{"title":"Pancratistatin Inhibits the Growth of Colorectal Cancer Cells by Inducing Apoptosis, Autophagy, and G2/M Cell Cycle Arrest.","authors":"Yong Xiong, Yi-Jia Xiong, Dong-Yang Liu, Rong-Rong Shen","doi":"10.12659/MSM.916116","DOIUrl":"10.12659/MSM.916116","url":null,"abstract":"<p><p>BACKGROUND Worldwide, colorectal cancer is ranked as the third most prevalent cancer. The natural compound, pancratistatin, extracted from the spider lily, has previously been shown to target apoptosis in cancer cells lines. This study aimed to investigate the effects of pancratistatin in human colorectal cancer cells in vitro. MATERIAL AND METHODS Human colorectal cancer cell lines, including HTC-15 cells, were compared with a normal human colonic fibroblast cell line, CDD-18Co. Cells were treated with increasing doses of pancratistatin. The MTT assay was used to assess cell viability. Fluorescence microscopy using DAPI and Annexin-V/propidium iodide (PI) was used to detect cell apoptosis. Cell autophagy was detected by electron microscopy. Cell migration was evaluated using a wound healing assay, and Western blot determined the expression levels of cell cycle proteins. RESULTS Pancratistatin inhibited the growth of the colorectal cancer cells with an IC₅₀ ranging from 15-25 µM, but had a limited effect in normal CCD-18Co cells, with an IC₅₀ of >100 µM. Pancratistatin reduced HCT-15 cell migration. Growth inhibition due to pancratistatin was associated with morphological changes of HCT-15 cells and included autophagy and apoptosis, and increased expression the autophagic proteins, LC3II, beclin-1, and Bax. Pancratistatin induced arrest of HCT-15 cells at G2/M of the cell cycle and inhibited phosphorylation of cdc2/cyclin-dependent kinase 1 (CDK1) and Cdc25c and the expression of cyclin B1. CONCLUSIONS Pancratistatin inhibited the growth of colorectal cancer cells in vitro by inducing apoptosis, autophagy, and G2/M cell cycle arrest.</p>","PeriodicalId":82116,"journal":{"name":"New theology review","volume":"14 1","pages":"6015-6022"},"PeriodicalIF":0.0,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90032318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Monasticism and the Catholic Charismatic Renewal Movement","authors":"Reginald Alva","doi":"10.17688/NTR.V29I2.1275","DOIUrl":"https://doi.org/10.17688/NTR.V29I2.1275","url":null,"abstract":"Christian monasticism is a gift of the Holy Spirit to the Church. Many centuries ago the Holy Spirit guided women and men to devote their lives to follow Jesus Christ closely and serve all the people. Since then, monasticism has greatly contributed in keeping the flame of the Holy Spirit alive and bringing renewal in the Church. The Catholic Charismatic Renewal Movement, which is a comparatively young movement within the Church, is also a Spirit-centered movement. Charismatics seek the renewal of their spiritual lives through the power of the Holy Spirit. In this paper, we shall examine the main features of both monasticism and the Charismatic Renewal Movement to explore the spiritual richness in these traditions. Further, this paper will also examine if these movements could help the contemporary people to discover the beauty of their faith and find meaning in it. The sources for our study will be the Church documents, literature on monasticism, Catholic Charismatic Renewal Movement and opinions of some experts in these fields.","PeriodicalId":82116,"journal":{"name":"New theology review","volume":"29 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42335367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Christian Faith in a Secular Age","authors":"Scott R. Paeth","doi":"10.17688/NTR.V29I2.1341","DOIUrl":"https://doi.org/10.17688/NTR.V29I2.1341","url":null,"abstract":"This article offers an analysis of secularization from within the Christian tradition, with an emphasis on the challenge that the moral and metaphysical dissensus created by secularization causes, not only for a Christian conception of the world, but even for the very possibility of establishing a persuasive case for Christianity in the midst of the social and ideological fragmentation of contemporary society. Beginning with Charles Taylor’s analysis of secularism, it will consider several perspectives on the relationship between modernity, secularism, and the breakdown of moral consensus in the modern world. Finally, it will turn to the question of how Christians should engage with integrity with the secular context of modernity.","PeriodicalId":82116,"journal":{"name":"New theology review","volume":"29 1","pages":"19-31"},"PeriodicalIF":0.0,"publicationDate":"2017-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48287088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Witnessing in the Field Hospital of the