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Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement最新文献

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Markers of exposure to aromatic amines and nitro-PAH. 暴露于芳香胺和硝基多环芳烃的标记物。
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement Pub Date : 1998-01-01 DOI: 10.1007/978-3-642-46856-8_16
H G Neumann, I Zwirner-Baier, C van Dorp
{"title":"Markers of exposure to aromatic amines and nitro-PAH.","authors":"H G Neumann, I Zwirner-Baier, C van Dorp","doi":"10.1007/978-3-642-46856-8_16","DOIUrl":"https://doi.org/10.1007/978-3-642-46856-8_16","url":null,"abstract":"","PeriodicalId":8353,"journal":{"name":"Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement","volume":"20 ","pages":"179-87"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20371839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Detection of low levels of DNA damage arising from exposure of humans to chemical carcinogens. 检测因人类接触化学致癌物而引起的低水平DNA损伤。
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement Pub Date : 1998-01-01 DOI: 10.1007/978-3-642-46856-8_18
P L Carmichael
{"title":"Detection of low levels of DNA damage arising from exposure of humans to chemical carcinogens.","authors":"P L Carmichael","doi":"10.1007/978-3-642-46856-8_18","DOIUrl":"https://doi.org/10.1007/978-3-642-46856-8_18","url":null,"abstract":"","PeriodicalId":8353,"journal":{"name":"Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement","volume":"20 ","pages":"199-205"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20368450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Development of in vitro models for cellular and molecular studies in toxicology and chemoprevention. 体外毒理学和化学预防的细胞和分子研究模型的建立。
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement Pub Date : 1998-01-01 DOI: 10.1007/978-3-642-46856-8_20
K Macé, E A Offord, C C Harris, A M Pfeifer
{"title":"Development of in vitro models for cellular and molecular studies in toxicology and chemoprevention.","authors":"K Macé,&nbsp;E A Offord,&nbsp;C C Harris,&nbsp;A M Pfeifer","doi":"10.1007/978-3-642-46856-8_20","DOIUrl":"https://doi.org/10.1007/978-3-642-46856-8_20","url":null,"abstract":"<p><p>Many natural dietary phytochemicals found compounds found in fruits, vegetables, spices and tea have been shown in recent years to be protective against cancer in various animal models. In the light of the potential impact of these compounds on human health it is important to elucidate the mechanisms involved. We therefore developed and characterized relevant in vitro models using immortalized human epithelial cell lines derived from target tissues in carcinogenesis, such as lung, liver and colon. Assays were established, allowing the evaluation of the cytotoxic and genotoxic effects of various procarcinogens, including nitrosamines, mycotoxins and heterocyclic amines on these metabolically-competent human epithelial cell lines. These cellular models appeared to be a useful tool to study the capacity of certain food components to block the initiation stage of carcinogenesis. The ability of carnosol and carnosic acid from rosemary as well as the synthetic dithiolethione, oltipraz, to block the formation of DNA adducts, and their effects on the expression of phase I and phase II enzymes was investigated. We have observed that both rosemary extracts and oltipraz inhibited benzo(a)pyrene- or aflatoxin B1-induced DNA adduct formation by strongly inhibiting CYP450 activities and inducing the expression of glutathione S-transferase. These results in human cell models give some insight into the different mechanisms involved in the chemopreventive action of both natural and synthetic compounds in relation to phase I and phase II enzymes.</p>","PeriodicalId":8353,"journal":{"name":"Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement","volume":"20 ","pages":"227-36"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20368452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Assessing toxicological impacts in life cycle assessment. 在生命周期评估中评估毒理学影响。
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement Pub Date : 1998-01-01 DOI: 10.1007/978-3-642-46856-8_30
S I Olsen, M Z Hauschild
{"title":"Assessing toxicological impacts in life cycle assessment.","authors":"S I Olsen,&nbsp;M Z Hauschild","doi":"10.1007/978-3-642-46856-8_30","DOIUrl":"https://doi.org/10.1007/978-3-642-46856-8_30","url":null,"abstract":"","PeriodicalId":8353,"journal":{"name":"Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement","volume":"20 ","pages":"331-45"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20368462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The environmental experience: ecosystem protection. 环境经验:生态系统保护。
