Annals of Clinical and Laboratory Research最新文献

{"title":"A Short Note on Physiotherapy and AccessBarriers in Persons with Multiple Sclerosis","authors":"Mamatha Dereddy","doi":"10.36648/2386-5180.21.9.362","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.362","url":null,"abstract":"Physiotherapy may aggravate the symptoms of Multiple Sclerosis. Physiotherapy accessibility and possible barriers in persons with MS are not very well known. Multiple sclerosis is a chronic degenerative and inflammatory disease of the central nervous system. This mainly occurs in early adulthood. Almost 2 million people are affected worldwide by this disease. Disease-Modifying treatments are very essential to minimize the damage and the loss and still, there is no specific treatment for multiple sclerosis. The drugs that better the clinical symptoms of Multiple Sclerosis are very rare. Therefore these symptoms should be managed with symptomatic forms of therapy like occupational and physical therapies. Physiotherapy is recommended for the treatment of multiple sclerosis symptoms","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81551865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Physical Exercise in Older Adults with Mild to Moderate Depression","authors":"S.H. Khan","doi":"10.36648/2386-5180.21.9.372","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.372","url":null,"abstract":"Depression is a common and disabling bug that affects additional than 120 million people worldwide and a minimum of 1 in every 5 people over the course of their date. Although depression is routinely treated with antidepressant medicaments and/ or inner corrective, other healing druthers have admitted growing attention in recent days. Physical exercise in particular might be beneficent for depressed cases and substitute to antidepressant treatment.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84346858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Short Note on Biological Biomarker","authors":"Preethi Kodali","doi":"10.36648/2386-5180.21.9.358","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.358","url":null,"abstract":"A biomarker, or biological marker may be a measurable indicator of some biological state or condition. Biomarkers area unit usually measured and evaluated to look at traditional biological processes, unhealthful processes, or pharmacological responses to a therapeutic intervention. Biomarkers area unit utilized in several scientific fields. Biomarkers used for drugs, or exactness drugs, area unit a region of a comparatively new clinical toolset. they are categorized in three primary ways that in line with their clinical applications they are classified as molecular biomarkers, cellular biomarkers, or imaging biomarkers. All three kinds of biomarkers have a clinical role in narrowing or guiding treatment selections and follow a sub-categorization of being either prophetic, prognostic, or diagnostic.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84029039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment is Better than Cure - what is Prevention? What Kinds of Things can be done about it?","authors":"Nikolova Tsekova","doi":"10.36648/2386-5180.21.9.374","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.374","url":null,"abstract":"Prevention of illness is a function of both the doctor and the person. Most preventive medication rehearsed today is performed by the essential consideration physician, not by the different public health authorities or teachers in college divisions of preventive medication. Exemptions are the grassland regions and British Columbia where the majority of inoculation methods, one of the more clear types of counteraction, are completed by health units. In other regions inmmunization is basically embraced by the essential consideration doctor. This is an aloof kind of anticipation for the person: he just has to introduce himself for the injection.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81646960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of Moringa Oleifera and Stevia Rebaudiana in boosting the nutritional health and alleviating poverty of East African women through value addition","authors":"Aisha Nakasujja","doi":"10.36648/2386-5180.21.9.342","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.342","url":null,"abstract":"Objective: To explore the law and distribution characteristics of acupoint sensitization among the IBS patients with meridian theory and graph theory, for further understanding of acupoint sensitization in clinical practice. Methods: For mathematical modeling, achieve the acupoints and their indications of diseases in the classic books of acupuncture and moxibustion. Establish the acupoint-indications network based on the graph theory and record the topological parameters such as clustering coefficient, vector centrality, etc. For the clinical trial part, the method of cohort study was adopted to include the patients meeting the diagnostic criteria of IBS, and the acupoint sensitivity data was measured through body meridian energy system. The topological indexes obtained by mathematical modeling were introduced to calculate the weighted average of topological parameters of the Yuan point, so as to further analyze its correlation with the disease and compare with the traditional analysis methods. Results: 1. Acupoint - symptom complex network of acupuncture and moxibustion classic books all show \"small world effect\", among which acupoint nodes' close centrality and feature vector centrality indexes present acupoint specificity, which can be used as acupoint weight index for weighted average algorithm; 2. The original point resistivity abnormality rate of patients with diarrhea irritable bowel syndrome was 40.71%, and that of healthy subjects was 29.49%.The resistance of patients with irritable bowel syndrome was higher than that of healthy subjects. 3. Based on the weighted average algorithm of intermediary centrality or eigenvector centrality, the weighted average of topological parameters of primary point resistance in patients with diarrhea irritable bowel syndrome was higher than that of healthy subjects. Conclusion: 1. Having \"small-world effect\" may be one of the topological characteristics of acupoint-symptom complex network; 2. The increase of skin primary point resistance in patients with IBS-D is a manifestation of acupoint sensitization; 3. Acupoint Hegu( LI4) sensitization on behalf of the large intestine meridian is one of the specific manifestations of primary acupoint sensitization in patients with diarrhea irritable bowel syndrome; 4. It is a feasible attempt to study and express the law of acupoint sensitization based on graph theory.