Analysis of the receptor for advanced glycation end-products proteome and protein-protein interactome in PANC-1 cancer cells

Abstract

Background: Pancreatic adenocarcinoma (PA) remains one of the leading causes of cancer related deaths worldwide. The pathogenesis of PA is unclear. However, studies show that the receptor for advanced glycation end-products (RAGE), a member of the immunoglobulin superfamily and pattern recognition receptor, likely plays a role in oncogenesis and cell proliferation. RAGE has multiple functions including amplification and perpetuation of the inflammatory response, protein transport and degradation, maintaining cell polarity, and promoting cell differentiation and division. RAGE may contribute to oncogenesis of PA through dysregulation of ubiquitin and tumor suppressor genes such as p53.