Amit P Amin, Sandeep Nathan, Arthur T Evans, Steve Attanasio, Ekanka Mukhopadhyay, Vijay Mehta, Russell F Kelly
{"title":"The effect of ethnicity on the relationship between premature coronary artery disease and traditional cardiac risk factors among uninsured young adults.","authors":"Amit P Amin, Sandeep Nathan, Arthur T Evans, Steve Attanasio, Ekanka Mukhopadhyay, Vijay Mehta, Russell F Kelly","doi":"10.1111/j.1751-7141.2009.00025.x","DOIUrl":"https://doi.org/10.1111/j.1751-7141.2009.00025.x","url":null,"abstract":"<p><p>Prior studies of premature coronary artery disease (CAD) in young adults did not address the association of race/ethnicity and risk factors. Therefore, the authors conducted a study of 400 patients 40 years and older undergoing coronary angiography at a large, urban public hospital that serves predominantly minority, uninsured populations. The prevalence of risk factors and their association with premature CAD varied markedly by ethnic group. Among blacks, dyslipidemia, diabetes, and smoking were independently associated with premature CAD. Among Hispanics, dyslipidemia, male sex, and family history of CAD were independently associated with premature CAD. Smoking was the only risk factor in whites, and no independent risk factor was identified in Asian Indians. Whites and Asian Indians had a higher prevalence of disease than blacks or Hispanics--before and after adjusting for risk factor imbalances across ethnic groups. In this ethnically diverse population, the authors' findings underscore the importance of identifying distinctive risk factors in various ethnic groups.</p>","PeriodicalId":83876,"journal":{"name":"Preventive cardiology","volume":"12 3","pages":"128-35"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1751-7141.2009.00025.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28249614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paul A Pirraglia, Tracey H Taveira, Lisa B Cohen, Andrea Dooley, Wen-Chih Wu
{"title":"Maintenance of cardiovascular risk goals in veterans with diabetes after discharge from a cardiovascular risk reduction clinic.","authors":"Paul A Pirraglia, Tracey H Taveira, Lisa B Cohen, Andrea Dooley, Wen-Chih Wu","doi":"10.1111/j.1751-7141.2008.00017.x","DOIUrl":"https://doi.org/10.1111/j.1751-7141.2008.00017.x","url":null,"abstract":"<p><p>The authors evaluated maintenance of achieved cardiovascular risk control after discharge from a pharmacist-coordinated cardiovascular risk reduction clinic. Using data from 2001 to 2004 divided by financial quarters (ie, 3-month periods), the authors performed survival analysis of diabetic patients who had attained at least one cardiovascular risk goal in the clinic. Mean times to failure were 7.1 +/- 0.21 quarters for hemoglobin A1c, 7.6 +/- 0.29 quarters for low-density lipoprotein cholesterol (LDL-C), and 2.5 +/- 0.24 quarters for systolic blood pressure (SBP). Body mass index predicted glycemic control failure (hazard ratio [HR], 1.08; 95% confidence interval [CI], 1.01-1.15; P = .02), insulin use predicted LDL-C control failure (HR, 3.08; 95% CI, 1.15-8.22; P = .03), and baseline SBP predicted SBP control failure (HR, 1.02; 95% CI, 1.01-1.03; P = .0003). The authors found good durability of effect for most cardiovascular risk targets. Worse control at entry predicted failure after successful attainment of a cardiovascular goal. More sustained attention or booster interventions for patients with worse control at entry may be necessary.</p>","PeriodicalId":83876,"journal":{"name":"Preventive cardiology","volume":"12 1","pages":"3-8"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1751-7141.2008.00017.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28134778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: summary and discussion of the American Society of Echocardiography consensus statement.","authors":"James H Stein, Claudia E Korcarz, Wendy S Post","doi":"10.1111/j.1751-7141.2008.00021.x","DOIUrl":"10.1111/j.1751-7141.2008.00021.x","url":null,"abstract":"","PeriodicalId":83876,"journal":{"name":"Preventive cardiology","volume":"12 1","pages":"34-8"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28135726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of potential immune targets in atherosclerosis for vaccine development.","authors":"Nandini Venkatesan, Vijay R Prabhakar","doi":"10.1111/j.1751-7141.2008.00001.x","DOIUrl":"https://doi.org/10.1111/j.1751-7141.2008.00001.x","url":null,"abstract":"","PeriodicalId":83876,"journal":{"name":"Preventive cardiology","volume":"11 4","pages":"185-8"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1751-7141.2008.00001.