发布求助
文献互助 智能选刊 最新文献

Journal of HIV therapy最新文献

筛选
英文 中文
The potential of heat shock protein-peptide complexes as a therapeutic HIV vaccine. 热休克蛋白-肽复合物作为治疗性HIV疫苗的潜力。
Journal of HIV therapy Pub Date : 2005-09-01
Daniel L Levey, Christian Brander, Pramod K Srivastava
{"title":"The potential of heat shock protein-peptide complexes as a therapeutic HIV vaccine.","authors":"Daniel L Levey,&nbsp;Christian Brander,&nbsp;Pramod K Srivastava","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>HIV evades host immune responses through multiple mechanisms including high mutation rate, downregulation of host-cell, HLA class I molecules and depletion of key immune cells. Accordingly, an effective therapeutic vaccine approach to controlling HIV infection will nost likely need to modulate several pathways of both the innate and adaptive immune system. We propose the use of heat shock protein-peptide complexes (HSPPCs) to address this challenge. HSPPCs have been tested for 10 years in cancer patients with signals of clinical activity in phase I and II trials, and the results of two randomised phase III trials are anticipated in the near future. As the cancer setting can also be considered one of chronic disease, the rationale for using HSPPCs to treat HIV infection is clear. Several types of HSPPC vaccines that may be manufactured for testing in HIV-positive patients are discussed, including generation of an autologous vaccine derived from peripheral blood monloonuclear cells (PBMCs) of infected individuals.</p>","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"10 3","pages":"56-9"},"PeriodicalIF":0.0,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25778040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approaches for therapeutic vaccination in HIV infection. HIV感染的治疗性疫苗接种方法。
Journal of HIV therapy Pub Date : 2005-09-01
Justin Stebbing
{"title":"Approaches for therapeutic vaccination in HIV infection.","authors":"Justin Stebbing","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"10 3","pages":"46-7"},"PeriodicalIF":0.0,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25777567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic vaccines and immunotherapy revisited. 重新审视治疗性疫苗和免疫疗法。
Journal of HIV therapy Pub Date : 2005-09-01
Frances Gotch
{"title":"Therapeutic vaccines and immunotherapy revisited.","authors":"Frances Gotch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Imunotherapy to induce long-term, non-progressor status in HIV-1-positive persons may be considered in the context of highly active antiretroviral therapy (HAART). The aim of such therapy must be to allow the induction or regeneration of HIV-1-specific immune responses which have the potential to control viraemia, and to alleviate the immunosuppression caused by HIV-1. Trials of therapeutic vaccines and/or cytokines and/or hormones have been conducted and are briefly described. In many cases, potentially beneficial transient HIV-1-specific responses which may translate into clinical advantage have been induced, but these do not persist. Future studies are warranted so that: 1) novel immunogens and other immunotherapeutic agents are further defined and optimised; 2) therapeutic regimens are carefully and rationally designed; and 3) patients are followed for protracted periods of time to observe clinical benefit.</p>","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"10 3","pages":"48-50"},"PeriodicalIF":0.0,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25777568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HIV-1 in the male genital tract: evidence and impact of compartmentalisation. HIV-1在男性生殖道:分区化的证据和影响。
Journal of HIV therapy Pub Date : 2005-06-01
Derek J Chan
{"title":"HIV-1 in the male genital tract: evidence and impact of compartmentalisation.","authors":"Derek J Chan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"10 2","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27366093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HIV in the lymphoid compartment. 淋巴细胞室中的HIV。
Journal of HIV therapy Pub Date : 2005-06-01
Roger J Garsia
{"title":"HIV in the lymphoid compartment.","authors":"Roger J Garsia","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"10 2","pages":"10-5"},"PeriodicalIF":0.0,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27366094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Importance of understanding what is happening with HIV in different body compartments. 了解艾滋病毒在不同身体部位发生的情况很重要。
Journal of HIV therapy Pub Date : 2005-06-01
Don Smith
{"title":"Importance of understanding what is happening with HIV in different body compartments.","authors":"Don Smith","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"10 2","pages":"3-4"},"PeriodicalIF":0.0,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27366092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical significance of central nervous system as sanctuary site for HIV. 中枢神经系统作为艾滋病病毒避难所的临床意义。
Journal of HIV therapy Pub Date : 2005-06-01
Julie Batmanian, Bruce J Brew
{"title":"Clinical significance of central nervous system as sanctuary site for HIV.","authors":"Julie Batmanian,&nbsp;Bruce J Brew","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"10 2","pages":"16-21"},"PeriodicalIF":0.0,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27366095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New drugs. 新药。
Journal of HIV therapy Pub Date : 2005-03-01
Laura Waters, Mark R Nelson
{"title":"New drugs.","authors":"Laura Waters,&nbsp;Mark R Nelson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"10 1","pages":"16-8"},"PeriodicalIF":0.0,"publicationDate":"2005-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25132758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salvage therapy. 抢救治疗。
Journal of HIV therapy Pub Date : 2005-03-01
Brian Gazzard
{"title":"Salvage therapy.","authors":"Brian Gazzard","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"10 1","pages":"3-5"},"PeriodicalIF":0.0,"publicationDate":"2005-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25132856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The clinical significance of viral fitness. 病毒适应度的临床意义。
Journal of HIV therapy Pub Date : 2005-03-01
Anna Maria Geretti
{"title":"The clinical significance of viral fitness.","authors":"Anna Maria Geretti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Increasing evidence indicates that antiretroviral drug resistance is associated with impaired viral fitness and that this impairment can translate, at least transiently, into a virological and immunological benefit. The optimal strategies for exploiting the fitness cost associated with drug resistance remain to be determined. For highly drug-experienced patients receiving salvage therapy with a detectable viral load and with limited or no remaining drug options, continuing the current regimen may be a useful strategy to delay disease progression. In this context, it remains controversial whether it is preferable to continue failing therapy with nucleoside reverse transcriptase inhibitors, protease inhibitors or both.</p>","PeriodicalId":81665,"journal":{"name":"Journal of HIV therapy","volume":"10 1","pages":"6-10"},"PeriodicalIF":0.0,"publicationDate":"2005-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25132756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信