Stephanie C DeMasi,Wesley H Self,Neil R Aggarawal,Michael D April,Luke Andrea,Christopher R Barnes,Jason Brainard,Veronika Blinder,Alon Dagan,Brian Driver,Kevin C Doerschug,Ivor Douglas,Matthew Exline,Daniel G Fein,John P Gaillard,Sheetal Gandotra,Kevin W Gibbs,Adit A Ginde,Stephen J Halliday,Jin H Han,Taylor Herbert,Kevin High,Christopher G Hughes,Akram Khan,Andrew J Latimer,Amelia W Maiga,Steven H Mitchell,Amelia L Muhs,Amira Mohamed,Ari Moskowitz,David B Page,Jessica A Palakshappa,Matthew E Prekker,Edward T Qian,Dan Resnick-Ault,Todd W Rice,Derek W Russel,Steven G Schauer,Kevin P Seitz,Nathan I Shapiro,Lane M Smith,Peter Sottile,Susan Stempek,Stacy A Trent,Derek J Vonderhaar,James E Walker,Li Wang,Micah R Whitson,Jonathan D Casey,Matthew W Semler,
{"title":"Association Between Neuromuscular Blocking Agents and Outcomes of Emergency Tracheal Intubation: A Secondary Analysis of Randomized Trials.","authors":"Stephanie C DeMasi,Wesley H Self,Neil R Aggarawal,Michael D April,Luke Andrea,Christopher R Barnes,Jason Brainard,Veronika Blinder,Alon Dagan,Brian Driver,Kevin C Doerschug,Ivor Douglas,Matthew Exline,Daniel G Fein,John P Gaillard,Sheetal Gandotra,Kevin W Gibbs,Adit A Ginde,Stephen J Halliday,Jin H Han,Taylor Herbert,Kevin High,Christopher G Hughes,Akram Khan,Andrew J Latimer,Amelia W Maiga,Steven H Mitchell,Amelia L Muhs,Amira Mohamed,Ari Moskowitz,David B Page,Jessica A Palakshappa,Matthew E Prekker,Edward T Qian,Dan Resnick-Ault,Todd W Rice,Derek W Russel,Steven G Schauer,Kevin P Seitz,Nathan I Shapiro,Lane M Smith,Peter Sottile,Susan Stempek,Stacy A Trent,Derek J Vonderhaar,James E Walker,Li Wang,Micah R Whitson,Jonathan D Casey,Matthew W Semler,","doi":"10.1016/j.annemergmed.2024.08.509","DOIUrl":"https://doi.org/10.1016/j.annemergmed.2024.08.509","url":null,"abstract":"STUDY OBJECTIVETo examine the association between the neuromuscular blocking agent received (succinylcholine versus rocuronium) and the incidences of successful intubation on the first attempt and severe complications during tracheal intubation of critically ill adults in an emergency department (ED) or ICU.METHODSWe performed a secondary analysis of data from 2 multicenter randomized trials in critically ill adults undergoing tracheal intubation in an ED or ICU. Using a generalized linear mixed-effects model with prespecified baseline covariates, we examined the association between the neuromuscular blocking agent received (succinylcholine versus rocuronium) and the incidences of successful intubation on the first attempt (primary outcome) and severe complications during tracheal intubation (secondary outcome).RESULTSAmong the 2,440 patients in the trial data sets, 2,339 (95.9%) were included in the current analysis; 475 patients (20.3%) received succinylcholine and 1,864 patients (79.7%) received rocuronium. Successful intubation on the first attempt occurred in 375 patients (78.9%) who received succinylcholine and 1,510 patients (81.0%) who received rocuronium (an adjusted odds ratio of 0.87; 95% CI 0.65 to 1.15). Severe complications occurred in 67 patients (14.1%) who received succinylcholine and 456 patients (24.5%) who received rocuronium (adjusted odds ratio, 0.88; 95% CI 0.62 to 1.26).CONCLUSIONAmong critically ill adults undergoing tracheal intubation, the incidences of successful intubation on the first attempt and severe complications were not significantly different between patients who received succinylcholine and patients who received rocuronium.","PeriodicalId":8236,"journal":{"name":"Annals of emergency medicine","volume":"38 4 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142436114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shu Utsumi, Shingo Ohki, Shunsuke Amagasa, Shinichiro Ohshimo, Nobuaki Shime