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28203064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Varenicline and its role in smoking cessation.","authors":"Shailendra Kapoor","doi":"10.1111/j.1751-7141.2008.08258.x","DOIUrl":"https://doi.org/10.1111/j.1751-7141.2008.08258.x","url":null,"abstract":"<p><p>Varenicline is a partial agonist of alpha4beta2 nicotinic receptors. It was recently approved for smoking cessation in the United States. It is administered at a dosage of 0.5 mg once a day for an initial period of 3 days followed by 0.5 mg twice a day for the next 4 days. Following this, the drug is administered at a dosage of 1.0 mg twice a day. The total duration of therapy is 12 weeks. Common adverse effects include nausea, headache, and insomnia. Recent studies show that varenicline is almost twice as effective as bupropion SR in smoking cessation. Given the increased risk of cardiovascular morbidity secondary to smoking, especially in the elderly, varenicline is a major therapeutic tool in the fight against smoking.</p>","PeriodicalId":83876,"journal":{"name":"Preventive cardiology","volume":"11 3","pages":"168-71"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1751-7141.2008.08258.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37434517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Brain natriuretic peptides as biomarkers for atherosclerosis.","authors":"Kellan E Ashley, John M Galla, Stephen J Nicholls","doi":"10.1111/j.1751-7141.2008.08578.x","DOIUrl":"https://doi.org/10.1111/j.1751-7141.2008.08578.x","url":null,"abstract":"<p><p>Identification of atherosclerotic risk factors provides targets for development of preventive therapies. Risk factor assessment permits evaluation of an individual's prospective risk of coronary heart disease (CHD). However, it has become apparent that traditional risk factors may not predict CHD in some patients. As a result, many individuals do not receive the benefit of intensive preventive strategies. Accordingly, considerable effort has focused on the identification of novel biomarkers to enhance risk stratification. Given its prognostic utility in heart failure and acute coronary syndrome, brain natriuretic peptide (BNP) and its amino-terminal fragment have received interest as possible biomarkers for CHD.</p>","PeriodicalId":83876,"journal":{"name":"Preventive cardiology","volume":"11 3","pages":"172-6"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1751-7141.2008.08578.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37434518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiovascular risk assessment--where are we going?","authors":"Peter W F Wilson","doi":"10.1111/j.1751-7141.2008.07770.x","DOIUrl":"https://doi.org/10.1111/j.1751-7141.2008.07770.x","url":null,"abstract":"","PeriodicalId":83876,"journal":{"name":"Preventive cardiology","volume":"11 3","pages":"183-4"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1751-7141.2008.07770.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37434520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dobutamine stress cardiac magnetic resonance imaging to detect myocardial ischemia in women.","authors":"Subha V Raman, Michael R Donnally, Beth McCarthy","doi":"10.1111/j.1751-7141.2008.08243.x","DOIUrl":"https://doi.org/10.1111/j.1751-7141.2008.08243.x","url":null,"abstract":"<p><p>This study sought to evaluate dobutamine stress cardiac magnetic resonance imaging (DCMRI) in women with abnormal stress nuclear testing results. Women with findings on stress nuclear exams, including electrocardiography and/or perfusion, thought to require further evaluation with invasive coronary angiography were prospectively enrolled. Multiplane cine imaging was obtained at rest and at each stage of inotropic stress with atropine as needed to achieve target heart rate. DCMRI results were compared with stress nuclear and invasive cardiac catheterization results. Of 23 patients enrolled successfully, 22 completed DCMRI examination without complications. In all cases, DCMRI imaging demonstrated appropriate stress response with no ischemia despite abnormalities on stress nuclear testing. In the 18 patients who also underwent invasive coronary angiography, no significant obstructive disease was identified. DCMRI may be a useful alternative to stress nuclear examination in women; larger studies are warranted to determine its potential to more accurately predict obstructive coronary artery disease.