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89926996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timeline for Corona Vaccine Trials","authors":"A. Gulia","doi":"10.36648/2386-5180.21.9.338","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.338","url":null,"abstract":"Coronavirus disease (2019) has become global pandemic disease with top threat to human health in 2019, there is a race going between vaccine makers to develop covid-19 vaccines, as vaccine development is a typical longest thing to develop with safety and efficacy, to meet challenges. There’s been urgent need for therapeutic counter measure for rapid developing virus for controlling the outbreak, first case of Covid was firstly seen In December, from then there are variable attempts to get and generate suitable vaccine in labs. The fastest vaccine trial had been done is corona vaccine with large trials, vaccine made by Pfizer and Biotech have done firstly tested immunization and got approved for vaccine for emergency use. From years there been trials going on related to corona virus which causes SARS – severe acute respiratory syndrome and efforts have paid off spectacularly","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75166454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Research Advancements in Corona Virus","authors":"A. Gulia","doi":"10.36648/2386-5180.21.9.337","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.337","url":null,"abstract":"In case of global pandemic corona virus disease 2019, clinical trials and research are assessing efficacy and safety for clinical patients for treating covid-19 as, it is evolving at unprecedented rate, by tracking clinical trials done and avoiding duplication efforts and phase2 clinical trials evaluate new therapeutics and by including investigational therapeutic effort on synthetic monoclonal antibodies (mAbs) for treating disease. Trials designed to elaborate test multiple different kind of monoclonal antibody treatment.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78137916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single strand conformation polymorphism: Principle and Troubleshoots","authors":"Mona Sharma","doi":"10.36648/2386-5180.21.9.336","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.336","url":null,"abstract":"One of the common techniques used to identify unknown mutations is single strand conformation polymorphism (SSCP).SSCP is used frequently because the technique is simple, fast, sensitive and reproducible. It has been frequently reported that it is very easy to establish this technique with minimal infrastructure and expenditure. This short communication presents the basic principles of SSCP and possible troubleshoots of standardization of this technique in the lab.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76095909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of blood exposure, increased catecholamine levels and inflammatory mediators on brain microvascular endothelial cell integrity in vitro","authors":"M. Smetak, Cora Ittner, M. Burek, M. Nagai, C. Förster","doi":"10.36648/2386-5180.21.9.344","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.344","url":null,"abstract":"Introduction: Recent studies have suggested the impact of increased catecholamine levels CAT and inflammatory mediators INF on blood on the integrity of the blood brain barrier (BBB), especially when occurring in combination with hemorrhagic stroke, a situation frequently observed in Taktosubo syndrome TTS. We investigated the possible effects of these stressors on the brain microvascular endothelium in vitro. Methods: As an in vitro model of the BBB we used an immortalized murine microvascular endothelial cell line from the cerebral cortex (cEND). The cEND were treated with medium or patient blood containing supraphysiological concentrations of stress factors such as catecholamines, TNF-α and Interleukin-6 as characteristically elevated in patient blood  suffering from acute takotsubo syndrome TTS. We investigated the impact on monolayer integrity and cellular morphology by light microscopy and immunofluorescence staining. Furthermore, alterations of representative tight and adherence junction proteins as well as integrins were determined by RT-PCR and/or Western Blot. Results: After stress factor/ patient blood treatment, reduced viability of brain capillary endothelial cells in vitro was observed. This was concomitant with a disruption of cellular monolayer integrity and changed localisation of BBB-forming tight junction proteins as determined by real-time RT-PCR (qPCR), western blot and immunofluorescence labeling. Monolayer integrity was moreover determined by measurement of transendothelial electrical resistance. Conclusion: Cellular monolayer integrity and the expression of proteins forming the BBB are clearly affected by exposure to patient blood, catecholamines CAT and inflammatory mediators INF, respectively. Most of barrier proteins are downregulated, so a negative impact on brain endothelial cells forming the blood-brain barrier can be assumed.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84072559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunology and Multiple Sclerosis Risk with Air Pollution","authors":"Divya Thir, As","doi":"10.36648/2386-5180.21.9.361","DOIUrl":"https://doi.org/10.36648/2386-5180.21.9.361","url":null,"abstract":"Neurological rehabilitation (rehab) could be a doctor-supervised program designed for folks with diseases, injury or disorders of the system nervous. Medical specialty rehab will usually improve operate, scale back symptoms, and improve the wellbeing of the patient. The primary objective of psychology rehabilitation is to boost the standard of lifetime of people United Nations agency have sustained medical specialty insult, which can involve psychological feature, behavioral, emotional, and social factors. Any and every one of those factors could have an effect on social, marital, vocational, instructional, and recreational domains, additionally to purposeful independence in activities of daily living. Various outcome studies have reported positive leads to defensive the effectuality of psychology rehabilitation programs, with relevance psychosocial standing.","PeriodicalId":8195,"journal":{"name":"Annals of Clinical and Laboratory Research","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74013156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}