{"title":"Tranexamic Acid in Pediatric Traumatic Brain Injury: A Multicenter Retrospective Observational Study.","authors":"Shu Utsumi, Shingo Ohki, Shunsuke Amagasa, Shinichiro Ohshimo, Nobuaki Shime","doi":"10.1016/j.annemergmed.2024.07.014","DOIUrl":"10.1016/j.annemergmed.2024.07.014","url":null,"abstract":"<p><strong>Study objective: </strong>Tranexamic acid (TXA) can be used after trauma to prevent bleeding. Our goal was to examine the influence of TXA on morbidity and mortality for children with severe traumatic brain injury (TBI).</p><p><strong>Methods: </strong>We identified children aged <18 years with a severe TBI (Glasgow Coma Scale score less than 8) presenting to 1 of the 291 hospitals contributing to the Japanese Trauma Data Bank between 2019 and 2023. The primary outcome was inhospital death, and the secondary outcome was poor neurologic outcome defined with Glasgow Outcome Scale (GOS) score of 1 to 3 at hospital discharge. Our primary exposure was any TXA administered in the hospital. Using propensity score-based inverse probability weighting, we used logistic regression to measure the association between TXA administration and death as well as poor neurologic outcome.</p><p><strong>Results: </strong>Of the 342 included patients, 30 (14%) died, and 102/225 (45%) had a GOS score less than 4 at discharge. After inverse propensity weighting, TXA administration was not associated with either mortality (adjusted odds ratio [aOR] 1.25, 95% confidence interval [CI] 0.61 to 2.54) or poor neurologic outcome (aOR 0.86, 95% CI 0.47 to 1.56).</p><p><strong>Conclusions: </strong>TXA administration was not associated with either death or poor neurologic outcome. Prospective clinical trials of TXA usage in children with severe TBI are needed.</p>","PeriodicalId":8236,"journal":{"name":"Annals of emergency medicine","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Rimawi, A. Sung, E. Lin, M. Pike, D. Haidar, C.-M. Chen, R. Medlin, M. Perry, C. Fung
{"title":"50 Time to Provider for Patients With Non-English Language Preferences in the Emergency Department","authors":"A. Rimawi, A. Sung, E. Lin, M. Pike, D. Haidar, C.-M. Chen, R. Medlin, M. Perry, C. Fung","doi":"10.1016/j.annemergmed.2024.08.057","DOIUrl":"10.1016/j.annemergmed.2024.08.057","url":null,"abstract":"","PeriodicalId":8236,"journal":{"name":"Annals of emergency medicine","volume":"84 4","pages":"Page S23"},"PeriodicalIF":5.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. McCormack, M. Gazzola, S.-M. Shin, I. Wittman, R. Gulati, K. Jahnes, K. Rahnemoon, A. Chitnis, S. Olafsson, A. Herring
{"title":"89EMF The Utility of High Dose Buprenorphine in Producing Prolonged Suppression of Opioid Withdrawal","authors":"R. McCormack, M. Gazzola, S.-M. Shin, I. Wittman, R. Gulati, K. Jahnes, K. Rahnemoon, A. Chitnis, S. Olafsson, A. Herring","doi":"10.1016/j.annemergmed.2024.08.094","DOIUrl":"10.1016/j.annemergmed.2024.08.094","url":null,"abstract":"","PeriodicalId":8236,"journal":{"name":"Annals of emergency medicine","volume":"84 4","pages":"Page S40"},"PeriodicalIF":5.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Goldberg, R. Crowe, G. Peters, A. Misra, R. Cash
{"title":"93EMF The Association of Emergency Medical Services Agency- and Clinician-Level Factors With Adherence to Evidence-Based Guidelines for the Prehospital Management of Traumatic Brain Injury","authors":"S. Goldberg, R. Crowe, G. Peters, A. Misra, R. Cash","doi":"10.1016/j.annemergmed.2024.08.098","DOIUrl":"10.1016/j.annemergmed.2024.08.098","url":null,"abstract":"","PeriodicalId":8236,"journal":{"name":"Annals of emergency medicine","volume":"84 4","pages":"Page S42"},"PeriodicalIF":5.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"20 Outcomes of Apixaban Versus Rivaroxaban in Patients With Nonvalvular Atrial Fibrillation","authors":"D. Jehle, K. Paul, B. Sorensen","doi":"10.1016/j.annemergmed.2024.08.029","DOIUrl":"10.1016/j.annemergmed.2024.08.029","url":null,"abstract":"","PeriodicalId":8236,"journal":{"name":"Annals of emergency medicine","volume":"84 4","pages":"Page S9"},"PeriodicalIF":5.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"1 Cost Comparison and Revenue Generation of Post-Graduate Education for Emergency Medicine Advanced Practice Providers","authors":"A. Brogan, L. O'Rourke, K. Row, T. Foote","doi":"10.1016/j.annemergmed.2024.08.010","DOIUrl":"10.1016/j.annemergmed.2024.08.010","url":null,"abstract":"","PeriodicalId":8236,"journal":{"name":"Annals of emergency medicine","volume":"84 4","pages":"Page S1"},"PeriodicalIF":5.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"61 Paxlovid Efficacy in Unvaccinated COVID-19 Patients: A Comprehensive Review of Outcomes","authors":"D. Jehle, K. Paul","doi":"10.1016/j.annemergmed.2024.08.069","DOIUrl":"10.1016/j.annemergmed.2024.08.069","url":null,"abstract":"","PeriodicalId":8236,"journal":{"name":"Annals of emergency medicine","volume":"84 4","pages":"Page S29"},"PeriodicalIF":5.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}