</p>","PeriodicalId":83876,"journal":{"name":"Preventive cardiology","volume":"11 3","pages":"135-40"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1751-7141.2008.08243.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37434589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicolas W Shammas, Eric J Dippel, Michael Jerin, Peter P Toth, Matthew Kapalis, Mythri Reddy, Harb Harb
{"title":"Elevated levels of homocysteine predict cardiovascular death, nonfatal myocardial infarction, and symptomatic bypass graft disease at 2-year follow-up following coronary artery bypass surgery.","authors":"Nicolas W Shammas, Eric J Dippel, Michael Jerin, Peter P Toth, Matthew Kapalis, Mythri Reddy, Harb Harb","doi":"10.1111/j.1751-7141.2008.08293.x","DOIUrl":"https://doi.org/10.1111/j.1751-7141.2008.08293.x","url":null,"abstract":"<p><p>Severe graft disease occurs in patients at a rate of approximately 15% within the first year of coronary artery bypass grafting (CABG). In this study, the authors examined predictors of the combined end point of death, nonfatal myocardial infarction (MI), and bypass graft disease at 2-year follow-up after CABG. One hundred twenty-one consecutive patients were included in this study after informed consent was obtained. In univariate analysis, there was a significantly (P<.05) higher homocysteine level (11.0 ng/mol vs 9.7 ng/mol, P=.04) in patients who met the combined end point vs those who did not. There were no statistically significant differences in the following: low-density lipoprotein cholesterol, high-sensitivity C-reactive protein, and lipoprotein(a) values; age; body mass index; smoking and diabetes status; statin or aspirin use; creatinine level; hematologic markers; left ventricular ejection fraction; number of bypass grafts; and distribution of coronary artery disease. Logistic regression analysis modeling for low-density lipoprotein cholesterol, lipoprotein(a), fibrinogen, and homocysteine showed that homocysteine value (P=.016) was an independent predictor of the primary combined end point.</p>","PeriodicalId":83876,"journal":{"name":"Preventive cardiology","volume":"11 2","pages":"95-9"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1751-7141.2008.08293.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27373628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adam T deJong, Michael J Gallagher, Keisha R Sandberg, Martin A Lillystone, Thomas Spring, Barry A Franklin, Peter A McCullough
{"title":"Peak oxygen consumption and the minute ventilation/carbon dioxide production relation slope in morbidly obese men and women: influence of subject effort and body mass index.","authors":"Adam T deJong, Michael J Gallagher, Keisha R Sandberg, Martin A Lillystone, Thomas Spring, Barry A Franklin, Peter A McCullough","doi":"10.1111/j.1751-7141.2008.07591.x","DOIUrl":"https://doi.org/10.1111/j.1751-7141.2008.07591.x","url":null,"abstract":"<p><p>The authors evaluated the minute ventilation/carbon dioxide production relation (VE/VCO2 slope) as a complementary measure to peak oxygen consumption (peak VO2) in 76 patients (mean +/- SD age = 44.3+/-10.8 years, 69.7% female) with morbid obesity (mean +/- SD body mass index [BMI] = 49.4+/-7.0 kg/m(2)), as it is not limited by effort. Nearly one-half (43%) of the patients achieved a peak respiratory exchange ratio <1.10. Mean peak VO2 and VE/VCO2 slope were 17.0+/-3.7 mL/kg/min and 27.8+/-4.0, respectively. Peak VO2 correlated with BMI (r=-0.45, P<.0001), while VE/VCO2 slope did not (r=-0.04, P=.73). There was a linear trend for declining mean peak VO2 (P=.001) but not for VE /VCO2 slope (P=.59) with increasing BMI quintiles. The VE/VCO2 slope is an effort-independent measure that is also independent of BMI and may serve as an adjunctive cardiorespiratory variable when evaluating morbidly obese men and women.</p>","PeriodicalId":83876,"journal":{"name":"Preventive cardiology","volume":"11 2","pages":"100-5"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1751-7141.2008.07591.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27373629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}