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Journal of HIV therapy最新文献

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Maturation inhibitors as new antiretroviral agents. 成熟抑制剂作为新的抗逆转录病毒药物。
Journal of HIV therapy Pub Date : 2008-12-01
John Richards, Scott McCallister
{"title":"Maturation inhibitors as new antiretroviral agents.","authors":"John Richards, Scott McCallister","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"13 4","pages":"79-82"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28154277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting the HIV integration process in antiviral therapy. 靶向HIV整合过程的抗病毒治疗。
Journal of HIV therapy Pub Date : 2008-12-01
Melissa McNeely, Frauke Christ, Wannes Thys, Zeger Debyser
{"title":"Targeting the HIV integration process in antiviral therapy.","authors":"Melissa McNeely, Frauke Christ, Wannes Thys, Zeger Debyser","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"13 4","pages":"83-92"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28154278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging techniques for Kaposi's sarcoma. 卡波西肉瘤的成像技术。
Journal of HIV therapy Pub Date : 2008-09-01
D O'Mahony, Ah Gandjbakche, M Hassan, A Vogel, R Yarchoan
{"title":"Imaging techniques for Kaposi's sarcoma.","authors":"D O'Mahony, Ah Gandjbakche, M Hassan, A Vogel, R Yarchoan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Kaposi[']s sarcoma (KS) is a multicentric tumour that most frequently involves the skin but can involve other tissues as well. Clinicians treating patients with KS or conducting clinical trials in this disease can benefit from imaging studies to document the extent of disease, to document changes with therapy, and to assess the extent of visceral and lymphatic involvement. A number of conventional techniques can be of use in meeting these needs, such as conventional light photography to assess skin or mucosal lesions, computed tomography of the chest to assess pulmonary disease, and magnetic resonance imaging. In addition, a number of techniques are being developed with the goals of providing improved differentiation of KS from other diseases or providing information about the degree of angiogenesis in the lesions and other physiological factors. We present here an overview of both established and experimental modalities of imaging in KS.</p>","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"13 3","pages":"65-71"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600536/pdf/nihms73422.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27864647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic resonance imaging and spectroscopy of the brain in HIV disease. HIV疾病中的脑磁共振成像和波谱。
Journal of HIV therapy Pub Date : 2008-09-01
Mjl Descamps, H Hyare, J Stebbing, A Winston
{"title":"Magnetic resonance imaging and spectroscopy of the brain in HIV disease.","authors":"Mjl Descamps,&nbsp;H Hyare,&nbsp;J Stebbing,&nbsp;A Winston","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Severe AIDS dementia complex is now a rare clinical condition in resource-rich settings in HIV-1-infected patients with access to modern antiretroviral therapies. However, minor neurocognitive decline and central nervous system abnormalities have been reported in clinical studies assessing HIV-1-infected subjects on modern antiretroviral therapy with undetectable plasma HIV-RNA. Ongoing characterisation and monitoring of these abnormalities are crucial to aid our understanding and assess future interventions. New magnetic resonance imaging (MRI) techniques, provide a non-invasive mechanism to assess impaired brain function (functional MRI, fMRI) and detect changes in brain biochemistry (magnetic resonance spectroscopy, MRS). In this review, changes described by fMRI and MRS in HIV disease both in the pre- and post-combination antiretroviral therapy eras are summarised.</p>","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"13 3","pages":"55-8"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27864516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging in multicentric Castleman's disease. 多中心Castleman病的影像学表现。
Journal of HIV therapy Pub Date : 2008-09-01
Robert Barker, Fahrad Kazmi, Mark Bower
{"title":"Imaging in multicentric Castleman's disease.","authors":"Robert Barker,&nbsp;Fahrad Kazmi,&nbsp;Mark Bower","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Multicentric Castleman[']s disease (MCD) is an uncommon lymphoproliferative disorder that presents with fevers, anaemia and multifocal lymphadenopathy and nowadays is most commonly diagnosed in individuals infected with HIV-1. CT scan findings are not sufficiently reliable to establish a diagnosis of MCD which requires histological confirmation. Newer imaging techniques have therefore been studied in patients with HIV-associated MCD in an attempt to improve diagnostic accuracy. Preliminary findings suggest that FDG PET-CT may assist in the monitoring of disease activity in MCD along with familiar clinical and laboratory tools and the more recently introduced plasma HHV8 DNA viral load measurement.</p>","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"13 3","pages":"72-4"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27864515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimaging of CNS involvement in HIV. 中枢神经系统参与HIV的神经影像学研究。
Journal of HIV therapy Pub Date : 2008-09-01
M J L Descamps, H Hyare, I Zerizer, H R Jäger
{"title":"Neuroimaging of CNS involvement in HIV.","authors":"M J L Descamps,&nbsp;H Hyare,&nbsp;I Zerizer,&nbsp;H R Jäger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Central nervous system involvement in HIV-positive patients is common with 40% of patients suffering neurological disease at some point in their lives. Neuroimaging is important to properly diagnose treatable conditions and to monitor response to treatment. In this article, we describe and illustrate the main CNS imaging findings. The following categories of pathology are addressed: direct neurological effects of HIV, opportunistic CNS infections and neoplasms, cerebrovascular complications of HIV and CNS effects of highly active retroviral therapy (HAART). Imaging techniques employed include computed tomography, magnetic resonance imaging, diffusion-weighted imaging, functional magnetic resonance imaging and magnetic resonance spectroscopy.</p>","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"13 3","pages":"48-54"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27864645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrointestinal imaging in HIV. HIV胃肠道成像。
Journal of HIV therapy Pub Date : 2008-09-01
H Neumann, Lc Fry, Cm Wilcox, K M O Nkem U Eller
{"title":"Gastrointestinal imaging in HIV.","authors":"H Neumann,&nbsp;Lc Fry,&nbsp;Cm Wilcox,&nbsp;K M O Nkem U Eller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Gastrointestinal opportunistic disorders are common in HIV-infection and are often the index AIDS-defining opportunistic illness. Almost 80% of HIV-infected patients experience gastrointestinal (GI) symptoms at some point during the course of their illness, and the incidence of GI disorders increases as immunodeficiency worsens. Endoscopy is the preferred invasive procedure for diagnosing most GI diseases in these patients because mucosal biopsy is often necessary to establish a specific diagnosis.</p>","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"13 3","pages":"58-64"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27864646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiological imaging in the context of HIV infection: size of the lesion is not everything. HIV感染的放射成像:病变的大小并不代表一切。
Journal of HIV therapy Pub Date : 2008-09-01
Mjl Descamps, Eleftheria Hatzimichael, Neel Bhuva, Justin Stebbing
{"title":"Radiological imaging in the context of HIV infection: size of the lesion is not everything.","authors":"Mjl Descamps,&nbsp;Eleftheria Hatzimichael,&nbsp;Neel Bhuva,&nbsp;Justin Stebbing","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"13 3","pages":"47-8"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27864643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New antiretroviral agents and the complexity of treatment practices. 新的抗逆转录病毒药物和治疗方法的复杂性。
Journal of HIV therapy Pub Date : 2008-06-01
Don Smith
{"title":"New antiretroviral agents and the complexity of treatment practices.","authors":"Don Smith","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"13 2","pages":"25-6"},"PeriodicalIF":0.0,"publicationDate":"2008-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27820388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New drugs. 新药。
Journal of HIV therapy Pub Date : 2008-06-01
Anton Pozniak
{"title":"New drugs.","authors":"Anton Pozniak","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"13 2","pages":"27-33"},"PeriodicalIF":0.0,"publicationDate":"2008-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27820389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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