Systemic Mastocytosis

Abstract

Systemic Mastocytosis is an abnormal proliferation of mast cells in the skin and multiple other organs. Its prognosis is variable, from indolent to very aggressive. The systemic signs and symptoms of mastocytosis are diverse and related to pharmacologic manifestations of mast cell mediators. They may mimic various conditions including chronic granulomatous disorders such as tuberculosis and sarcoid, connective tissue disorders, occult visceral malignancies, and even lymphoma. We report a patient with systemic mastocytosis and review the diagnosis and management of the disorder.