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The Guthrie journal of the Donald Guthrie Foundation for Medical Research Pub Date : 2001-04-01 DOI: 10.3138/guthrie.70.2.057
William Friedenberg
{"title":"Renewal","authors":"William Friedenberg","doi":"10.3138/guthrie.70.2.057","DOIUrl":"https://doi.org/10.3138/guthrie.70.2.057","url":null,"abstract":"","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78515382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guthrie Photodynamic Therapy Program 格思里光动力治疗计划
The Guthrie journal of the Donald Guthrie Foundation for Medical Research Pub Date : 2001-04-01 DOI: 10.3138/guthrie.70.2.072
J. McCaughan
{"title":"Guthrie Photodynamic Therapy Program","authors":"J. McCaughan","doi":"10.3138/guthrie.70.2.072","DOIUrl":"https://doi.org/10.3138/guthrie.70.2.072","url":null,"abstract":"Photodynamic therapy has been approved by the FDA for treatment of lung and esophageal cancer, pre-cancerous skin lesions and macular degeneration. Many other cancers are under study. Therapy begins with sensitization of abnormal tissue with injection of a light absorbing photoactive medication that is inert until exposed to light of a specific wavelength which induces free-radical formation and thromboxane-2 generation, destroying intracellular organelles. Light penetration is 4 to 8 mm, so repeat therapy is often needed. It is curative for some early cancers and an important adjunct in others.","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"229 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79017201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic Mastocytosis
The Guthrie journal of the Donald Guthrie Foundation for Medical Research Pub Date : 2001-04-01 DOI: 10.3138/guthrie.70.2.075
Madhuri Yalamanchili, Anamika Patel, P. Bergevin
{"title":"Systemic Mastocytosis","authors":"Madhuri Yalamanchili, Anamika Patel, P. Bergevin","doi":"10.3138/guthrie.70.2.075","DOIUrl":"https://doi.org/10.3138/guthrie.70.2.075","url":null,"abstract":"Systemic Mastocytosis is an abnormal proliferation of mast cells in the skin and multiple other organs. Its prognosis is variable, from indolent to very aggressive. The systemic signs and symptoms of mastocytosis are diverse and related to pharmacologic manifestations of mast cell mediators. They may mimic various conditions including chronic granulomatous disorders such as tuberculosis and sarcoid, connective tissue disorders, occult visceral malignancies, and even lymphoma. We report a patient with systemic mastocytosis and review the diagnosis and management of the disorder.","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74447014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuesdays with Morrie: An old man, a young man, and life's greatest lesson 与莫里共度的星期二:一个老人，一个年轻人，生命中最重要的一课
The Guthrie journal of the Donald Guthrie Foundation for Medical Research Pub Date : 2001-04-01 DOI: 10.3138/guthrie.70.2.092
W. Friedenberg
{"title":"Tuesdays with Morrie: An old man, a young man, and life's greatest lesson","authors":"W. Friedenberg","doi":"10.3138/guthrie.70.2.092","DOIUrl":"https://doi.org/10.3138/guthrie.70.2.092","url":null,"abstract":"","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87965140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving Outcomes in Cancer of the Pancreas at Guthrie Cancer Center 格思里癌症中心胰腺癌预后的改善
The Guthrie journal of the Donald Guthrie Foundation for Medical Research Pub Date : 2001-04-01 DOI: 10.3138/guthrie.70.2.065
D. Jaffurs, T. Vandermeer
{"title":"Improving Outcomes in Cancer of the Pancreas at Guthrie Cancer Center","authors":"D. Jaffurs, T. Vandermeer","doi":"10.3138/guthrie.70.2.065","DOIUrl":"https://doi.org/10.3138/guthrie.70.2.065","url":null,"abstract":"Significant advances have been made in the treatment of pancreatic cancer in the past decade. Decreased morbidity and mortality following pancreatic surgery has improved survival in specialized centers. The purpose of this study was to review outcomes of pancreatic surgery in the context of the multidisciplinary approach to the treatment of pancreatic cancer at Guthrie Cancer Center. Operative morbidity and mortality compare favorably to other centers specializing in pancreatic surgery. Early detection was accomplished in the majority of cases and low surgical morbidity enabled most patients with ductal adenocarcinoma of the pancreas to receive adjuvant treatment. Recent advances in the multidisciplinary treatment of pancreatic cancer patients have improved the treatment of patients with pancreatic cancer at Guthrie Cancer Center and are described in this review.","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"146 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88636841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Guthrie cDNA Resource Center 格思里cDNA资源中心
