: 10.1016/1071-5576(95)94331-N

E. Spaziani, M. Lantz, R. Benoit, W. F. O'brien

引用次数: 12

Mass spectrometry of lipids: by Robert C. Murphy Handbook of Lipis Research Vol 7, Series Editor: Fred Snyder; Publisher: Plenum Publishing Corporation 脂质谱:由罗伯特C.墨菲脂质研究手册第7卷，系列编辑:弗雷德·斯奈德;出版社:全会出版公司

Research in prostaglandins Pub Date : 1994-01-01 DOI: 10.1016/0090-6980(94)90069-8

S. Cathapermal

引用次数: 0

Isoproterenol activation of prostaglandin production in guinea-pig airway muscle preparations from immature and mature animals. 异丙肾上腺素对未成熟和成熟豚鼠气道肌制剂中前列腺素生成的激活作用。

Research in prostaglandins Pub Date : 1990-07-01 DOI: 10.1016/0014-2999(90)92957-K

C. Labat, G. Braunstein, C. Brink

引用次数: 0

Prostaglandins, leukotrienes and lipoxins 1991 XIth International Washington Spring symposium May 13–17 前列腺素，白三烯和脂质1991年第十一届国际华盛顿春季研讨会，5月13-17日

Research in prostaglandins Pub Date : 1990-02-01 DOI: 10.1016/0090-6980(90)90066-5

J. Bailey

引用次数: 0

Changes in urinary thromboxane level in man during cardiopulmonary bypass: effect of thromboxane on renal tubules. 体外循环患者尿血栓素水平的变化:血栓素对肾小管的影响。

Research in prostaglandins Pub Date : 1989-03-15 DOI: 10.2199/JJSCA.9.156

T. Arima, T. Shiramatsu, M. Matsuura, S. Nakamura, I. Matsumoto, T. Hori

{"title":"Changes in urinary thromboxane level in man during cardiopulmonary bypass: effect of thromboxane on renal tubules.","authors":"T. Arima, T. Shiramatsu, M. Matsuura, S. Nakamura, I. Matsumoto, T. Hori","doi":"10.2199/JJSCA.9.156","DOIUrl":"https://doi.org/10.2199/JJSCA.9.156","url":null,"abstract":"ONO-3708, a thromboxane A2 (TXA2) antagonist, was administered at a dose of 2 micrograms/kg/min by a double blind method as compared with inactive placebo during cardiopulmonary bypass (CPB) procedure to study the changes of thromboxane B2 (TXB2) levels in plasma and urine and N-acetyl-glucosaminidase (NAG) level in urine. TXB2 levels in plasma and urine increased significantly (P less than 0.01) during CPB in the patients given ONO-3708 (ONO-3708 group) and in those given placebo (placebo group). The plasma TXB2 level as expected from the urinary TXB2 level was higher than the measured plasma TXB2 level showing increases in TXB2 originating from the kidney. The urinary NAG level, increased significantly (P less than 0.01) during CPB the NAG level in ONO-3708 group was significantly low as compared to placebo group. The levels of TXB2 in plasma and urine in ONO-3708 group were not different from those of the patients receiving placebo, indicating that ONO-3708 does not have any effect on TXA2 production. We concluded that the elevation of urinary TXB2 level might be due to increased TXA2 production in the kidney under hypoxic condition induced by hypotension and lowered perfusion during CPB. Furthermore, the increased production of TXA2 appears to suppress the functions of the renal proximal tubules.","PeriodicalId":83897,"journal":{"name":"Research in prostaglandins","volume":"10 1","pages":"319-38"},"PeriodicalIF":0.0,"publicationDate":"1989-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85238916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Increased production of prostacyclin (PGI2) by vascular intimal smooth muscle cells from atherosclerotic rabbit aorta. 动脉粥样硬化兔主动脉血管内膜平滑肌细胞产生前列环素(PGI2)增加。

Research in prostaglandins Pub Date : 1988-12-01 DOI: 10.5551/jat1973.14.5_1047

Y. Kanemaru, T. Noguchi, Y. Kazama, M. Wakasugi, T. Onaya, Y. Yoshida

{"title":"Increased production of prostacyclin (PGI2) by vascular intimal smooth muscle cells from atherosclerotic rabbit aorta.","authors":"Y. Kanemaru, T. Noguchi, Y. Kazama, M. Wakasugi, T. Onaya, Y. Yoshida","doi":"10.5551/jat1973.14.5_1047","DOIUrl":"https://doi.org/10.5551/jat1973.14.5_1047","url":null,"abstract":"In vitro PGI2 synthesis by aortic strips obtained from thoracic aorta of rabbits fed a high cholesterol diet was examined and compared with that of control rabbits fed a normal diet. In this report, the amounts of PGI2 produced were shown as 6-keto-PGF1 alpha per microgram of aortic tissue DNA instead of per mg wet weight. We also investigated PGI2 synthesis by cultured smooth muscle cells (SMC) obtained from atherosclerotic intima. Basal PGI2 production by aortic strips from atherosclerotic rabbit aorta was significantly augmented compared with that of controls. Arachidonic acid (AA)-induced PGI2 production by atherosclerotic aorta was also significantly higher than that of controls. PGI2 producing capacities of intimal and medial layers, separated from atherosclerotic aorta, were examined and the intimal layer was found to elicit a significantly greater PGI2 production than the medial layer. Furthermore, cultured intimal SMC obtained from atherosclerotic rabbit aorta produced a greater amount of PGI2 than medial SMC from normal rabbit aorta at various cultured conditions. These results suggest that the possibility of enhanced PGI2 production by atherosclerotic aorta may well be considered as a defence mechanism of the vessel wall against damaging stimuli.","PeriodicalId":83897,"journal":{"name":"Research in prostaglandins","volume":"38 1","pages":"881-90"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73994752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

PAF-acether in the carrageenan-induced inflammatory reaction in mice paf -醚在卡拉胶诱导小鼠炎症反应中的作用

Research in prostaglandins Pub Date : 1988-05-01 DOI: 10.1016/0090-6980(88)90244-4

M. Henriques, R. Cordeiro, V. Weg, P. Fernandes, M. Martins, P. M. Martins, B. Vargaftig

引用次数: 1

Inhibition of the binding and aggregation to PAF in vitro in comparison with PAF-antagonism in vivo: An investigation using different types of PAF-antagonists 体外对PAF结合和聚集的抑制作用与体内PAF拮抗剂的比较:使用不同类型PAF拮抗剂的研究

Research in prostaglandins Pub Date : 1988-05-01 DOI: 10.1016/0090-6980(88)90240-7

H. Heuer, F. Birke, J. Casals-stenzel, K. Weber

引用次数: 9

In vitro and in vivo effects of SM-10661, a newly synthesized platelet-activating factor (PAF) antagonist 新合成的血小板活化因子(PAF)拮抗剂SM-10661的体内外作用

Research in prostaglandins Pub Date : 1988-05-01 DOI: 10.1016/0090-6980(88)90243-2

S. Morooka, Y. Komuro, R. Ando, M. Uchida

引用次数: 5