The Guthrie journal of the Donald Guthrie Foundation for Medical Research最新文献

{"title":"Guthrie Health, a Renaissance Institution","authors":"W. Friedenberg","doi":"10.3138/guthrie.71.2.043","DOIUrl":"https://doi.org/10.3138/guthrie.71.2.043","url":null,"abstract":"","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77025565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic Repair of Iatrogenic Esophageal Perforation Following Dilatation of Peptic Stricture","authors":"K. Moinuddeen, J. Ayerdi, Kamlesh Vyas, Steven Simon","doi":"10.3138/guthrie.71.2.078","DOIUrl":"https://doi.org/10.3138/guthrie.71.2.078","url":null,"abstract":"Esophageal perforation is a potentially lethal complication of esophageal endoscopy. Customarily, this complication is treated surgically via either a laparotomy or a thoracotomy. We report a minimally invasive transperitoneal laparoscopic repair of a distal esophageal laceration in a patient with peptic stricture. In addition to a primary repair of the perforation, a Nissen fundoplication was also performed to buttress the esophageal repair and to treat the patient’s underlying condition. The patient recovered well. We present details of the procedure. This minimally invasive approach is safe and well tolerated in selected patients.","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74763049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory of Immunobiology","authors":"D. Beezhold","doi":"10.3138/guthrie.71.2.053","DOIUrl":"https://doi.org/10.3138/guthrie.71.2.053","url":null,"abstract":"The group was established in the summer of 2007 The central theme of our research is the molecular and functional characterization of innate immune mechanisms involved in the process of sterile inflammation, developmental tissue remodelling and chronic inflammatory diseases Our main effort is focused on Toll-like receptors and other TIR domaincontaining immune-related proteins and their role in the early embryogenesis Data accumulated so far point to the spatially and temporarily regulated expression of TLRs on embryonal phagocytes, suggesting their involvement in sterile inflammation during early development The characterization of a complete set of innate immune receptors (IIRs) expressed on embryonal phagocytes and evaluation of their signalling competence, together with elucidation of the nature of endogenous ligands for these IIRs represent our main objectives Further, the cDNA microarray analyses performed on embryonal phagocytes revealed cell-specific expression of several uncharacterized molecules that could play an essential role in the processes supporting embryonal homeostasis In collaboration with our partner laboratories we have also characterized immunomodulatory activities of enzymatically synthesized oligofuranosides (1) Recent data indicate their robust adjuvant properties with prophylactic and therapeutic potential Our research is also geared towards the understanding of the contribution of cellular and humoral innate immune factors to the onset and maintenance of autoimmune processes In collaboration with clinical laboratories we were able to demonstrate increased levels of defensin expression in recently diagnosed patients suffering from autoimmune diseases Our main mission here is to characterize novel predictive biomarkers suitable for diagnosis of these diseases in the pre-clinical phase of their development In this context we have also characterized the distribution and tissue-specific functions of alpha-defensins in rat experimental models (2) We also continue in our effort to understand very early biochemical events leading to activation of T cells Our previous study showed that the critical event in this process is the translocation and subsequent enrichment of kinase active Lck in lipid rafts (LR) (3) While other regulatory proteins are also recruited to LR upon T-cell activation, the mechanism of these translocations, indispensable for T-cell activation, is largely unknown The main goal of this line of research is the characterization of the molecular mechanism and its structural elements underpinning the recruitment of Lck and other signalling molecules to LR In addition, we provide technical and knowledge support for exploration of several molecular approaches in unrelated projects (4, 5)","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74854226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory of Molecular Neurobiology","authors":"H. Puhl","doi":"10.3138/guthrie.71.2.062","DOIUrl":"https://doi.org/10.3138/guthrie.71.2.062","url":null,"abstract":"","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72717731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reigning Cats & Dogs by Katharine MacDonough","authors":"A. King","doi":"10.3138/guthrie.71.1.015","DOIUrl":"https://doi.org/10.3138/guthrie.71.1.015","url":null,"abstract":"","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76022328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managed Care: Fundamentals and Future Perspectives","authors":"J. Freije, James Baumgartner","doi":"10.3138/guthrie.71.1.010","DOIUrl":"https://doi.org/10.3138/guthrie.71.1.010","url":null,"abstract":"","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"2013 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87740286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts from the Proceedings of the Tenth Annual Clinical Campus Poster Session","authors":"","doi":"10.3138/guthrie.72.1.042","DOIUrl":"https://doi.org/10.3138/guthrie.72.1.042","url":null,"abstract":"The Clinical (Binghamton) Campus of Syracuse-based SUNY Upstate Medical University provides innovative educational programs emphasizing the training of generalist physicians with special emphasis on primary health care, health mainte- nance, and collaborative medical education. Guthrie clinicians and scientists have served on the faculty of the community-based educational program since its inception. The Clinical Campus is also dedicated to fostering collaborative and interdisciplinary research, and improving coope rative activities among its affiliate institutions in the Southern Tier of New York and northern Tier of Pennsylvania. As part of this mission, the Clinical Campus sponsors an annual Research Poster Session. The tenth Annual Clinical Campus Poster Session was held on November 21, 2002, in Binghamton, NY. Abstracts from the work presented at this meeting follow:","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84787976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conversion of Type 2 von Willebrand Disease to Type 1 von Willebrand Disease Associated with Repair of Valvular Heart Disease","authors":"Mikesh C. Shah, W. Friedenberg, J. Mazza, R. Montgomery","doi":"10.3138/guthrie.71.1.006","DOIUrl":"https://doi.org/10.3138/guthrie.71.1.006","url":null,"abstract":"","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83465300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthur B.King, BA, MD, DNB, FACS, Colonel, USAR (infantry) Ret.","authors":"","doi":"10.3138/guthrie.71.1.018","DOIUrl":"https://doi.org/10.3138/guthrie.71.1.018","url":null,"abstract":"","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77855923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethylene Glycol Intoxication","authors":"A. Ghanem, J. Walsh","doi":"10.3138/guthrie.71.1.002","DOIUrl":"https://doi.org/10.3138/guthrie.71.1.002","url":null,"abstract":"","PeriodicalId":83043,"journal":{"name":"The Guthrie journal of the Donald Guthrie Foundation for Medical Research","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79658449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}