Annals of Pancreatic Cancer最新文献_第2页

Association of a genetic variant in the adenosine triphosphate transmembrane glycoprotein and risk of pancreatic cancer 三磷酸腺苷跨膜糖蛋白基因变异与胰腺癌风险的关系

Annals of Pancreatic Cancer Pub Date : 2023-07-01 DOI: 10.21037/apc-22-7

Fatemeh Khojasteh-Leylakoohi, Ghazaleh Khalili-Tanha, N. Sardarzadeh, Nima Khalili‐Tanha, Mohammad Dashtiahangar, S. Mehrabadi, Alireza Asadnia, A. Avan, S. Amoueian, S. Hassanian, H. Esmaily, M. Khazaei, G. Ferns, M. Aliakbarian, Alireza Khooei

引用次数: 1

Analysis of the receptor for advanced glycation end-products proteome and protein-protein interactome in PANC-1 cancer cells PANC-1癌细胞中晚期糖基化终产物蛋白质组和蛋白质相互作用组受体的分析

Annals of Pancreatic Cancer Pub Date : 2023-06-01 DOI: 10.21037/apc-22-4

Chaitanya Doshi, Nicholle M. Johnson, Charles A. Downs

引用次数: 0

Direct identification of T cell epitopes in cancer tissues. 直接识别癌症组织中的 T 细胞表位。

Annals of Pancreatic Cancer Pub Date : 2023-04-20 DOI: 10.21037/apc-2023-1

Yingkuan Shao, Tengyi Zhang, Betul Celiker, Kenji Fujiwara

{"title":"Direct identification of T cell epitopes in cancer tissues.","authors":"Yingkuan Shao, Tengyi Zhang, Betul Celiker, Kenji Fujiwara","doi":"10.21037/apc-2023-1","DOIUrl":"10.21037/apc-2023-1","url":null,"abstract":"Prediction of tumor-specific T cell epitopes is an important part of cancer immunotherapies. In the past, tumor-specific T cell epitopes were identified by mapping the epitopes on the known cancer-testis antigens and tumor-associated antigens or antigens that react to the T cells induced by the cancer vaccine therapy. More recently, in silico prediction of mutation-associated neoepitopes from the whole-exome sequencing (WES) results has become another approach. However, although this approach often identifies many predicted peptides, only few have been shown to be immunogenic. Mass spectrometry (MS) has also been used to directly identify the T cell epitopes presented on tumor cell by eluting the peptides from human leukocyte antigens (HLA) class I and class II molecules. This approach of identifying neoepitopes was demonstrated to be feasible in high tumor mutation burden (TMB) tumors such as melanoma. However, identifying low-TMB-tumor-specific T cell epitopes has been challenging. Recently, Fujiwara et al. reported their successful result in identifying T cell epitopes in a low TMB tumor, namely pancreatic ductal adenocarcinoma (PDAC). Using the MS approach, they identified T cell epitopes shared by multiple pancreatic cancer patients with different HLA types. Moreover, they demonstrated that the identified epitopes bound non-matched HLA molecules and induced T cell response in peripheral T cells from non-HLA-type matched patients. Their study has opened a new venue for identifying T cell epitopes in a non-immunogenic tumor such as PDAC for the design and development of vaccine and T cell therapy.","PeriodicalId":8372,"journal":{"name":"Annals of Pancreatic Cancer","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10722904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76663165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The anti-metastasis effect of low-dose carbon monoxide 低剂量一氧化碳的抗转移作用

Annals of Pancreatic Cancer Pub Date : 2023-02-01 DOI: 10.21037/apc-2022-4

Binghe Wang, Y. Du

引用次数: 1

Pancreatic metastasis of a primary osteosarcoma with genomic profiling analysis: case report and review of the literature 原发性骨肉瘤的胰腺转移与基因组分析:病例报告和文献回顾

Annals of Pancreatic Cancer Pub Date : 2023-02-01 DOI: 10.21037/apc-22-5

Roya P. Darioosh, A. Singhi, M. Reeves, Wasseem Skef

引用次数: 0

A prognostic machine learning model for the prediction of pancreatic adenocarcinoma prognosis based on genomic expression of four cell-cycle associated hub genes 基于四个细胞周期相关中心基因的基因组表达的预测胰腺腺癌预后的预后机器学习模型

Annals of Pancreatic Cancer Pub Date : 2023-01-01 DOI: 10.21037/apc-22-6

Y. Ahmed, A. Al-Bzour, M. Qaddoura, Maen Ahmed, S. A. Alryalat

引用次数: 0

Patients’ characteristics, diagnosis, and management of pancreatic masses in low resource settings 低资源环境下胰腺肿块的患者特征、诊断和管理

Annals of Pancreatic Cancer Pub Date : 2022-12-01 DOI: 10.21037/apc-22-3

N. E. Kivuyo, L. Akoko

引用次数: 0

Battling pancreatic cancer: the role of Chinese surgeons. 抗击胰腺癌:中国外科医生的角色。

Annals of Pancreatic Cancer Pub Date : 2022-10-31 DOI: 10.21037/apc-2022-3

Lei Zheng

引用次数: 0

A tumor intrinsic role of CD73 in pancreatic adenocarcinoma CD73在胰腺腺癌中的内在作用

Annals of Pancreatic Cancer Pub Date : 2022-10-01 DOI: 10.21037/apc-2022-2

Antao Chang, J. Hao

引用次数: 0

"RHAMM knockout" mice express a truncated RHAMM protein that promotes pancreatic cancer progression with dysfunctional p53. “RHAMM敲除”小鼠表达一种截断的RHAMM蛋白，该蛋白促进胰腺癌进展并伴有功能失调的p53。

Annals of Pancreatic Cancer Pub Date : 2022-07-01 DOI: 10.21037/apc-2022-1

Xiang Chen, Yi-Chieh Nancy Du

{"title":"\"RHAMM knockout\" mice express a truncated RHAMM protein that promotes pancreatic cancer progression with dysfunctional p53.","authors":"Xiang Chen, Yi-Chieh Nancy Du","doi":"10.21037/apc-2022-1","DOIUrl":"https://doi.org/10.21037/apc-2022-1","url":null,"abstract":"Pancreatic cancer, which lacks effective treatment, has the highest mortality rate of all major cancers (1). A recent study by Lin et al. published in Cancer Letters (2) sought out to investigate whether RHAMM is a therapeutic target in pancreatic cancer using a Rhamm −/− mouse strain. Surprisingly, a truncated HMMR Δexon8–16 protein expressed at higher levels than wild-type RHAMM protein was found in this “knockout” strain and HMMR Δexon8–16 accelerated pancreatic cancer progression in genetic engineered mouse models. Pancreatic cancer is projected to become the second leading cause of cancer-related death by 2030 (3). The most common type of pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC). Pancreatic neuroendocrine tumor (PNET) is the second common malignancy of pancreas and its incidence is increasing (4). Pancreatic cancer patients are often diagnosed at advanced stages. Despite intense efforts in improved diagnostic methods and development of targeted therapies, the overall survival for pancreatic cancer has changed little. It is critical to understand the biology of pancreatic cancer and identify novel therapeutic targets for this devastating disease.","PeriodicalId":8372,"journal":{"name":"Annals of Pancreatic Cancer","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/59/73/nihms-1821921.PMC9733914.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0