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Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology最新文献

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[Comparative activity of new semisynthetic penicillins and their combinations with gentamycin against gram-negative bacteria]. [新型半合成青霉素及其与庆大霉素联用对革兰氏阴性菌的活性比较]。
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-11-01
O S Treskina, L M Slepchenko, V N Nasonov, E N Dutova
{"title":"[Comparative activity of new semisynthetic penicillins and their combinations with gentamycin against gram-negative bacteria].","authors":"O S Treskina,&nbsp;L M Slepchenko,&nbsp;V N Nasonov,&nbsp;E N Dutova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Comparative antibacterial activity of two novel ureidopenicillins (azlocillin and piperacillin), carbenicillin and ampicillin against 170 clinical strains of Enterobacteriaceae and 43 strains of Pseudomonadaceae was studied. Higher antibacterial activity of azlocillin and piperacillin evident from lower frequency of resistant strains and lower MICs for the majority of the isolates was shown. Impact of the inoculum size on the MIC values was observed with respect to all the penicillins. The study on the kinetics of Pseudomonadaceae death under the effect of azlocillin and carbenicillin revealed an increase in the bacteria growth after 6- to 8-hour contact with therapeutic concentrations of azlocillin and 4-hour contact with carbenicillin. Nor renewal of the culture growth was observed within 10-hour contact with combinations of the penicillins and 2 micrograms/ml of gentamicin.</p>","PeriodicalId":8252,"journal":{"name":"Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology","volume":"32 11","pages":"855-9"},"PeriodicalIF":0.0,"publicationDate":"1987-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14564719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Design of a hybrid gene coding for the leader sequence of Bacillus amyloliquefaciens alpha-amylase and for human proinsulin]. [解淀粉芽孢杆菌α -淀粉酶前导序列和人胰岛素原基因的杂交基因设计]。
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-11-01
N G Dem'ianova, A P Bolotin, A A Novikov, A V Sorokin, A N Lebedev
{"title":"[Design of a hybrid gene coding for the leader sequence of Bacillus amyloliquefaciens alpha-amylase and for human proinsulin].","authors":"N G Dem'ianova,&nbsp;A P Bolotin,&nbsp;A A Novikov,&nbsp;A V Sorokin,&nbsp;A N Lebedev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The chemically synthesized structure gene of human proinsulin was cloned in E. coli on the secretory vector containing regulatory elements of the Bacillus amyloliquefaciens alpha-amylase gene. The proinsulin gene was inserted by the EcoRI site located immediately after the DNA area encoding the alpha-amylase signal peptide. The E. coli cells transformed by such a plasmid produced hybrid protein consisting of the alpha-amylase signal peptide, five amino acid residues after the gene mating and human proinsulin. For accurate mating of the alpha-amylase gene leader sequence and proinsulin gene directed mutagenesis was performed on the filiform phage M13 mp9 with synthetic oligonucleotide. The hybrid gene was transferred to the vector molecule capable of replicating in Bacillus subtilis. It was shown that in the cells of both E. coli and B. subtilis there is synthesized protein interacting by the radio-immunological data with antibodies to porcine insulin, a large portion of immunologically active protein being detected in the periplasmic space of E. coli cells and in the culture fluid of B. subtilis cells which was indicative of proinsulin secretion directed by the alpha-amilase regulatory elements.</p>","PeriodicalId":8252,"journal":{"name":"Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology","volume":"32 11","pages":"820-4"},"PeriodicalIF":0.0,"publicationDate":"1987-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14452823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Sensitivity to beta-lactam and aminoglycoside antibiotics of clinical Proteus strains as dependent upon on their species classification and the source of their isolation]. [临床变形杆菌菌株对β -内酰胺类和氨基糖苷类抗生素的敏感性取决于其种类分类和分离来源]。
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-11-01
I G Shvidenko