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement Pub Date : 1997-01-01 DOI: 10.1007/978-3-642-60682-3_14
F Bro-Rasmussen
{"title":"The environmental experience: ecosystem protection.","authors":"F Bro-Rasmussen","doi":"10.1007/978-3-642-60682-3_14","DOIUrl":"https://doi.org/10.1007/978-3-642-60682-3_14","url":null,"abstract":"","PeriodicalId":8353,"journal":{"name":"Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement","volume":"19 ","pages":"155-66"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20032064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is sustainable development a practical possibility given the continued use of plant protection products?--the scientific view. 考虑到持续使用植物保护产品，可持续发展是否具有实际的可能性?——科学的观点。
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement Pub Date : 1997-01-01 DOI: 10.1007/978-3-642-60682-3_15
M Herrchen, W Klein
{"title":"Is sustainable development a practical possibility given the continued use of plant protection products?--the scientific view.","authors":"M Herrchen,&nbsp;W Klein","doi":"10.1007/978-3-642-60682-3_15","DOIUrl":"https://doi.org/10.1007/978-3-642-60682-3_15","url":null,"abstract":"","PeriodicalId":8353,"journal":{"name":"Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement","volume":"19 ","pages":"167-76"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20032065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bovine chromaffin cells as in vitro model for the study of non-cholinergic toxic effects of organophosphorus compounds. 牛嗜铬细胞作为研究有机磷化合物非胆碱能毒性作用的体外模型。
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement Pub Date : 1997-01-01 DOI: 10.1007/978-3-642-60682-3_33
M A Sogorb, S Bas, L M Gutiérrez, E Vilanova, S Viniegra
{"title":"Bovine chromaffin cells as in vitro model for the study of non-cholinergic toxic effects of organophosphorus compounds.","authors":"M A Sogorb,&nbsp;S Bas,&nbsp;L M Gutiérrez,&nbsp;E Vilanova,&nbsp;S Viniegra","doi":"10.1007/978-3-642-60682-3_33","DOIUrl":"https://doi.org/10.1007/978-3-642-60682-3_33","url":null,"abstract":"","PeriodicalId":8353,"journal":{"name":"Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement","volume":"19 ","pages":"347-55"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20032630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Interactions of TCDD with signal transduction and neoplastic development in c-myc transgenic and TGF-alpha transgenic mice. TCDD与c-myc转基因和tgf - α转基因小鼠信号转导和肿瘤发展的相互作用。
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement Pub Date : 1997-01-01 DOI: 10.1007/978-3-642-60682-3_35
D Schrenk, M Müller, G Merlino, S S Thorgeirsson
{"title":"Interactions of TCDD with signal transduction and neoplastic development in c-myc transgenic and TGF-alpha transgenic mice.","authors":"D Schrenk,&nbsp;M Müller,&nbsp;G Merlino,&nbsp;S S Thorgeirsson","doi":"10.1007/978-3-642-60682-3_35","DOIUrl":"https://doi.org/10.1007/978-3-642-60682-3_35","url":null,"abstract":"","PeriodicalId":8353,"journal":{"name":"Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement","volume":"19 ","pages":"367-75"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20031878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of antidotes in the management of central nervous system depression. 解毒剂在治疗中枢神经系统抑郁中的应用。
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement Pub Date : 1997-01-01 DOI: 10.1007/978-3-642-60682-3_26
A Ferrer, E Civeira, P Lopez, B Loren
{"title":"The use of antidotes in the management of central nervous system depression.","authors":"A Ferrer,&nbsp;E Civeira,&nbsp;P Lopez,&nbsp;B Loren","doi":"10.1007/978-3-642-60682-3_26","DOIUrl":"https://doi.org/10.1007/978-3-642-60682-3_26","url":null,"abstract":"","PeriodicalId":8353,"journal":{"name":"Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement","volume":"19 ","pages":"289-98"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20032623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nasal lavage biomarkers in air pollution epidemiology. 鼻腔灌洗物在空气污染流行病学中的应用。
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement Pub Date : 1997-01-01 DOI: 10.1007/978-3-642-60682-3_19
P A Steerenberg, P H Fischer, L van Bree, H van Loveren
{"title":"Nasal lavage biomarkers in air pollution epidemiology.","authors":"P A Steerenberg,&nbsp;P H Fischer,&nbsp;L van Bree,&nbsp;H van Loveren","doi":"10.1007/978-3-642-60682-3_19","DOIUrl":"https://doi.org/10.1007/978-3-642-60682-3_19","url":null,"abstract":"","PeriodicalId":8353,"journal":{"name":"Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement","volume":"19 ","pages":"207-16"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-642-60682-3_19","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20032616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
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