Church","authors":"D. Organ","doi":"10.17688/NTR.V29I2.1330","DOIUrl":"https://doi.org/10.17688/NTR.V29I2.1330","url":null,"abstract":"In this paper, I work to correlate three aspects of a specific event (a community gathered around a woman considering suicide) with the salvific promise of the life, death, and resurrection of Jesus Christ in order to elucidate the potential power of narrative in preaching to name and call forth a real and durable hope in our times. To do this, I base my method on David Tracy’s analogical imagination, and develop some of the contrasts and connecting points of contemporary trauma theory regarding memory and experience with Johann Baptist Metz’s notion of memory as it relates to the eruption of apocalyptic hope in our times. I also reflect on the implications of an often neglected Holy Saturday faith for preaching. My hope is that this work will be a resource and a caution to preachers as they work to articulate the vision of hope erupting into division and hopelessness in concrete parish, social, and global contexts today.","PeriodicalId":82116,"journal":{"name":"New theology review","volume":"29 1","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"2017-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41914283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lessons of Martyrdom on Contemporary Immigration","authors":"Simon C. Kim, Elizabeth Oh","doi":"10.17688/NTR.V29I1.1251","DOIUrl":"https://doi.org/10.17688/NTR.V29I1.1251","url":null,"abstract":"Confucianism greatly influenced the dynamics of the Korean monarchy and family hierarchical system in the 19th century when Catholicism was introduced by the educated yangban class. Catholic teachings so impressed Koreans that their loyalties toward the king were challenged by their new love for God, which went against societal norms based on filial piety. Eventually their disloyalty to the king led to thousands of martyrs. While some scholars may wonder at their courage, others felt their self-sacrifice might have been easier than other non-Confucian based cultures, as they had merely transferred their loyalty from a king to God. Thus, filial piety never disappeared with the appearance of the Catholic faith, as martyrs continued unto death while being loyal in their minds. Today, however, Korean American Catholics struggle with this Confucian heritage embedded in the Catholic faith, especially within the immigration context. The expectations of filial piety from the next generation causes friction because they lack sufficient cultural and historical awareness. Thus, this article looks at the Korean martyrs for re-envisioning traditional values especially when immigration radically transforms the ethnic faith narrative.","PeriodicalId":82116,"journal":{"name":"New theology review","volume":"29 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2016-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68096118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In the Aftermath of a Synod: The Sacramental Vision of the Universe and a Case for the Development of Doctrine","authors":"A. McGill","doi":"10.17688/NTR.V29I1.1219","DOIUrl":"https://doi.org/10.17688/NTR.V29I1.1219","url":null,"abstract":"In the aftermath of the Synod on the Family, the question of the development of doctrine has gained renewed prominence. This article considers the question in light of the principle of sacramentality. If all of creation is infused with potential to mediate the divine, then this applies to reason, experience, and derived processes of communication, interpretation, and development. Understood within this sacramental framework, the development of doctrine is not a matter of compromising eternal truths so as to meet the demands of secular modernity so much as a grace-filled sharing of wisdom between the Word of God and the People of God, the Mystical Body of Christ in a given epoch. The article contrasts Alfred Loisy’s intrinsicist model of development wherein reason is infused with grace with the dualistic assumptions of Neo-Scholasticism. It explores Pope St. John XXIII’s distinction between the changeable manner in which doctrine is articulated and understood and its unchanging substance, that is, the eternal truths. Finally, in the dialogical disposition of Vatican II in relation to the modern world, the article detects an intrinsicist perspective on the development of doctrine, offering hope for the possibility of more complete expressions of timeless truths.","PeriodicalId":82116,"journal":{"name":"New theology review","volume":"29 1","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"2016-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68096007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tradition and Church Reform: Perspectives on Catholic Moral Teaching","authors":"Kate