{"title":"[Sensitivity to beta-lactam and aminoglycoside antibiotics of clinical Proteus strains as dependent upon on their species classification and the source of their isolation].","authors":"I G Shvidenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sensitivity of 130 Proteus clinical strains was studied. Among beta-lactam antibiotics cefotaxime showed marked advantages with respect to various Proteus species. All the isolates of Proteus mirabilis were sensitive to cefuroxime. Cefamezin and cephapirin were inferior by their activity to cefotaxime and cefuroxime. They were characterized by close antibacterial activity and almost complete cross resistance. Ampicillin and carbenicillin proved to be the least efficient among the tested beta-lactam antibiotics. Isolates of Proteus vulgaris and Proteus penneri were more resistant to the penicillins and cephalosporins than the cultures of Proteus mirabilis. Sensitivity of separate Proteus species to gentamicin, tobramycin, sisomicin and amikacin was close. No cross resistance to the aminoglycosides was detected. Studies on the effect of different doses of the antibiotics revealed pronounced heterogeneity of Proteus by the feature of sensitivity to the tested antibiotics. The level of the heterogeneity was not the same for separate antibiotics. Cultures of Proteus mirabilis resistant to ampicillin, carbenicillin, cefamezin and cephapirin were more frequent in patients with urogenital infections as compared to patients with intestinal infections and suppurative-inflammatory processes of other localization.</p>","PeriodicalId":8252,"journal":{"name":"Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology","volume":"32 11","pages":"850-5"},"PeriodicalIF":0.0,"publicationDate":"1987-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14452824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The development of antibiotic science in the USSR]. [苏联抗生素科学的发展]。
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-11-01
S M Navashin
{"title":"[The development of antibiotic science in the USSR].","authors":"S M Navashin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8252,"journal":{"name":"Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology","volume":"32 11","pages":"806-10"},"PeriodicalIF":0.0,"publicationDate":"1987-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14564713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Rifampicin pharmacokinetics in experimental hepatitis]. 利福平在实验性肝炎中的药代动力学研究。
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-11-01
O I Nazarova, V I Bobrov
{"title":"[Rifampicin pharmacokinetics in experimental hepatitis].","authors":"O I Nazarova,&nbsp;V I Bobrov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rifampicin pharmacokinetics in rats with acute affection of the liver with carbon tetrachloride did not alter. Chronic affection with carbon tetrachloride resulted in retarded elimination of the antibiotic from blood. There was observed no relationship between increased activities of transamination enzymes such as alanine aminotransferase and aspartate aminotransferase in blood serum of animals and changes in rifampicin pharmacokinetics.</p>","PeriodicalId":8252,"journal":{"name":"Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology","volume":"32 11","pages":"859-61"},"PeriodicalIF":0.0,"publicationDate":"1987-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14564720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mechanism of the interaction of the individual components of levorin and nystatin preparations with lipid membranes]. [左旋素和制霉菌素制剂中单个成分与脂质膜相互作用的机制]。
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-11-01
Kh M Kasumov, A A Samedova, Iu D Shenin
{"title":"[Mechanism of the interaction of the individual components of levorin and nystatin preparations with lipid membranes].","authors":"Kh M Kasumov,&nbsp;A A Samedova,&nbsp;Iu D Shenin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mechanism of interaction between separate levorin and nystatin component and lipid membranes was studied. It was shown that components A0, A1, A2 and A3 of levorin and components A1, A2, A3 and B1 of nystatin had a markedly pronounced membranotropic activity. Ion channel assembly and membrane conductivity were irreversibly controlled by concentration and membrane potential. Changes in selectivity of biomolecular lipid membranes depended on the structure of the antibiotics. The action of the levorin and nystatin components was based on increasing membrane conductivity by the mechanism of ion channel formation with parameters altering in relation to the antibiotic structure. Recommendations for directed synthesis of the antibiotic derivatives with high therapeutic efficacy are presented.</p>","PeriodicalId":8252,"journal":{"name":"Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology","volume":"32 11","pages":"824-8"},"PeriodicalIF":0.0,"publicationDate":"1987-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13598154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Use of different nutrient medium variants in determining the antimicrobial activity of neomycin]. [利用不同的营养培养基变体测定新霉素的抗菌活性]。
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-11-01
O B Ermolova, V M Grigor'eva, E M Bershteĭn, M S Poliak