The Guthrie journal of the Donald Guthrie Foundation for Medical Research Pub Date : 2001-04-01 DOI: 10.3138/guthrie.70.2.058
H. Puhl, R. Aronstam, S. Ikeda
{"title":"The Guthrie cDNA Resource Center","authors":"H. Puhl, R. Aronstam, S. Ikeda","doi":"10.3138/guthrie.70.2.058","DOIUrl":"https://doi.org/10.3138/guthrie.70.2.058","url":null,"abstract":"In January 2000, the Guthrie Research Institute established a cDNA Resource Center. The mission of the center is to accelerate scientific discovery in human biology and pathology by providing full length cDNA clones of human proteins involved in signal transduction processes. The Center provides clones of human proteins that are: 1) full length; 2) sequence verified; 3) propagated in a versatile mammalian expression vector; 4) free of extraneous 3’ and 5’ untranslated regions; and 5) available in wild-type, epitope-tagged and common mutant forms (e.g., constitutively-active or dominant negative). The clones are supplied solely for non-commercial research purposes. There is no charge for these clones, although a handling and shipping fee is assessed. Between July 1 and December 31, 2000, 490 clones were shipped to customers in 65 institutions on 3 continents and the catalogue was expanded to over 130 unique clones, at least four of which have not been previously described.","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78154890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VIII: A Druidic Wind That Rages 八:德鲁伊之风怒吼
The Guthrie journal of the Donald Guthrie Foundation for Medical Research Pub Date : 2001-04-01 DOI: 10.3138/guthrie.70.2.084
Nicholas H. Bartenhagen
{"title":"VIII: A Druidic Wind That Rages","authors":"Nicholas H. Bartenhagen","doi":"10.3138/guthrie.70.2.084","DOIUrl":"https://doi.org/10.3138/guthrie.70.2.084","url":null,"abstract":"","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77346984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On Becoming President of the American Heart Association: As a Personal Journey to a Very Personal Destination 关于成为美国心脏协会主席:作为一个非常私人的目的地的个人旅程
The Guthrie journal of the Donald Guthrie Foundation for Medical Research Pub Date : 2001-04-01 DOI: 10.3138/guthrie.70.2.089
L. Smaha
{"title":"On Becoming President of the American Heart Association: As a Personal Journey to a Very Personal Destination","authors":"L. Smaha","doi":"10.3138/guthrie.70.2.089","DOIUrl":"https://doi.org/10.3138/guthrie.70.2.089","url":null,"abstract":"","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80920488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An 80-year-old White Male with Multiple Bruises and a Large Swelling in the Left Hypochondriac Region 一名80岁白人男性，左侧疑病症区多处瘀伤和大肿胀
The Guthrie journal of the Donald Guthrie Foundation for Medical Research Pub Date : 2001-01-01 DOI: 10.3138/guthrie.70.1.022
Kalpesh D. Ganatra
{"title":"An 80-year-old White Male with Multiple Bruises and a Large Swelling in the Left Hypochondriac Region","authors":"Kalpesh D. Ganatra","doi":"10.3138/guthrie.70.1.022","DOIUrl":"https://doi.org/10.3138/guthrie.70.1.022","url":null,"abstract":"","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81056225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VII: Children of the Mist 迷雾之子
The Guthrie journal of the Donald Guthrie Foundation for Medical Research Pub Date : 2001-01-01 DOI: 10.3138/guthrie.70.1.026
Nicholas H. Bartenhagen
{"title":"VII: Children of the Mist","authors":"Nicholas H. Bartenhagen","doi":"10.3138/guthrie.70.1.026","DOIUrl":"https://doi.org/10.3138/guthrie.70.1.026","url":null,"abstract":"","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88738497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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