Ward","doi":"10.17688/NTR.V29I1.1255","DOIUrl":"https://doi.org/10.17688/NTR.V29I1.1255","url":null,"abstract":"","PeriodicalId":82116,"journal":{"name":"New theology review","volume":"29 1","pages":"59-60"},"PeriodicalIF":0.0,"publicationDate":"2016-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68095776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Theme of Communion in Laudato Si' and Its Implications for Ecclesiology","authors":"C. R. Ryan","doi":"10.17688/NTR.V29I1.1228","DOIUrl":"https://doi.org/10.17688/NTR.V29I1.1228","url":null,"abstract":"This article explores the theme of communion in the encyclical Laudato Si’ and in other writings and addresses of Pope Francis. It depicts the connections between Francis’s appeal to this theme in his ecological theology and his employment of it in his descriptions of the church. It describes the way in which communion is foundational for Francis’s theological anthropology, ecological theology, and ecclesiology. The author also adduces recent critiques of communio ecclesiology, especially that of Australian theologian Neil Ormerod. He explores whether the ecclesiology of Pope Francis meets the concerns of these critiques. The article concludes with an affirmation of the significance of communion for contemporary ecclesiology, especially in light of two current pastoral concerns.","PeriodicalId":82116,"journal":{"name":"New theology review","volume":"29 1","pages":"19-29"},"PeriodicalIF":0.0,"publicationDate":"2016-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68096029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incarnating the Feminine Genius in the Contemporary Catholic Church","authors":"L. Westenberg","doi":"10.17688/NTR.V29I1.1260","DOIUrl":"https://doi.org/10.17688/NTR.V29I1.1260","url":null,"abstract":"As Western society has seemingly become apathetic about faith and religion [1] , many within the Catholic Church have simultaneously become concerned with issues of relevance. The call from Pope Benedict XVI and Pope Francis has been to examine the fruits of the Second Vatican Council, with a view to evangelisation, emphasising the role of the Church in modern society. Responses to this call on a pastoral level, however, often fail to recognise the specific needs of women in society and in the Church today. The goal of this article is to examine practical movements in the contemporary Church that are instigated by women, addressing the distinct needs of women in our communities in terms of vocation, spiritual motherhood and the ‘feminine genius’ (Edith Stein), with receptivity and empathy for others, including the disenfranchised and excluded. Is the Church on a local level utilising women’s ‘care thinking’ [2] in the practical outpourings of its faith and charity? In answer to this question, this article discusses the emergence of grassroots movements that exemplify the incarnation of the feminine genius in the contemporary Catholic Church. [1] Roy Williams, Post God Nation? How religion fell off the radar in Australia – and what might be done to get it back on, (Sydney, Australia: ABC Books, 2015) 28. [2] Carol Gilligan, In a different voice: Psychological theory and women's development , (Cambridge, MA: Harvard University Press, 1982.1983). Leonie Westenberg Associate Lecturer, Theology University of Notre Dame Australia, Sydney campus 104 Broadway (P.O. Box 944) Broadway NSW 2007 E: leonie.westenberg@nd.edu.au T: (02) 8204 4175 (School) Degrees: Masters of Theology, Charles Sturt University, Australia. Postgraduate Diploma Theological Studies, Flinders University, Australia. Postgraduate Certificate Theological Studies, Flinders University, Australia. Diploma Teaching, Edith Cowan University, Australia. Biographical information: Leonie Westenberg is an Associate Lecturer in Theology at Notre Dame University Australia, Sydney campus. She lectures in theology in the Logos programme, the university’s core curriculum. She has been the author of and contributor to several books on education and has written for The Conversation on ‘The paradox of work over the summer season’, and “Blessed are the Hunger Games? Katniss Everdeen lives the Beatitudes’. She has presented papers at the Society for the Study of Theology April 2015 conference at the University of Nottingham on ‘Thinking the Church Today: What are the implications of the Second Vatican Council, fifty years, on for women, in light of the discussion of Mary in Lumen Gentium ?’, and at the 2016 Marian Conference at Notre Dame University Australia on Literary Apologetics. Email address: leonie.westenberg@nd.edu.au","PeriodicalId":82116,"journal":{"name":"New theology review","volume":"29 1","pages":"30-37"},"PeriodicalIF":0.0,"publicationDate":"2016-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68096986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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