{"title":"[Use of different nutrient medium variants in determining the antimicrobial activity of neomycin].","authors":"O B Ermolova,&nbsp;V M Grigor'eva,&nbsp;E M Bershteĭn,&nbsp;M S Poliak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Gel diffusion regularities with respect to neomycin sulfate substances differing in their composition and the antibiotic separate components were studied on nutrient media of diverse composition. Optimal conditions for standardization of neomycin sulfate antimicrobial activity with using the agar diffusion method and synthetic medium are determined.</p>","PeriodicalId":8252,"journal":{"name":"Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology","volume":"32 11","pages":"841-3"},"PeriodicalIF":0.0,"publicationDate":"1987-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14257820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Determination of azlocillin in the air]. [空气中氮唑青霉素的测定]。
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-11-01
N K Churagulova
{"title":"[Determination of azlocillin in the air].","authors":"N K Churagulova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A method for determination of air-borne azlocillin in production areas was developed. The method is based on redox reaction proceeding with reduction of the molybdenum blue heteropolycomplex. The reaction involves the antibiotic preliminarily hydrolyzed by alkali with heating. The blue solutions are photometered at 750 nm. The detection limit in the assay sample volume is 0.005 mg. The method may be useful in development of maximum permissible concentration of azlocillin and its control in ambient air of production areas.</p>","PeriodicalId":8252,"journal":{"name":"Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology","volume":"32 11","pages":"837-41"},"PeriodicalIF":0.0,"publicationDate":"1987-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14564717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Benzylpenicillin interaction with amines in the organic phase]. [青霉素与胺在有机相中的相互作用]。
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-10-01
V B Kurochkina, L I Sokal'skaia, S A Zhukovskaia, N G Zhukova, G S Libinson
{"title":"[Benzylpenicillin interaction with amines in the organic phase].","authors":"V B Kurochkina,&nbsp;L I Sokal'skaia,&nbsp;S A Zhukovskaia,&nbsp;N G Zhukova,&nbsp;G S Libinson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Benzylpenicillin interaction with amines in the nonaqueous phase was studied by pH dependence of the coefficient of the antibiotic distribution in the system of amine butyl acetate solution--water. A distribution scheme involving interaction of the amine molecular and cationic forms with benzylpenicillin and amine dissociation equilibrium in organic solution is described. On the basis of the experimental data the interaction and dissociation constants were determined for a number of aromatic and aliphatic amines.</p>","PeriodicalId":8252,"journal":{"name":"Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology","volume":"32 10","pages":"743-7"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14551350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pharmacokinetic study of aclarubicin. The pharmacokinetics of the preparation and its biologically active metabolites in the blood of rats]. 阿克鲁比星药动学研究。制剂的药代动力学及其在大鼠血液中的生物活性代谢物。
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-10-01
S V Geodakian, A A Firsov, I P Fomina
{"title":"[Pharmacokinetic study of aclarubicin. The pharmacokinetics of the preparation and its biologically active metabolites in the blood of rats].","authors":"S V Geodakian,&nbsp;A A Firsov,&nbsp;I P Fomina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Blood pharmacokinetics of the antitumor antibiotic aclarubicin and its metabolites was studied in rats with high performance liquid chromatography. The drug was administered intravenously in single doses of 5 and 10 mg/kg and orally in a single dose of 10 mg/kg. Aclarubicin pharmacokinetics was shown to be nonlinear. However, within every dose level it obeyed a two-compartment model. The nonlinearity could be due to saturation of aclarubicin binding to blood plasma proteins. The blood concentrations of metabolites MA144 N1 and MA144 T1 were close and after 12-18 hours exceeded those of unchanged aclarubicin. The half-lives of aclarubicin and its metabolites ranged from 16 to 21 hours. The MA144 T1 content was not significant. Following oral administration aclarubicin was rapidly absorbed and its bioavailability amounted to 35 per cent. Total bioavailability of aclarubicin, MA144 N1 and MA144 T1 was equal to 89 per cent. This enabled to consider the oral route of aclarubicin administration promising in tumor therapy.</p>","PeriodicalId":8252,"journal":{"name":"Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology","volume":"32 10","pages":"768-72"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14605695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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