利福平在实验性肝炎中的药代动力学研究。

Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-11-01

O I Nazarova, V I Bobrov

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引用次数: 0

摘要

利福平在四氯化碳急性肝损伤大鼠体内的药代动力学没有改变。长期使用四氯化碳导致抗生素从血液中消除迟缓。动物血清中谷丙转氨酶、天冬氨酸转氨酶等转氨酶活性的升高与利福平药代动力学的变化没有关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[Rifampicin pharmacokinetics in experimental hepatitis].

Rifampicin pharmacokinetics in rats with acute affection of the liver with carbon tetrachloride did not alter. Chronic affection with carbon tetrachloride resulted in retarded elimination of the antibiotic from blood. There was observed no relationship between increased activities of transamination enzymes such as alanine aminotransferase and aspartate aminotransferase in blood serum of animals and changes in rifampicin pharmacokinetics.

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Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology

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